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公开(公告)号：US20080269259A1
公开(公告)日：2008-10-30
申请号：US11814365
申请日：2006-01-19
申请人： Craig B. Thompson , Julian Lum , Daniel Bauer
发明人： Craig B. Thompson , Julian Lum , Daniel Bauer
CPC分类号： C12Q1/26 , A61K31/00 , A61K31/4706 , A61K31/675 , A61K45/06 , G01N33/574 , G01N2500/00 , A61K2300/00
摘要： Methods of treating an individual who has been identified as having glycolysis dependent cancer are disclosed. The methods comprise the step of: administering to such an individual a combination of an anti-cancer composition that renders the cancer incapable of glycolysis and an autophagy inhibitor. Pharmaceutical compositions and kits comprising that renders the cancer incapable of glycolysis and an autophagy inhibit are also disclosed. Methods of treating an individual who has a disease characterized b cell degeneration and cell death due to autophagy are disclosed. The methods comprise administering to the individual a permeable form of a metabolic substrate that can be oxidized in the tricarboxylic acid cycle to produce NADH. Methods for identifying an autophagy inhibitor comprising performing a test assay using an apopto sis-resistant cell are disclosed.
摘要翻译： 公开了已经鉴定为具有糖酵解依赖性癌症的个体的治疗方法。 所述方法包括以下步骤：向这样的个体施用使癌症不能糖酵解的抗癌组合物与自噬抑制剂的组合。 还公开了包含其的药物组合物和试剂盒，使癌症不能进行糖酵解和自噬抑制。 公开了治疗患有由于自噬引起的b细胞变性和细胞死亡的疾病的个体的方法。 所述方法包括向个体施用可在三羧酸循环中被氧化以产生NADH的代谢底物的可渗透形式。 公开了用于鉴定自噬抑制剂的方法，包括使用抗凋亡细胞进行测试测定。
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公开(公告)号：US09060993B2
公开(公告)日：2015-06-23
申请号：US10556220
申请日：2004-05-07
CPC分类号： A61K31/34 , A61K51/0491
摘要： Methods of treating individuals identified as having cancer using ATP citrate lyase inhibitor and/or tricarboxylate transporter inhibitor are disclosed. Methods of inducing apoptosis in cancer cells using an ATP citrate lyase inhibitor and/or tri-carboxylate transporter inhibitor are disclosed. of treating an individual who has cancer comprising the steps of identifying the cancer as having a high rate of aerobic glycolysis, and administering an ATP citrate lyase inhibitor and/or tricarboxylate transporter inhibitor are disclosed. Methods of treating individuals who have cancer using compounds that inhibit the expression of ATP citrate lyase or tricarboxylate transporter are disclosed. Methods of identifying a compound with anticancer activity are disclosed.
摘要翻译： 公开了使用ATP柠檬酸裂解酶抑制剂和/或三羧酸转运蛋白抑制剂治疗被鉴定为具有癌症的个体的方法。 公开了使用ATP柠檬酸裂解酶抑制剂和/或三羧酸酯转运蛋白抑制剂诱导癌细胞凋亡的方法。 公开了治疗患有癌症的个体的步骤，所述方法包括以下步骤：将癌症识别为具有高比例的需氧糖酵解，以及施用ATP柠檬酸裂解酶抑制剂和/或三羧酸转运蛋白抑制剂。 公开了使用抑制ATP柠檬酸裂合酶或三羧酸转运蛋白的表达的化合物治疗患有癌症的个体的方法。 公开了鉴定具有抗癌活性的化合物的方法。
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公开(公告)号：US20120245964A1
公开(公告)日：2012-09-27
申请号：US13488484
申请日：2012-06-05
IPC分类号： G06Q40/08
CPC分类号： G06Q40/08
摘要： A system for providing flight accident insurance at low price and fixed coverage comprises means for limiting the number of policies that can be sold on any given flight to not more than a predetermined number. The predetermined number may be 20. The system comprises an input device for receiving information from a traveler and an output device for providing an insurance quote to said traveler.
摘要翻译： 以低价和固定覆盖面提供飞行事故保险的系统包括将任何给定航班上可以出售的政策数量限制在不超过预定数量的手段。 预定数量可以是20.系统包括用于从旅行者接收信息的输入装置和用于向所述旅行者提供保险报价的输出装置。
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公开(公告)号：US20070259956A1
公开(公告)日：2007-11-08
申请号：US10556220
申请日：2004-05-07
IPC分类号： A61K31/215 , A61K31/21
CPC分类号： A61K31/34 , A61K51/0491
摘要： Methods of treating individuals identified as having cancer using ATP citrate lyase inhibitor and/or tricarboxylate transporter inhibitor are disclosed. Methods of inducing apoptosis in cancer cells using an ATP citrate lyase inhibitor and/or tricarboxylate transporter inhibitor are disclosed. Methods of treating an individual who has cancer comprising the steps of identifying the cancer as having a high rate of aerobic glycolysis, and administering an ATP citrate lyase inhibitor and/or tricarboxylate transporter inhibitor are disclosed. Methods of treating individuals who have cancer using compounds that inhibit the expression of ATP citrate lyase or tricarboxylate transporter are disclosed. Methods of identifying a compound with anticancer activity are disclosed.
摘要翻译： 公开了使用ATP柠檬酸裂解酶抑制剂和/或三羧酸转运蛋白抑制剂治疗被鉴定为具有癌症的个体的方法。 公开了使用ATP柠檬酸裂解酶抑制剂和/或三羧酸转运蛋白抑制剂诱导癌细胞凋亡的方法。 公开了治疗患有癌症的个体的方法，包括将癌症鉴定为具有高比例的有氧糖酵解的步骤，以及施用ATP柠檬酸裂解酶抑制剂和/或三羧酸转运蛋白抑制剂。 公开了使用抑制ATP柠檬酸裂合酶或三羧酸转运蛋白的表达的化合物治疗患有癌症的个体的方法。 公开了鉴定具有抗癌活性的化合物的方法。
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5.发明授权Cosmetic composition containing an aqueous polymer dispersion and an insoluble silicone, and process and use thereof 失效含有聚合物水分散体和不溶性硅氧烷的化妆品组合物及其工艺和用途公开(公告)号：US06703028B1
公开(公告)日：2004-03-09
申请号：US09689818
申请日：2000-10-13
申请人： Henri Samain , Daniel Bauer , Jean-Michel Sturla
发明人： Henri Samain , Daniel Bauer , Jean-Michel Sturla
IPC分类号： A61K700
CPC分类号： A61Q19/00 , A61K8/046 , A61K8/8152 , A61K8/891 , A61Q5/06 , Y10S514/844 , Y10S514/943
摘要： An aqueous or aqueous/alcoholic cosmetic composition which can be sprayed, comprising an aqueous dispersion of insoluble film-forming polymer particles and at least one insoluble silicone, wherein the polymer particles are present in a concentration greater than 15%, relative to the total weight of the composition, and further wherein the glass transition temperature of the insoluble polymer particles ranges from 15 to 35° C. The invention also relates to a process for the cosmetic treatment of keratinous substances using these compositions and to the use of the silicone for improving the quality of the spraying of the composition.
摘要翻译： 可喷雾的水性或水性/醇类化妆品组合物，其包含不溶性成膜聚合物颗粒和至少一种不溶性硅氧烷的水性分散体，其中聚合物颗粒以相对于总重量的大于15％的浓度存在 的组合物，并且其中不溶性聚合物颗粒的玻璃化转变温度为15-35℃。本发明还涉及使用这些组合物和使用硅氧烷来改善角质化物质的美容处理方法 喷涂组合物的质量。
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6.发明授权Dyeing process employing indole dyes and oxidation dye precursors and dyeing agents employed 失效使用吲哚染料和氧化染料前体的染色工艺和使用的染色剂
公开(公告)号：US5073174A
公开(公告)日：1991-12-17
申请号：US554873
申请日：1990-07-20
申请人： Charles Vayssie , Daniel Bauer , Francoise Richard , Alex Junino
发明人： Charles Vayssie , Daniel Bauer , Francoise Richard , Alex Junino
摘要： A process for dyeing keratinous fibers comprises a two-step operation in which in the first step the fibers are contacted with an indole dye in a medium suitable for dyeing the fibers, the medium being free from any oxidation catalyst and oxidation catalyst. Thereafter, in the second step the fibers are contacted with a para type oxidation dye precursor in a medium which is also suitable for dyeing the fibers and is free from any oxidation catalyst and oxidation agent. A multi-compartment kit housing the indole dye and para type oxidation dye precursor is also provided.
摘要翻译： 用于染色角质纤维的方法包括两步操作，其中在第一步中，纤维在适于染色纤维的介质中与吲哚染料接触，所述介质不含任何氧化催化剂和氧化催化剂。 此后，在第二步中，纤维在培养基中与对位型氧化染料前体接触，该介质也适用于染色纤维，不含任何氧化催化剂和氧化剂。 还提供了容纳吲哚染料和对位氧化染料前体的多室试剂盒。
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7.发明授权Process for dyeing keratinous fibres with a hydroxyindole in combination with a quinone derivative; and novel 1,4-benzoquinones 失效用喹啉衍生物联合羟基染色剂的染色剂纤维的方法; 和新的1,4-苯并噻喃酮
公开(公告)号：US5053053A
公开(公告)日：1991-10-01
申请号：US446544
申请日：1989-12-06
申请人： Arnaud De Labbey , Alain Baudry , Daniel Bauer , Pierre Bore
发明人： Arnaud De Labbey , Alain Baudry , Daniel Bauer , Pierre Bore
IPC分类号： D06P3/08 , A61K8/00 , A61K8/34 , A61K8/35 , A61K8/40 , A61K8/41 , A61K8/44 , A61K8/46 , A61K8/49 , A61Q5/10 , D06M13/12 , D06M13/35 , D06P3/04
摘要： Process for dyeing keratinous fibres, comprising the step of applying to these fibres at least one composition A containing, in a medium appropriate for dyeing, at least one mono- or di-hydroxyindole the application of the composition A being preceded or followed by the application of a composition B containing, in a medium appropriate for dyeing, at least one quinone derivative chosen from ortho- or para-benzoquinones, monoimines or diimines of ortho- or para-benzoquinones, 1,2- or 1,4-naphthoquinones, sulphonimides of ortho- or para-benzoquinones, .alpha., .omega.-alkylene-bis-1,4-benzoquinones, or 1,2- or 1,4-naphthoquinone-monoimines or -diimines; the mono- or di-hydroxyindoles and the quinone derivatives being chosen such that the oxidation-reduction potential difference .DELTA.E between the oxidation-reduction potential E.sub.i of the mono- or di-hydroxyindoles, determined at pH 7 in a phosphate medium on a vitreous carbon electrode by voltametry, and the oxidation-reduction potential E.sub.q of the quinone derivative determined at pH 7 in a phosphate medium by polarography on a mercury electrode and relative to a saturated calomel electrode is such that.DELTA.E=E.sub.i -E.sub.q .ltoreq.320 mV.
摘要翻译： 用于染色角质纤维的方法，包括向这些纤维施加至少一种组合物A的步骤，该组合物A在适于染色的培养基中含有至少一种单羟基吲哚和二羟基吲哚，组合物A在施用之前或之后施用 在适于染色的培养基中含有至少一种选自邻 - 或对 - 苯醌，邻 - 或对 - 苯醌的单亚胺或二亚胺，1,2-或1,4-萘醌，磺酰亚胺的醌衍生物的组合物B 邻 - 或对 - 苯醌，α，ω-亚烷基 - 双-1,4-苯醌或1,2-或1,4-萘醌 - 单亚胺或二亚胺; 选择单羟基吲哚和二羟基吲哚和醌衍生物，使得在磷酸盐介质中在玻璃质上在pH 7下测定的单羟基吲哚或二羟基吲哚的氧化还原电位Ei之间的氧化还原电位差DELTA E 碳电极，通过在汞电极上并相对于饱和甘汞电极的极谱法在pH7下测定的醌衍生物的氧化还原电位Eq为DELTA E = Ei-Eq≤320 mV。
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公开(公告)号：US4214677A
公开(公告)日：1980-07-29
申请号：US923990
申请日：1978-07-12
申请人： Daniel Bauer , Gerard Braque
发明人： Daniel Bauer , Gerard Braque
CPC分类号： B05B11/3087
摘要： A dispenser having a reciprocating pump to feed a liquid product to a mixing chamber and an air pump with a piston to simultaneously compress and feed compressed air to the mixing chamber. The body containing the mixing chamber is mounted on the product pump and the air piston is mounted on the body. Manual pressure on the air piston is transmitted to the body which moves down to cause the product pump to reciprocate. The product pump includes a chamber with a valve which opens only after the pressure in the chamber exceeds a certain value. The air pump includes a valve which opens only after the air pressure exceeds a certain value. The air pressure valve is selected to open at the same time as the pump valve opens so that the product is dispensed as a spray.
摘要翻译： 一种具有往复泵以将液体产物供给到混合室的分配器和具有活塞的空气泵，以同时压缩并将压缩空气供给到混合室。 包含混合室的主体安装在产品泵上，空气活塞安装在主体上。 空气活塞上的手动压力传递到主体，向下移动以使产品泵往复运动。 产品泵包括具有阀的室，仅在室中的压力超过一定值后才打开。 气泵包括仅在空气压力超过一定值后打开的阀门。 选择空气压力阀在泵阀打开的同时打开，以便产品以喷雾方式分配。
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公开(公告)号：US09389922B2
公开(公告)日：2016-07-12
申请号：US13046008
申请日：2011-03-11
申请人： Daniel Bauer , Nicholas D. Butler , Han Chen , Kristijan Dragicevic , Luis Garces-Erice , Gidon Gershinsky , Minkyong Kim , Hui Lei , David Rushall , Marc-Thomas H. Schmidt , Konstantin Shagin , Hao Yang , Liangzhao Zeng
发明人： Daniel Bauer , Nicholas D. Butler , Han Chen , Kristijan Dragicevic , Luis Garces-Erice , Gidon Gershinsky , Minkyong Kim , Hui Lei , David Rushall , Marc-Thomas H. Schmidt , Konstantin Shagin , Hao Yang , Liangzhao Zeng
IPC分类号： G06F9/50
CPC分类号： H04L41/5003 , G06F9/5061 , H04L41/0806 , H04L41/5009 , H04L67/2838
摘要： A mechanism for declarative service domain federation uses a declarative approach to both the visibility aspect and the management aspect of service domain federation. Instead of manually exporting services, that is, selecting individual services from source domains to be visible in the target domain, using the present system, a federation architect uses a federation console to specify federation intent. The federation intent may include federation rule, query-based service group, and quality-of-service (QoS) policy. Based on the declared federation intent, a planning engine resolves the individual services based on the group query, generates the service visibility configuration, and creates the necessary service proxies and/or mediation objects to satisfy the goal. At runtime, a service monitor collects the performance metrics of federated services and dynamically adjusts the mediation/proxy configurations to maintain the QoS objectives specified by the federation architect.
摘要翻译： 声明性服务域联合的机制对服务域联合的可见性方面和管理方面使用声明式方法。 代替手动导出服务，即从源域中选择单个服务在目标域中可见，使用本系统，联合架构师使用联合控制台来指定联合意图。 联盟意图可以包括联合规则，基于查询的服务组和服务质量（QoS）策略。 基于声明的联盟意图，计划引擎基于组查询来解析各个服务，生成服务可见性配置，并创建必要的服务代理和/或中介对象以满足目标。 在运行时，服务监视器收集联合服务的性能指标，并动态调整中介/代理配置，以维护联盟架构师指定的QoS目标。
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公开(公告)号：US08423389B2
公开(公告)日：2013-04-16
申请号：US13488484
申请日：2012-06-05
IPC分类号： G06Q40/00
CPC分类号： G06Q40/08
摘要： A system for providing flight accident insurance at low price and fixed coverage comprises means for limiting the number of policies that can be sold on any given flight to not more than a predetermined number. The predetermined number may be 20. The system comprises an input device for receiving information from a traveler and an output device for providing an insurance quote to said traveler.
摘要翻译： 以低价和固定覆盖面提供飞行事故保险的系统包括将任何给定航班上可以出售的政策数量限制在不超过预定数量的手段。 预定数量可以是20.系统包括用于从旅行者接收信息的输入装置和用于向所述旅行者提供保险报价的输出装置。
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