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    OPTICAL PROBE WITH FEEDBACK CORRECTION
    1.
    发明申请
    OPTICAL PROBE WITH FEEDBACK CORRECTION 失效
    具有反馈校正的光学探头

    公开(公告)号：US20120113491A1

    公开(公告)日：2012-05-10

    申请号：US13320601

    申请日：2010-05-10

    申请人： Cornelius Antonius Hezemans ,  Bernardus Hendrikus Wilhelmus Hendriks ,  Waltherus Cornelis Jozef Bierhoff ,  Augustinus Laurentius Braun ,  Nenad Mihajlovic

    发明人： Cornelius Antonius Hezemans ,  Bernardus Hendrikus Wilhelmus Hendriks ,  Waltherus Cornelis Jozef Bierhoff ,  Augustinus Laurentius Braun ,  Nenad Mihajlovic

    IPC分类号： G02B26/10

    CPC分类号： A61B5/6848 ,  A61B5/0068 ,  A61B5/0084 ,  G02B21/0012 ,  G02B21/0036 ,  G02B23/2423 ,  G02B23/26 ,  G02B26/103

    摘要： The present invention relates to an optical probe (1) suitable for miniature applications. An example application is a fibre-based confocal miniaturized microscope. The optical probe comprises a coil-based actuation system (9, 10) comprising drive coils (9) capable of displacing the distal end (3) of an optical guide (2) housed (4) by the optical probe. The probe makes use of a feedback loop which alternate between driving the displacement of the optical guide by driving a current through the drive coils and switching off the current through the drive coils, and while the drive current being switched off, measure the speed of the distal end of the optical guide. The measured speed is compared to the set-point speed, and if a difference is detected, the drive current is adjusted to eliminate, or at least bring down, this difference.

    摘要翻译： 本发明涉及适合于微型应用的光学探头（1）。 一个示例应用是基于光纤的共聚焦微型显微镜。 光探头包括基于线圈的致动系统（9,10），其包括驱动线圈（9），该驱动线圈能够移动由光学探头容纳（4）的光导（2）的远端（3）。 探头利用反馈回路，通过驱动通过驱动线圈的电流驱动光导的位移和切断通过驱动线圈的电流之间的交替，并且在驱动电流被切断时，测量速度 光导的远端。 将测量的速度与设定点速度进行比较，并且如果检测到差异，则调节驱动电流以消除或至少降低该差异。

    OPTICAL SCANNING PROBE ASSEMBLY
    3.
    发明申请
    OPTICAL SCANNING PROBE ASSEMBLY 有权
    光学扫描探头组件

    公开(公告)号：US20110201941A1

    公开(公告)日：2011-08-18

    申请号：US13125392

    申请日：2009-10-19

    申请人： Franciscus Martinus Antonius Maria Van Gaal ,  Bernardus Hendrikus Wilhelmus Hendriks ,  Augustinus Laurentius Braun ,  Cornelius Antonius Hezemans ,  Waltherus Cornelis Jozef Bierhoff

    发明人： Franciscus Martinus Antonius Maria Van Gaal ,  Bernardus Hendrikus Wilhelmus Hendriks ,  Augustinus Laurentius Braun ,  Cornelius Antonius Hezemans ,  Waltherus Cornelis Jozef Bierhoff

    IPC分类号： A61B6/00

    CPC分类号： A61B5/0062 ,  A61B5/0084 ,  G02B23/2461 ,  G02B26/103

    摘要： The present invention relates to an optical scanning probe assembly for microscopic guide optic scanning and inspection of tissues suitable for application in, e.g. in vivo medical inspection and biopsy. The assembly comprises an outer housing (3) comprising: i) a spring element for a scanning motor, the spring element formed as a hollow tube (5) adapted to receive an optical guide, the hollow tube having mechanical stiffness larger than the optical guide to be received, ii) a lens system (7) and iii) N means for deflecting (6) the distal end of the hollow tube in directions transverse to the longitudinal extension of the hollow tube, so as to form an optical scan pattern. The optical assembly is particularly advantageous as it increases the freedom to optimize the optical and mechanical performance of the system which is defined respectively by the optical guide and by the hollow tube. The probe can be used in resonant and non-resonant scanning modes.

    摘要翻译： 本发明涉及一种光学扫描探针组件，用于微观引导光学扫描和检查适用于例如， 体内检查和活检。 该组件包括外壳（3），包括：i）用于扫描电机的弹簧元件，弹簧元件形成为适于容纳光导的中空管（5），所述中空管的机械刚度大于光导 ii）透镜系统（7），以及iii）用于使中空管的远端沿垂直于中空管的纵向延伸的方向偏转（6）的装置，以形成光学扫描图案。 光学组件是特别有利的，因为它增加了由光导和中空管分别限定的优化系统的光学和机械性能的自由度。 探头可用于谐振和非谐振扫描模式。

    Optical probe system with increased scanning speed
    5.
    发明授权
    Optical probe system with increased scanning speed 有权
    光探头系统，扫描速度更快

    公开(公告)号：US09036140B2

    公开(公告)日：2015-05-19

    申请号：US13496213

    申请日：2010-09-10

    申请人： Nenad Mihajlovic ,  Jeroen Jan Lambertus Horikx ,  Waltherus Cornelis Jozef Bierhoff ,  Cornelius Antonius Hezemans ,  Bernardus Hendrikus Wilhelmus Hendriks

    发明人： Nenad Mihajlovic ,  Jeroen Jan Lambertus Horikx ,  Waltherus Cornelis Jozef Bierhoff ,  Cornelius Antonius Hezemans ,  Bernardus Hendrikus Wilhelmus Hendriks

    IPC分类号： G01J1/00 ,  A61B5/00 ,  G02B26/10

    CPC分类号： A61B5/0062 ,  A61B5/0068 ,  A61B5/0084 ,  G02B26/103

    摘要： An optical probe system having a probe with an optical guide (G) having a distal end. The optical guide (G) is mounted inside a housing (H) so that the distal end is displaceable with respect to the housing (H). A set of actuators (A), e.g. electromagnetic drive coils, can displace the distal end by application of a drive signal (Vx, Vy). A control unit (CU) generates the drive signal (Vx, Vy) so as to provide a scanning frequency which varies according to an amplitude of the drive signal (Vx, Vy). With such probe system it is possible to scan a field of view with a scanning frequency that varies with the scanning radius. Taking into account the maximum allowable drive current, it is possible to increase scanning speed compared to scanning at the mechanical resonance frequency of the optical system, since small radii can be scanned at a high scanning frequency.

    摘要翻译： 一种光探头系统，其具有具有远端的具有光导（G）的探针。 光导（G）安装在壳体（H）内，使得远端可相对于壳体（H）移动。 一组致动器（A），例如。 电磁驱动线圈可通过施加驱动信号（Vx，Vy）来移位远端。 控制单元（CU）产生驱动信号（Vx，Vy），以提供根据驱动信号（Vx，Vy）的振幅而变化的扫描频率。 利用这种探测系统，可以扫描具有随扫描半径变化的扫描频率的视场。 考虑到最大允许驱动电流，与在光学系统的机械共振频率下的扫描相比，可以增加扫描速度，因为可以以高扫描频率扫描小半径。

    OPTICAL PROBE SYSTEM WITH INCREASED SCANNING SPEED
    6.
    发明申请
    OPTICAL PROBE SYSTEM WITH INCREASED SCANNING SPEED 有权
    光学探头系统具有增加的扫描速度

    公开(公告)号：US20120170030A1

    公开(公告)日：2012-07-05

    申请号：US13496213

    申请日：2010-09-10

    申请人： Nenad Mihajlovic ,  Jeroen Jan Lambertus Horikx ,  Waltherus Cornelis Jozef Bierhoff ,  Cornelius Antonius Hezemans ,  Bernardus Hendrikus Wilhelmus Hendriks

    发明人： Nenad Mihajlovic ,  Jeroen Jan Lambertus Horikx ,  Waltherus Cornelis Jozef Bierhoff ,  Cornelius Antonius Hezemans ,  Bernardus Hendrikus Wilhelmus Hendriks

    IPC分类号： G01J1/00

    CPC分类号： A61B5/0062 ,  A61B5/0068 ,  A61B5/0084 ,  G02B26/103

    摘要： An optical probe system having a probe with an optical guide (G) having a distal end. The optical guide (G) is mounted inside a housing (H) so that the distal end is displaceable with respect to the housing (H). A set of actuators (A), e.g. electromagnetic drive coils, can displace the distal end by application of a drive signal (Vx, Vy). A control unit (CU) generates the drive signal (Vx, Vy) so as to provide a scanning frequency which varies according to an amplitude of the drive signal (Vx, Vy). With such probe system it is possible to scan a field of view with a scanning frequency that varies with the scanning radius. Taking into account the maximum allowable drive current, it is possible to increase scanning speed compared to scanning at the mechanical resonance frequency of the optical system, since small radii can be scanned at a high scanning frequency.

    摘要翻译： 一种光探头系统，其具有具有远端的具有光导（G）的探针。 光导（G）安装在壳体（H）内，使得远端可相对于壳体（H）移动。 一组致动器（A），例如。 电磁驱动线圈可通过施加驱动信号（Vx，Vy）来移位远端。 控制单元（CU）产生驱动信号（Vx，Vy），以提供根据驱动信号（Vx，Vy）的振幅而变化的扫描频率。 利用这种探测系统，可以扫描具有随扫描半径变化的扫描频率的视场。 考虑到最大允许驱动电流，与在光学系统的机械共振频率下的扫描相比，可以增加扫描速度，因为可以以高扫描频率扫描小半径。

    OPTICAL PROBE
    7.
    发明申请
    OPTICAL PROBE 审中-公开
    光学探头

    公开(公告)号：US20100282954A1

    公开(公告)日：2010-11-11

    申请号：US12810523

    申请日：2008-12-22

    申请人： Bernardus Hendrikus Wilhelmus Hendriks ,  Waltherus Cornelis Jozef Bierhoff ,  Augustinus Laurentius Braun ,  Nenad Mihajlovic ,  Gert 'T Hooft

    发明人： Bernardus Hendrikus Wilhelmus Hendriks ,  Waltherus Cornelis Jozef Bierhoff ,  Augustinus Laurentius Braun ,  Nenad Mihajlovic ,  Gert 'T Hooft

    IPC分类号： G01J1/58 ,  G01J1/00 ,  G02B26/10

    CPC分类号： A61B5/0062 ,  A61B1/00096 ,  A61B1/00165 ,  A61B1/00183 ,  A61B1/0019 ,  A61B5/0084

    摘要： The present invention relates to an optical probe (1) with an optical guide (2), e.g. an optical fibre, and a lens system (6) rigidly coupled to an end portion (2a) of the optical guide. The probe has a housing (3) with a cavity for the optical guide, the housing having at its distal end a transparent window (4), the window having an insignificant optical power as compared to the optical power of the said lens system (6). Actuation means (8) displaces the 5 lens system so as to enable optical scanning of a region of interest (ROI). The invention is particularly suited for miniature applications e.g. for in-vivo medical application. By attaching the lens system (6) to the optical guide (2) via the mount (7), the field of view (FOV) of the optical probe (1) may be determined directly by the transverse stroke of the optical fibre (2). Hence only a relatively small stroke is required. The field of view is thus 10 effectively no longer limited by the transverse stroke. The optical probe is especially advantageous for non-linear optical imaging where the optical guide may be an optical fibre with a relatively low exit numerical aperture.

    摘要翻译： 本发明涉及一种具有光导（2）的光学探针（1），例如， 光纤，以及刚性地耦合到光导的端部（2a）的透镜系统（6）。 该探针具有一个具有用于光导的空腔的壳体（3），该壳体在其远端处具有透明窗口（4），该窗口与所述透镜系统（6）的光焦度相比具有无效的光焦度 ）。 驱动装置（8）使5透镜系统移位，以便对感兴趣区域（ROI）进行光学扫描。 本发明特别适用于微型应用，例如 用于体内医疗应用。 通过经由安装件（7）将透镜系统（6）附接到光导（2），光学探头（1）的视场（FOV）可以直接由光纤（2）的横向行程确定 ）。 因此，只需要相对较小的行程。 因此，视场10不再受横向行程的限制。 光学探头对于非线性光学成像特别有利，其中光导可以是具有相对低的出射数值孔径的光纤。

    FIBER-OPTIC SCANNER
    8.
    发明申请
    FIBER-OPTIC SCANNER 有权
    光纤扫描仪

    公开(公告)号：US20100207015A1

    公开(公告)日：2010-08-19

    申请号：US12668905

    申请日：2008-07-14

    申请人： Waltherus Cornelis Jozef Bierhoff ,  Bernardus Hendrikus Wilhelmus Hendriks ,  Augustinus Laurentius Braun ,  Nanad Mihajlovic

    发明人： Waltherus Cornelis Jozef Bierhoff ,  Bernardus Hendrikus Wilhelmus Hendriks ,  Augustinus Laurentius Braun ,  Nanad Mihajlovic

    IPC分类号： G02B26/10

    CPC分类号： G02B26/101 ,  A61B5/0062 ,  A61B5/0084

    摘要： A fiber scanning system is provided comprising a housing (102) with a fiber (13), the fiber (13) comprising a fixed part and a free end, the fixed part being attached to a bottom of the housing (102) and the fiber (13) extending parallel to the wall of the housing (102). At least one electrical coil (12) is attached to the wall at a position in between the fixed part and the free end of the fiber (13), a winding of the electrical coil (12) being in a plane parallel to the fiber (13). A magnet (11) is attached to the fiber (13), such that the electrical coil (12) may induce a force on the magnet (11). The magnet (11) is attached to the fiber (13) at a position just before or after the electrical coil (12), a width of the magnet (11) being such that the magnet (11) extends over the electrical coil (12).

    摘要翻译： 提供一种纤维扫描系统，其包括具有纤维（13）的壳体（102），所述纤维（13）包括固定部分和自由端，所述固定部分附接到所述壳体（102）的底部，并且所述纤维 （13）平行于壳体（102）的壁延伸。 至少一个电线圈（12）在所述固定部分和所述光纤（13）的所述自由端之间的位置处附接到所述壁，所述电线圈（12）的绕组处于与所述光纤平行的平面（ 13）。 磁体（11）附着在光纤（13）上，使得电线圈（12）可以在磁铁（11）上产生一个力。 磁体（11）在刚好在电线圈（12）之前或之后的位置处附接到光纤（13），磁体（11）的宽度使得磁体（11）在电线圈（12）上方延伸 ）。

    Fiber scanning system having a magnet attached to the fiber at a position before or after an electrical coil with improved tip positioning
    9.
    发明授权
    Fiber scanning system having a magnet attached to the fiber at a position before or after an electrical coil with improved tip positioning 有权
    光纤扫描系统，其具有在具有改进的尖端定位的电线圈之前或之后的位置附接到光纤的磁体

    公开(公告)号：US08324562B2

    公开(公告)日：2012-12-04

    申请号：US12668905

    申请日：2008-07-14

    申请人： Waltherus Cornelis Jozef Bierhoff ,  Bernardus Hendrikus Wilhelmus Hendriks ,  Augustinus Laurentius Braun ,  Nanad Mihajlovic

    发明人： Waltherus Cornelis Jozef Bierhoff ,  Bernardus Hendrikus Wilhelmus Hendriks ,  Augustinus Laurentius Braun ,  Nanad Mihajlovic

    IPC分类号： H01J3/14

    CPC分类号： G02B26/101 ,  A61B5/0062 ,  A61B5/0084

    摘要： A fiber scanning system is provided comprising a housing (102) with a fiber (13), the fiber (13) comprising a fixed part and a free end, the fixed part being attached to a bottom of the housing (102) and the fiber (13) extending parallel to the wall of the housing (102). At least one electrical coil (12) is attached to the wall at a position in between the fixed part and the free end of the fiber (13), a winding of the electrical coil (12) being in a plane parallel to the fiber (13). A magnet (11) is attached to the fiber (13), such that the electrical coil (12) may induce a force on the magnet (11). The magnet (11) is attached to the fiber (13) at a position just before or after the electrical coil (12), a width of the magnet (11) being such that the magnet (11) extends over the electrical coil (12).

    摘要翻译： 提供一种纤维扫描系统，其包括具有纤维（13）的壳体（102），所述纤维（13）包括固定部分和自由端，所述固定部分附接到所述壳体（102）的底部，并且所述纤维 （13）平行于壳体（102）的壁延伸。 至少一个电线圈（12）在所述固定部分和所述光纤（13）的所述自由端之间的位置附接到所述壁，所述电线圈（12）的绕组处于与所述光纤平行的平面（ 13）。 磁体（11）附着在光纤（13）上，使得电线圈（12）可以在磁铁（11）上产生一个力。 磁体（11）在刚好在电线圈（12）之前或之后的位置处附接到光纤（13），磁体（11）的宽度使得磁体（11）在电线圈（12）上方延伸 ）。