专利检索 ap:("Colin Houston MacPhee" OR "David Graham Tew" OR "Christopher Donald Southan" OR "Deirdre Mary Bernadette Hickey" OR "Israel Simon Gloger" OR "Geoffrey Mark Prouse Lawrence" OR "Simon Quentyn John Rice") AND inv:"Geoffrey Mark Prouse Lawrence" 第 1 页

1.

发明授权
Lipoprotein associated phospholipase A2, inhibitors thereof and use of the same in diagnosis and therapy 有权
标题翻译：脂蛋白相关磷脂酶A2，其抑制剂及其在诊断和治疗中的应用

公开(公告)号：US06177257B1

公开(公告)日：2001-01-23

申请号：US09294384

申请日：1999-04-20

申请人： Colin Houston Macphee , David Graham Tew , Christopher Donald Southan , Deirdre Mary Bernadette Hickey , Israel Simon Gloger , Geoffrey Mark Prouse Lawrence , Simon Quentyn John Rice

发明人： Colin Houston Macphee , David Graham Tew , Christopher Donald Southan , Deirdre Mary Bernadette Hickey , Israel Simon Gloger , Geoffrey Mark Prouse Lawrence , Simon Quentyn John Rice

IPC分类号： G01N33573

CPC分类号： C12N9/20 , A61K38/005 , C12N9/18 , C12Q1/44 , G01N33/6893 , G01N2800/323 , G01N2800/324 , Y10S435/81

摘要： The enzyme Lp-PLA2 in purified form, an isolated nucleic acid molecule encoding Lp-PLA2, the use of an inhibitor of the enzyme Lp-PLA2 in therapy and a method of screening compounds to identify those compounds which inhibit the enzyme.

摘要翻译： 纯化形式的酶Lp-PLA2，编码Lp-PLA2的分离的核酸分子，在治疗中使用酶Lp-PLA2的抑制剂，以及筛选化合物以鉴定抑制酶的化合物的方法。

2.

发明授权
Lipoprotein associated phospholipase A2, inhibitors thereof and use of the same in diagnosis and therapy 失效

公开(公告)号：US07045329B2

公开(公告)日：2006-05-16

申请号：US09922067

申请日：2001-08-03

申请人： Colin Houston MacPhee , David Graham Tew , Christopher Donald Southan , Deirdre Mary Bernadette Hickey , Israel Simon Gloger , Geoffrey Mark Prouse Lawrence , Simon Quentyn John Rice

发明人： Colin Houston MacPhee , David Graham Tew , Christopher Donald Southan , Deirdre Mary Bernadette Hickey , Israel Simon Gloger , Geoffrey Mark Prouse Lawrence , Simon Quentyn John Rice

IPC分类号： C12N9/00 , C12N9/20 , C07H21/04

CPC分类号： C12N9/20 , A61K38/005 , C12N9/18 , C12Q1/44 , G01N33/6893 , G01N2800/323 , G01N2800/324 , Y10S435/81

摘要： The enzyme Lp-PLA2 in purified form, an isolated nucleic acid molecule encoding Lp-PLA2, the use of an inhibitor of the enzyme Lp-PLA2 in therapy and a method of screening compounds to identify those compounds which inhibit the enzyme.

3.

发明授权
Lipoprotein associated phospholipase A2, inhibitors thereof and use of the same in diagnosis and therapy 失效
标题翻译：脂蛋白相关磷脂酶A2，其抑制剂及其在诊断和治疗中的应用

公开(公告)号：US07314742B2

公开(公告)日：2008-01-01

申请号：US11108519

申请日：2005-04-18

申请人： Colin Houston MacPhee , David Graham Tew , Christopher Donald Southan , Deirdre Mary Bernadette Hickey , Israel Simon Gloger , Geoffrey Mark Prouse Lawrence , Simon Quentyn John Rice

发明人： Colin Houston MacPhee , David Graham Tew , Christopher Donald Southan , Deirdre Mary Bernadette Hickey , Israel Simon Gloger , Geoffrey Mark Prouse Lawrence , Simon Quentyn John Rice

IPC分类号： C12N9/00 , C12N9/20

CPC分类号： C12N9/20 , A61K38/005 , C12N9/18 , C12Q1/44 , G01N33/6893 , G01N2800/323 , G01N2800/324 , Y10S435/81

摘要： The enzyme Lp-PLA2 in purified form, an isolated nucleic acid molecule encoding Lp-PLA2, the use of an inhibitor of the enzyme Lp-PLA2 in therapy and a method of screening compounds to identify those compounds which inhibit the enzyme.

摘要翻译： 纯化形式的酶Lp-PLA 2 2，编码Lp-PLA 2的分离的核酸分子，使用酶Lp-PLA2的抑制剂在治疗中，以及筛选化合物以鉴定那些抑制酶的化合物的方法。

4.

发明授权
Lipoprotein associated phospholipase A2, inhibitors thereof and use of the same in diagnosis and therapy 失效

公开(公告)号：US5968818A

公开(公告)日：1999-10-19

申请号：US557892

申请日：1995-11-14

申请人： Israel Simon Gloger , Geoffrey Mark Prouse Lawrence , Simon Quentyn John Rice

发明人： Israel Simon Gloger , Geoffrey Mark Prouse Lawrence , Simon Quentyn John Rice

IPC分类号： G01N33/53 , A61K31/739 , A61K38/00 , A61K38/55 , A61K39/395 , A61P9/10 , C07H21/04 , C07K14/47 , C07K16/40 , C12N1/21 , C12N9/16 , C12N9/18 , C12N9/20 , C12N15/00 , C12N15/09 , C12N15/55 , C12N15/74 , C12P21/08 , C12Q1/44 , G01N33/573 , C12Q1/68 , C12N5/06 , C12P21/06

CPC分类号： C12N9/20 , A61K38/005 , C12N9/18 , C12Q1/44 , G01N33/6893 , G01N2800/323 , G01N2800/324 , Y10S435/81

摘要： The enzyme Lp-PLA.sub.2 in purified form, an isolated nucleic acid molecule encoding Lp-PLA.sub.2, the use of an inhibitor of the enzyme Lp-PLA.sub.2 in therapy and a method of screening compounds to identify those compounds which inhibit the enzyme.