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公开(公告)号:US10441256B2
公开(公告)日:2019-10-15
申请号:US15062749
申请日:2016-03-07
发明人: Ram H. Paul, Jr. , Cleon Stanley , Brian L. Bates , F. Joseph Obermiller , Thomas A. Osborne , Sean D. Chambers
摘要: Among other things, there are disclosed apparatuses and methods for medically sealing an opening in a vessel or wall. For example, in medical applications, a delivery tube is provided for insertion through a sheath into a vessel (e.g. a blood vessel). A dome-shaped seal fixed to a filament, an absorbent and/or compressible buffer, and a locking member are provided in the delivery tube. The delivery tube is configured so that it can be inserted into the vessel through a sheath. Tension is maintained on the filament to hold the seal against the tube or sheath. The sheath is pulled out, which pulls out the tube at the same time, leaving the seal over the opening in the vessel wall. The locking member compresses the buffer against the outside of the vessel and with the filament holds the seal in place against the inside of a vessel.
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公开(公告)号:US09918824B2
公开(公告)日:2018-03-20
申请号:US14324878
申请日:2014-07-07
发明人: Ram H. Paul, Jr.
CPC分类号: A61F2/07 , A61B2017/1107 , A61B2017/1132 , A61F2/06 , A61F2/848 , A61F2/86 , A61F2/89 , A61F2/915 , A61F2002/075 , A61F2002/8483 , A61F2002/91558 , A61F2002/91575 , A61F2210/0076 , A61F2220/005 , A61F2220/0058 , A61F2220/0066 , A61F2220/0075 , A61F2250/0023 , A61F2250/0036 , A61F2250/0037
摘要: A delivery system deploys a prosthesis for open surgical repair of a body vessel. The system includes a sleeve to retain segments of a prosthesis in a compressed configuration and retraction members. The sleeve has outer segments associated with each end of the prosthesis. Retraction of the retraction members removes the outer segments of the sleeve from the prosthesis outer ends to allow for expansion of the outer ends of the prosthesis in an outside-in direction. The system can include a handle and an actuation member movably attached to the handle. The actuation member is coupled to the sleeve outer segments so that movement of the actuation member corresponds to removal of the sleeve. The system can include elements to retain the sleeve outer segments to the actuation member and to redirect the retraction members to a direction different from the axis of the prosthesis.
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公开(公告)号:US09980732B2
公开(公告)日:2018-05-29
申请号:US15088583
申请日:2016-04-01
发明人: Ram H. Paul, Jr. , Brian C. Case , Jacob A. Flagle
CPC分类号: A61B17/12031 , A61B17/12022 , A61B17/12109 , A61B17/12181 , A61B17/1219 , A61B2017/00778 , A61B2017/00867 , A61B2017/00898 , A61B2017/1205 , A61B2017/22038
摘要: Described are devices, methods, and systems for achieving occlusion of vascular vessels. Further described are certain reduced or low profile procedures and devices for the percutaneous occlusion of the saphenous vein, such as in the treatment of a varicose vein condition caused by venous reflux.
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公开(公告)号:US10070850B2
公开(公告)日:2018-09-11
申请号:US14056429
申请日:2013-10-17
发明人: Cleon Stanley , Ram H. Paul, Jr. , Dennis Griffin
IPC分类号: A61B17/00
CPC分类号: A61B17/0057 , A61B2017/00615 , A61B2017/00619 , A61B2017/00623
摘要: Among other things, methods and apparatus for inserting devices for closing a tissue opening are disclosed. An anchoring or sealing member has one or more stems and/or filaments that are offset from the center of the member, so that lateral adjustments or movements of the anchoring or sealing member do not uncover the opening, cause the anchoring or sealing member to stick through or pull through the opening. Embodiments including a valve adapted to accommodate a guide wire for addressing emergencies are also disclosed.
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公开(公告)号:US09943298B2
公开(公告)日:2018-04-17
申请号:US14056470
申请日:2013-10-17
发明人: Cleon Stanley , Ram H. Paul, Jr.
IPC分类号: A61B17/00
CPC分类号: A61B17/0057 , A61B2017/00628
摘要: Among other things, there is disclosed devices for closing an internal opening, e.g. a hole in a blood vessel, that includes a shape memory function. Particular substances have been found to provide advantages in use, and in particular forms of closure structures.
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公开(公告)号:US09149279B2
公开(公告)日:2015-10-06
申请号:US14556666
申请日:2014-12-01
发明人: Ram H. Paul, Jr.
IPC分类号: A61M29/00 , A61B17/12 , C07D471/04
CPC分类号: A61B17/12177 , A61B17/12022 , A61B17/12109 , A61B17/12172 , A61B17/1219 , A61B2017/12054 , C07D471/04
摘要: An occluding device is provided for occluding fluid flow through a lumen of a body vessel. The occluding device includes an expandable tubular body having a tubular wall defining a lumen formed therethrough. The tubular wall has a proximal end extending to a distal end along a longitudinal axis of the tubular body. A plurality of longitudinal slits is formed through the tubular wall to define a plurality of flexible strips bound by a proximal non-slit portion and a distal non-slit portion. A plurality of barbs is disposed on the flexible strips. The tubular body is configured to open radially to engage the barbs with the vessel wall defining an expanded state and to collapse along the longitudinal axis to draw the vessel wall radially inward defining a collapsed state. Occluding material is housed within the lumen of the tubular body and the occluding material is configured to move between a collapsed state and an expanded state with the tubular body.
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公开(公告)号:US09078746B2
公开(公告)日:2015-07-14
申请号:US13775465
申请日:2013-02-25
发明人: Dusan Pavcnik , Brian C. Case , Jacob A. Flagle , Michael Garrison , Andrew K. Hoffa , Raymond B. Leonard, II , Thomas A. Osborne , Ram H. Paul, Jr. , Darin G. Schaeffer , Richard B Sisken
CPC分类号: A61F2/24 , A61F2/01 , A61F2/2418 , A61F2/2475 , A61F2002/018 , A61F2002/8483 , A61F2230/0008 , A61F2230/001 , A61F2230/0023 , A61F2230/0026 , A61F2230/0054 , A61F2230/0058 , A61F2230/0069 , A61F2230/0095
摘要: A valve prosthesis, such as an artificial venous valve, is described. The valve prosthesis has a support frame formed from a cannula and an attached covering that defines an opening adapted to move between a first position in which the opening is open to fluid flow and a second position in which the opening is closed to fluid flow. The support frame includes a leaflet support portion and a circumferential centering support element disposed adjacent the leaflet support portion with respect to a lengthwise axis of the support frame and mirroring the leaflet support portion with respect to a transverse axis of the support frame.
摘要翻译: 描述了阀门假体,例如人造静脉瓣。 瓣膜假体具有由套管形成的支撑框架和附接的覆盖物,该覆盖物限定适于在开口与流体流动打开的第一位置和开口关闭到流体流动的第二位置之间移动的开口。 支撑框架包括相对于支撑框架的纵向轴线邻近叶片支撑部分设置的小叶支撑部分和圆周定心支撑元件,并且相对于支撑框架的横向轴线镜像小叶支撑部分。
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公开(公告)号:US11638654B2
公开(公告)日:2023-05-02
申请号:US17096056
申请日:2020-11-12
发明人: Alec E. Cerchiari , Brian Feng , Timothy Foley , Christopher Mobley , Gary Neff , Ram H. Paul, Jr.
摘要: The present embodiments provide systems and methods for treating a medical condition. In one embodiment, the system comprises a stent having proximal and distal regions, and further having a delivery state and an expanded state. A therapeutic agent is disposed on a segment of the stent. The stent is disposed around an exterior surface of a core assembly in the delivery state. A coupling assembly releasably secures the proximal region of the stent to the exterior surface of the core assembly. The coupling assembly secures the stent to the core assembly for a predetermined period while the stent is in the expanded state and during release of the therapeutic agent at a target site. The coupling assembly further enables the stent to be disengaged from the core assembly and deployed in a bodily passageway.
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公开(公告)号:US10849607B2
公开(公告)日:2020-12-01
申请号:US15491205
申请日:2017-04-19
发明人: Cleon Stanley , Ram H. Paul, Jr.
摘要: Systems and methods for sealing an opening in a wall within the body of a patient are disclosed. In one embodiment, the system has an elongated body coupled to a vascular closure device and a resisting member, the elongated body having a high resistance portion and a low resistance portion and being constructed and arranged to interface with a resisting member to apply a conforming force to a vascular closure device. In some exemplary embodiments, the elongated body comprises a large diameter portion positioned in a proximal end region of the elongated body. Methods and other embodiments are disclosed.
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公开(公告)号:US10729416B2
公开(公告)日:2020-08-04
申请号:US15954725
申请日:2018-04-17
发明人: Cleon Stanley , Ram H. Paul, Jr.
IPC分类号: A61B17/00
摘要: Devices for closing an internal opening, e.g. a hole in a blood vessel, include a shape memory function. Particular substances have been found to provide advantages in use, and in particular forms of closure structures.
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