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    Dual fiber bioreactor
    1.
    发明授权
    Dual fiber bioreactor 失效
    双纤维生物反应器

    公开(公告)号：US5712154A

    公开(公告)日：1998-01-27

    申请号：US488185

    申请日：1995-06-07

    申请人： Claudy Jean Paul Mullon ,  Kerry Ann Gagnon ,  Christine Marie Tosone ,  Hugo Osyaldo Jauregui

    发明人： Claudy Jean Paul Mullon ,  Kerry Ann Gagnon ,  Christine Marie Tosone ,  Hugo Osyaldo Jauregui

    IPC分类号： A61M1/34 ,  A61M1/36 ,  C12M3/06 ,  C12N5/06 ,  C12M1/22

    CPC分类号： C12M21/08 ,  A61M1/3475 ,  A61M1/3489 ,  C12M25/10 ,  C12M29/10 ,  C12M29/16 ,  A61M1/3679

    摘要： A cell culture unit is disclosed herewith comprising a shell having two ends with an elongated chamber them between. A liquid and a gas perfusion port are located on each end. Liquid perfusion fibers are connected to the liquid perfusion ports and gas perfusion fibers are connected to the gas perfusion ports. These fibers thereby define an extracapillary and intracapillary space. The cell culture unit further comprises means for communicating with the intracapillary space of the gas perfusion fibers, means for communicating with the intracapillary space of the liquid perfusion fibers, and means for communicating with the extracapillary space.

    摘要翻译： 本文公开了一种细胞培养单元，其包括具有其两端之间的细长室的两端的壳体。 液体和气体灌注口位于每端。 液体灌注纤维连接到液体灌注口，气体灌注纤维连接到气体灌注口。 因此，这些纤维限定了毛细管外和毛细血管内空间。 细胞培养单元还包括用于与气体灌注纤维的毛细血管空间连通的装置，用于与液体灌注纤维的毛细血管空间连通的装置，以及用于与毛细血管空间连通的装置。

    Dual fiber bioreactor
    2.
    发明授权
    Dual fiber bioreactor 失效
    双纤维生物反应器

    公开(公告)号：US06680166B1

    公开(公告)日：2004-01-20

    申请号：US09228382

    申请日：1999-03-29

    申请人： Claudy Jean Paul Mullon ,  Kerry Ann Gagnon ,  Christine Marie Tosone ,  Hugo Osvaldo Jauregui

    发明人： Claudy Jean Paul Mullon ,  Kerry Ann Gagnon ,  Christine Marie Tosone ,  Hugo Osvaldo Jauregui

    IPC分类号： A01N102

    CPC分类号： C12M21/08 ,  A61M1/3475 ,  A61M1/3489 ,  A61M1/3679 ,  C12M25/10 ,  C12M29/10 ,  C12M29/16

    摘要： A cell culture unit is disclosed herewith comprising a shell having two ends with an elongated chamber there between. A liquid and a gas perfusion port are located on each end. Liquid perfusion fibers are connected to the liquid perfusion ports and gas perfusion fibers are connected to the gas perfusion ports. These fibers thereby define an extracapillary and intracapillary space. The cell culture unit further comprises means for communicating with the intracapillary space of the gas perfusion fibers means for communicating with the intracapillary space of the liquid perfusion fibers, and means for communicating with the extracapillary space.

    摘要翻译： 本文公开了一种细胞培养单元，其包括具有两端的壳体之间的细长室。 液体和气体灌注口位于每端。 液体灌注纤维连接到液体灌注口，气体灌注纤维连接到气体灌注口。 因此，这些纤维限定了毛细管外和毛细血管内空间。 细胞培养单元还包括用于与气体灌注纤维的腔内空间连通的装置，用于与液体灌注纤维的毛细血管空间连通，以及用于与毛细血管空间连通的装置。

    Artificial pancreatic perfusion device
    4.
    发明授权
    Artificial pancreatic perfusion device 失效
    人工胰灌注装置

    公开(公告)号：US5741334A

    公开(公告)日：1998-04-21

    申请号：US732146

    申请日：1996-10-16

    申请人： Claudy Jean Paul Mullon ,  Karen E. Dunleavy

    发明人： Claudy Jean Paul Mullon ,  Karen E. Dunleavy

    IPC分类号： A61F2/02 ,  A61L27/38 ,  A61F2/04

    CPC分类号： A61L27/3804 ,  A61F2/022 ,  A61L27/3839

    摘要： An artifical pancreatic perfusion device comprising a hollow fiber having a porosity ranging from about 25 Kd to about 200 Kd. The hollow fiber has one end connected to a blood vessel for receiving blood and a second end connected to a blood vessel for returning said blood. Islets of Langerhans surround the hollow fiber. The hollow fiber and islets are surrounded by a housing comprising a semipermeable membrane having a pore size small enough to offer protection to the islets and host from immune reactive substances. Further disclosed is a method for providing and regulating insulin to insulin deficient individuals.

    摘要翻译： 一种人造胰腺灌注装置，其包括孔隙度范围为约25Kd至约200Kd的中空纤维。 中空纤维的一端连接到血管，用于接收血液，第二端连接到血管以返回血液。 朗格汉斯岛围绕中空纤维。 中空纤维和胰岛由壳体包围，该壳体包括具有足够小孔径的半透膜以提供对胰岛和宿主免疫反应性物质的保护。 进一步公开了一种用于向胰岛素缺乏个体提供和调节胰岛素的方法。