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1.发明授权Lipoprotein associated phospholipase A2, inhibitors thereof and use of the same in diagnosis and therapy 有权脂蛋白相关磷脂酶A2，其抑制剂及其在诊断和治疗中的应用公开(公告)号：US06177257B1
公开(公告)日：2001-01-23
申请号：US09294384
申请日：1999-04-20
申请人： Colin Houston Macphee , David Graham Tew , Christopher Donald Southan , Deirdre Mary Bernadette Hickey , Israel Simon Gloger , Geoffrey Mark Prouse Lawrence , Simon Quentyn John Rice
发明人： Colin Houston Macphee , David Graham Tew , Christopher Donald Southan , Deirdre Mary Bernadette Hickey , Israel Simon Gloger , Geoffrey Mark Prouse Lawrence , Simon Quentyn John Rice
IPC分类号： G01N33573
CPC分类号： C12N9/20 , A61K38/005 , C12N9/18 , C12Q1/44 , G01N33/6893 , G01N2800/323 , G01N2800/324 , Y10S435/81
摘要： The enzyme Lp-PLA2 in purified form, an isolated nucleic acid molecule encoding Lp-PLA2, the use of an inhibitor of the enzyme Lp-PLA2 in therapy and a method of screening compounds to identify those compounds which inhibit the enzyme.
摘要翻译： 纯化形式的酶Lp-PLA2，编码Lp-PLA2的分离的核酸分子，在治疗中使用酶Lp-PLA2的抑制剂，以及筛选化合物以鉴定抑制酶的化合物的方法。
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公开(公告)号：US07045329B2
公开(公告)日：2006-05-16
申请号：US09922067
申请日：2001-08-03
申请人： Colin Houston MacPhee , David Graham Tew , Christopher Donald Southan , Deirdre Mary Bernadette Hickey , Israel Simon Gloger , Geoffrey Mark Prouse Lawrence , Simon Quentyn John Rice
发明人： Colin Houston MacPhee , David Graham Tew , Christopher Donald Southan , Deirdre Mary Bernadette Hickey , Israel Simon Gloger , Geoffrey Mark Prouse Lawrence , Simon Quentyn John Rice
CPC分类号： C12N9/20 , A61K38/005 , C12N9/18 , C12Q1/44 , G01N33/6893 , G01N2800/323 , G01N2800/324 , Y10S435/81
摘要： The enzyme Lp-PLA2 in purified form, an isolated nucleic acid molecule encoding Lp-PLA2, the use of an inhibitor of the enzyme Lp-PLA2 in therapy and a method of screening compounds to identify those compounds which inhibit the enzyme.
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3.发明授权Lipoprotein associated phospholipase A2, inhibitors thereof and use of the same in diagnosis and therapy 失效脂蛋白相关磷脂酶A2，其抑制剂及其在诊断和治疗中的应用公开(公告)号：US07314742B2
公开(公告)日：2008-01-01
申请号：US11108519
申请日：2005-04-18
申请人： Colin Houston MacPhee , David Graham Tew , Christopher Donald Southan , Deirdre Mary Bernadette Hickey , Israel Simon Gloger , Geoffrey Mark Prouse Lawrence , Simon Quentyn John Rice
发明人： Colin Houston MacPhee , David Graham Tew , Christopher Donald Southan , Deirdre Mary Bernadette Hickey , Israel Simon Gloger , Geoffrey Mark Prouse Lawrence , Simon Quentyn John Rice
CPC分类号： C12N9/20 , A61K38/005 , C12N9/18 , C12Q1/44 , G01N33/6893 , G01N2800/323 , G01N2800/324 , Y10S435/81
摘要： The enzyme Lp-PLA2 in purified form, an isolated nucleic acid molecule encoding Lp-PLA2, the use of an inhibitor of the enzyme Lp-PLA2 in therapy and a method of screening compounds to identify those compounds which inhibit the enzyme.
摘要翻译： 纯化形式的酶Lp-PLA 2 2，编码Lp-PLA 2的分离的核酸分子，使用酶Lp-PLA2的抑制剂 在治疗中，以及筛选化合物以鉴定那些抑制酶的化合物的方法。
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公开(公告)号：US5968818A
公开(公告)日：1999-10-19
申请号：US557892
申请日：1995-11-14
IPC分类号： G01N33/53 , A61K31/739 , A61K38/00 , A61K38/55 , A61K39/395 , A61P9/10 , C07H21/04 , C07K14/47 , C07K16/40 , C12N1/21 , C12N9/16 , C12N9/18 , C12N9/20 , C12N15/00 , C12N15/09 , C12N15/55 , C12N15/74 , C12P21/08 , C12Q1/44 , G01N33/573 , C12Q1/68 , C12N5/06 , C12P21/06
CPC分类号： C12N9/20 , A61K38/005 , C12N9/18 , C12Q1/44 , G01N33/6893 , G01N2800/323 , G01N2800/324 , Y10S435/81
摘要： The enzyme Lp-PLA.sub.2 in purified form, an isolated nucleic acid molecule encoding Lp-PLA.sub.2, the use of an inhibitor of the enzyme Lp-PLA.sub.2 in therapy and a method of screening compounds to identify those compounds which inhibit the enzyme.
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公开(公告)号：US06426405B2
公开(公告)日：2002-07-30
申请号：US09795232
申请日：2001-02-28
申请人： Anthony M Brown , Conrad Gerald Chapman , Israel Simon Gloger , Joanne Rachel Evans , William Cairns , Hugh Jonathan Herdon
发明人： Anthony M Brown , Conrad Gerald Chapman , Israel Simon Gloger , Joanne Rachel Evans , William Cairns , Hugh Jonathan Herdon
IPC分类号： C07K1400
CPC分类号： C07K14/47
摘要： The SC6 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing SC6 polypeptides and polynucleotides in therapy, and diagnostic assays for such.
摘要翻译： 公开了通过重组技术产生这种多肽的SC6多肽和多核苷酸和方法。 还公开了在治疗中利用SC6多肽和多核苷酸的方法，以及用于其的诊断测定法。
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公开(公告)号：US06238883B1
公开(公告)日：2001-05-29
申请号：US09182728
申请日：1998-10-29
申请人： Anthony M Brown , Conrad Gerald Chapman , Israel Simon Gloger , Joanne Rachel Evans , William Cairns , Hugh Jonathan Herdon
发明人： Anthony M Brown , Conrad Gerald Chapman , Israel Simon Gloger , Joanne Rachel Evans , William Cairns , Hugh Jonathan Herdon
IPC分类号： C12N1512
CPC分类号： C07K14/47
摘要： The SC6 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing SC6 polypeptides and polynucleotides in therapy, and diagnostic assays for such.
摘要翻译： 公开了通过重组技术产生这种多肽的SC6多肽和多核苷酸和方法。 还公开了在治疗中利用SC6多肽和多核苷酸的方法，以及用于其的诊断测定法。
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公开(公告)号：US06187908B1
公开(公告)日：2001-02-13
申请号：US08977865
申请日：1997-11-25
申请人： Jonathan Alexander Terrett , Tania Tamson Testa , Israel Simon Gloger , Stephen A. Hughes , Trudy Rachel Doe
发明人： Jonathan Alexander Terrett , Tania Tamson Testa , Israel Simon Gloger , Stephen A. Hughes , Trudy Rachel Doe
IPC分类号： C07K100
摘要： Tubby 2 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing Tubby 2 polypeptides and polynucleotides in the design of protocols for the treatment of diabetes, obesity, and atherosclerosis, among others, and diagnostic assays for such conditions.
摘要翻译： 公开了通过重组技术制备这种多肽的Tubby 2多肽和多核苷酸和方法。 还公开了在设计用于治疗糖尿病，肥胖症和动脉粥样硬化以及其他疾病的诊断测定方案中使用Tubby 2多肽和多核苷酸的方法。
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