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21 条记录 (耗时 0.016 秒)

    Nitroimidazolyl pyrimidines
    2.
    发明授权
    Nitroimidazolyl pyrimidines 失效
    硝基咪唑基嘧啶

    公开(公告)号：US3966732A

    公开(公告)日：1976-06-29

    申请号：US568117

    申请日：1975-04-14

    申请人： Clemens Rufer ,  Eberhard Schroder ,  Hans-Joachim Kessler

    发明人： Clemens Rufer ,  Eberhard Schroder ,  Hans-Joachim Kessler

    IPC分类号： C07D403/04 ,  C07D409/14 ,  C07D277/06

    CPC分类号： C07D409/14 ,  C07D403/04

    摘要： Nitroimidazolyl pyrimidines of the formula ##SPC1##And physiologically acceptable acid addition salts thereon wherein X is alkyl of 1-4 carbon atoms, R.sub.1 and R.sub.2 each are a hydrogen atom, alkyl of 1-4 carbon atoms, phenyl triflouromethyl or a monocyclic heterocyclic ring and R.sub.3 is a hydrogen atoms, alkyl of 1-4 carbon atoms, hydroxyalkoxy of 2-4 carbon atoms or an ester thereof of an alkanocarboxylic acid of 1-4 carbon atoms, oxoalkyl of 8-6 carbon atoms, or, when R.sub.1 or R.sub.2 is phenyl, alkylene having 1-2 carbon atoms in the chain joined to the 2-position of the phenyl ring possess trichomonicidal activity.

    摘要翻译： 式的硝基咪唑基嘧啶及其生理学上可接受的酸的添加剂其中X是1-4个碳原子的烷基，R1和R2各自是氢原子，1-4个碳原子的烷基，苯基三氟乙基或单环杂环，R3是 1-4个碳原子的烷基，2-4个碳原子的羟基烷氧基或其1-4个碳原子的链烷酸的酯，8-6个碳原子的氧代烷基，或当R1或R2是苯基时 在与苯环的2-位连接的链中具有1-2个碳原子的亚烷基具有杀虫活性。

    Indanyl derivatives and their use
    5.
    发明授权
    Indanyl derivatives and their use 失效
    茚基衍生物及其用途

    公开(公告)号：US4244960A

    公开(公告)日：1981-01-13

    申请号：US61779

    申请日：1979-07-27

    申请人： Eberhard Schroder ,  Clemens Rufer ,  Irmgard Bottcher ,  Joachim-Friedrich Kapp

    发明人： Eberhard Schroder ,  Clemens Rufer ,  Irmgard Bottcher ,  Joachim-Friedrich Kapp

    IPC分类号： C07C205/38 ,  C07C205/45 ,  C07D213/65 ,  C07D213/70 ,  A61K31/44 ,  A61K31/18 ,  C07D213/63

    CPC分类号： C07D213/70 ,  C07C205/38 ,  C07C205/45 ,  C07D213/65

    摘要： Indanyl derivatives of the formula ##STR1## wherein AR is phenyl, pyridyl, or phenyl or pyridyl substituted by halogen, alkyl of 1-4 carbon atoms or trifluoromethyl; X is oxygen or a sulfur; R.sub.1 is alkyl of 1-4 carbon atoms or alkyl of 1-4 carbon atoms substituted by fluorine or chlorine; A is ##STR2## Y is oxo, oximino, C.sub.1-4 -alkoximino of 1-4 carbon atoms, phenylhydrazono or p-toluenesulfonylhydrazono; n is 0, 1 or 2; R.sub.2 is alkyl of 1-4 carbon atoms, phenyl or phenyl substituted by halogen, alkyl of 1-4 carbon atoms, nitro or carboxy; Z is hydroxy, acyloxy of 1 to 6 carbon atoms, R.sub.1 SO.sub.3 -- amino, acylamino of 1 to 6 carbon atoms, R.sub.1 SO.sub.2 NH-- or cyano, and V is hydrogen, acyl of 1 to 6 carbon atoms or R.sub.1 SO.sub.2 --, and the salts thereof with physiologically acceptable bases or acids have valuable pharmacological and herbicidal activity.

    摘要翻译： 其中AR为苯基，吡啶基或苯基或被卤素取代的吡啶基，1-4个碳原子的烷基或三氟甲基; X是氧或硫; R1是1-4个碳原子的烷基或被氟或氯取代的1-4个碳原子的烷基; A是CH 2 CH 2 CH 2，CHCHCH 2，Y，Y是氧代，肟基，1-4个碳原子的C1-4-肟基，苯基亚肼基或对甲苯磺酰肼; n为0,1或2; R2是1-4个碳原子的烷基，苯基或被卤素取代的苯基，1-4个碳原子的烷基，硝基或羧基; Z是羟基，1至6个碳原子的酰氧基，R1SO3-氨基，1至6个碳原子的酰氨基，R1SO2NH-或氰基，V是氢，1至6个碳原子的酰基或R1SO2-，其盐与 生理上可接受的碱或酸具有有价值的药理学和除草活性。

    Diphosphonic acid derivatives and pharmaceutical preparations containing them
    8.
    发明授权
    Diphosphonic acid derivatives and pharmaceutical preparations containing them 失效
    二膦酸衍生物和含有它们的药物制剂

    公开(公告)号：US4473560A

    公开(公告)日：1984-09-25

    申请号：US461412

    申请日：1983-01-27

    申请人： Helmut Biere ,  Clemens Rufer ,  Irmgard Boettcher

    发明人： Helmut Biere ,  Clemens Rufer ,  Irmgard Boettcher

    IPC分类号： C07F9/38 ,  C07F9/40 ,  C07F9/6553 ,  A61K31/67 ,  A61K31/66

    CPC分类号： C07F9/404 ,  C07F9/386 ,  C07F9/655345

    摘要： Compounds of the formula ##STR1## wherein n is 0, 1, or 2;R.sup.1 is hydrogen or alkyl of 1-4 carbon atoms;R.sup.2 is hydrogen, an alkali metal atom, an alkaline earth metal atom, or alkyl of 1-4 carbon atoms; andAr is phenyl; phenyl substituted by fluorine, chlorine, alkyl of 1-4 carbon atoms, or alkoxy of 1-4 carbon atoms; naphthyl; biphenyl; or thienyl;or when R.sup.2 is H, a physiologically acceptable salt thereof with an organic basehave valuable antiinflammatory properties.

    摘要翻译： 其中n为0,1或2的式（I）的化合物; R1是氢或1-4个碳原子的烷基; R2是氢，碱金属原子，碱土金属原子或1-4个碳原子的烷基; 和Ar是苯基; 被氟，氯，1-4个碳原子的烷基或1-4个碳原子的烷氧基取代的苯基; 萘基; 联苯 或噻吩基; 或当R 2为H时，其与有机碱的生理上可接受的盐具有有价值的抗炎性质。

    1,2-Biguanides
    10.
    发明授权
    1,2-Biguanides 失效
    1,2双胍

    公开(公告)号：US3960949A

    公开(公告)日：1976-06-01

    申请号：US486758

    申请日：1974-07-09

    申请人： Hanns Ahrens ,  Clemens Rufer ,  Helmut Biere ,  Eberhard Schroder ,  Wolfgang Losert ,  Olaf Loge ,  Ekkehard Schillinger

    发明人： Hanns Ahrens ,  Clemens Rufer ,  Helmut Biere ,  Eberhard Schroder ,  Wolfgang Losert ,  Olaf Loge ,  Ekkehard Schillinger

    IPC分类号： C07C279/26 ,  C07C129/16

    CPC分类号： C07C279/26

    摘要： 1,2-Substituted biguanides of the formula ##EQU1## wherein R.sub.1 is saturated or unsaturated, straight-chain or branched hydrocarbon of 1-12 carbon atoms which is unsubstituted or substituted by one or more fluorine atoms; a cycloalkyl group of 3-6 carbon atoms; or an aryl or aralkyl group of the formula ##SPC1##With n being the integer 0, 1 or 2 and X being hydrogen or halogen; and R'.sub.1 is a hydrogen atom or a saturated or unsaturated, straight-chain or branched hydrocarbon group of 1-12 carbon atoms; or R.sub.1 and R'.sub.1 collectively with the nitrogen atom to which they are attached are a heterocyclic ring containing one or more hetero atoms; and R.sub.2 is saturated or unsaturated, straight-chain or branched hydrocarbon of 1-12 carbon atoms which is unsubstituted or substituted by one or more fluorine atoms; or cycloalkyl of 3-6 carbon atoms, alkoxyalkyl containing a total of 2-12 carbon atoms, or alkoxy of 1-6 atoms; mixtures thereof, and pharmaceutically acceptable acid addition salts thereof, are useful in the treatment of diabetes mellitus.

    摘要翻译： 1,2-取代的式R'1 | R1-NC-NH-C-NH2的平行二亚胺平行平行NNH | R2其中R1是1-12个碳原子的饱和或不饱和的直链或支链烃，未取代或未取代的 被一个或多个氟原子取代; 3-6个碳原子的环烷基; 或下式的芳基或芳烷基：其中N为整数0,1或2且X为氢或卤素; 并且R'1是1-12个碳原子的氢原子或饱和或不饱和的直链或支链烃基; 或者R1和R'1与它们所连接的氮原子一起是含有一个或多个杂原子的杂环; R2是未被取代或被一个或多个氟原子取代的1-12个碳原子的饱和或不饱和的直链或支链烃基; 或3-6个碳原子的环烷基，总共2-12个碳原子的烷氧基烷基或1-6个原子的烷氧基; 其混合物及其药学上可接受的酸加成盐可用于治疗糖尿病。