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公开(公告)号：US3966732A
公开(公告)日：1976-06-29
申请号：US568117
申请日：1975-04-14
IPC分类号： C07D403/04 , C07D409/14 , C07D277/06
CPC分类号： C07D409/14 , C07D403/04
摘要： Nitroimidazolyl pyrimidines of the formula ##SPC1##And physiologically acceptable acid addition salts thereon wherein X is alkyl of 1-4 carbon atoms, R.sub.1 and R.sub.2 each are a hydrogen atom, alkyl of 1-4 carbon atoms, phenyl triflouromethyl or a monocyclic heterocyclic ring and R.sub.3 is a hydrogen atoms, alkyl of 1-4 carbon atoms, hydroxyalkoxy of 2-4 carbon atoms or an ester thereof of an alkanocarboxylic acid of 1-4 carbon atoms, oxoalkyl of 8-6 carbon atoms, or, when R.sub.1 or R.sub.2 is phenyl, alkylene having 1-2 carbon atoms in the chain joined to the 2-position of the phenyl ring possess trichomonicidal activity.
摘要翻译： 式的硝基咪唑基嘧啶及其生理学上可接受的酸的添加剂其中X是1-4个碳原子的烷基，R1和R2各自是氢原子，1-4个碳原子的烷基，苯基三氟乙基或单环杂环，R3是 1-4个碳原子的烷基，2-4个碳原子的羟基烷氧基或其1-4个碳原子的链烷酸的酯，8-6个碳原子的氧代烷基，或当R1或R2是苯基时 在与苯环的2-位连接的链中具有1-2个碳原子的亚烷基具有杀虫活性。
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公开(公告)号：US4053472A
公开(公告)日：1977-10-11
申请号：US287852
申请日：1972-09-11
IPC分类号： C07C209/36 , C07D233/92 , C07D233/94 , C07D233/95 , C07D403/04 , C07D405/14
CPC分类号： C07D233/95 , C07C209/36 , C07D233/92 , C07D233/94
摘要： 2-(5-Nitro-2-imidazolyl)-benzimidazoles of the formula ##STR1## wherein R.sub.1 and R.sub.2 are H, halo, alkyl, alkoxy, nitro, trifluoromethyl or carboxy; A is H, alkyl, hydroxyalkyl or an ester thereof, haloalkyl, phenyl or a tertiary aminoalkyl group; and X is alkyl, hydroxyalkyl or an ester thereof, are antimicrobials, especially against Trichomonas vaginalis.
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公开(公告)号：US4038410A
公开(公告)日：1977-07-26
申请号：US557539
申请日：1975-03-12
IPC分类号： C07D233/94 , C07D233/95 , A61K9/22 , C07D239/22 , C07D403/04
CPC分类号： C07D233/94 , C07D233/95
摘要： Nitroimidazoles of the formula ##STR1## wherein R is dialkylaminoacryloyl; 3-, 4-, or 5-pyrazolyl or a mixture thereof which is unsubstituted or substituted by alkyl or, at the 1-position, by hydroxyalkyl or a nitro ester thereof, acyloxyalkyl, nitro, phenyl or phenyl p-substituted by halo, alkoxy or nitro, or, in the 3- or 5-position or a mixture thereof by nitro; 3- or 5-alkyl-4-isooxazolyl or a mixture thereof; or 4-alkyl-5-pyrimidinyl, unsubstituted or substituted by alkyl, amino, 2-furyl or 5-nitro-2-furyl, and the physiologically acceptable acid addition salts thereof, possess anti-protozoal activity, e.g., against trichomonas vaginalis and Entamoeba histolytica.
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公开(公告)号：US3992374A
公开(公告)日：1976-11-16
申请号：US484067
申请日：1974-06-28
IPC分类号： C07D233/92 , C07D233/95 , C07D401/12 , C07D401/14
CPC分类号： C07D233/95
摘要： Amino-substituted nitroimidazolyl-methyleneaminoimidazolidinones of the formula ##SPC1##Wherein --NR.sub.2 R.sub.3 is dialkylamino or heterocyclic amino, and the physiologically acceptable salts thereof, possess antitrichomonial activity.
摘要翻译： 具有式WHEREIN -NR2R3的氨基取代的硝基咪唑基 - 亚甲基氨基咪唑烷酮是二烷基氨基或杂环氨基，并且其生理上可接受的盐具有抗静电活性。
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5.发明授权Amino-, mercapto- and -oxy-substituted-phenyl and -phenalkyl imidazoles 失效氨基，巯基和 - 氧基取代的苯基和 - 苯基烷基咪唑
公开(公告)号：US4006243A
公开(公告)日：1977-02-01
申请号：US567361
申请日：1975-04-11
IPC分类号： C07D233/56 , A61K31/415 , A61P31/00 , C07C45/71 , C07C205/37 , C07D233/58 , C07D233/60 , C07D233/61 , C07D521/00
CPC分类号： C07D231/12 , C07C205/37 , C07C45/71 , C07D233/56 , C07D249/08
摘要： Compounds of the formula ##STR1## wherein Z is a direct bond or alkylene of 1 - 3 carbon atoms which is unsubstituted or substituted on the carbon atom alpha to the phenyl group by alkyl or unsubstituted or substituted phenyl, R.sub.2 and R.sub.3 singly are H, alkyl, alkoxy, alkylmercapto, halo, nitro or, collectively, C.sub.4 H.sub.4, and R.sub.4 is alkenyl, alkinyl, unsubstituted or substituted phenyl or phenylalkyl, or, when Z is substituted methylene, also alkyl, are useful in combating Germatophyte infections, especially Trichophyton rubrum and mentagrophytes, and yeast infections, especially Candida albicans, as well as bacterial and fungal infections.
摘要翻译： 其中Z是直链键或1-3个碳原子的亚烷基，未被取代或被烷基或未取代或取代的苯基的苯基的α-碳原子取代，R2和R3单独为H， 烷基，烷氧基，烷基巯基，卤素，硝基，或者共同的C4H4和R4是烯基，炔基，未取代的或取代的苯基或苯基烷基，或当Z是取代亚甲基也是烷基时，可用于防治生殖癣菌感染，特别是红色毛癣菌 和营养元素，酵母感染，特别是白色念珠菌，以及细菌和真菌感染。
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6.发明授权Certain halothien-2-yl 5-nitrothiazol-2-yl ketones and fungicidal composition 失效某些噻吩-2-基5-硝基噻唑-2-基酮和杀真菌组合物
公开(公告)号：US4006241A
公开(公告)日：1977-02-01
申请号：US489161
申请日：1974-07-17
IPC分类号： C07D417/06 , C07D417/00
CPC分类号： C07D417/06
摘要： 2-ACYL-5-NITROTHIAZOLES OF THE FORMULA ##STR1## wherein A' is furyl, thienyl or pyrrolyl substituted by halo, or phenyl substituted by 3 to 5 of halo, hydroxy, alkyl or alkoxy of 1-4 carbon atoms, possess antifungal activity, e.g., against Candida albicans, Trichophyton metagrophytes and Trichophyton rubrum.
摘要翻译： 其中A'是被卤素取代的呋喃基，噻吩基或吡咯基，或被3至5个卤素，1-4个碳原子的羟基，烷基或烷氧基取代的苯基，具有抗真菌剂 活动，例如针对白色念珠菌，毛发毛癣菌和红色毛癣菌。
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公开(公告)号：US3965103A
公开(公告)日：1976-06-22
申请号：US507684
申请日：1974-09-20
IPC分类号： C07D471/04 , C07D471/02
CPC分类号： C07D471/04
摘要： Compounds of the formula v,2/12Wherein R.sub.1 is H, lower-alkyl, hydroxyalkyl, phenyl, aralkyl, or --(CH.sub.2) .sub.n --X wherein n is 0-4 and X is --COO-lower-alkyl, C.tbd.N or --COOH and R.sub.2 is H, lower-alkyl or aralkyl, produced by condensing a diamine of the formula ##SPC1##With a nitro compound of the formula R.sub.1 --CH.sub.2 --NO.sub.2 in the presence of formalin or paraformaldehyde, or with the R.sub.1 -- C(CH.sub.2 OH).sub.2 NO.sub.2 reaction product of the above nitro compound and formalin or paraformaldehyde, or with formalin or paraformaldehyde followed by reaction with the above nitro compound, and their acid addition salts, possess antimicrobial activity against both gram-positive and gram-negative bacteria and also against dermatophytes, yeasts and other fungi.
摘要翻译： 式v，2/12的化合物，其中R 1是H，低级烷基，羟基烷基，苯基，芳烷基或 - （CH 2）n X，其中n是0-4，X是-COO-低级烷基，C 3或N或 -COOH和R 2是H，低级烷基或芳烷基，其通过在甲醛或多聚甲醛的存在下将式II的二胺与式R 1 -CH 2 -NO 2的硝基化合物或与R 1 -C（CH 2 OH） 上述硝基化合物和福尔马林或多聚甲醛的2NO2反应产物，或与福尔马林或多聚甲醛反应，随后与上述硝基化合物及其酸加成盐反应，具有抗革兰氏阳性和革兰氏阴性菌以及皮肤真菌的抗微生物活性 ，酵母和其他真菌。
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