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1.发明授权公开(公告)号：US07186832B2
公开(公告)日：2007-03-06
申请号：US10845586
申请日：2004-05-14
申请人： Connie Li Sun , Congxin Liang , Ping Huang , G. Davis Harris, Jr. , Huiping Guan
发明人： Connie Li Sun , Congxin Liang , Ping Huang , G. Davis Harris, Jr. , Huiping Guan
IPC分类号： C07D471/00 , C07D487/00 , C07D491/00 , C07D495/00 , C07D497/00
CPC分类号： C07D487/04
摘要： The present invention relates to substituted imidazopyrazines of the general Formula I which modulate the activity of protein kinases (“PKs”). The compounds of this invention are therefore useful in treating disorders related to abnormal PK activity. Pharmaceutical compositions comprising these compounds, methods of treating diseases utilizing pharmaceutical compositions comprising these compounds and methods of preparing them are also disclosed.
摘要翻译： 本发明涉及调节蛋白激酶（“PKs”）活性的通式I的取代咪唑并吡嗪。 因此，本发明的化合物可用于治疗与异常PK活性相关的疾病。 还公开了包含这些化合物的药物组合物，利用包含这些化合物的药物组合物治疗疾病的方法及其制备方法。
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2.发明授权公开(公告)号：US07157460B2
公开(公告)日：2007-01-02
申请号：US10781928
申请日：2004-02-20
申请人： Connie Li Sun , Congxin Liang , Ping Huang , G. Davis Harris, Jr. , Huiping Guan
发明人： Connie Li Sun , Congxin Liang , Ping Huang , G. Davis Harris, Jr. , Huiping Guan
IPC分类号： A01N43/58 , A61K31/50 , C07D413/00 , C07D471/00 , C07D487/00
CPC分类号： C07D487/04
摘要： The present invention relates to 8-amino-aryl-substituted imidazopyrazines which modulate the activity of protein kinases (“PKs”). The compounds of this invention are therefore useful in treating disorders related to abnormal PK activity. Pharmaceutical compositions comprising these compounds, methods of treating diseases utilizing pharmaceutical compositions comprising these compounds and methods of preparing them are also disclosed.
摘要翻译： 本发明涉及调节蛋白激酶（“PK”）活性的8-氨基 - 芳基取代的咪唑并吡嗪。 因此，本发明的化合物可用于治疗与异常PK活性相关的疾病。 还公开了包含这些化合物的药物组合物，利用包含这些化合物的药物组合物治疗疾病的方法及其制备方法。
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3.发明申请公开(公告)号：US20050009832A1
公开(公告)日：2005-01-13
申请号：US10845586
申请日：2004-05-14
申请人： Connie Sun , Congxin Liang , Ping Huang , G. Harris , Huiping Guan
发明人： Connie Sun , Congxin Liang , Ping Huang , G. Harris , Huiping Guan
IPC分类号： C07D487/04 , A61K31/498
CPC分类号： C07D487/04
摘要： The present invention relates to 8-amino-aryl-substituted imidazopyrazines which modulate the activity of protein kinases (“PKs”). The compounds of this invention are therefore useful in treating disorders related to abnormal PK activity. Pharmaceutical compositions comprising these compounds, methods of treating diseases utilizing pharmaceutical compositions comprising these compounds and methods of preparing them are also disclosed.
摘要翻译： 本发明涉及调节蛋白激酶（“PK”）活性的8-氨基 - 芳基取代的咪唑并吡嗪。 因此，本发明的化合物可用于治疗与异常PK活性相关的疾病。 还公开了包含这些化合物的药物组合物，利用包含这些化合物的药物组合物治疗疾病的方法及其制备方法。
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4.发明授权3-(4-amidopyrrol-2-ylmethylidene)-2-indolinone derivatives as protein kinase inhibitors 失效3-（4-氨基吡咯-2-基亚甲基）-2-二氢吲哚酮衍生物作为蛋白激酶抑制剂公开(公告)号：US07582756B2
公开(公告)日：2009-09-01
申请号：US11779807
申请日：2007-07-18
申请人： Huiping Guan , Congxin Liang , Li Sun , Peng Cho Tang , Chung Chen Wei , Tomas Vojkovsky , Qingwu Jin , Paul M. Herrinton , Michael A. Mauragis
发明人： Huiping Guan , Congxin Liang , Li Sun , Peng Cho Tang , Chung Chen Wei , Tomas Vojkovsky , Qingwu Jin , Paul M. Herrinton , Michael A. Mauragis
IPC分类号： C07D413/14
CPC分类号： C07D403/06 , C07D403/14 , C07D471/04
摘要： The present invention provides a method to make a pyrrole substituted 2-indolinone compound of the formula
摘要翻译： 本发明提供了制备下式的吡咯取代的2-二氢吲哚酮化合物的方法
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5.发明授权3-(4-amidopyrrol-2-ylmethylidene)-2-indolinone der derivatives as protein kinase inhibitors 失效3-（4-氨基吡咯-2-基亚甲基）-2-二氢吲哚衍生物作为蛋白激酶抑制剂公开(公告)号：US07256189B2
公开(公告)日：2007-08-14
申请号：US11511981
申请日：2006-08-28
申请人： Huiping Guan , Congxin Liang , Li Sun , Peng Cho Tang , Chung Chen Wei , Tomas Vojkovsky , Qingwu (Alan) Jin , Paul M. Herrinton , Michael A. Mauragis
发明人： Huiping Guan , Congxin Liang , Li Sun , Peng Cho Tang , Chung Chen Wei , Tomas Vojkovsky , Qingwu (Alan) Jin , Paul M. Herrinton , Michael A. Mauragis
IPC分类号： A61K31/5377 , C07D413/14
CPC分类号： C07D403/06 , C07D403/14 , C07D471/04
摘要： The present invention relates to pyrrole substituted 2-indolinone compounds and their pharmaceutically acceptable salts which modulate the activity of protein kinases and therefore are expected to be useful in the prevention and treatment of protein kinase related cellular disorders such as cancer.
摘要翻译： 本发明涉及吡咯取代的2-二氢吲哚酮化合物及其药学上可接受的盐，其调节蛋白激酶的活性，因此预期可用于预防和治疗与蛋白激酶相关的细胞病症例如癌症。
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6.发明授权3-(4-amidopyrrol-2-ylmethlidene)-2-indolinone derivatives as protein kinase inhibitors 失效3-（4-氨基吡咯-2-基亚甲基）-2-二氢吲哚酮衍生物作为蛋白激酶抑制剂公开(公告)号：US07179910B2
公开(公告)日：2007-02-20
申请号：US10656907
申请日：2003-09-08
申请人： Huiping Guan , Congxin Liang , Li Sun , Peng Cho Tang , Chung Chen Wei , Tomas Vojkovsky , Qingwu (Alan) Jin , Paul M. Herrinton , Michael A. Mauragis
发明人： Huiping Guan , Congxin Liang , Li Sun , Peng Cho Tang , Chung Chen Wei , Tomas Vojkovsky , Qingwu (Alan) Jin , Paul M. Herrinton , Michael A. Mauragis
IPC分类号： C07D279/12 , C07D413/14 , C07D209/34 , C07D249/02 , C07D257/04 , C07D403/14
CPC分类号： C07D403/06 , C07D403/14 , C07D471/04
摘要： The present invention relates to pyrrole substituted 2-indolinone compounds and their pharmaceutically acceptable salts which modulate the activity of protein kinases and therefore are expected to be useful in the prevention and treatment of protein kinase related cellular disorders such as cancer.
摘要翻译： 本发明涉及吡咯取代的2-二氢吲哚酮化合物及其药学上可接受的盐，其调节蛋白激酶的活性，因此预期可用于预防和治疗与蛋白激酶相关的细胞病症例如癌症。
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7.发明授权3-(4,5,6,7-tetrahydroindol-2-ylmethylidiene-2-indolinone derivatives as kinase inhibitors 失效作为激酶抑制剂的3-（4,5,6,7-四氢吲哚-2-基亚甲基-2-二氢吲哚酮衍生物）公开(公告)号：US06777417B2
公开(公告)日：2004-08-17
申请号：US10238051
申请日：2002-09-10
申请人： Congxin Liang , Huiping Guan , Peng Cho Tang , Robert A. Blake
发明人： Congxin Liang , Huiping Guan , Peng Cho Tang , Robert A. Blake
IPC分类号： A61K31495
CPC分类号： C07D401/12 , C07D209/34 , C07D401/14
摘要： The present invention relates to certain 3-(4,5,6,7-tetrahydroindol-2-yl-methylidene)-2-indolinone derivatives that inhibit kinases, in particular Src kinase. Pharmaceutical compositions comprising these compounds, methods of treating diseases mediated by kinases utilizing pharmaceutical compositions comprising these compounds, and methods of preparing them are also disclosed.
摘要翻译： 本发明涉及抑制激酶，特别是Src激酶的某些3-（4,5,6,7-四氢吲哚-2-基 - 亚甲基）-2-二氢吲哚酮衍生物。 还公开了包含这些化合物的药物组合物，使用包含这些化合物的药物组合物治疗由激酶介导的疾病的方法及其制备方法。
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8.发明授权3-(4-amidopyrrol-2-ylmethylidene)-2-indolinone derivatives as protein kinase inhibitors 失效3-（4-氨基吡咯-2-基亚甲基）-2-二氢吲哚酮衍生物作为蛋白激酶抑制剂公开(公告)号：US06653308B2
公开(公告)日：2003-11-25
申请号：US10076140
申请日：2002-02-15
申请人： Huiping Guan , Congxin Liang , Li Sun , Peng Cho Tang , Chung Chen Wei , Tomas Vojkovsky , Qingwu Jin , Paul M. Herrinton , Michael A. Mauragis
发明人： Huiping Guan , Congxin Liang , Li Sun , Peng Cho Tang , Chung Chen Wei , Tomas Vojkovsky , Qingwu Jin , Paul M. Herrinton , Michael A. Mauragis
IPC分类号： A61K31404
CPC分类号： C07D403/06 , C07D403/14 , C07D471/04
摘要： The present invention relates to pyrrole substituted 2-indolinone compounds and their pharmaceutically acceptable salts which modulate the activity of protein kinases and therefore are expected to be useful in the prevention and treatment of protein kinase related cellular disorders such as cancer.
摘要翻译： 本发明涉及吡咯取代的2-二氢吲哚酮化合物及其药学上可接受的盐，其调节蛋白激酶的活性，因此预期可用于预防和治疗与蛋白激酶相关的细胞病症例如癌症。
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9.发明申请公开(公告)号：US20070027149A1
公开(公告)日：2007-02-01
申请号：US11511981
申请日：2006-08-28
申请人： Huiping Guan , Congxin Liang , Connie Sun , Peng Cho Tang , Chung Chen Wei , Tomas Vojkovsky , Qingwu Jin , Paul Herrinton , Michael Mauragis
发明人： Huiping Guan , Congxin Liang , Connie Sun , Peng Cho Tang , Chung Chen Wei , Tomas Vojkovsky , Qingwu Jin , Paul Herrinton , Michael Mauragis
IPC分类号： A61K31/5377 , A61K31/4192 , A61K31/405 , C07D403/14 , C07D413/14
CPC分类号： C07D403/06 , C07D403/14 , C07D471/04
摘要： The present invention relates to pyrrole substituted 2-indolinone compounds and their pharmaceutically acceptable salts which modulate the activity of protein kinases and therefore are expected to be useful in the prevention and treatment of protein kinase related cellular disorders such as cancer.
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![3-[4-Substituted heterocyclyl)-pyrrol-2-ylmethylidene]-2- indolinone derivatives as kinase inhibitors](/abs-image/US/2003/11/04/US06642232B2/abs.jpg.150x150.jpg)
10.发明授权公开(公告)号：US06642232B2
公开(公告)日：2003-11-04
申请号：US10268082
申请日：2002-10-10
申请人： Matthew Mattson , Tomas Vojkovsky , Congxin Liang , Peng Cho Tang , Huiping Guan
发明人： Matthew Mattson , Tomas Vojkovsky , Congxin Liang , Peng Cho Tang , Huiping Guan
IPC分类号： A61K315377
CPC分类号： C07D401/14 , C07D403/12 , C07D403/14
摘要： The present invention relates to certain 3-[4-(substituted heterocyclyl)-pyrrol-2-ylmethylidene]-2-indolinone derivatives that inhibit kinases, in particular VEGFR and/or PDGFR kinases. Pharmaceutical compositions comprising these compounds, methods of treating diseases mediated by kinases utilizing pharmaceutical compositions comprising these compounds, and methods of preparing them are also disclosed.
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