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1.发明授权Lipoprotein associated phospholipase A2, inhibitors thereof and use of the same in diagnosis and therapy 失效脂蛋白相关磷脂酶A2，其抑制剂及其在诊断和治疗中的应用公开(公告)号：US07416853B2
公开(公告)日：2008-08-26
申请号：US11603741
申请日：2006-11-22
Applicant: Colin H. MacPhee , David Graham Tew
Inventor： Colin H. MacPhee , David Graham Tew
IPC: G01N33/573
CPC classification number: C12N9/20 , A61K38/005 , C12N9/18 , C12Q1/44 , G01N33/6893 , G01N2800/323 , G01N2800/324 , Y10S435/81
Abstract: The enzyme Lp-PLA2 in purified form, an isolated nucleic acid molecule encoding Lp-PLA2, the use of an inhibitor of the enzyme Lp-PLA2 in therapy and a method of screening compounds to identify those compounds.
Abstract translation: 纯化形式的酶Lp-PLA 2 2，编码Lp-PLA 2的分离的核酸分子，使用酶Lp-PLA2的抑制剂 在治疗和筛选化合物鉴定那些化合物的方法。
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2.发明授权Lipoprotein associated phospholipase A2, inhibitors thereof and use of the same in diagnosis and therapy 失效脂蛋白相关磷脂酶A2，其抑制剂及其在诊断和治疗中的应用公开(公告)号：US07217535B2
公开(公告)日：2007-05-15
申请号：US10973467
申请日：2004-10-26
Applicant: Colin H. MacPhee , David Graham Tew
Inventor： Colin H. MacPhee , David Graham Tew
IPC: C12Q1/34
CPC classification number: C12N9/20 , A61K38/005 , C12N9/18 , C12Q1/44 , G01N33/6893 , G01N2800/323 , G01N2800/324 , Y10S435/81
Abstract: The enzyme Lp-PLA2 in purified form, an isolated nucleic acid molecule encoding Lp-PLA2, the use of an inhibitor of the enzyme Lp-PLA2 in therapy and a method of screening compounds to identify those compounds.
Abstract translation: 纯化形式的酶Lp-PLA 2 2，编码Lp-PLA 2的分离的核酸分子，使用酶Lp-PLA2的抑制剂 在治疗和筛选化合物鉴定那些化合物的方法。
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3.发明授权Lipoprotein associated phospholipase A2, inhibitors thereof and use of the same in diagnosis and therapy 有权脂蛋白相关磷脂酶A2，其抑制剂及其在诊断和治疗中的应用公开(公告)号：US07052862B2
公开(公告)日：2006-05-30
申请号：US10173233
申请日：2002-06-14
Applicant: Colin H. MacPhee , David Graham Tew
Inventor： Colin H. MacPhee , David Graham Tew
IPC: C12Q1/34
CPC classification number: C12N9/20 , A61K38/005 , C12N9/18 , C12Q1/44 , G01N33/6893 , G01N2800/323 , G01N2800/324 , Y10S435/81
Abstract: The enzyme Lp-PLA2 in purified form, an isolated nucleic acid molecule encoding Lp-PLA2, the use of an inhibitor of the enzyme Lp-PLA2 in therapy and a method of screening compunds to identify those compounds.
Abstract translation: 纯化形式的酶Lp-PLA 2 2，编码Lp-PLA 2的分离的核酸分子，使用酶Lp-PLA2的抑制剂 在治疗中的筛选方法和鉴定这些化合物的方法。
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4.发明授权Phospholipase A2 inhibitors thereof and use of same in diagnosis and therapy 失效磷脂酶A2抑制剂及其在诊断和治疗中的用途公开(公告)号：US06369045B1
公开(公告)日：2002-04-09
申请号：US08717079
申请日：1996-10-08
Applicant: Colin Houston Macphee , David Graham Tew , Deirdre Mary Bernadette Hickey
IPC: A61K3166
CPC classification number: C12N9/20 , A61K38/005 , C12N9/18 , C12Q1/44 , G01N33/6893 , G01N2800/323 , G01N2800/324 , Y10S435/81
Abstract: The enzyme Lp-PLA2 in purified form, an isolated nucleic acid molecule incoding Lp-PLA2, the use of an inhibitor of the enzyme Lp-PLA2 in therapy and a method of screening compounds to identify those compounds which inhibit the enzyme.
Abstract translation: 纯化形式的酶Lp-PLA2，包含Lp-PLA2的分离的核酸分子，Lp-PLA2酶的抑制剂在治疗中的应用以及筛选化合物鉴定那些抑制酶的化合物的方法。
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5.发明申请Lipoprotein Associated Phospholipase A2, Inhibitors Thereof and Use of the Same in Diagnosis and Therapy 审中-公开脂蛋白相关磷脂酶A2，其抑制剂及其在诊断和治疗中的应用公开(公告)号：US20120045774A1
公开(公告)日：2012-02-23
申请号：US13208015
申请日：2011-08-11
Applicant: Colin Houston MacPhee , David Graham Tew
Inventor： Colin Houston MacPhee , David Graham Tew
IPC: G01N33/573
CPC classification number: C12N9/20 , A61K38/005 , C12N9/18 , C12Q1/44 , G01N33/6893 , G01N2800/323 , G01N2800/324 , Y10S435/81
Abstract: The enzyme Lp-PLA2 in purified form, an isolated nucleic acid molecule encoding Lp-PLA2, the use of an inhibitor of the enzyme Lp-PLA2 in therapy and a method of screening compounds to identify those compounds which inhibit the enzyme.
Abstract translation: 纯化形式的酶Lp-PLA2，编码Lp-PLA2的分离的核酸分子，在治疗中使用酶Lp-PLA2的抑制剂，以及筛选化合物以鉴定抑制酶的化合物的方法。
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Patent Agency Ranking
6.发明授权Lipoprotein associated phospholipase A2, inhibitors thereof and use of the same in diagnosis and therapy 失效脂蛋白相关磷脂酶A2，其抑制剂及其在诊断和治疗中的应用公开(公告)号：US07314742B2
公开(公告)日：2008-01-01
申请号：US11108519
申请日：2005-04-18
Applicant: Colin Houston MacPhee , David Graham Tew , Christopher Donald Southan , Deirdre Mary Bernadette Hickey , Israel Simon Gloger , Geoffrey Mark Prouse Lawrence , Simon Quentyn John Rice
Inventor： Colin Houston MacPhee , David Graham Tew , Christopher Donald Southan , Deirdre Mary Bernadette Hickey , Israel Simon Gloger , Geoffrey Mark Prouse Lawrence , Simon Quentyn John Rice
CPC classification number: C12N9/20 , A61K38/005 , C12N9/18 , C12Q1/44 , G01N33/6893 , G01N2800/323 , G01N2800/324 , Y10S435/81
Abstract: The enzyme Lp-PLA2 in purified form, an isolated nucleic acid molecule encoding Lp-PLA2, the use of an inhibitor of the enzyme Lp-PLA2 in therapy and a method of screening compounds to identify those compounds which inhibit the enzyme.
Abstract translation: 纯化形式的酶Lp-PLA 2 2，编码Lp-PLA 2的分离的核酸分子，使用酶Lp-PLA2的抑制剂 在治疗中，以及筛选化合物以鉴定那些抑制酶的化合物的方法。
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7.发明申请Lipoprotein Associated Phospholipase A2, Inhibitors Thereof and Use of the Same in Diagnosis and Therapy 审中-公开脂蛋白相关磷脂酶A2，其抑制剂及其在诊断和治疗中的应用公开(公告)号：US20090136969A1
公开(公告)日：2009-05-28
申请号：US11930629
申请日：2007-10-31
Applicant: Colin Houston MacPhee , David Graham Tew
Inventor： Colin Houston MacPhee , David Graham Tew
IPC: G01N33/573 , C12Q1/44
CPC classification number: C12N9/20 , A61K38/005 , C12N9/18 , C12Q1/44 , G01N33/6893 , G01N2800/323 , G01N2800/324 , Y10S435/81
Abstract: The enzyme Lp-PLA2 in purified form, an isolated nucleic acid molecule encoding Lp-PLA2, the use of an inhibitor of the enzyme Lp-PLA2 in therapy and a method of screening compounds to identify those compounds which inhibit the enzyme.
Abstract translation: 纯化形式的酶Lp-PLA2，编码Lp-PLA2的分离的核酸分子，在治疗中使用酶Lp-PLA2的抑制剂，以及筛选化合物以鉴定抑制酶的化合物的方法。
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公开(公告)号：US07045329B2
公开(公告)日：2006-05-16
申请号：US09922067
申请日：2001-08-03
Applicant: Colin Houston MacPhee , David Graham Tew , Christopher Donald Southan , Deirdre Mary Bernadette Hickey , Israel Simon Gloger , Geoffrey Mark Prouse Lawrence , Simon Quentyn John Rice
Inventor： Colin Houston MacPhee , David Graham Tew , Christopher Donald Southan , Deirdre Mary Bernadette Hickey , Israel Simon Gloger , Geoffrey Mark Prouse Lawrence , Simon Quentyn John Rice
CPC classification number: C12N9/20 , A61K38/005 , C12N9/18 , C12Q1/44 , G01N33/6893 , G01N2800/323 , G01N2800/324 , Y10S435/81
Abstract: The enzyme Lp-PLA2 in purified form, an isolated nucleic acid molecule encoding Lp-PLA2, the use of an inhibitor of the enzyme Lp-PLA2 in therapy and a method of screening compounds to identify those compounds which inhibit the enzyme.
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公开(公告)号：US5990102A
公开(公告)日：1999-11-23
申请号：US860162
申请日：1997-11-21
Applicant: Deirdre Mary Bernadette Hickey , Dashyant Dhanak , Colin Andrew Leach , Robert John Ife , David Graham Tew
Inventor： Deirdre Mary Bernadette Hickey , Dashyant Dhanak , Colin Andrew Leach , Robert John Ife , David Graham Tew
IPC: A61K31/395 , A61K31/397 , A61P3/06 , A61P3/08 , A61P3/10 , A61P9/00 , A61P9/10 , A61P9/12 , A61P25/00 , A61P29/00 , A61P43/00 , C07D205/09
CPC classification number: C07D205/09
Abstract: Compounds of formula (I) in which R.sup.1 and R.sup.2, which may be the same or different, is each selected from hydrogen, halogen or C.sub.(1-8) alkyl; R.sup.3 is aryl or aryl C.sub.(1-4) alkyl which may be optionally substituted; X is a linker group; Y is an optionally substituted aryl group; and n is 0, 1 or 2; are inhibitors of the enzyme Lp-PLA.sub.2 and thereof of use in treating atherosclerosis.
Abstract translation: PCT No.PCT / EP95 / 05130 Sec。 371日期：1997年11月21日 102（e）1997年11月21日日期PCT 1995年12月20日PCT PCT。 WO96 / 19451 PCT公开号 日期：1996年6月27日，式（I）化合物，其中R 1和R 2可以相同或不同，各自选自氢，卤素或C（1-8）烷基; R 3是可任选被取代的芳基或芳基C（1-4）烷基; X是连接基团; Y是任选取代的芳基; 且n为0,1或2; 是用于治疗动脉粥样硬化的酶Lp-PLA2及其抑制剂。
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10.发明授权Lipoprotein associated phospholipase A.sub.2, inhibitors thereof and use of the same in diagnosis and therapy 失效脂蛋白相关磷脂酶A2，其抑制剂及其在诊断和治疗中的应用
公开(公告)号：US5981252A
公开(公告)日：1999-11-09
申请号：US387858
申请日：1995-02-24
Applicant: Colin Houston MacPhee , David Graham Tew
Inventor： Colin Houston MacPhee , David Graham Tew
IPC: G01N33/53 , A61K31/739 , A61K38/00 , A61K38/55 , A61K39/395 , A61P9/10 , C07H21/04 , C07K14/47 , C07K16/40 , C12N1/21 , C12N9/16 , C12N9/18 , C12N9/20 , C12N15/00 , C12N15/09 , C12N15/55 , C12N15/74 , C12P21/08 , C12Q1/44 , G01N33/573
CPC classification number: C12N9/20 , A61K38/005 , C12N9/18 , C12Q1/44 , G01N33/6893 , G01N2800/323 , G01N2800/324 , Y10S435/81
Abstract: The enzyme Lp-PLA.sub.2 in purified form, an isolated nucleic acid molecule encoding Lp-PLA.sub.2, the use of an inhibitor of the enzyme Lp-PLA.sub.2 in therapy and a method of screening compounds to identify those compounds which inhibit the enzyme.
Abstract translation: PCT No.PCT / GB94 / 01374 Sec。 371日期：1995年2月24日 102（e）1995年2月24日PCT 1994年6月24日PCT公布。 公开号WO95 / 00649 日期1995年1月5日纯化形式的酶Lp-PLA2，编码Lp-PLA2的分离的核酸分子，Lp-PLA2酶的抑制剂在治疗中的用途以及筛选化合物以鉴定抑制 酶。
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