专利检索 ap:("Huiping Guan" OR "Congxin Liang" OR "Connie Sun" OR "Peng Cho Tang" OR "Chung Chen Wei" OR "Tomas Vojkovsky" OR "Qingwu Jin" OR "Paul Herrinton" OR "Michael Mauragis") AND inv:"Congxin Liang" 第 1 页

1.

发明申请
3-(4-amidopyrrol-2-ylmethylidene)-2-indolinone der derivatives as protein kinase inhibitors 失效

公开(公告)号：US20070027149A1

公开(公告)日：2007-02-01

申请号：US11511981

申请日：2006-08-28

申请人： Huiping Guan , Congxin Liang , Connie Sun , Peng Cho Tang , Chung Chen Wei , Tomas Vojkovsky , Qingwu Jin , Paul Herrinton , Michael Mauragis

发明人： Huiping Guan , Congxin Liang , Connie Sun , Peng Cho Tang , Chung Chen Wei , Tomas Vojkovsky , Qingwu Jin , Paul Herrinton , Michael Mauragis

IPC分类号： A61K31/5377 , A61K31/4192 , A61K31/405 , C07D403/14 , C07D413/14

CPC分类号： C07D403/06 , C07D403/14 , C07D471/04

摘要： The present invention relates to pyrrole substituted 2-indolinone compounds and their pharmaceutically acceptable salts which modulate the activity of protein kinases and therefore are expected to be useful in the prevention and treatment of protein kinase related cellular disorders such as cancer.

2.

发明申请
3-(4-AMIDOPYRROL-2-YLMETHYLIDENE)-2-INDOLINONE DERIVATIVES AS PROTEIN KINASE INHIBITORS 失效
标题翻译：作为蛋白激酶抑制剂的3-（4-氨基吡咯-2-基甲基）-2-吲哚啉酮衍生物

公开(公告)号：US20080045709A1

公开(公告)日：2008-02-21

申请号：US11779807

申请日：2007-07-18

申请人： Huiping Guan , Congxin Liang , Li Sun , Peng Cho Tang , Chung Wei , Tomas Vojkovsky , Qingwu Jin , Paul Herrinton , Michael Mauragis

发明人： Huiping Guan , Congxin Liang , Li Sun , Peng Cho Tang , Chung Wei , Tomas Vojkovsky , Qingwu Jin , Paul Herrinton , Michael Mauragis

IPC分类号： C07D413/14

CPC分类号： C07D403/06 , C07D403/14 , C07D471/04

摘要： The present invention provides a method to make a pyrrole substituted 2-indolinone compound of the formula

摘要翻译： 本发明提供了制备下式的吡咯取代的2-二氢吲哚酮化合物的方法

3.

发明授权
3-(4-amidopyrrol-2-ylmethylidene)-2-indolinone derivatives as protein kinase inhibitors 失效
标题翻译： 3-（4-氨基吡咯-2-基亚甲基）-2-二氢吲哚酮衍生物作为蛋白激酶抑制剂

公开(公告)号：US07582756B2

公开(公告)日：2009-09-01

申请号：US11779807

申请日：2007-07-18

申请人： Huiping Guan , Congxin Liang , Li Sun , Peng Cho Tang , Chung Chen Wei , Tomas Vojkovsky , Qingwu Jin , Paul M. Herrinton , Michael A. Mauragis

发明人： Huiping Guan , Congxin Liang , Li Sun , Peng Cho Tang , Chung Chen Wei , Tomas Vojkovsky , Qingwu Jin , Paul M. Herrinton , Michael A. Mauragis

IPC分类号： C07D413/14

CPC分类号： C07D403/06 , C07D403/14 , C07D471/04

摘要： The present invention provides a method to make a pyrrole substituted 2-indolinone compound of the formula

摘要翻译： 本发明提供了制备下式的吡咯取代的2-二氢吲哚酮化合物的方法

4.

发明授权
3-(4-amidopyrrol-2-ylmethylidene)-2-indolinone derivatives as protein kinase inhibitors 失效
标题翻译： 3-（4-氨基吡咯-2-基亚甲基）-2-二氢吲哚酮衍生物作为蛋白激酶抑制剂

公开(公告)号：US06653308B2

公开(公告)日：2003-11-25

申请号：US10076140

申请日：2002-02-15

申请人： Huiping Guan , Congxin Liang , Li Sun , Peng Cho Tang , Chung Chen Wei , Tomas Vojkovsky , Qingwu Jin , Paul M. Herrinton , Michael A. Mauragis

发明人： Huiping Guan , Congxin Liang , Li Sun , Peng Cho Tang , Chung Chen Wei , Tomas Vojkovsky , Qingwu Jin , Paul M. Herrinton , Michael A. Mauragis

IPC分类号： A61K31404

CPC分类号： C07D403/06 , C07D403/14 , C07D471/04

摘要： The present invention relates to pyrrole substituted 2-indolinone compounds and their pharmaceutically acceptable salts which modulate the activity of protein kinases and therefore are expected to be useful in the prevention and treatment of protein kinase related cellular disorders such as cancer.

摘要翻译： 本发明涉及吡咯取代的2-二氢吲哚酮化合物及其药学上可接受的盐，其调节蛋白激酶的活性，因此预期可用于预防和治疗与蛋白激酶相关的细胞病症例如癌症。

5.

发明授权
3-(4-amidopyrrol-2-ylmethylidene)-2-indolinone der derivatives as protein kinase inhibitors 失效
标题翻译： 3-（4-氨基吡咯-2-基亚甲基）-2-二氢吲哚衍生物作为蛋白激酶抑制剂

公开(公告)号：US07256189B2

公开(公告)日：2007-08-14

申请号：US11511981

申请日：2006-08-28

申请人： Huiping Guan , Congxin Liang , Li Sun , Peng Cho Tang , Chung Chen Wei , Tomas Vojkovsky , Qingwu (Alan) Jin , Paul M. Herrinton , Michael A. Mauragis

发明人： Huiping Guan , Congxin Liang , Li Sun , Peng Cho Tang , Chung Chen Wei , Tomas Vojkovsky , Qingwu (Alan) Jin , Paul M. Herrinton , Michael A. Mauragis

IPC分类号： A61K31/5377 , C07D413/14

CPC分类号： C07D403/06 , C07D403/14 , C07D471/04

摘要： The present invention relates to pyrrole substituted 2-indolinone compounds and their pharmaceutically acceptable salts which modulate the activity of protein kinases and therefore are expected to be useful in the prevention and treatment of protein kinase related cellular disorders such as cancer.

摘要翻译： 本发明涉及吡咯取代的2-二氢吲哚酮化合物及其药学上可接受的盐，其调节蛋白激酶的活性，因此预期可用于预防和治疗与蛋白激酶相关的细胞病症例如癌症。

6.

发明授权
3-(4-amidopyrrol-2-ylmethlidene)-2-indolinone derivatives as protein kinase inhibitors 失效
标题翻译： 3-（4-氨基吡咯-2-基亚甲基）-2-二氢吲哚酮衍生物作为蛋白激酶抑制剂

公开(公告)号：US07179910B2

公开(公告)日：2007-02-20

申请号：US10656907

申请日：2003-09-08

申请人： Huiping Guan , Congxin Liang , Li Sun , Peng Cho Tang , Chung Chen Wei , Tomas Vojkovsky , Qingwu (Alan) Jin , Paul M. Herrinton , Michael A. Mauragis

发明人： Huiping Guan , Congxin Liang , Li Sun , Peng Cho Tang , Chung Chen Wei , Tomas Vojkovsky , Qingwu (Alan) Jin , Paul M. Herrinton , Michael A. Mauragis

IPC分类号： C07D279/12 , C07D413/14 , C07D209/34 , C07D249/02 , C07D257/04 , C07D403/14

CPC分类号： C07D403/06 , C07D403/14 , C07D471/04

摘要： The present invention relates to pyrrole substituted 2-indolinone compounds and their pharmaceutically acceptable salts which modulate the activity of protein kinases and therefore are expected to be useful in the prevention and treatment of protein kinase related cellular disorders such as cancer.

摘要翻译： 本发明涉及吡咯取代的2-二氢吲哚酮化合物及其药学上可接受的盐，其调节蛋白激酶的活性，因此预期可用于预防和治疗与蛋白激酶相关的细胞病症例如癌症。

7.

发明授权
3-[4-Substituted heterocyclyl)-pyrrol-2-ylmethylidene]-2- indolinone derivatives as kinase inhibitors 失效

公开(公告)号：US06642232B2

公开(公告)日：2003-11-04

申请号：US10268082

申请日：2002-10-10

申请人： Matthew Mattson , Tomas Vojkovsky , Congxin Liang , Peng Cho Tang , Huiping Guan

发明人： Matthew Mattson , Tomas Vojkovsky , Congxin Liang , Peng Cho Tang , Huiping Guan

IPC分类号： A61K315377

CPC分类号： C07D401/14 , C07D403/12 , C07D403/14

摘要： The present invention relates to certain 3-[4-(substituted heterocyclyl)-pyrrol-2-ylmethylidene]-2-indolinone derivatives that inhibit kinases, in particular VEGFR and/or PDGFR kinases. Pharmaceutical compositions comprising these compounds, methods of treating diseases mediated by kinases utilizing pharmaceutical compositions comprising these compounds, and methods of preparing them are also disclosed.

8.

发明授权
Pyrrole substituted 2-indolinone protein kinase inhibitors 有权
标题翻译：吡咯取代的2-二氢吲哚酮蛋白激酶抑制剂

公开(公告)号：US07572924B2

公开(公告)日：2009-08-11

申请号：US11517529

申请日：2006-09-06

申请人： Peng Cho Tang , Todd Anthony Miller , Xiaoyuan Li , Connie Li Sun , Chung Chen Wei , Shahrzad Shirazian , Congxin Liang , Tomas Vojkovsky , Asaad S. Nematalla , Michael Hawley

发明人： Peng Cho Tang , Todd Anthony Miller , Xiaoyuan Li , Connie Li Sun , Chung Chen Wei , Shahrzad Shirazian , Congxin Liang , Tomas Vojkovsky , Asaad S. Nematalla , Michael Hawley

IPC分类号： A61K31/404 , C07D403/06

CPC分类号： C07D233/56 , C07D207/33 , C07D209/44 , C07D231/12 , C07D249/08 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/12 , C07D403/14

摘要： The present invention relates to pyrrole substituted-2-indolinone compounds and their pharmaceutically acceptable salts which modulate the activity of protein kinases and therefore are expected to be useful in the prevention and treatment of protein kinase related cellular disorders such as cancer.

摘要翻译： 本发明涉及吡咯取代-2-二氢吲哚酮化合物及其药学上可接受的盐，其调节蛋白激酶的活性，因此预期可用于预防和治疗与蛋白激酶相关的细胞病症例如癌症。