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    TECHNOLOGY PORTFOLIO HEALTH ASSESSMENT SYSTEM AND METHOD
    9.
    发明申请
    TECHNOLOGY PORTFOLIO HEALTH ASSESSMENT SYSTEM AND METHOD 有权
    技术组合健康评估系统及方法

    公开(公告)号：US20060224479A1

    公开(公告)日：2006-10-05

    申请号：US10907319

    申请日：2005-03-29

    申请人： Fred Bishop ,  Sherry Easterwood ,  Pradeep George ,  Robert Gilmore ,  James Mathews ,  Lawrence Mitsch ,  James Rottman ,  James Thornton

    发明人： Fred Bishop ,  Sherry Easterwood ,  Pradeep George ,  Robert Gilmore ,  James Mathews ,  Lawrence Mitsch ,  James Rottman ,  James Thornton

    IPC分类号： G06Q40/00

    CPC分类号： G06Q40/00 ,  G06Q40/04 ,  G06Q40/06

    摘要： A system and method for producing infrastructure health assessments enabling enterprises to monitor the health of individual technology portfolios and plan accordingly is disclosed. The tool uses two primary assessments to determine: 1) an infrastructure score based the general health of asset components; and 2) adaptability score based on asset components ability to interact with other elements within the asset. To generate the assessment scores, the tool accepts inventory input specific to a portfolio's assets and components. A user interacting with the tool provides classification information relating to each asset and component. The tool then calculates health assessment scores for both individual portfolio assets and for the portfolio as a whole.

    摘要翻译： 披露了一种用于生产基础设施健康评估的系统和方法，使企业能够相应地监测个别技术组合的健康和计划。 该工具使用两个主要评估来确定：1）基于资产组成部分的总体健康状况的基础设施评分; 和2）基于资产组件与资产内其他元素交互的能力的适应性评分。 为了产生评估分数，该工具接受特定于投资组合的资产和组件的库存输入。 与工具交互的用户提供与每个资产和组件相关的分类信息。 该工具然后计算个人投资组合资产和整个投资组合的健康评估分数。

    Modulation of systemic memory T cell trafficking
    10.
    发明申请
    Modulation of systemic memory T cell trafficking 审中-公开
    调节系统记忆T细胞运输

    公开(公告)号：US20050169918A1

    公开(公告)日：2005-08-04

    申请号：US11061052

    申请日：2005-02-17

    申请人： Eugene Butcher ,  James Campbell ,  Lijun Wu ,  James Rottman

    发明人： Eugene Butcher ,  James Campbell ,  Lijun Wu ,  James Rottman

    IPC分类号： A61K45/00 ,  A61K38/00 ,  A61K38/19 ,  A61K39/395 ,  A61P17/02 ,  A61P17/06 ,  A61P19/02 ,  A61P29/00 ,  A61P31/12 ,  A61P37/02 ,  A61P37/08 ,  C07K16/24 ,  C07K16/28 ,  G01N33/567

    CPC分类号： C07K16/2866 ,  A61K38/195 ,  A61K2039/505 ,  C07K16/24

    摘要： Methods are provided to specifically modulate the trafficking of systemic memory T cells, particularly CD4+ T cells, without affecting naive T cells or intestinal memory T cells. It is shown that systemic memory T cells, which are characterized as CD45Ra−, and integrin α4β7−, express high levels of CCR4. Ligands of CCR4, such as TARC or MDC, act as an adhesion trigger, wherein upon CCR4 binding, these cells undergo integrin-dependent arrest to the appropriate vascular receptor(s). This arrest acts to localize the cells at the target site. The methods of the invention manipulate this triggering, and CCR4 mediated chemotaxis, to affect the localization of T cells in targeted tissues. In one embodiment of the invention, the active agent is a CCR4 agonist, that acts to enhance T cell localization. In an alternative embodiment, the agent is an antagonist that blocks CCR4 biological activity. An advantage of the invention is the selectivity for systemic memory T cells, without affecting native T cells or intestinal memory T cells.

    摘要翻译： 提供方法以特异性调节系统记忆T细胞，特别是CD4 + T细胞的运输，而不影响幼稚T细胞或肠内记忆T细胞。 其表征为CD45Rα和/或整合素α4beta7的系统记忆T细胞表达高水平的CCR4。 CCR4的配体如TARC或MDC作为粘附触发剂，其中在CCR4结合时，这些细胞经受整合素依赖性阻滞至合适的血管受体。 这次逮捕行动使细胞在目标地点本地化。 本发明的方法操纵这种触发和CCR4介导的趋化性，以影响T细胞在靶向组织中的定位。 在本发明的一个实施方案中，活性剂是用于增强T细胞定位的CCR4激动剂。 在替代实施方案中，所述试剂是阻断CCR4生物活性的拮抗剂。 本发明的优点是对全身记忆性T细胞的选择性，而不影响天然T细胞或肠内记忆T细胞。