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公开(公告)号：US5263944A
公开(公告)日：1993-11-23
申请号：US949388
申请日：1992-09-22
CPC分类号： A61B17/3462 , A61B2017/3419
摘要： An adapter seal adapted to facilitate the use of a small instrument within a laparoscopic cannula. The adapter seal comprises a body portion formed of elastomeric material, and a relatively rigid insertion guide mounted on the body portion The body portion has an aperture therein adapted to sealingly engage and support the small instrument while permitting movement of the instrument through the aperture The insertion guide has a wall forming a generally conical passageway for guiding small instruments toward the aperture of the body portion. A tether may be provided for holding the adapter seal adjacent the cannula when the body portion is disconnected from the cannula, and the insertion guide may be color-coded to indicate the size aperture through the body portion of the adapter seal.
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公开(公告)号：US4633971A
公开(公告)日：1987-01-06
申请号：US796016
申请日：1985-11-06
申请人： David L. Robbins
发明人： David L. Robbins
IPC分类号： A61B7/02
CPC分类号： A61B7/02
摘要： A low-pass filter is incorporated into the binaural tube of a stethoscope to selectively attenuate high frequency noise. The filter includes a small diameter inertance tube communicating with a large volume compliance chamber and is preferably located as far as possible from the chestpiece of the stethoscope to filter noise not only transmitted from the chestpiece, but also transmitted directly to the binaural tube.
摘要翻译： 低通滤波器被并入到听诊器的双耳管中以选择性地衰减高频噪声。 该过滤器包括与大体积依从室连通的小直径惯性管，并且优选地尽可能远离听诊器的胸部，以过滤不仅从胸部传递的噪声，而且还直接传递到双耳管。
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公开(公告)号：US20140030232A1
公开(公告)日：2014-01-30
申请号：US13816723
申请日：2011-08-12
申请人： Daniel Shoemaker , Pratik Multani , Caroline Desponts , David L. Robbins , Paul Grayson , John Mendlein
发明人： Daniel Shoemaker , Pratik Multani , Caroline Desponts , David L. Robbins , Paul Grayson , John Mendlein
IPC分类号： C12N5/0789 , A61K35/28
摘要： The invention provides improved methods for cell therapy. In particular, the invention provides therapeutic compositions of modified hematopoietic stem and/or progenitor cells having improved engraftment and homing properties, and methods of making the therapeutic composition. The invention further provides methods of improving the efficacy of hematopoietic stem and progenitor cell transplantation including transplanting the therapeutic composition to subjects in need of hematopoietic system reconstitution.
摘要翻译： 本发明提供了改进的细胞治疗方法。 特别地，本发明提供了具有改善的植入和归巢性质的修饰的造血干细胞和/或祖细胞的治疗组合物，以及制备治疗组合物的方法。 本发明还提供了改善造血干细胞和祖细胞移植功效的方法，包括将治疗组合物移植到需要造血系统重建的受试者身上。
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公开(公告)号：US4466433A
公开(公告)日：1984-08-21
申请号：US327552
申请日：1981-12-04
申请人： David L. Robbins
发明人： David L. Robbins
IPC分类号： A61M16/00
CPC分类号： A61M16/00
摘要： An infant ventilator is described of the type that switches between an inspiration phase during which gas under pressure is applied through a mouthpiece to cause involuntary inspiration of the infant to which the mouthpiece is coupled, and an expiration phase during which the infant is allowed to exhale or voluntarily inhale through the mouthpiece while gas flows past the mouthpiece. An overpressure relief system is included to monitor the pressure in the patient circuit and react to pressures above an operator-selected level by halting inflow of gas into the patient circuit, exhausting patient pressure to the atomsphere, and producing an alarm.
摘要翻译： 描述了一种婴儿呼吸机，其类型是在吸气阶段之间切换，在该阶段期间通过吸嘴施加压力下的气体，引起接口与其接合的婴儿的不自主的吸引，以及允许婴儿呼气的呼吸阶段 或者当气体流过喉舌时自愿吸入口腔。 包括超压释放系统以监测患者回路中的压力，并通过停止气体进入患者回路，排出患者对原子团的压力和产生警报而对操作员选择的水平以上的压力作出反应。
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公开(公告)号：US4457304A
公开(公告)日：1984-07-03
申请号：US327553
申请日：1981-12-04
申请人： Hugo Molnar , David L. Robbins
发明人： Hugo Molnar , David L. Robbins
IPC分类号： A61M16/00
CPC分类号： A61M16/00
摘要： An infant ventilator of the type that switches between an inspiration phase during which gas under pressure is applied through a mouthpiece to cause involuntary inspiration of an infant to which the mouthpiece is coupled, and an expiration phase during which the infant is allowed to exhale or voluntarily inhale through the mouthpiece while gas flows past the mouthpiece. The gas delivery system in the ventilator is interconnected so as to regulate the gas pressure at the mouthpiece during the expiration phase to generally atmospheric pressure (in the absence of operator selected PEEP) for any flow rate of gas past the mouthpiece in the expiration phase in the range of about 0 to 25 liters per minute as selected by a flow control valve without the need for further manual adjustments.
摘要翻译： 一种婴儿呼吸机，其在吸气阶段之间切换，在该阶段期间，通过吸嘴施加压力下的气体，引起接口与其接合的婴儿的不自主的吸气，以及允许婴儿呼气或自愿的呼吸阶段 当气体流过喉舌时，通过喉舌吸气。 呼吸机中的气体输送系统是相互连接的，以便在呼气阶段将吸气口处的气体压力调节到一般大气压（在没有操作者选择的PEEP的情况下），以使气体在呼气期间通过吸嘴的任何流速 通过流量控制阀选择约0至25升/分钟的范围，而不需要进一步的手动调节。
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公开(公告)号：US20100304978A1
公开(公告)日：2010-12-02
申请号：US12657723
申请日：2010-01-26
CPC分类号： C12Q1/6879 , C12Q1/6841 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16
摘要： The present invention provides methods and compositions for specifically identifying a fetal cell. An initial screening of approximately 400 candidate genes by digital PCR in different fetal and adult tissues identified a subset of 24 gene markers specific for fetal nucleated RBC and trophoblasts. The specific expression of those genes was further evaluated and verified in more defined tissues and isolated cells through quantitative RT-PCR using custom Taqman probes specific for each gene. A subset of fetal cell specific markers (FCM) was tested and validated by RNA fluorescent in situ hybridization (FISH) in blood samples from non-pregnant women, and pre-termination and post-termination pregnant women. Applications of these gene markers include, but are not limited to, distinguishing a fetal cell from a maternal cell for fetal cell identification and genetic diagnosis, identifying circulating fetal cell types in maternal blood, purifying or enriching one or more fetal cells, and enumerating one or more fetal cells during fetal cell enrichment.
摘要翻译： 本发明提供用于特异性鉴定胎儿细胞的方法和组合物。 通过数字PCR在不同的胎儿和成体组织中初步筛选约400个候选基因，鉴定了胎儿有核RBC和滋养细胞特异性的24个基因标记的子集。 通过使用特定于每个基因的定制的Taqman探针通过定量RT-PCR进一步评估和验证了在更确定的组织和分离的细胞中这些基因的特异性表达。 胎儿细胞特异性标志物（FCM）的子集在非孕妇血液样本和终止前和终止后的孕妇中通过RNA荧光原位杂交（FISH）进行测试和验证。 这些基因标记物的应用包括但不限于胎儿细胞区分胎儿细胞鉴定和遗传诊断的胎儿细胞，识别母体血液中的循环胎儿细胞类型，纯化或富集一个或多个胎儿细胞，并列举一个 胎儿细胞富集的胎儿细胞。
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公开(公告)号：US5154335A
公开(公告)日：1992-10-13
申请号：US583175
申请日：1990-09-14
IPC分类号： A61B5/0402 , A61B5/0408 , B65D83/08 , B65D85/672 , B65H35/00
CPC分类号： A61B5/0408 , A61B5/04026 , B65D85/672 , B65H35/002 , Y10T225/239 , Y10T225/257 , Y10T225/297
摘要： The present invention provides in combination, a supply roll comprising an elongate liner, a multiplicity of electrodes, and a coating of moist adhesive on the electrodes that releasably adheres the electrodes in spaced relationship along the liner, and a refillable air-restricting dispenser comprising a plurality of walls forming a housing. The walls comprise a hollow tubular peripheral wall, and first and second opposite end walls, and define a central cavity within the housing. The peripheral wall has a slot communicating between inner and outer surfaces of the peripheral wall. The slot is adapted to afford passage of the liner with electrodes adhered thereto. A shield is present which covers the slot, and an element mounts the shield on the housing for movement between an open position spaced from at least a portion of the slot to afford withdrawing the end portion of the liner with the electrodes adhered thereto through the slot, and a closed position over at least the portion of the slot adjacent the liner to restrict entry of air into the cavity. One of the end walls is removable to afford replacement of a depleted supply roll.
摘要翻译： 本发明组合提供一种包括细长衬垫，多个电极以及电极上的湿粘合剂涂层的供应辊，其沿着衬垫沿间隔开的方式可释放地粘附电极，以及可再填充空气限制分配器，其包括： 多个壁形成壳体。 壁包括中空的管状周壁，以及第一和第二相对端壁，并且在壳体内限定中心空腔。 周壁具有在周壁的内表面和外表面之间连通的槽。 该槽适于提供衬垫与其附着的电极的通过。 存在覆盖狭槽的屏蔽件，并且元件将屏蔽件安装在壳体上以在与槽的至少一部分间隔开的打开位置之间移动，以提供衬垫的端部，其中电极通过狭槽粘附到其上 ，并且至少靠近衬套的槽的部分处的关闭位置以限制空气进入空腔。 其中一个端壁是可拆卸的，以便更换耗尽的供应辊。
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8.发明授权
公开(公告)号：US5004025A
公开(公告)日：1991-04-02
申请号：US413207
申请日：1989-09-27
申请人： David L. Robbins
发明人： David L. Robbins
IPC分类号： E03C1/30
摘要： An anti-drain clogging device used to containerize and dispense anti-clogging solution into a drain pipe in a controlled slow flow manner over an extended period of time. The anti-drain clogging device has a main container section for holding anti-drain clogging solution and a dispensing section for directing the anti-drain clogging solution from the container section to the inlet of a drain pipe. The device has both a liquid-tight, stable storage mode that the device is placed in prior to use and an operational mode where the device is adjustably fixed over a drain pipe inlet. In the operational mode, the dispensing section is adjusted to a chosen position over the opening of the drain pipe inlet by adjusting a support collar attached to the device. In this position, anti-clogging drain solution drips from the dispensing section in a controlled, slow manner into the drain pipe to steadily dissolve, layer by layer, the clogging and sediment in the pipe over a period of time.
摘要翻译： 一种防排水堵塞装置，用于在长时间内以受控的缓慢流动方式将防堵塞溶液集中和分配到排水管中。 防排水堵塞装置具有用于保持防漏堵塞溶液的主容器部分和用于将排泄堵塞溶液从容器部分引导到排水管入口的分配部分。 该装置具有液体密封，稳定的存储模式，该装置在使用之前被放置，以及操作模式，其中装置可调节地固定在排水管入口上。 在操作模式中，通过调节附接到该装置的支撑轴环，将分配部分调节到排水管入口的开口上的选定位置。 在这种位置上，防堵漏排水溶液以控制缓慢的方式从分配部分滴入排水管中，一段时间内逐渐地溶解管道中的堵塞和沉淀物。
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