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1.发明授权Lipoprotein associated phospholipase A2, inhibitors thereof and use of the same in diagnosis and therapy 有权脂蛋白相关磷脂酶A2，其抑制剂及其在诊断和治疗中的应用公开(公告)号：US06177257B1
公开(公告)日：2001-01-23
申请号：US09294384
申请日：1999-04-20
申请人： Colin Houston Macphee , David Graham Tew , Christopher Donald Southan , Deirdre Mary Bernadette Hickey , Israel Simon Gloger , Geoffrey Mark Prouse Lawrence , Simon Quentyn John Rice
发明人： Colin Houston Macphee , David Graham Tew , Christopher Donald Southan , Deirdre Mary Bernadette Hickey , Israel Simon Gloger , Geoffrey Mark Prouse Lawrence , Simon Quentyn John Rice
IPC分类号： G01N33573
CPC分类号： C12N9/20 , A61K38/005 , C12N9/18 , C12Q1/44 , G01N33/6893 , G01N2800/323 , G01N2800/324 , Y10S435/81
摘要： The enzyme Lp-PLA2 in purified form, an isolated nucleic acid molecule encoding Lp-PLA2, the use of an inhibitor of the enzyme Lp-PLA2 in therapy and a method of screening compounds to identify those compounds which inhibit the enzyme.
摘要翻译： 纯化形式的酶Lp-PLA2，编码Lp-PLA2的分离的核酸分子，在治疗中使用酶Lp-PLA2的抑制剂，以及筛选化合物以鉴定抑制酶的化合物的方法。
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公开(公告)号：US5968818A
公开(公告)日：1999-10-19
申请号：US557892
申请日：1995-11-14
IPC分类号： G01N33/53 , A61K31/739 , A61K38/00 , A61K38/55 , A61K39/395 , A61P9/10 , C07H21/04 , C07K14/47 , C07K16/40 , C12N1/21 , C12N9/16 , C12N9/18 , C12N9/20 , C12N15/00 , C12N15/09 , C12N15/55 , C12N15/74 , C12P21/08 , C12Q1/44 , G01N33/573 , C12Q1/68 , C12N5/06 , C12P21/06
CPC分类号： C12N9/20 , A61K38/005 , C12N9/18 , C12Q1/44 , G01N33/6893 , G01N2800/323 , G01N2800/324 , Y10S435/81
摘要： The enzyme Lp-PLA.sub.2 in purified form, an isolated nucleic acid molecule encoding Lp-PLA.sub.2, the use of an inhibitor of the enzyme Lp-PLA.sub.2 in therapy and a method of screening compounds to identify those compounds which inhibit the enzyme.
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公开(公告)号：US07045329B2
公开(公告)日：2006-05-16
申请号：US09922067
申请日：2001-08-03
申请人： Colin Houston MacPhee , David Graham Tew , Christopher Donald Southan , Deirdre Mary Bernadette Hickey , Israel Simon Gloger , Geoffrey Mark Prouse Lawrence , Simon Quentyn John Rice
发明人： Colin Houston MacPhee , David Graham Tew , Christopher Donald Southan , Deirdre Mary Bernadette Hickey , Israel Simon Gloger , Geoffrey Mark Prouse Lawrence , Simon Quentyn John Rice
CPC分类号： C12N9/20 , A61K38/005 , C12N9/18 , C12Q1/44 , G01N33/6893 , G01N2800/323 , G01N2800/324 , Y10S435/81
摘要： The enzyme Lp-PLA2 in purified form, an isolated nucleic acid molecule encoding Lp-PLA2, the use of an inhibitor of the enzyme Lp-PLA2 in therapy and a method of screening compounds to identify those compounds which inhibit the enzyme.
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4.发明授权Lipoprotein associated phospholipase A2, inhibitors thereof and use of the same in diagnosis and therapy 失效脂蛋白相关磷脂酶A2，其抑制剂及其在诊断和治疗中的应用公开(公告)号：US07314742B2
公开(公告)日：2008-01-01
申请号：US11108519
申请日：2005-04-18
申请人： Colin Houston MacPhee , David Graham Tew , Christopher Donald Southan , Deirdre Mary Bernadette Hickey , Israel Simon Gloger , Geoffrey Mark Prouse Lawrence , Simon Quentyn John Rice
发明人： Colin Houston MacPhee , David Graham Tew , Christopher Donald Southan , Deirdre Mary Bernadette Hickey , Israel Simon Gloger , Geoffrey Mark Prouse Lawrence , Simon Quentyn John Rice
CPC分类号： C12N9/20 , A61K38/005 , C12N9/18 , C12Q1/44 , G01N33/6893 , G01N2800/323 , G01N2800/324 , Y10S435/81
摘要： The enzyme Lp-PLA2 in purified form, an isolated nucleic acid molecule encoding Lp-PLA2, the use of an inhibitor of the enzyme Lp-PLA2 in therapy and a method of screening compounds to identify those compounds which inhibit the enzyme.
摘要翻译： 纯化形式的酶Lp-PLA 2 2，编码Lp-PLA 2的分离的核酸分子，使用酶Lp-PLA2的抑制剂 在治疗中，以及筛选化合物以鉴定那些抑制酶的化合物的方法。
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公开(公告)号：US06693167B1
公开(公告)日：2004-02-17
申请号：US09581068
申请日：2000-06-08
IPC分类号： C07K702
CPC分类号： C07K5/1019 , A61K47/641 , A61K48/00 , C07K5/0606 , C07K5/0815 , C12N15/88
摘要： New peptide-based Gemini compounds comprising two linked chains (a) each having: (1) a positively charged hydrophilic head, Q1 or Q2 formed from one or more amino acids and/or amines, (2) a central portion, P1 or P2, having a polypeptide backbone, and (3) a hydrophobic tail, R1 or R2, the central sections of each chain being linked together by bridge Y through residues in P1 and P2, are disclosed. Methods for their preparation and uses are also disclosed. Such uses include transfection of polynucleotides into cells in vivo.
摘要翻译： 新的基于肽的双子座化合物，其包含两个连接的链（a），各自具有：（1）由一个或多个氨基酸和/或胺形成的带正电荷的亲水头，Q 1或Q 2，（2） 具有多肽主链的中心部分P1或P2，以及（3）疏水性尾巴R 1或R 2，每个链的中心部分通过桥Y通过P 1中的残基和 P <2>。 还公开了其制备和用途的方法。 这样的用途包括将体内多核苷酸转染到细胞中。
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