公开(公告)号：US20120029360A1

公开(公告)日：2012-02-02

申请号：US13264388

申请日：2010-04-12

申请人： Bernardus Hendrikus Wilhelmus Hendriks ,  Augustinus Laurentius Braun ,  Rik Habers ,  Marjolein Van Der Voort ,  Adrien Desjardins ,  Rami Nachabe

发明人： Bernardus Hendrikus Wilhelmus Hendriks ,  Augustinus Laurentius Braun ,  Rik Habers ,  Marjolein Van Der Voort ,  Adrien Desjardins ,  Rami Nachabe

IPC分类号： A61B6/00

CPC分类号： A61B5/0084 ,  A61B5/0075 ,  A61B5/6848

摘要： A needle comprises a tip part, a holder part, a shaft, and fibers capable of transmitting light, wherein the shaft comprises a distal end connected to the tip part, and a proximal end connected to the holder part, wherein the tip part comprises a bevel, cutting facets, and at least one channel for accommodating a fiber, and wherein an end section of the fiber is located in the channel and an end surface of the fiber is located at one of the cutting facets. By way of the facets an introduction of the needle into tissue may be facilitated. A further aspect of the invention is a method for producing such a needle.

摘要翻译： 针包括尖端部分，保持器部分，轴和能够透射光的光纤，其中所述轴包括连接到所述尖端部分的远端以及连接到所述保持器部分的近端，其中所述尖端部分包括 斜面，切割面和用于容纳纤维的至少一个通道，并且其中光纤的端部位于通道中，并且光纤的端表面位于一个切割平面上。 通过这些方面，可以促进将针引入组织中。 本发明的另一方面是制造这种针的方法。

公开(公告)号：US20110251494A1

公开(公告)日：2011-10-13

申请号：US13129171

申请日：2009-11-18

申请人： Bernardus Hendrikus Wilhelmus Hendriks ,  Augustinus Laurentius Braun ,  Rik Harbers ,  Marjolein Van Der Voort ,  Adrien Desjardins ,  Rami Nachabe

发明人： Bernardus Hendrikus Wilhelmus Hendriks ,  Augustinus Laurentius Braun ,  Rik Harbers ,  Marjolein Van Der Voort ,  Adrien Desjardins ,  Rami Nachabe

IPC分类号： A61B6/00

CPC分类号： A61B5/0084 ,  A61B5/0075 ,  A61B5/1459 ,  A61B5/6848 ,  A61B10/0233 ,  A61B10/0283 ,  A61B17/3401 ,  A61B18/1477 ,  A61B2017/00057 ,  A61B2018/1425

摘要： Needle interventions are widely used in the field of oncology for taking biopsies of tissue in order to inspect whether tissue is cancerous or not. To make these interventions more reliable feedback of what kind of tissue is in front of the needle is required. A way to achieve this is by making use of optical spectroscopy. This requires integration of fibers into the needle. These fibers are used to deliver light to illuminate the tissue in front of the needle and to collect back the reflected light from the tissue. The present invention proposes to integrate the fiber distal ends in the slanted bevel of the needle in such a way that at least one source-detector fiber pair has a distance that is larger than the outer diameter of the needle.

摘要翻译： 针刺干预广泛用于肿瘤学领域，用于检查组织的活组织检查，以检查组织是否癌变。 要使这些干预措施更为可靠，就需要在针前方使用什么样的组织。 实现这一目标的一个方法是利用光谱学。 这需要将纤维整合到针中。 这些纤维用于传递光以照射针前面的组织并收集来自组织的反射光。 本发明提出将光纤远端集成在针的倾斜斜面中，使得至少一个源 - 检测器光纤对的距离大于针的外径。

公开(公告)号：US09131846B2

公开(公告)日：2015-09-15

申请号：US13125392

申请日：2009-10-19

申请人： Franciscus Martinus Antonius Maria Van Gaal ,  Bernardus Hendrikus Wilhelmus Hendriks ,  Augustinus Laurentius Braun ,  Cornelius Antonius Hezemans ,  Waltherus Cornelis Jozef Bierhoff

发明人： Franciscus Martinus Antonius Maria Van Gaal ,  Bernardus Hendrikus Wilhelmus Hendriks ,  Augustinus Laurentius Braun ,  Cornelius Antonius Hezemans ,  Waltherus Cornelis Jozef Bierhoff

IPC分类号： A61B6/00 ,  A61B5/00 ,  G02B23/24 ,  G02B26/10

CPC分类号： A61B5/0062 ,  A61B5/0084 ,  G02B23/2461 ,  G02B26/103

摘要： An optical scanning probe assembly for microscopic guide optic scanning and inspection of tissues includes an outer housing having a spring element for a scanning motor. The spring element is formed as a hollow tube configured to receive an optical guide, where the hollow tube has a mechanical stiffness larger than the optical guide to be received. The assembly further includes a lens system and a deflector configured to deflect the distal end of the hollow tube in directions transverse to the longitudinal extension of the hollow tube, so as to form an optical scan pattern.

摘要翻译： 用于微小导向光学扫描和组织检查的光学扫描探针组件包括具有用于扫描电机的弹簧元件的外壳。 弹簧元件形成为构造成接收光导的中空管，其中中空管具有比要接收的光导更大的机械刚度。 组件还包括透镜系统和偏转器，其被配置为使中空管的远端沿垂直于中空管的纵向延伸的方向偏转，以形成光学扫描图案。

公开(公告)号：US08717654B2

公开(公告)日：2014-05-06

申请号：US13320601

申请日：2010-05-10

申请人： Cornelius Antonius Hezemans ,  Bernardus Hendrikus Wilhelmus Hendriks ,  Waltherus Cornelis Jozef Bierhoff ,  Augustinus Laurentius Braun ,  Nenad Mihajlovic

发明人： Cornelius Antonius Hezemans ,  Bernardus Hendrikus Wilhelmus Hendriks ,  Waltherus Cornelis Jozef Bierhoff ,  Augustinus Laurentius Braun ,  Nenad Mihajlovic

IPC分类号： G02B26/08 ,  A61B5/05

CPC分类号： A61B5/6848 ,  A61B5/0068 ,  A61B5/0084 ,  G02B21/0012 ,  G02B21/0036 ,  G02B23/2423 ,  G02B23/26 ,  G02B26/103

摘要： The present invention relates to an optical probe (1) suitable for miniature applications. An example application is a fiber-based confocal miniaturized microscope. The optical probe comprises a coil-based actuation system (9, 10) comprising drive coils (9) capable of displacing the distal end (3) of an optical guide (2) housed (4) by the optical probe. The probe makes use of a feedback loop which alternate between driving the displacement of the optical guide by driving a current through the drive coils and switching off the current through the drive coils, and while the drive current being switched off, measure the speed of the distal end of the optical guide. The measured speed is compared to the set-point speed, and if a difference is detected, the drive current is adjusted to eliminate, or at least bring down, this difference.

摘要翻译： 本发明涉及适合于微型应用的光学探头（1）。 一个示例应用是基于光纤的共聚焦微型显微镜。 光探头包括基于线圈的致动系统（9,10），其包括驱动线圈（9），该驱动线圈能够移动由光学探头容纳（4）的光导（2）的远端（3）。 探头利用反馈回路，通过驱动通过驱动线圈的电流驱动光导的位移和切断通过驱动线圈的电流之间的交替，并且当驱动电流被切断时，测量速度 光导的远端。 将测量的速度与设定点速度进行比较，并且如果检测到差异，则调节驱动电流以消除或至少降低该差异。

公开(公告)号：US20100207015A1

公开(公告)日：2010-08-19

申请号：US12668905

申请日：2008-07-14

申请人： Waltherus Cornelis Jozef Bierhoff ,  Bernardus Hendrikus Wilhelmus Hendriks ,  Augustinus Laurentius Braun ,  Nanad Mihajlovic

发明人： Waltherus Cornelis Jozef Bierhoff ,  Bernardus Hendrikus Wilhelmus Hendriks ,  Augustinus Laurentius Braun ,  Nanad Mihajlovic

IPC分类号： G02B26/10

CPC分类号： G02B26/101 ,  A61B5/0062 ,  A61B5/0084

摘要： A fiber scanning system is provided comprising a housing (102) with a fiber (13), the fiber (13) comprising a fixed part and a free end, the fixed part being attached to a bottom of the housing (102) and the fiber (13) extending parallel to the wall of the housing (102). At least one electrical coil (12) is attached to the wall at a position in between the fixed part and the free end of the fiber (13), a winding of the electrical coil (12) being in a plane parallel to the fiber (13). A magnet (11) is attached to the fiber (13), such that the electrical coil (12) may induce a force on the magnet (11). The magnet (11) is attached to the fiber (13) at a position just before or after the electrical coil (12), a width of the magnet (11) being such that the magnet (11) extends over the electrical coil (12).

摘要翻译： 提供一种纤维扫描系统，其包括具有纤维（13）的壳体（102），所述纤维（13）包括固定部分和自由端，所述固定部分附接到所述壳体（102）的底部，并且所述纤维 （13）平行于壳体（102）的壁延伸。 至少一个电线圈（12）在所述固定部分和所述光纤（13）的所述自由端之间的位置处附接到所述壁，所述电线圈（12）的绕组处于与所述光纤平行的平面（ 13）。 磁体（11）附着在光纤（13）上，使得电线圈（12）可以在磁铁（11）上产生一个力。 磁体（11）在刚好在电线圈（12）之前或之后的位置处附接到光纤（13），磁体（11）的宽度使得磁体（11）在电线圈（12）上方延伸 ）。

公开(公告)号：US20120113491A1

公开(公告)日：2012-05-10

申请号：US13320601

申请日：2010-05-10

申请人： Cornelius Antonius Hezemans ,  Bernardus Hendrikus Wilhelmus Hendriks ,  Waltherus Cornelis Jozef Bierhoff ,  Augustinus Laurentius Braun ,  Nenad Mihajlovic

发明人： Cornelius Antonius Hezemans ,  Bernardus Hendrikus Wilhelmus Hendriks ,  Waltherus Cornelis Jozef Bierhoff ,  Augustinus Laurentius Braun ,  Nenad Mihajlovic

IPC分类号： G02B26/10

CPC分类号： A61B5/6848 ,  A61B5/0068 ,  A61B5/0084 ,  G02B21/0012 ,  G02B21/0036 ,  G02B23/2423 ,  G02B23/26 ,  G02B26/103

摘要： The present invention relates to an optical probe (1) suitable for miniature applications. An example application is a fibre-based confocal miniaturized microscope. The optical probe comprises a coil-based actuation system (9, 10) comprising drive coils (9) capable of displacing the distal end (3) of an optical guide (2) housed (4) by the optical probe. The probe makes use of a feedback loop which alternate between driving the displacement of the optical guide by driving a current through the drive coils and switching off the current through the drive coils, and while the drive current being switched off, measure the speed of the distal end of the optical guide. The measured speed is compared to the set-point speed, and if a difference is detected, the drive current is adjusted to eliminate, or at least bring down, this difference.

摘要翻译： 本发明涉及适合于微型应用的光学探头（1）。 一个示例应用是基于光纤的共聚焦微型显微镜。 光探头包括基于线圈的致动系统（9,10），其包括驱动线圈（9），该驱动线圈能够移动由光学探头容纳（4）的光导（2）的远端（3）。 探头利用反馈回路，通过驱动通过驱动线圈的电流驱动光导的位移和切断通过驱动线圈的电流之间的交替，并且在驱动电流被切断时，测量速度 光导的远端。 将测量的速度与设定点速度进行比较，并且如果检测到差异，则调节驱动电流以消除或至少降低该差异。

公开(公告)号：US20110201941A1

公开(公告)日：2011-08-18

申请号：US13125392

申请日：2009-10-19

申请人： Franciscus Martinus Antonius Maria Van Gaal ,  Bernardus Hendrikus Wilhelmus Hendriks ,  Augustinus Laurentius Braun ,  Cornelius Antonius Hezemans ,  Waltherus Cornelis Jozef Bierhoff

发明人： Franciscus Martinus Antonius Maria Van Gaal ,  Bernardus Hendrikus Wilhelmus Hendriks ,  Augustinus Laurentius Braun ,  Cornelius Antonius Hezemans ,  Waltherus Cornelis Jozef Bierhoff

IPC分类号： A61B6/00

CPC分类号： A61B5/0062 ,  A61B5/0084 ,  G02B23/2461 ,  G02B26/103

摘要： The present invention relates to an optical scanning probe assembly for microscopic guide optic scanning and inspection of tissues suitable for application in, e.g. in vivo medical inspection and biopsy. The assembly comprises an outer housing (3) comprising: i) a spring element for a scanning motor, the spring element formed as a hollow tube (5) adapted to receive an optical guide, the hollow tube having mechanical stiffness larger than the optical guide to be received, ii) a lens system (7) and iii) N means for deflecting (6) the distal end of the hollow tube in directions transverse to the longitudinal extension of the hollow tube, so as to form an optical scan pattern. The optical assembly is particularly advantageous as it increases the freedom to optimize the optical and mechanical performance of the system which is defined respectively by the optical guide and by the hollow tube. The probe can be used in resonant and non-resonant scanning modes.

摘要翻译： 本发明涉及一种光学扫描探针组件，用于微观引导光学扫描和检查适用于例如， 体内检查和活检。 该组件包括外壳（3），包括：i）用于扫描电机的弹簧元件，弹簧元件形成为适于容纳光导的中空管（5），所述中空管的机械刚度大于光导 ii）透镜系统（7），以及iii）用于使中空管的远端沿垂直于中空管的纵向延伸的方向偏转（6）的装置，以形成光学扫描图案。 光学组件是特别有利的，因为它增加了由光导和中空管分别限定的优化系统的光学和机械性能的自由度。 探头可用于谐振和非谐振扫描模式。

公开(公告)号：US06851119B2

公开(公告)日：2005-02-01

申请号：US10236185

申请日：2002-09-06

申请人： Augustinus Laurentius Braun ,  Leonardus Petrus Maria Tielemans

发明人： Augustinus Laurentius Braun ,  Leonardus Petrus Maria Tielemans

IPC分类号： G11B25/04 ,  G11B33/14 ,  G11B5/12 ,  B01J8/04

CPC分类号： G11B33/14 ,  G11B25/043

摘要： A filter arrangement for a recording/reproducing wherein an air filter is adapted to filter an air flow of ambient air present within the housing during operation of the device flowing over an information surface of a rotating information disc disposed adjacent to the information surface in parallel spaced relation thereto, a casing within the housing encasing an information surface of an information disc disposed on the disc driving arrangement and provided with an air inlet for air to be filtered and an air exhaust for filtered air. To decrease the energy consumption of air filtering while ensuring good filtering results, the air filter arranged stationary within the housing to extend over the disc information surface, the airflow flowing axially through the filter and being induced by the naturally occurring pumping action of the rotating information disc, while the air flow resistance of the air inlet, the air filter and the air exhaust exhibit mutually adapted air flow resistance values substantially preventing any air flow from outside the casing, through the casing and out of the exhaust different from the air flow from the air inlet, through the air filter, the casing and out of the exhaust.

摘要翻译： 一种用于记录/再现的过滤器装置，其中空气过滤器适于在存在于与信息表面相邻设置的旋转信息盘的信息表面上并行间隔开的​​流动的装置的操作期间过滤存在于壳体内的环境空气的气流 壳体内部包围设置在盘驱动装置上的信息盘的信息表面，并且设置有用于要过滤的空气的空气入口和用于过滤空气的排气。为了降低空气过滤的能量消耗，同时确保 良好的过滤结果，空气过滤器在壳体内静止地布置以在盘信息表面上延伸，气流轴向地流过过滤器并且由旋转信息盘的自然产生的泵送动作引起，而空气的气流阻力 入口，空气过滤器和排气表现出相互适应的气流阻力val 基本上防止任何空气从壳体外部流出，通过壳体和排出不同于来自空气入口的空气流，通过空气过滤器，壳体和排出的废气。

公开(公告)号：US08812080B2

公开(公告)日：2014-08-19

申请号：US13376702

申请日：2010-06-07

申请人： Rami Nachabe ,  Bernardus Hendrikus Wilhelmus Hendriks ,  Augustinus Laurentius Braun ,  Marjolein Van Der Voort ,  Adrien Desjardins ,  Drazenko Babic ,  Nenad Mihajlovic

发明人： Rami Nachabe ,  Bernardus Hendrikus Wilhelmus Hendriks ,  Augustinus Laurentius Braun ,  Marjolein Van Der Voort ,  Adrien Desjardins ,  Drazenko Babic ,  Nenad Mihajlovic

IPC分类号： A61B5/05

CPC分类号： G06F19/321 ,  A61B5/0066 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/0091 ,  A61B5/14503 ,  A61B5/6848 ,  A61B5/7435 ,  A61B5/7475 ,  A61B6/467 ,  A61B6/469 ,  A61B6/545 ,  A61B8/0833 ,  A61B8/461 ,  A61B8/467 ,  A61B8/469 ,  A61B8/585 ,  A61B17/3401 ,  A61B17/3403 ,  A61B34/20 ,  A61B90/92 ,  A61B90/96 ,  A61B90/98 ,  A61B2017/00199 ,  A61B2017/00225 ,  A61B2034/2055 ,  A61B2090/376 ,  A61B2090/3908 ,  A61B2090/3945 ,  A61B2562/08 ,  G06F19/00 ,  G16H40/63

摘要： Needles are widely used in interventional radiology. Each medical application requires a specific needle type. The same holds for the photonic needles which analysis depends on the type of application the clinician aims for. Therefore, it is relevant to have the X-ray machine recognize the type of needle that is being used and to load the required software for the tissue analysis. It is therefore proposed to have a data link established between the imaging modality used for the acquisition of the patient anatomy (X-ray, CT, MR or US) and the system that processes optical data from the needle, so that the information from this imaging modality can be used to guide the processing. In a preferred embodiment the selection is made by reading out the code present in the disposable needle when it is connected to the console.

摘要翻译： 针头广泛用于介入放射学。 每个医疗应用都需要特殊的针型。 同样适用于光子针，分析取决于临床医生的应用类型。 因此，使X射线机器识别正在使用的针的类型并加载组织分析所需的软件是相关的。 因此，建议在用于获取患者解剖结构（X射线，CT，MR或US）的成像模式和处理来自针的光学数据的系统之间建立数据链路，使得来自该信息的信息 成像模式可用于指导处理。 在优选实施例中，通过在连接到控制台时读出一次性针头中存在的代码来进行选择。

公开(公告)号：US08324562B2

公开(公告)日：2012-12-04

申请号：US12668905

申请日：2008-07-14

申请人： Waltherus Cornelis Jozef Bierhoff ,  Bernardus Hendrikus Wilhelmus Hendriks ,  Augustinus Laurentius Braun ,  Nanad Mihajlovic

发明人： Waltherus Cornelis Jozef Bierhoff ,  Bernardus Hendrikus Wilhelmus Hendriks ,  Augustinus Laurentius Braun ,  Nanad Mihajlovic

IPC分类号： H01J3/14

CPC分类号： G02B26/101 ,  A61B5/0062 ,  A61B5/0084

摘要： A fiber scanning system is provided comprising a housing (102) with a fiber (13), the fiber (13) comprising a fixed part and a free end, the fixed part being attached to a bottom of the housing (102) and the fiber (13) extending parallel to the wall of the housing (102). At least one electrical coil (12) is attached to the wall at a position in between the fixed part and the free end of the fiber (13), a winding of the electrical coil (12) being in a plane parallel to the fiber (13). A magnet (11) is attached to the fiber (13), such that the electrical coil (12) may induce a force on the magnet (11). The magnet (11) is attached to the fiber (13) at a position just before or after the electrical coil (12), a width of the magnet (11) being such that the magnet (11) extends over the electrical coil (12).

摘要翻译： 提供一种纤维扫描系统，其包括具有纤维（13）的壳体（102），所述纤维（13）包括固定部分和自由端，所述固定部分附接到所述壳体（102）的底部，并且所述纤维 （13）平行于壳体（102）的壁延伸。 至少一个电线圈（12）在所述固定部分和所述光纤（13）的所述自由端之间的位置附接到所述壁，所述电线圈（12）的绕组处于与所述光纤平行的平面（ 13）。 磁体（11）附着在光纤（13）上，使得电线圈（12）可以在磁铁（11）上产生一个力。 磁体（11）在刚好在电线圈（12）之前或之后的位置处附接到光纤（13），磁体（11）的宽度使得磁体（11）在电线圈（12）上方延伸 ）。