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    HEMATOPOIETIC STEM AND PROGENITOR CELL THERAPY
    1.
    发明申请
    HEMATOPOIETIC STEM AND PROGENITOR CELL THERAPY 审中-公开

    公开(公告)号：US20140030232A1

    公开(公告)日：2014-01-30

    申请号：US13816723

    申请日：2011-08-12

    申请人： Daniel Shoemaker ,  Pratik Multani ,  Caroline Desponts ,  David L. Robbins ,  Paul Grayson ,  John Mendlein

    发明人： Daniel Shoemaker ,  Pratik Multani ,  Caroline Desponts ,  David L. Robbins ,  Paul Grayson ,  John Mendlein

    IPC分类号： C12N5/0789 ,  A61K35/28

    摘要： The invention provides improved methods for cell therapy. In particular, the invention provides therapeutic compositions of modified hematopoietic stem and/or progenitor cells having improved engraftment and homing properties, and methods of making the therapeutic composition. The invention further provides methods of improving the efficacy of hematopoietic stem and progenitor cell transplantation including transplanting the therapeutic composition to subjects in need of hematopoietic system reconstitution.

    摘要翻译： 本发明提供了改进的细胞治疗方法。 特别地，本发明提供了具有改善的植入和归巢性质的修饰的造血干细胞和/或祖细胞的治疗组合物，以及制备治疗组合物的方法。 本发明还提供了改善造血干细胞和祖细胞移植功效的方法，包括将治疗组合物移植到需要造血系统重建的受试者身上。

    Inhibition of SHIP to enhance stem cell harvest and transplantation
    7.
    发明授权
    Inhibition of SHIP to enhance stem cell harvest and transplantation 有权
    抑制SHIP增强干细胞的收获和移植

    公开(公告)号：US07691821B2

    公开(公告)日：2010-04-06

    申请号：US10709801

    申请日：2004-05-28

    申请人： Caroline Desponts ,  Joseph Wahle ,  John Ninos ,  William G. Kerr

    发明人： Caroline Desponts ,  Joseph Wahle ,  John Ninos ,  William G. Kerr

    IPC分类号： A01N43/04 ,  C12N5/08 ,  C12P19/34 ,  C07H21/02 ,  C07H21/04

    CPC分类号： C12N15/1137 ,  C12N2310/111 ,  C12N2310/14 ,  C12N2310/53

    摘要： The instant invention teaches the inhibition of SHIP expression, or function, for the increased efficacy of autologous stem cell transplants. In another embodiment, interference with SHIP function can be used to temporarily expand and mobilize the hematopoietic stem cell compartment to assist with leukapheresis, to promote hematopoietic recovery after myeloablation treatments, to deplete target stem cell clones (such a leukemic clones and other tumor stem cell types), and to deplete, or damage, the repopulating ability of the endogenous hematopoietic stem cell pool in order to allow transplanted hematopoietic stem cells to better home and engraft and to promote in vivo expansion and mobilization of other organ-specific stem cell populations (e.g., mesenchymal, mammary).

    摘要翻译： 本发明教导了对自体干细胞移植物增加功效的SHIP表达或功能的抑制。 在另一个实施方案中，可以使用与SHIP功能的干扰来暂时扩增和动员造血干细胞隔室以协助白细胞分离术，以促进骨髓消融治疗后的造血恢复，以消耗目标干细胞克隆（如白血病克隆和其他肿瘤干细胞 类型），并且消耗或损害内源性造血干细胞池的再生能力，以便允许移植的造血干细胞更好地回家和移植并促进其他器官特异性干细胞群的体内扩增和动员（ 例如间充质，乳腺）。

    Inhibition of SHIP to Enhance Stem Cell Harvest and Transplantation
    9.
    发明申请
    Inhibition of SHIP to Enhance Stem Cell Harvest and Transplantation 审中-公开
    抑制SHIP增强干细胞收获和移植

    公开(公告)号：US20110052546A1

    公开(公告)日：2011-03-03

    申请号：US12689167

    申请日：2010-01-18

    申请人： Caroline Desponts ,  Joseph Wahle ,  John M. Ninos ,  William G. Kerr

    发明人： Caroline Desponts ,  Joseph Wahle ,  John M. Ninos ,  William G. Kerr

    IPC分类号： A61K35/12 ,  A61P35/00 ,  A61P9/00 ,  A61P25/00 ,  C12N5/074

    CPC分类号： C12N15/1137 ,  C12N2310/111 ,  C12N2310/14 ,  C12N2310/53

    摘要： The instant invention teaches the inhibition of SHIP expression, or function for the increased efficacy of autologous stem cell transplants. In another embodiment, interference with SHIP function can be used to temporarily expand and mobilize the hematopoietic stem cell compartment to assist with leukapheresis, to promote hematopoietic recovery after myeloablation treatments, to deplete target stem cell clones (such as leukemic clones and other tumor stem cell types), and to deplete, or damage, the repopulating ability of the endogenous hematopoietic stem cell pool in order to allow transplanted hematopoietic stem cells to better home and engraft and to promote in vivo expansion and mobilization of other organ-specific stem cell populations (e.g., mesenchymal, mammary).

    摘要翻译： 本发明教导了SHIP表达的抑制或自体干细胞移植增加功效的功能。 在另一个实施方案中，可以使用与SHIP功能的干扰来暂时扩增和动员造血干细胞隔室以协助白细胞分离术，促进骨髓消融治疗后的造血恢复，从而耗尽目标干细胞克隆（如白血病克隆和其他肿瘤干细胞 类型），并且消耗或损害内源性造血干细胞池的再生能力，以便允许移植的造血干细胞更好地回家和移植并促进其他器官特异性干细胞群的体内扩增和动员（ 例如间充质，乳腺）。