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公开(公告)号：US4043998A
公开(公告)日：1977-08-23
申请号：US712534
申请日：1976-08-09
IPC分类号： G21H5/02 , C07C113/04 , C07G7/00
CPC分类号： G21H5/02 , Y10S424/06
摘要： 1-(P-Benzenediazonium)-ethylenediaminetetraacetic acid is described. This material is a chelating agent which forms stable complexes with the ions of heavy metals including those having radioactive properties and also reacts readily and rapidly with biological molecules. The compound is a versatile reactive agent useful in introducing metal ions into biological molecules.
摘要翻译： 描述了1-（对苯二氮） - 亚乙二胺四乙酸。 该物质是与重金属离子（包括那些具有放射性的那些）离子形成稳定的络合物并且与生物分子容易且快速地反应的螯合剂。 该化合物是用于将金属离子引入生物分子的通用反应剂。
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公开(公告)号：US3994966A
公开(公告)日：1976-11-30
申请号：US293083
申请日：1972-09-28
IPC分类号： C09K3/00 , C07C67/00 , C07C227/00 , C07C227/08 , C07C227/16 , C07C229/16 , C07C301/00 , C07C303/06 , C07C309/46 , C07C101/42 , C07C101/48 , C07C143/52
CPC分类号： C07C255/00
摘要： Chelating agents having in addition to their metal sequestering groups a functional group capable of reacting with bio-organic molecules are disclosed, in particular, substituted ethylenedinitrilotetraacetic acids such as 1-p-nitrophenylethylenedinitrilotetraacetic acid, 1-p-aminophenylethylenedinitrilotetraacetic acid and their derivatives are disclosed. These compounds are effective chelating agents and in addition are useful in the perturbed angular correlation method of studying molecular behavior.
摘要翻译： 公开了具有除了它们的金属螯合基团能够与生物有机分子反应的官能团之外的螯合剂，特别是公开了取代的亚乙基三硝基四乙酸，例如1-对硝基苯乙基亚乙基三
亚乙基四乙酸，1-对氨基苯乙基亚乙基三
亚乙基四乙酸及其衍生物 。 这些化合物是有效的螯合剂，此外还可用于研究分子行为的扰动角度相关方法。-
3.发明授权Calcium complexing dyes and their use in analytical compositions, elements and methods 失效钙络合染料及其在分析组合物，元素和方法中的应用
公开(公告)号：US4795712A
公开(公告)日：1989-01-03
申请号：US37303
申请日：1987-04-10
IPC分类号： C09B23/14 , C09B29/36 , C09B57/00 , C09B57/06 , C09B57/10 , C09B69/00 , G01N33/84 , G01N31/22
CPC分类号： C09B23/145 , C09B29/36 , C09B57/06 , C09B57/10 , C09B69/00 , G01N33/84 , G01N2800/04
摘要： Novel chromogenic derivatives of 1,2-bis-(o-aminoaryloxy)ethane-N,N,N',N'-tetraacetic acid are useful for the determination of calcium ions in both solution and dry assays. These compounds comprise a dye moiety which is directly conjugated to the acetic acid substituted-nitrogen atom and which enables the compounds to exhibit maximum absorbance at a wavelength generally greater than 400 nm before complexation. When the compounds are complexed with calcium ions, the absorbance shifts to a shorter wavelength.
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公开(公告)号：US4752572A
公开(公告)日：1988-06-21
申请号：US771548
申请日：1985-08-30
IPC分类号： G01N33/52 , G01N33/532 , G01N33/543 , G01N33/544 , G01N33/549 , G01N33/58 , G01N33/92 , G01N33/53 , G01N33/535
CPC分类号： G01N33/525 , G01N33/532 , G01N33/54386 , G01N33/544 , Y10S435/805 , Y10S435/81 , Y10S435/97 , Y10S435/975 , Y10S436/808 , Y10S436/81 , Y10S436/829 , Y10T428/2984
摘要： Vesicles comprising a matrix of lipid membranes prepared from lipid materials are useful in biomedical studies and immunoassays. A labeled species is encapsulated within the vesicles and released when the vesicles are lysed with a surface active agent. The outer surface of the vesicles is essentially free of the labeled species. Immunoassays can be carried out in solution or with a dry analytical element.
摘要翻译： 包含由脂质材料制备的脂质膜基质的囊泡可用于生物医学研究和免疫测定。 标记的物质被包封在囊泡内并且当囊泡与表面活性剂裂解时被释放。 泡囊的外表面基本上没有标记的物种。 免疫测定可以在溶液中或用干的分析元件进行。
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公开(公告)号：US20100221757A1
公开(公告)日：2010-09-02
申请号：US12779358
申请日：2010-05-13
IPC分类号： G01N33/555
CPC分类号： G01N15/042 , G01N15/0211 , G01N15/05 , G01N33/4905 , G01N33/80
摘要： An apparatus for classifying a liquid patient sample includes at least one sample container having a quantity of a sample that is aggressively acted upon so as to create a flow field. A measurement mechanism includes at least one low angle light emitter aligned with a measurement window of the at leas tone sample container and a detector oppositely disposed relative to the measurement window. Measurement of the scattered light detects particle characteristics of a moving flow field from the sample to determine, for example, the amount of agglutination of the sample so as to perform blood typing or other classifications without spatial separation.
摘要翻译： 用于对液体患者样品进行分类的装置包括至少一个样品容器，该样品容器具有积极作用的样品数量以产生流场。 测量机构包括至少一个与倾斜色调样本容器的测量窗对准的低角度光发射器和相对于测量窗相对设置的检测器。 散射光的测量检测来自样品的移动流场的粒子特性，以确定例如样品的凝集量，以进行血液分型或其它分类而不进行空间分离。
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6.发明授权Labeled hydantoin conjugate and its use in analytical element and immunoassays 失效标记的乙内酰脲缀合物及其在分析元件和免疫测定中的应用
公开(公告)号：US4752568A
公开(公告)日：1988-06-21
申请号：US818303
申请日：1986-01-13
IPC分类号： G01N33/53 , G01N33/532 , G01N33/535 , G01N33/94 , C07D235/30 , C12N9/96 , G01N21/77 , G01N33/543 , G01N33/544 , G01N33/566
CPC分类号： G01N33/532 , G01N33/535 , G01N33/9473 , Y10S435/805 , Y10S435/97 , Y10S436/816
摘要： A heterogeneous, competitive binding immunoassay for either phenytoin or phenobarbital is conducted with a labeled conjugate comprising a derivative of hydantoin and a label. The hydantoin derivative is 5-ethyl,5-phenyl hydantoin and it is linked to the label (e.g. an enzyme) with a linkage derived from an aliphatic monocarboxylic acid. The immunoassay can be carried out either in solution or with a dry analytical element.
摘要翻译： 用含有乙内酰脲衍生物和标记物的标记缀合物进行苯妥英或苯巴比妥的异质竞争性结合免疫测定。 乙内酰脲衍生物是5-乙基-5-苯基乙内酰脲，并且用衍生自脂族一元羧酸的连接物与标记（例如酶）连接。 免疫测定可以在溶液中或用干的分析元件进行。
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公开(公告)号：US4259313A
公开(公告)日：1981-03-31
申请号：US66962
申请日：1979-08-16
CPC分类号： G01N33/585 , G01N33/533 , Y10S436/80
摘要： There are described stabilized fluorescent labels comprising rare earth chelate incorporated in polymeric beads derived from a latex. Labeled reactive proteinaceous species such as labeled immunoreagents comprising the stabilized fluorescent labels having protein absorbed or covalently bonded thereto are also described.
摘要翻译： 描述了稳定的荧光标记，其包含掺入衍生自胶乳的聚合物珠中的稀土螯合物。 还描述了标记的反应性蛋白质物质，例如标记的免疫反应物，其包含具有吸收或共价键合的蛋白质的稳定的荧光标记物。
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公开(公告)号：US09310286B2
公开(公告)日：2016-04-12
申请号：US12779358
申请日：2010-05-13
CPC分类号： G01N15/042 , G01N15/0211 , G01N15/05 , G01N33/4905 , G01N33/80
摘要： An apparatus for classifying a liquid patient sample includes at least one sample container having a quantity of a sample that is aggressively acted upon so as to create a flow field. A measurement mechanism includes at least one low angle light emitter aligned with a measurement window of the at least one sample container and a detector oppositely disposed relative to the measurement window. Measurement of the scattered light detects particle characteristics of a moving flow field from the sample to determine, for example, the amount of agglutination of the sample so as to perform blood typing or other classifications without spatial separation.
摘要翻译： 用于对液体患者样品进行分类的装置包括至少一个样品容器，该样品容器具有积极作用的样品数量以产生流场。 测量机构包括与至少一个样品容器的测量窗对准的至少一个低角度光发射器和相对于测量窗相对设置的检测器。 散射光的测量检测来自样品的移动流场的粒子特性，以确定例如样品的凝集量，以进行血液分型或其它分类而不进行空间分离。
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9.发明授权Hydrolyzable fluorescent substrates for phosphatases and analytical use thereof 失效用于磷酸酶的可水解荧光底物及其分析用途
公开(公告)号：US4803157A
公开(公告)日：1989-02-07
申请号：US824752
申请日：1986-01-31
申请人： Michael W. Sundberg , Bruce Babb , Gregory McClune
发明人： Michael W. Sundberg , Bruce Babb , Gregory McClune
CPC分类号： C07F9/12 , C12Q1/42 , C12Q2334/00 , Y10S436/80
摘要： Hydrolyzable substrates for acid and alkaline phosphatases comprise blocked dye moieties which, when cleaved from the substrate during hydrolysis, provide fluorescent dyes having maximum absorptions above about 530 nm and maximum fluorescent emissions at least about 580 nm. The dyes are blocked prior to hydrolysis with a phosphono or thioxophosphono group or a salt thereof. These substrates can be used in analytical determinations of acid or alkaline phosphatase, or in competitive binding reactions to determine immunologically reactive substances.
摘要翻译： 用于酸和碱性磷酸酶的可水解底物包括封闭的染料部分，其在水解期间从底物切割时提供具有高于约530nm的最大吸收和至少约580nm的最大荧光发射的荧光染料。 在用膦酰基或硫代膦酰基或其盐水解之前将染料封闭。 这些底物可用于酸或碱性磷酸酶的分析测定，或用于竞争性结合反应以确定免疫反应性物质。
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10.发明授权Heterogeneous immunoassay utilizing horizontal separation in an analytical element 失效在分析元件中利用水平分离的非均相免疫测定
公开(公告)号：US4670381A
公开(公告)日：1987-06-02
申请号：US757111
申请日：1985-07-19
申请人： Paul H. Frickey , Karl J. Sanford , Glen M. Dappen , Allen L. Thunberg , Michael W. Sundberg , Susan J. Danielson
发明人： Paul H. Frickey , Karl J. Sanford , Glen M. Dappen , Allen L. Thunberg , Michael W. Sundberg , Susan J. Danielson
IPC分类号： G01N33/543 , G01N33/52 , G01N33/538 , G01N33/50 , G01N33/545 , G01N33/558
CPC分类号： G01N33/538 , G01N33/526 , Y10S435/97 , Y10S436/81 , Y10S436/816
摘要： A heterogeneous, competitive binding immunoassay is conducted with a dry analytical element. The immunoassay is useful for determining a ligand (e.g. a therapeutic drug) and includes contacting a finite area of the element spreading layer with a sample of a liquid in the presence of a labeled ligand analog and an immobilized receptor. An immobilized ligand-receptor complex is formed within the finite area. Simultaneously, the uncomplexed ligand migrates horizontally away from the immobilized complex which remains in the center of the finite area. At least five seconds after the completion of the contacting, the amount of immobilized complex is measured in the center of the finite area.
摘要翻译： 用干燥的分析元件进行异质竞争性结合免疫测定。 免疫测定可用于测定配体（例如治疗药物），并且包括在标记的配体类似物和固定化受体的存在下使元件铺展层的有限区域与液体样品接触。 在有限区域内形成固定化的配体 - 受体复合体。 同时，未络合的配体水平地迁移离开固定复合物，其保留在有限区域的中心。 接触完成后至少5秒钟，在有限区域的中心测量固定化复合物的量。
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