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1.发明申请SOLUBLE VEGFR-1 VARIANTS AND ASSAYS AND METHODS OF USE THEREOF FOR DIAGNOSIS 审中-公开可溶性VEGFR-1变异体及其测定方法及其用于诊断的方法公开(公告)号：US20160216281A1
公开(公告)日：2016-07-28
申请号：US15096123
申请日：2016-04-11
申请人： Compugen Ltd.
发明人： Osnat Sella-Tavor , Sarah Pollock , Gad S. Cojocaru , Amit Novik , Lily Bazak , Elena Tsypkin , Shira Wallach , Shirley Sameah-Greenwald
IPC分类号： G01N33/74 , C07K16/40 , G01N33/574 , C07K16/28
CPC分类号： G01N33/74 , C07K14/47 , C07K16/2863 , C07K16/40 , G01N33/574 , G01N33/57492 , G01N33/689 , G01N33/6893 , G01N2333/71 , G01N2800/52
摘要： Novel splice variants, amino acid sequences and nucleotide sequences thereof, and methods of using same.
摘要翻译： 新型剪接变体，氨基酸序列及其核苷酸序列及其使用方法。
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公开(公告)号：US10550173B2
公开(公告)日：2020-02-04
申请号：US15048975
申请日：2016-02-19
申请人： Compugen Ltd.
发明人： Mark White , Sandeep Kumar , Christopher Chan , Spencer Liang , Lance Stapleton , Andrew W. Drake , Yosi Gozlan , Ilan Vaknin , Shirley Sameah-Greenwald , Liat Dassa , Zohar Tiran , Gad S. Cojocaru , Amir Toporik , Yossef Kliger , Ofer Levy , Arthur Machlenkin , Sergey Nemzer , Yair Benita , Amit Novik
摘要： The present invention is directed to PVRIG polypeptides and their uses.
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公开(公告)号：US10098934B2
公开(公告)日：2018-10-16
申请号：US13845420
申请日：2013-03-18
申请人： Compugen Ltd.
发明人： Zurit Levine , Amir Toporik , Amit Novik , Anat Cohen-Dayag , Avi Rosenberg , Cynthia Koifman , Dalit Landesman-Milo , Eve Montia , Galit Rotman , Liat Dassa , Marina Bubis , Merav Beiman , Ofer Levy , Sergey Nemzer , Shira Walach , Shirley Sameach- Greenwald , Tania Pergam , Yaron Kinar
IPC分类号： C07K16/28 , A61K39/00 , C07K14/705 , C07K16/30 , G01N33/564 , G01N33/574 , A61K31/7088 , C07K14/47 , C07K14/82 , A61K39/395 , A61K45/06 , C07K14/00 , A61K39/39 , A61K47/48 , A61N5/10 , A61K38/00
摘要： This invention relates to a novel target for production of immune and non-immune based therapeutics and for disease diagnosis. More particularly, the invention provides therapeutic antibodies against VSIG1, ILDR1, LOC253012, AI216611, C1ORF32 or FXYD3 antigens, which are predicted co-stimulatory family members and which are differentially expressed in cancers including, lung cancer, ovarian cancer, and colon cancer, and diagnostic and therapeutic usages. The use of these antibodies for modulating B7 costimulation and related therapies such as the treatment of autoimmunity are also provided. This invention further relates to the discovery of extracellular domains of VSIG1 and its variants, FXYD3 and its variants, ILDR1 and its variants, LOC253012 and its variants, AI216611 and its variants, and C1ORF32 and its variants awhich are suitable targets for immunotherapy, cancer therapy, and drug development.
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4.发明授权Polypeptides and polynucleotides, and uses thereof as a drug target for producing drugs and biologics 有权多肽和多核苷酸，及其用作药物和生物制剂的药物靶标公开(公告)号：US09107862B2
公开(公告)日：2015-08-18
申请号：US13767891
申请日：2013-02-15
申请人： Compugen Ltd.
发明人： Amir Toporik , Amit Novik , Anat Cohen-Dayag , Avi Yeshah Rosenberg , Cynthia Koifman , Dalit Landesman-Milo , Eve Montia , Galit Rotman , Liat Dassa , Marina Bubis , Merav Beiman , Ofer Levy , Sergey Nemzer , Tania Pergam , Yaron Kinar , Shirley Sameach-Greenwald , Zurit Levine , Shira Walach
IPC分类号： C07K14/00 , C07K16/46 , A61K39/00 , C07K14/705 , C07K16/30 , G01N33/564 , G01N33/574 , A61K31/7088 , C07K14/47 , C07K14/82 , A61K39/395 , A61K45/06 , C07K16/28 , A61K39/39 , A61K47/48 , A61N5/10 , A61K38/00
CPC分类号： C07K16/30 , A61K31/7088 , A61K38/00 , A61K39/00 , A61K39/0005 , A61K39/0008 , A61K39/39 , A61K39/395 , A61K39/3955 , A61K39/39558 , A61K45/06 , A61K2039/505 , A61K2039/545 , A61N5/10 , C07K14/00 , C07K14/47 , C07K14/4702 , C07K14/705 , C07K14/70503 , C07K14/82 , C07K16/28 , C07K2317/21 , C07K2317/76 , C07K2319/00 , C07K2319/30 , C07K2319/60 , C07K2319/70 , G01N33/564 , G01N33/57419 , G01N33/57423 , G01N33/57449 , G01N33/57484 , G01N33/57492 , G01N2500/04
摘要： This invention relates to a novel target for production of immune and non-immune based therapeutics and for disease diagnosis. More particularly, the invention provides therapeutic antibodies against VSIG1, ILDR1, LOC253012, AI216611, C1ORF32 or FXYD3 antigens, which are predicted co-stimulatory family members and which are differentially expressed in cancers including, lung cancer, ovarian cancer, and colon cancer, and diagnostic and therapeutic usages. The use of these antibodies for modulating B7 costimulation and related therapies such as the treatment of autoimmunity are also provided. This invention further relates to the discovery of extracellular domains of VSIG1 and its variants, FXYD3 and its variants, ILDR1 and its variants, LOC253012 and its variants, AI216611 and its variants, and C1ORF32 and its variants which are suitable targets for immunotherapy, cancer therapy, and drug development.
摘要翻译： 本发明涉及用于产生免疫和非免疫的治疗剂和疾病诊断的新靶标。 更具体地，本发明提供了针对VSIG1，ILDR1，LOC253012，AI216611，C1ORF32或FXYD3抗原的治疗性抗体，其是预测的共刺激家族成员，并且在包括肺癌，卵巢癌和结肠癌在内的癌症中差异表达， 诊断和治疗用途。 还提供了这些抗体用于调节B7共刺激和相关疗法（例如治疗自身免疫）的用途。 本发明还涉及VSIG1及其变体FXYD3及其变体ILDR1及其变体，LOC253012及其变体，AI216611及其变体和作为免疫治疗，癌症治疗的合适靶标的C1ORF32及其变体的细胞外结构域的发现 ，药物开发。
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公开(公告)号：US20240287174A1
公开(公告)日：2024-08-29
申请号：US18460276
申请日：2023-09-01
申请人： Compugen Ltd.
发明人： Yosef Dicken , Liat Dassa , Amit Novik , Amir Toporik , Gad S. Cojocaru , Yossef Kliger , Yair Benita , Ofer Levy , Ilan Vaknin , Arthur Machlenkin , Iris Hecht , Jungmin Kim , Andrew Pow , Andrew W. Drake
IPC分类号： C07K16/28 , A61K31/513 , A61K39/00 , A61K39/395 , A61K45/06 , A61P35/00 , C07K14/705
CPC分类号： C07K16/2803 , A61K31/513 , A61K39/3955 , A61K45/06 , A61P35/00 , C07K14/70503 , A61K2039/505 , A61K2039/572 , C07K2317/524 , C07K2317/526 , C07K2317/53 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/732 , C07K2317/734 , C07K2317/92 , C07K2317/94 , C07K2319/30
摘要： According to at least some embodiments of the present invention is directed to anti-HIDE1 antibodies and polypeptides and methods of using same.
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公开(公告)号：US11795209B2
公开(公告)日：2023-10-24
申请号：US16775133
申请日：2020-01-28
申请人： Compugen Ltd.
发明人： Mark White , Sandeep Kumar , Christopher Chan , Spencer Liang , Lance Stapleton , Andrew W. Drake , Yosi Gozlan , Ilan Vaknin , Shirley Sameah-Greenwald , Liat Dassa , Zohar Tiran , Gad S. Cojocaru , Amir Toporik , Yossef Kliger , Ofer Levy , Arthur Machlenkin , Sergey Nemzer , Yair Benita , Amit Novik
IPC分类号： G01N33/53 , C07K16/10 , G01N33/574 , G01N33/50 , C12N15/113 , C07K16/28 , C07K7/06 , C07K14/705 , A61K39/00
CPC分类号： C07K16/1009 , C07K7/06 , C07K14/70503 , C07K16/2803 , C07K16/2818 , C12N15/1138 , G01N33/502 , G01N33/505 , G01N33/5011 , G01N33/574 , A61K2039/507 , C07K2317/74 , C07K2319/30 , C12N2310/14 , G01N2333/70596 , G01N2500/02 , G01N2500/10 , Y02A50/30
摘要： The present invention is directed to PVRIG polypeptides and their uses.
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7.发明授权Polypeptides and polynucleotides, and uses thereof as a drug target for producing drugs and biologics 有权多肽和多核苷酸，及其用作药物和生物制剂的药物靶标公开(公告)号：US09375466B2
公开(公告)日：2016-06-28
申请号：US13904028
申请日：2013-05-29
申请人： Compugen Ltd.
发明人： Anat Cohen-Dayag , Merav Beiman , Liat Dassa , Marina Bubis , Shirley Sameach- Greenwald , Dalit Landesman-Milo , Cynthia Koifman , Ofer Levy , Sergey Nemzer , Tania Pergam , Yaron Kinar , Zurit Levine , Avi Rosenberg , Galit Rotman , Eve Montia , Amit Novik , Amir Toporik , Shira Walach
IPC分类号： C07K14/705 , C07K16/46 , A61K39/00 , A61K38/17 , C07K16/30 , G01N33/564 , G01N33/574 , A61K31/7088 , C07K14/47 , C07K14/82 , A61K39/395 , A61K45/06 , C07K14/00 , C07K16/28 , A61K39/39 , A61K47/48 , A61N5/10 , A61K38/00
CPC分类号： C07K16/30 , A61K31/7088 , A61K38/00 , A61K39/00 , A61K39/0005 , A61K39/0008 , A61K39/39 , A61K39/395 , A61K39/3955 , A61K39/39558 , A61K45/06 , A61K2039/505 , A61K2039/545 , A61N5/10 , C07K14/00 , C07K14/47 , C07K14/4702 , C07K14/705 , C07K14/70503 , C07K14/82 , C07K16/28 , C07K2317/21 , C07K2317/76 , C07K2319/00 , C07K2319/30 , C07K2319/60 , C07K2319/70 , G01N33/564 , G01N33/57419 , G01N33/57423 , G01N33/57449 , G01N33/57484 , G01N33/57492 , G01N2500/04
摘要： This invention relates to a novel target for production of immune and non-immune based therapeutics and for disease diagnosis. More particularly, the invention provides therapeutic antibodies against VSIG1, ILDR1, LOC253012, AI216611, C1ORF32 or FXYD3 antigens, which are predicted co-stimulatory family members and which are differentially expressed in cancers including, lung cancer, ovarian cancer, and colon cancer, and diagnostic and therapeutic usages. The use of these antibodies for modulating B7 costimulation and related therapies such as the treatment of autoimmunity are also provided. This invention further relates to the discovery of extracellular domains of VSIG1 and its variants, FXYD3 and its variants, ILDR1 and its variants, LOC253012 and its variants, AI216611 and its variants, and C1ORF32 and its variants awhich are suitable targets for immunotherapy, cancer therapy, and drug development.
摘要翻译： 本发明涉及用于产生免疫和非免疫的治疗剂和疾病诊断的新靶标。 更具体地，本发明提供了针对VSIG1，ILDR1，LOC253012，AI216611，C1ORF32或FXYD3抗原的治疗性抗体，其是预测的共刺激家族成员，并且在包括肺癌，卵巢癌和结肠癌在内的癌症中差异表达， 诊断和治疗用途。 还提供了这些抗体用于调节B7共刺激和相关疗法（例如治疗自身免疫）的用途。 本发明还涉及发现VSIG1及其变体FXYD3及其变体，ILDR1及其变体，LOC253012及其变体，AI216611及其变体和C1ORF32及其变体的细胞外结构域，其是免疫治疗，癌症治疗的合适靶标 ，药物开发。
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公开(公告)号：US20160177395A1
公开(公告)日：2016-06-23
申请号：US14990762
申请日：2016-01-07
申请人： COMPUGEN, LTD.
发明人： Yaron Kinar , Merav Beiman , Eve Montia , Shira Wallach , Tania Pergam , Amit Novik , Shirley Sameah-Greenwald , Gad S. Cojocaru , Anat Cohen-Dayag , Yael Furman
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/112 , C12Q2600/118 , C12Q2600/142 , C12Q2600/158 , C12Q2600/16 , G01N33/6893 , G01N2800/347 , G01N2800/52 , Y10T436/143333
摘要： The present invention relates to means and methods for predicting the onset of renal injury based on measuring the expression of polynucleotides and proteins, particularly on measuring the expression of sets of novel as well as known polynucelotides and proteins, and to kits utilizing same.
摘要翻译： 本发明涉及用于通过测量多核苷酸和蛋白质的表达来预测肾损伤发作的方法和方法，特别是关于测量新颖和已知的多肽酶和蛋白质的组合的表达，以及使用它们的试剂盒。
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公开(公告)号：US09347952B2
公开(公告)日：2016-05-24
申请号：US14594772
申请日：2015-01-12
申请人： Compugen Ltd.
发明人： Osnat Sella-Tavor , Sarah Pollock , Gad S. Cojocaru , Amit Novik , Lily Bazak , Elena Tsypkin , Shira Wallach , Shirley Sameah-Greenwald
IPC分类号： G01N33/68 , C07K14/47 , G01N33/574
CPC分类号： G01N33/74 , C07K14/47 , C07K16/2863 , C07K16/40 , G01N33/574 , G01N33/57492 , G01N33/689 , G01N33/6893 , G01N2333/71 , G01N2800/52
摘要： Novel splice variants, amino acid sequences and nucleotide sequences thereof, and methods of using same.
摘要翻译： 新型剪接变体，氨基酸序列及其核苷酸序列及其使用方法。
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公开(公告)号：US20150132318A1
公开(公告)日：2015-05-14
申请号：US14594772
申请日：2015-01-12
申请人： Compugen Ltd.
发明人： Osnat Sella-Tavor , Sarah Pollock , Gad S. Cojocaru , Amit Novik , Lily Bazak , Elena Tsypkin , Shira Wallach , Shirley Sameah-Greenwald
IPC分类号： G01N33/68
CPC分类号： G01N33/74 , C07K14/47 , C07K16/2863 , C07K16/40 , G01N33/574 , G01N33/57492 , G01N33/689 , G01N33/6893 , G01N2333/71 , G01N2800/52
摘要： Novel splice variants, amino acid sequences and nucleotide sequences thereof, and methods of using same.
摘要翻译： 新型剪接变体，氨基酸序列及其核苷酸序列及其使用方法。
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