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1.Aptamer therapeutics useful in the treatment of complement-related disorders 有权
标题翻译: 适用于治疗补体相关疾病的适体药物公开(公告)号:US07803931B2
公开(公告)日:2010-09-28
申请号:US11058134
申请日:2005-02-14
申请人: Claude Benedict , John Diener , David Epstein , Dilara Grate , Sara Chesworth Keene , Jeffrey Kurz , Markus Kurz , Thomas Greene McCauley , James Rottman , Kristin Thompson , Charles Wilson , Anna J. Zoltoski
发明人: Claude Benedict , John Diener , David Epstein , Dilara Grate , Sara Chesworth Keene , Jeffrey Kurz , Markus Kurz , Thomas Greene McCauley , James Rottman , Kristin Thompson , Charles Wilson , Anna J. Zoltoski
IPC分类号: C07H21/04
CPC分类号: C12N15/115 , A61K47/60 , C12N2310/16 , C12N2310/317 , C12N2310/321 , C12N2310/322 , C12N2310/344 , C12N2310/351 , C12N2310/3533 , C12N2310/3521
摘要: The invention provides nucleic acid therapeutics and methods for using these nucleic acid therapeutics in the treatment of complement-related disorders.
摘要翻译: 本发明提供了使用这些核酸治疗剂治疗补体相关疾病的核酸治疗剂和方法。
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公开(公告)号:US07538211B2
公开(公告)日:2009-05-26
申请号:US11318227
申请日:2005-12-22
申请人: Claude Benedict , John Diener , David Epstein , Dilara Grate , Sara Chesworth Keene , Jeffrey Kurz , Markus Kurz , Thomas Greene McCauley , James Rottman , Kristin Thompson , Charles Wilson , Anna J. Zoltoski
发明人: Claude Benedict , John Diener , David Epstein , Dilara Grate , Sara Chesworth Keene , Jeffrey Kurz , Markus Kurz , Thomas Greene McCauley , James Rottman , Kristin Thompson , Charles Wilson , Anna J. Zoltoski
IPC分类号: C07H21/04 , G01N33/551
CPC分类号: C12N15/115 , C12N2310/16 , C12N2310/317 , C12N2310/321 , C12N2310/322 , C12N2310/3521
摘要: The invention provides nucleic acid therapeutics and methods for using these nucleic acid therapeutics in the treatment of complement-related disorders.
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公开(公告)号:US20060018871A1
公开(公告)日:2006-01-26
申请号:US11058134
申请日:2005-02-14
申请人: Claude Benedict , John Diener , David Epstein , Dilara Grate , Sara Keene , Jeffrey Kurz , Markus Kurz , Thomas McCauley , James Rottman , Kristin Thompson , Charles Wilson , Anna Zoltoski
发明人: Claude Benedict , John Diener , David Epstein , Dilara Grate , Sara Keene , Jeffrey Kurz , Markus Kurz , Thomas McCauley , James Rottman , Kristin Thompson , Charles Wilson , Anna Zoltoski
CPC分类号: C12N15/115 , A61K47/60 , C12N2310/16 , C12N2310/317 , C12N2310/321 , C12N2310/322 , C12N2310/344 , C12N2310/351 , C12N2310/3533 , C12N2310/3521
摘要: The invention provides nucleic acid therapeutics and methods for using these nucleic acid therapeutics in the treatment of complement-related disorders.
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公开(公告)号:US20060105980A1
公开(公告)日:2006-05-18
申请号:US11318227
申请日:2005-12-22
申请人: Claude Benedict , John Diener , David Epstein , Dilara Grate , Sara Keene , Jeffrey Kurz , Markus Kurz , Thomas McCauley , James Rottman , Kristin Thompson , Charles Wilson , Anna Zoltoski
发明人: Claude Benedict , John Diener , David Epstein , Dilara Grate , Sara Keene , Jeffrey Kurz , Markus Kurz , Thomas McCauley , James Rottman , Kristin Thompson , Charles Wilson , Anna Zoltoski
CPC分类号: C12N15/115 , C12N2310/16 , C12N2310/317 , C12N2310/321 , C12N2310/322 , C12N2310/3521
摘要: The invention provides nucleic acid therapeutics and methods for using these nucleic acid therapeutics in the treatment of complement-related disorders.
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公开(公告)号:US08436164B2
公开(公告)日:2013-05-07
申请号:US13525680
申请日:2012-06-18
申请人: Claude Benedict , David Epstein , Charles Wilson , Dilara McCauley , Jeffrey Kurz , Markus Kurz , Thomas Greene McCauley , James Rottman
发明人: Claude Benedict , David Epstein , Charles Wilson , Dilara McCauley , Jeffrey Kurz , Markus Kurz , Thomas Greene McCauley , James Rottman
IPC分类号: C07H21/04
CPC分类号: C12N15/115 , A61K47/60 , C12N2310/16 , C12N2310/317 , C12N2310/321 , C12N2310/322 , C12N2310/344 , C12N2310/351 , C12N2310/3533 , C12N2310/3521
摘要: The invention provides nucleic acid therapeutics and methods for using these nucleic acid therapeutics in the treatment of complement-related disorders.
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6.Aptamer therapeutics useful in the treatment of complement-related disorders 有权
标题翻译: 适用于治疗补体相关疾病的适体药物公开(公告)号:US08236773B2
公开(公告)日:2012-08-07
申请号:US11884411
申请日:2006-02-14
申请人: Claude Benedict , David Epstein , Charles Wilson , Dilara McCauley , Jeffrey Kurz , Markus Kurz , Thomas Greene McCauley , James Rottman
发明人: Claude Benedict , David Epstein , Charles Wilson , Dilara McCauley , Jeffrey Kurz , Markus Kurz , Thomas Greene McCauley , James Rottman
IPC分类号: C12N15/11
CPC分类号: C12N15/115 , A61K47/60 , C12N2310/16 , C12N2310/317 , C12N2310/321 , C12N2310/322 , C12N2310/344 , C12N2310/351 , C12N2310/3533 , C12N2310/3521
摘要: The invention provides nucleic acid therapeutics and methods for using these nucleic acid therapeutics in the treatment of complement-related disorders.
摘要翻译: 本发明提供了使用这些核酸治疗剂治疗补体相关疾病的核酸治疗剂和方法。
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7.Aptamer therapeutics useful in the treatment of complement-related disorders 有权
标题翻译: 适用于治疗补体相关疾病的适体药物公开(公告)号:US07579456B2
公开(公告)日:2009-08-25
申请号:US11354657
申请日:2006-02-14
申请人: Claude Benedict , David Epstein , Dilârâ McCauley , Jeffrey Kurz , Markus Kurz , Thomas Greene McCauley , James Rottman , Charles Wilson
发明人: Claude Benedict , David Epstein , Dilârâ McCauley , Jeffrey Kurz , Markus Kurz , Thomas Greene McCauley , James Rottman , Charles Wilson
IPC分类号: C07H21/04 , G01N33/551
CPC分类号: C12N15/115 , C12N2310/16 , C12N2310/317 , C12N2310/321 , C12N2310/322 , C12N2310/3521
摘要: The invention provides nucleic acid therapeutics and methods for using these nucleic acid therapeutics in the treatment of complement-related disorders.
摘要翻译: 本发明提供了使用这些核酸治疗剂治疗补体相关疾病的核酸治疗剂和方法。
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8.Aptamer therapeutics useful in the treatment of complement-related disorders 有权
标题翻译: 适用于治疗补体相关疾病的适体药物公开(公告)号:US20070048248A1
公开(公告)日:2007-03-01
申请号:US11354657
申请日:2006-02-14
申请人: Claude Benedict , David Epstein , Dilara McCauley , Jeffrey Kurz , Markus Kurz , Thomas McCauley , James Rottman , Charles Wilson
发明人: Claude Benedict , David Epstein , Dilara McCauley , Jeffrey Kurz , Markus Kurz , Thomas McCauley , James Rottman , Charles Wilson
IPC分类号: A61K48/00
CPC分类号: C12N15/115 , C12N2310/16 , C12N2310/317 , C12N2310/321 , C12N2310/322 , C12N2310/3521
摘要: The invention provides nucleic acid therapeutics and methods for using these nucleic acid therapeutics in the treatment of complement-related disorders.
摘要翻译: 本发明提供了使用这些核酸治疗剂治疗补体相关疾病的核酸治疗剂和方法。
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公开(公告)号:US07125660B2
公开(公告)日:2006-10-24
申请号:US10215982
申请日:2002-08-09
申请人: Martin Stanton , David Epstein , Nobuko Hamaguchi , Markus Kurz , Tony Keefe , Charles Wilson , Dilara Grate , Kristin A. Marshall , Thomas G. McCauley , Jeffrey C. Kurz
发明人: Martin Stanton , David Epstein , Nobuko Hamaguchi , Markus Kurz , Tony Keefe , Charles Wilson , Dilara Grate , Kristin A. Marshall , Thomas G. McCauley , Jeffrey C. Kurz
CPC分类号: B82Y30/00 , B01J2219/00385 , B01J2219/00479 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00626 , B01J2219/0063 , B01J2219/00637 , B01J2219/00653 , B01J2219/00662 , B01J2219/00691 , B01J2219/00722 , C07H21/02 , C07H21/04 , C12Q1/485 , C12Q1/6816 , C12Q1/6825 , C40B40/06 , C40B60/14 , C12Q2565/101 , C12Q2525/179 , C12Q2521/337 , C12Q2521/501
摘要: Methods for engineering a nucleic acid sensor molecule are provided. Biosensors comprise a plurality of nucleic acid sensor molecules labeled with a first signaling moiety and a second signaling moiety. The nucleic acid sensor molecules recognizes target molecules which do not naturally bind to DNA. Binding of a target molecule to the sensor molecules triggers a change in the proximity of the signaling moieties which leads to a change in the optical properties of the nucleic acid sensor molecules on the biosensor. Reagents and systems for performing the method are also provided. The method is useful in diagnostic applications and drug optimization.
摘要翻译: 提供了设计核酸传感器分子的方法。 生物传感器包含用第一信号传导部分和第二信号传导部分标记的多个核酸传感器分子。 核酸传感器分子识别不天然结合DNA的靶分子。 靶分子与传感器分子的结合触发信号部分的接近度的变化,导致生物传感器上的核酸传感器分子的光学性质的变化。 还提供了用于执行该方法的试剂和系统。 该方法可用于诊断应用和药物优化。
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10.Multivalent aptamer therapeutics with improved pharmacodynamic properties and methods of making and using the same 审中-公开
标题翻译: 具有改善的药效学性质的多价适体治疗剂及其制备和使用方法公开(公告)号:US20070009476A1
公开(公告)日:2007-01-11
申请号:US11482671
申请日:2006-07-06
申请人: Charles Wilson , David Epstein , Jeffrey Kurz , Markus Kurz
发明人: Charles Wilson , David Epstein , Jeffrey Kurz , Markus Kurz
IPC分类号: A61K38/22 , A61K31/785 , C08G63/91
CPC分类号: C12N15/115 , C07H21/04 , C12N2310/16 , C12N2310/3183
摘要: Materials and methods are provided for producing aptamer therapeutics having improved pharmacokinetic and pharmacodymanic properties, as well as increased target valency. The aptamers produced by the methods of the invention are useful as therapeutics for treating disease.
摘要翻译: 提供材料和方法用于生产具有改善的药代动力学和药效学性质的适配剂治疗剂以及提高的目标化合价。 通过本发明的方法产生的适体可用作治疗疾病的治疗剂。
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