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    Multivalent salts of pyridostigmine and related compounds
    1.
    发明授权
    Multivalent salts of pyridostigmine and related compounds 有权
    吡斯的明和相关化合物的多价盐

    公开(公告)号：US06211201B1

    公开(公告)日：2001-04-03

    申请号：US09308723

    申请日：1999-06-29

    申请人： Colin Granger ,  Robert Orr ,  Kandasamy Ramasamy

    发明人： Colin Granger ,  Robert Orr ,  Kandasamy Ramasamy

    IPC分类号： A61K31444

    CPC分类号： C07D239/34 ,  C07C271/42 ,  C07D213/65

    摘要： A quaternary ammonium cholinergic agent is complexed with a multivalent anion, or with multiple monovalent anions. The complex may be administered orally to a patient to treat pain, or for some other purpose. Numerous modifications are contemplated, including modifications to the ring structure of the compound, substitution and functionalization of the ring. Other contemplated modifications include the use of different anions, including various monovalent and polyvalent anions, and both organic and inorganic anions. The compounds have utility as cholinergic agents, and especially in the treatment of mysasthenia gravis, chest pain, and carpal tunnel syndrome.

    摘要翻译： 季铵胆碱能药剂与多价阴离子或多价单价阴离子络合。 复合物可以口服给予患者以治疗疼痛或用于其它目的。 考虑到许多修饰，包括化合物的环结构的修饰，环的取代和官能化。 其他预期的修改包括使用不同的阴离子，包括各种单价和多价阴离子，以及有机和无机阴离子。 该化合物具有胆碱能药物的功效，特别是治疗重症肌无力，胸痛和腕管综合症。

    Intranasal Anti-Convulsive Compositions And Methods
    2.
    发明申请
    Intranasal Anti-Convulsive Compositions And Methods 失效
    鼻内抗惊厥组合物和方法

    公开(公告)号：US20090088421A1

    公开(公告)日：2009-04-02

    申请号：US12244093

    申请日：2008-10-02

    申请人： Robert Orr

    发明人： Robert Orr

    IPC分类号： A61K31/5513

    CPC分类号： A61K9/0043 ,  A61K47/10 ,  A61K47/20 ,  A61K47/32 ,  A61K47/44

    摘要： Contemplated pharmaceutical compositions comprise a benzodiazepine anti-convulsive compound for intranasal administration in a single phase, multi-component solvent system with water content of at least 15 vol % and a benzodiazepine concentration of at least 30 mg/ml. It is noted that contrary to common expectation, the concentration of the anti-convulsive compound was increased by increasing water content in the multi-component solvent. Moreover, the anti-convulsive compound remained chemically stable and substantially completely dissolved over large periods of time. Thus, stable and highly concentrated spray formulations for intranasal administration could be prepared having sufficiently high concentrations of the anti-convulsive compounds that now allow single spray administration to achieve clinically relevant dosages.

    摘要翻译： 考虑的药物组合物包含苯并二氮杂抗惊厥化合物，用于在单相中鼻内给药，含水量至少为15体积％，苯并二氮浓度为至少30mg / ml的多组分溶剂体系。 应注意的是，与常见的预期相反，通过增加多组分溶剂中的水含量来增加抗惊厥化合物的浓度。 此外，抗惊厥化合物在大量时间内保持化学稳定并基本上完全溶解。 因此，可以制备用于鼻内给药的稳定和高度浓缩的喷雾制剂，其具有足够高浓度的抗惊厥化合物，现在允许单次喷雾给药以达到临床相关剂量。

    Network endpoint health check
    3.
    发明申请
    Network endpoint health check 审中-公开
    网络端点健康检查

    公开(公告)号：US20050108389A1

    公开(公告)日：2005-05-19

    申请号：US10712677

    申请日：2003-11-13

    申请人： Christopher Kempin ,  Robert Orr ,  Rosalind Radcliffe

    发明人： Christopher Kempin ,  Robert Orr ,  Rosalind Radcliffe

    IPC分类号： G06F15/173 ,  H04L12/26

    CPC分类号： H04L43/065 ,  H04L43/0811

    摘要： In a system and method for monitoring the integrity of a plurality of endpoint devices in a network, each endpoint device is in communication with a gateway device and transmits a periodic message to this gateway device. When the gateway device fails to receive a periodic message from an endpoint, the gateway device marks the endpoint as in trouble. The next time the gateway device fails to receive a periodic message from the same endpoint, the gateway device marks the endpoint as removed. The gateway is in communication with a central server and sends status update messages to this central server.

    摘要翻译： 在用于监视网络中的多个端点设备的完整性的系统和方法中，每个端点设备与网关设备通信，并向该网关设备发送周期性消息。 当网关设备无法从端点接收周期性消息时，网关设备会像终端那样标记端点。 下一次网关设备无法从同一端点接收到周期性消息时，网关设备将端点标记为已删除。 网关与中央服务器通信，并向该中央服务器发送状态更新消息。

    Bioabsorbable Drain Tube
    6.
    发明申请
    Bioabsorbable Drain Tube 审中-公开
    生物可吸收排水管

    公开(公告)号：US20090005762A1

    公开(公告)日：2009-01-01

    申请号：US11768876

    申请日：2007-06-26

    申请人： Vasu Nishtala ,  Michael O'Grady ,  Robert Orr ,  Robert Young

    发明人： Vasu Nishtala ,  Michael O'Grady ,  Robert Orr ,  Robert Young

    IPC分类号： A61M27/00

    CPC分类号： A61M27/00

    摘要： A bioabsorbable drain tube for the evacuation of fluids and gases from a body cavity or wound to promote healing, such as after chest surgery. The bioabsorbable drain tube includes a first elongated section molded from a bioabsorbable polymer, the first elongated section having a first end, a second end and a plurality of drain openings; and a second elongated section, the second elongated section having a first end and a second end, the first end of the second elongated section in fluid communication with the second end of the first elongated section. A method of draining fluid from a surgical site or wound of a patient is also provided.

    摘要翻译： 一种生物吸收式排水管，用于从体腔或伤口排出流体和气体，以促进愈合，如胸部手术后。 生物可吸收排出管包括由生物可吸收聚合物模制的第一细长部分，第一细长部分具有第一端部，第二端部和多个排出开口; 和第二细长部分，所述第二细长部段具有第一端部和第二端部，所述第二细长部分的第一端与所述第一细长部分的第二端部流体连通。 还提供了从患者的手术部位或伤口排出流体的方法。

    Intranasal anti-convulsive compositions and methods
    7.
    发明授权
    Intranasal anti-convulsive compositions and methods 失效
    鼻内抗惊厥组合物和方法

    公开(公告)号：US08507468B2

    公开(公告)日：2013-08-13

    申请号：US12244093

    申请日：2008-10-02

    申请人： Robert Orr

    发明人： Robert Orr

    IPC分类号： A01N43/00 ,  A61K31/33

    CPC分类号： A61K9/0043 ,  A61K47/10 ,  A61K47/20 ,  A61K47/32 ,  A61K47/44

    摘要： Contemplated pharmaceutical compositions comprise a benzodiazepine anti-convulsive compound for intranasal administration in a single phase, multi-component solvent system with water content of at least 15 vol % and a benzodiazepine concentration of at least 30 mg/ml. It is noted that contrary to common expectation, the concentration of the anti-convulsive compound was increased by increasing water content in the multi-component solvent. Moreover, the anti-convulsive compound remained chemically stable and substantially completely dissolved over large periods of time. Thus, stable and highly concentrated spray formulations for intranasal administration could be prepared having sufficiently high concentrations of the anti-convulsive compounds that now allow single spray administration to achieve clinically relevant dosages.

    摘要翻译： 考虑的药物组合物包含苯并二氮杂抗惊厥化合物，用于在单相中鼻内给药，含水量至少为15体积％，苯并二氮浓度为至少30mg / ml的多组分溶剂体系。 应注意的是，与常见的预期相反，通过增加多组分溶剂中的水含量来增加抗惊厥化合物的浓度。 此外，抗惊厥化合物在大量时间内保持化学稳定并基本上完全溶解。 因此，可以制备用于鼻内给药的稳定和高度浓缩的喷雾制剂，其具有足够高浓度的抗惊厥化合物，现在允许单次喷雾给药以达到临床相关剂量。

    Method, system, and computer program product for capacity planning by function
    9.
    发明申请
    Method, system, and computer program product for capacity planning by function 审中-公开
    方法，系统和计算机程序产品，通过功能进行容量规划

    公开(公告)号：US20060089982A1

    公开(公告)日：2006-04-27

    申请号：US10974099

    申请日：2004-10-26

    申请人： John Abbott ,  Eric Libow ,  Robert Orr

    发明人： John Abbott ,  Eric Libow ,  Robert Orr

    IPC分类号： G06F15/173

    CPC分类号： G06F11/3442

    摘要： The present invention provides a method, system, and computer program product for capacity planning by function. The method comprises: periodically collecting metrics for a plurality of components in a dynamic system; periodically determining dynamic system membership for a function provided by the dynamic system; providing at least one summation formula; and determining system wide metrics by function using the component metrics, the dynamic system membership for the function, and the at least one summation formula.

    摘要翻译： 本发明提供一种通过功能进行容量规划的方法，系统和计算机程序产品。 该方法包括：在动态系统中周期性地收集多个组件的度量; 定期确定由动态系统提供的功能的动态系统成员资格; 提供至少一个求和公式; 以及使用所述组件度量，所述功能的动态系统成员资格以及所述至少一个求和公式，通过功能确定系统范围的度量。

    Method and system for content delivery
    10.
    发明申请
    Method and system for content delivery 审中-公开
    内容传递的方法和系统

    公开(公告)号：US20050108361A1

    公开(公告)日：2005-05-19

    申请号：US10954601

    申请日：2004-09-30

    申请人： Stewart Scott ,  Robert Orr ,  Jerad Harbaugh ,  James Comstock ,  Brett Goldberg ,  JP Goldberg

    发明人： Stewart Scott ,  Robert Orr ,  Jerad Harbaugh ,  James Comstock ,  Brett Goldberg ,  JP Goldberg

    IPC分类号： G06F20060101 ,  G06F15/16 ,  G06F15/173

    CPC分类号： H04L67/06 ,  H04L63/08 ,  H04L63/10 ,  H04L67/1095

    摘要： According to one embodiment, a method is described. The method includes receiving a request from a client computer sited on a first network to access one or more media files at a data server sited on a second network, determining whether a predetermined number of media files stored at the client computer would be exceeded if the one or more media files are transmitted to the client computer, and transmitting the one or more media files from a distribution server sited on the first network to the client computer if the predetermined number of media files stored at the client computer would not be exceeded if the one or more media files are transmitted to the client computer.

    摘要翻译： 根据一个实施例，描述了一种方法。 该方法包括：接收来自位于第一网络上的客户端计算机的请求，以访问位于第二网络上的数据服务器上的一个或多个媒体文件，确定是否超过客户端计算机上存储的预定数量的媒体文件，如果 如果在客户端计算机上存储的预定数量的媒体文件不被超过，则一个或多个媒体文件被传送到客户端计算机，并且将一个或多个媒体文件从位于第一网络上的分发服务器传送到客户端计算机，如果 一个或多个媒体文件被发送到客户端计算机。