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1.发明授权Aqueous alcoholic antiperspirant composition containing calcium enhanced antiperspirant salt 有权含有钙增强止汗剂的含水酒精止汗剂组合物公开(公告)号：US06942850B2
公开(公告)日：2005-09-13
申请号：US10641926
申请日：2003-08-15
申请人： Craig M. Coe , Yan-Fei Shen
发明人： Craig M. Coe , Yan-Fei Shen
摘要： Disclosed is a liquid aqueous alcoholic antiperspirant composition comprising, by weight, about 10% to about 60% ethanol, water, and about 8% to about 22% (USP) antiperspirant salt dissolved in the composition, wherein said antiperspirant salt comprises a calcium enhanced aluminum-zirconium chlorohydrate. The composition may optionally include a thickening agent to increase the viscosity of the solution. A more viscous solution is less prone to dripping from the skin or leaking from the dispensing container. Ideally, the composition will provide an absolute sweat reduction significantly higher than currently available antiperspirant products, typically at least 60% sweat reduction or higher.
摘要翻译： 公开了一种液体含水酒精止汗剂组合物，其包含按重量计约10％至约60％的乙醇，水和约8％至约22％（USP）止汗剂盐溶解在该组合物中，其中所述止汗剂盐包含增强钙 水合铝 - 锆。 组合物可以任选地包括增稠剂以增加溶液的粘度。 更粘稠的溶液不容易从皮肤滴落或从分配容器泄漏。 理想地，组合物将提供显着高于目前可用的止汗剂产品的绝对汗液减少量，通常至少60％的汗液还原或更高。
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公开(公告)号：US20050036968A1
公开(公告)日：2005-02-17
申请号：US10641348
申请日：2003-08-14
申请人： Yan-Fei Shen
发明人： Yan-Fei Shen
摘要： The present invention relates to enhanced efficacy antiperspirant salts containing strontium and an amino acid or a hydroxy acid and particularly to stabilized aqueous solutions of such salts. The present invention also embraces methods of making these antiperspirant salts and solutions and compositions containing same.
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公开(公告)号：US5635155A
公开(公告)日：1997-06-03
申请号：US712136
申请日：1996-09-11
CPC分类号： C01G45/02 , C01B37/00 , C01G45/00 , C01P2002/02 , C01P2002/72 , C01P2002/77 , C01P2002/88
摘要： A process of synthesizing synthetic manganese oxide hydrates having various structures including hollandite and todorokite structure by hydrothermal synthesis. The products have a high degree of crystallinity, and thermal stability.
摘要翻译： 通过水热合成合成具有各种结构的合成氧化锰水合物的方法，包括胡萝卜素和硬球形结构。 该产品具有高度的结晶度和热稳定性。
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4.发明申请公开(公告)号：US20050036969A1
公开(公告)日：2005-02-17
申请号：US10641926
申请日：2003-08-15
申请人： Craig Coe , Yan-Fei Shen
发明人： Craig Coe , Yan-Fei Shen
摘要： Disclosed is a liquid aqueous alcoholic antiperspirant composition comprising, by weight, about 10% to about 60% ethanol, water, and about 8% to about 22% (USP) antiperspirant salt dissolved in the composition, wherein said antiperspirant salt comprises a calcium enhanced aluminum-zirconium chlorohydrate. The composition may optionally include a thickening agent to increase the viscosity of the solution. A more viscous solution is less prone to dripping from the skin or leaking from the dispensing container. Ideally, the composition will provide an absolute sweat reduction significantly higher than currently available antiperspirant products, typically at least 60% sweat reduction or higher.
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公开(公告)号：US6074632A
公开(公告)日：2000-06-13
申请号：US369611
申请日：1999-08-06
申请人： Yan-Fei Shen
发明人： Yan-Fei Shen
IPC分类号： A61K8/26 , A61K8/28 , A61K8/34 , A61K8/44 , A61Q15/00 , C01F7/48 , C01F7/56 , C01F7/64 , C01F7/66 , A61K7/38
CPC分类号： C01F7/66 , A61K8/26 , A61K8/28 , A61K8/34 , A61K8/345 , A61K8/44 , A61Q15/00 , C01F7/48 , C01F7/56
摘要： The present invention relates to methods of making enhanced efficacy antiperspirant salts and particularly stabilized aqueous polyhydric alcohol solutions of such salts. One such method involves stabilizing an aqueous solution of an enhanced efficacy antiperspirant salt by adding an effective amount of a polyhydric alcohol having from 3 to 6 carbon atoms and from 3 to 6 hydroxyl groups. A second disclosed method involves preparing an enhanced efficacy aluminum antiperspirant salt by heating an aqueous solution of an aluminum antiperspirant salt in the presence of a polyhydric alcohol having from 3 to 6 carbon atoms and from 3 to 6 hydroxyl groups at a temperature of at least 50.degree. C. for a time sufficient to convert the salt to an enhanced salt. A third disclosed method is an improvement in the method of making an aluminum hydroxy halide or an aluminum hydroxy nitrate by reacting aluminum with an aqueous solution of aluminum halide or aluminum nitrate (or with aqueous hydrogen halide or nitric acid), wherein the improvement comprises including a polyhydric alcohol having from 3 to 6 carbon atoms and from 3 to 6 hydroxyl groups in the reaction mixture. Also disclosed are compositions produced by the foregoing methods.
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公开(公告)号：US6010688A
公开(公告)日：2000-01-04
申请号：US881237
申请日：1997-06-25
申请人： Yan-Fei Shen
发明人： Yan-Fei Shen
IPC分类号： A61K8/26 , A61K8/28 , A61K8/34 , A61K8/44 , A61Q15/00 , C01F7/48 , C01F7/56 , C01F7/64 , C01F7/66 , A61K7/34
CPC分类号： C01F7/66 , A61K8/26 , A61K8/28 , A61K8/34 , A61K8/345 , A61K8/44 , A61Q15/00 , C01F7/48 , C01F7/56
摘要： The present invention relates to methods of making enhanced efficacy antiperspirant salts and particularly stabilized aqueous polyhydric alcohol solutions of such salts. One such method involves stabilizing an aqueous solution of an enhanced efficacy antiperspirant salt by adding an effective amount of a polyhydric alcohol having from 3 to 6 carbon atoms and from 3 to 6 hydroxyl groups. A second disclosed method involves preparing an enhanced efficacy aluminum antiperspirant salt by heating an aqueous solution of an aluminum antiperspirant salt in the presence of a polyhydric alcohol having from 3 to 6 carbon atoms and from 3 to 6 hydroxyl groups at a temperature of at least 50.degree. C. for a time sufficient to convert the salt to an enhanced salt. A third disclosed method is an improvement in the method of making an aluminum hydroxy halide or an aluminum hydroxy nitrate by reacting aluminum with an aqueous solution of aluminum halide or aluminum nitrate (or with aqueous hydrogen halide or nitric acid), wherein the improvement comprises including a polyhydric alcohol having from 3 to 6 carbon atoms and from 3 to 6 hydroxyl groups in the reaction mixture. Also disclosed are compositions produced by the foregoing methods.
摘要翻译： 本发明涉及制备增强功效的止汗剂盐和特别稳定的这类盐的多元醇水溶液的方法。 一种这样的方法包括通过加入有效量的具有3至6个碳原子和3至6个羟基的多元醇来稳定增强的功效止汗剂盐的水溶液。 第二个所公开的方法包括通过在至少50℃的温度下，在具有3至6个碳原子的多元醇和3至6个羟基的存在下加热铝止汗剂盐水溶液来制备增强的功效性的铝止汗剂盐 在足够的时间将盐转化成增强的盐。 第三个公开的方法是通过使铝与卤化铝或硝酸铝（或卤化氢或硝酸水溶液）的水溶液反应制备铝羟基卤化物或羟基硝酸铝的方法的改进，其中改进包括 在反应混合物中具有3至6个碳原子和3至6个羟基的多元醇。 还公开了通过上述方法制备的组合物。
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公开(公告)号：US5523509A
公开(公告)日：1996-06-04
申请号：US335319
申请日：1994-11-07
CPC分类号： C07C45/002 , B01J23/34 , B01J23/8892 , C07C1/20 , C07C2529/04
摘要： Synthetic manganese oxide octahedral molecular sieves, e.g., OMS-1 and OMS-2, are employed as acid-base catalysts in a variety of acid-base organic conversion reactions.
摘要翻译： 在各种酸碱有机转化反应中，使用合成的氧化锰八面体分子筛，例如OMS-1和OMS-2作为酸碱催化剂。
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8.发明授权Gel antiperspirant composition containing volatile linear silicone and calcium enhanced antiperspirant salt 有权凝胶止汗组合物含挥发性线性硅胶和钙增强止汗剂盐公开(公告)号：US06911195B2
公开(公告)日：2005-06-28
申请号：US10320202
申请日：2002-12-16
申请人： Tuan M. Vu , Yan-Fei Shen
发明人： Tuan M. Vu , Yan-Fei Shen
IPC分类号： A61K8/06 , A61K8/28 , A61K8/58 , A61K8/894 , A61K8/898 , A61Q15/00 , A61K7/32 , A61K7/34 , A61K7/38 , A61K7/00
CPC分类号： A61K8/894 , A61K8/0216 , A61K8/042 , A61K8/06 , A61K8/064 , A61K8/28 , A61K8/585 , A61K2800/262 , A61K2800/882 , A61Q5/065 , A61Q5/10 , A61Q15/00
摘要： Disclosed are antiperspirant compositions, particularly clear gel antiperspirant compositions, that are water-in-silicone oil emulsions. The emulsion includes a water phase, typically comprising about 65% to about 95% by weight of the emulsion, and a silicone oil phase, typically comprising about 5% to about 35% by weight of the emulsion. The water phase includes an antiperspirant salt dissolved therein, typically in an amount of about 8% to about 30% by weight of the emulsion, the antiperspirant salt comprising a calcium enhanced aluminum-zirconium chlorohydrate. The silicone oil phase contains less than about 5% by weight of the emulsion of a non-volatile oil and includes about 2% to about 25% by weight of the emulsion of a volatile linear silicone.
摘要翻译： 公开了防水剂组合物，特别是透明的凝胶止汗组合物，其是水包硅油乳液。 乳液包括水相，通常占乳液重量的约65％至约95％，硅油相通常占乳液重量的约5％至约35％。 水相包括其中溶解的止汗盐，通常为乳液重量的约8％至约30％，止汗剂盐包含钙增强的铝 - 锆氯化水合物。 硅油相包含小于非挥发性油的乳液的约5重量％，并且包含挥发性线性硅氧烷的乳液的约2重量％至约25重量％。
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公开(公告)号：US06649152B2
公开(公告)日：2003-11-18
申请号：US10138476
申请日：2002-05-03
IPC分类号： A61K732
CPC分类号： A61Q15/00 , A61K8/28 , C01G25/006 , C01P2002/87 , Y10S424/05
摘要： Disclosed are enhanced efficacy aluminum-zirconium antiperspirant salt compositions which exhibit an HPLC peak 5 area content of about 33% or more, preferably at least 45%, more preferably at least 50%, most preferably at least 55%. Especially preferred are aluminum-zirconium antiperspirant salt compositions which, in addition to the aforementioned high peak 5 content, also exhibit an HPLC peak 4 to peak 3 area ratio of at least 0.4, preferably at least 0.7. The aforementioned salt compositions will preferably have a metal (Al+Zr) to chloride (or anion) ratio of about 0.90 to about 1.00. Also disclosed are methods of making such antiperspirant salt compositions and aqueous solutions of such antiperspirant salt compositions. Further disclosed are topical compositions comprising a dermatologically acceptable carrier vehicle and a perspiration reducing effective amount of an aluminum-zirconium antiperspirant salt composition as described above.
摘要翻译： 公开了增强的效力铝锆止汗剂盐组合物，其显示出HPLC峰值5面积含量为约33％或更高，优选至少45％，更优选至少50％，最优选至少55％。 特别优选的是铝 - 锆止汗剂盐组合物，除了上述高峰5含量之外，还显示HPLC峰4至峰3面积比至少为0.4，优选至少0.7。 上述盐组合物优选具有约0.90至约1.00的金属（Al + Zr）与氯化物（或阴离子）的比例。 还公开了制备这种止汗剂盐组合物和这种止汗剂盐组合物的水溶液的方法。 进一步公开的是包含皮肤病学可接受的载体载体和减少有效量的如上所述的铝 - 锆止汗剂盐组合物的汗液的局部组合物。
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公开(公告)号：US06436381B1
公开(公告)日：2002-08-20
申请号：US09696271
申请日：2000-10-25
IPC分类号： A61K732
CPC分类号： A61Q15/00 , A61K8/28 , C01G25/006 , C01P2002/87 , Y10S424/05
摘要： Disclosed are enhanced efficacy aluminum-zirconium antiperspirant salt compositions which exhibit an HPLC peak 5 area content of about 33% or more. Especially preferred are aluminum-zirconium antiperspirant salt compositions which, in addition to the aforementioned high peak 5 content, also exhibit an HPLC peak 4 to peak 3 area ratio of at least 0.4. The aforementioned salt compositions will preferably have a metal (Al+Zr) to chloride (or anion) ratio of about 0.90 to about 1.00. Also disclosed are methods of making such antiperspirant salt compositions and aqueous solutions of such antiperspirant salt compositions. Further disclosed are topical compositions comprising a dermatologically acceptable carrier vehicle and a perspiration reducing effective amount of an aluminum-zirconium antiperspirant salt composition as described above.
摘要翻译： 公开了增强的效能铝锆防汗剂盐组合物，其显示出HPLC峰值5面积含量为约33％或更高。 特别优选的是铝 - 锆止汗剂盐组合物，除了上述高峰5含量之外，还显示HPLC峰4至峰3面积比至少为0.4。 上述盐组合物优选具有约0.90至约1.00的金属（Al + Zr）与氯化物（或阴离子）的比例。 还公开了制备这种止汗剂盐组合物和这种止汗剂盐组合物的水溶液的方法。 进一步公开的是包含皮肤病学可接受的载体载体和减少有效量的如上所述的铝 - 锆止汗剂盐组合物的汗液的局部组合物。
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