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公开(公告)号：US3994966A
公开(公告)日：1976-11-30
申请号：US293083
申请日：1972-09-28
IPC分类号： C09K3/00 , C07C67/00 , C07C227/00 , C07C227/08 , C07C227/16 , C07C229/16 , C07C301/00 , C07C303/06 , C07C309/46 , C07C101/42 , C07C101/48 , C07C143/52
CPC分类号： C07C255/00
摘要： Chelating agents having in addition to their metal sequestering groups a functional group capable of reacting with bio-organic molecules are disclosed, in particular, substituted ethylenedinitrilotetraacetic acids such as 1-p-nitrophenylethylenedinitrilotetraacetic acid, 1-p-aminophenylethylenedinitrilotetraacetic acid and their derivatives are disclosed. These compounds are effective chelating agents and in addition are useful in the perturbed angular correlation method of studying molecular behavior.
摘要翻译： 公开了具有除了它们的金属螯合基团能够与生物有机分子反应的官能团之外的螯合剂，特别是公开了取代的亚乙基三硝基四乙酸，例如1-对硝基苯乙基亚乙基三
亚乙基四乙酸，1-对氨基苯乙基亚乙基三
亚乙基四乙酸及其衍生物 。 这些化合物是有效的螯合剂，此外还可用于研究分子行为的扰动角度相关方法。-
公开(公告)号：US4043998A
公开(公告)日：1977-08-23
申请号：US712534
申请日：1976-08-09
IPC分类号： G21H5/02 , C07C113/04 , C07G7/00
CPC分类号： G21H5/02 , Y10S424/06
摘要： 1-(P-Benzenediazonium)-ethylenediaminetetraacetic acid is described. This material is a chelating agent which forms stable complexes with the ions of heavy metals including those having radioactive properties and also reacts readily and rapidly with biological molecules. The compound is a versatile reactive agent useful in introducing metal ions into biological molecules.
摘要翻译： 描述了1-（对苯二氮） - 亚乙二胺四乙酸。 该物质是与重金属离子（包括那些具有放射性的那些）离子形成稳定的络合物并且与生物分子容易且快速地反应的螯合剂。 该化合物是用于将金属离子引入生物分子的通用反应剂。
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公开(公告)号：US07528235B2
公开(公告)日：2009-05-05
申请号：US10350555
申请日：2003-01-23
IPC分类号： C12P21/08
CPC分类号： C07K16/44 , C07K16/1282 , C07K2317/31 , C07K2317/55 , G01N33/574
摘要： The present invention provides a mutant antibody comprising a reactive site not present in the wild-type of the antibody and a antigen recognition domain that specifically binds to a metal chelate, wherein the reactive site is in a position proximate to or within the antigen recognition domain.
摘要翻译： 本发明提供了包含野生型抗体中不存在的反应性位点和与金属螯合物特异性结合的抗原识别结构域的突变体抗体，其中反应性位点处于接近或位于抗原识别结构域内的位置 。
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公开(公告)号：US06783936B2
公开(公告)日：2004-08-31
申请号：US09832510
申请日：2001-04-10
IPC分类号： C12G168
CPC分类号： C07K14/70539 , A61K39/0005 , C12Q1/6886 , C12Q2600/106 , C12Q2600/172 , Y10S435/975
摘要： This invention provides novel peptide epitopes recognized by the non-Hodgkin's B cell lymphoma reactive Lym-1 antibody. These novel peptide epitopes are capable of generating antibodies directed against Lym-1 peptide epitope expressing B-NHL cells. This invention is also directed to the treatment of B-NHL.
摘要翻译： 本发明提供由非霍奇金B细胞淋巴瘤反应性Lym-1抗体识别的新型肽表位。 这些新型肽表位能够产生针对表达B-NHL细胞的Lym-1肽表位的抗体。 本发明还涉及B-NHL的治疗。
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公开(公告)号：US4678667A
公开(公告)日：1987-07-07
申请号：US751769
申请日：1985-07-02
IPC分类号： A61K47/48 , A61K49/08 , A61K51/04 , A61K51/08 , A61K51/10 , A61K39/00 , A61K39/42 , A61K43/00 , A61K49/00
CPC分类号： A61K51/1093 , A61K47/48707 , A61K49/085 , A61K49/106 , A61K49/16 , A61K51/0482 , A61K2121/00 , A61K2123/00
摘要： A copper chelate conjugate which is stable in human serum. The conjugate includes the copper chelate of a cyclic tetraaza di-, tri-, or tetra-acetic acid, a linker attached at one linker end to a ring carbon of the chelate, and a biomolecule joined at the other end of the linker. The conjugate, or the linker-copper chelate compound used in forming the conjugate, are designed for use in diagnostic and therapeutic applications which involve Cu(II) localization via the systemic route.
摘要翻译： 在人血清中稳定的铜螯合物缀合物。 缀合物包括环状四氮杂二 - ，三 - 或四 - 乙酸的铜螯合物，在一个连接端与螯合物的环碳连接的连接体和在连接体另一端连接的生物分子。 缀合物或用于形成缀合物的接头 - 铜螯合物被设计用于通过全身途径进行Cu（II）定位的诊断和治疗应用中。
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公开(公告)号：US07820787B2
公开(公告)日：2010-10-26
申请号：US10625047
申请日：2003-07-22
IPC分类号： A61K39/395
CPC分类号： C07K16/1282 , C07K16/44 , C07K2317/31 , C07K2317/55 , G01N33/574
摘要： The present invention provides antibodies comprising an antigen recognition domain that specifically binds to a metal chelate: mutant antibodies comprising a reactive site not present in the wild-type of the antibody, wherein the reactive site is in a position proximate to or within the antigen recognition domain; and methods of using such antibodies to diagnose and treat disease.
摘要翻译： 本发明提供了包含与金属螯合物特异性结合的抗原识别结构域的抗体：包含在野生型抗体中不存在的反应性位点的突变抗体，其中反应位点处于接近或在抗原识别内的位置 域; 以及使用这些抗体诊断和治疗疾病的方法。
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公开(公告)号：US07214545B2
公开(公告)日：2007-05-08
申请号：US10835533
申请日：2004-04-28
IPC分类号： G01N33/532 , G01N33/24 , G01N24/00 , G01N33/53 , C12Q1/64 , C07K1/14 , C07D257/02
CPC分类号： G01N33/543 , C12Q1/6806 , C12Q1/6886 , G01N33/582 , G01N2458/40 , Y10S435/81 , Y10S435/973 , Y10S435/975 , Y10T436/145555 , Y10T436/24 , C12Q2563/167 , C12Q2563/137
摘要： The present invention provides compositions and methods for detecting, analyzing, and identifying biomolecules. More particularly, the invention provides Element Coded Affinity Tags comprising a metal chelate and a metal ion and methods of using the tags to detect, analyze, and identify biomolecules including polypeptides, nucleic acids, lipids, and polysaccharides.
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公开(公告)号：US4634586A
公开(公告)日：1987-01-06
申请号：US612759
申请日：1984-05-21
申请人： David A. Goodwin , Claude F. Meares
发明人： David A. Goodwin , Claude F. Meares
CPC分类号： A61K51/1093 , A61K2123/00 , Y10S424/806
摘要： Leukocytes are radioimmunoimaged by injecting patients with an immunoreactive nonleukocidal conjugate of an anti-leukocyte antibody and a gamma-emitting radioactive metal chelate, waiting for the conjugate to localize on the leukocytes, injecting the patient with an antibody to the conjugate to clear the blood of background nonlocalized conjugate, and visualizing the leukocytes by scintillation scanning.
摘要翻译： 通过注射患有抗白血球抗体和γ发射放射性金属螯合物的免疫反应性非白细胞过性偶联物的放射免疫的白细胞，等待缀合物定位于白细胞上，向患者注射抗体至缀合物以清除 背景非本地化缀合物，并通过闪烁扫描显示白细胞。
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公开(公告)号：US07267994B2
公开(公告)日：2007-09-11
申请号：US10854735
申请日：2004-05-24
申请人： Claude F. Meares , Carlito B. Lebrilla , Nathaniel G. Butlin , Sarah M. Cheal , Todd M. Corneillie , Susan Lee , Paul A. Whetstone , Nicolas L. Young
发明人： Claude F. Meares , Carlito B. Lebrilla , Nathaniel G. Butlin , Sarah M. Cheal , Todd M. Corneillie , Susan Lee , Paul A. Whetstone , Nicolas L. Young
IPC分类号： G01N33/532 , G01N33/24 , G01N24/00 , G01N33/53 , C07K1/14 , C07D257/02
CPC分类号： G01N33/582 , C12Q1/6886 , G01N2458/40 , Y10S435/81 , Y10S435/973 , Y10S435/975 , Y10T436/145555 , Y10T436/24
摘要： The present invention provides compositions and methods for detecting, analyzing, and identifying biomolecules. More particularly, the invention provides Element Coded Affinity Tags comprising a metal chelate and a metal ion and methods of using the tags to detect, analyze, and identify biomolecules including polypeptides, nucleic acids, lipids, and polysaccharides.
摘要翻译： 本发明提供用于检测，分析和鉴定生物分子的组合物和方法。 更具体地，本发明提供了包含金属螯合物和金属离子的元件编码亲和标签，以及使用标签来检测，分析和鉴定包括多肽，核酸，脂质和多糖的生物分子的方法。
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公开(公告)号：US06217871B1
公开(公告)日：2001-04-17
申请号：US09181896
申请日：1998-10-28
IPC分类号： A61K3900
CPC分类号： C07K14/70539 , A61K39/0005 , C12Q1/6886 , C12Q2600/106 , C12Q2600/172 , Y10S435/975
摘要： This invention provides novel peptide epitopes recognized by the non-Hodgkin's B cell lymphoma reactive Lym-1 antibody. These novel peptide epitopes are capable of generating antibodies directed against Lym-1 peptide epitope expressing B-NHL cells. This invention is also directed to the treatment of B-NHL.
摘要翻译： 本发明提供由非霍奇金B细胞淋巴瘤反应性Lym-1抗体识别的新型肽表位。 这些新型肽表位能够产生针对表达B-NHL细胞的Lym-1肽表位的抗体。 本发明还涉及B-NHL的治疗。
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