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公开(公告)号：US10947196B2
公开(公告)日：2021-03-16
申请号：US16831370
申请日：2020-03-26
发明人： Anthony P. Ford , Wei Chen , David Scott Carter , Jiaxin Yu
IPC分类号： C07D213/30 , C07D209/42 , A61K9/00 , A61P25/30 , A61P25/28 , A61P25/16
摘要： The present disclosure is directed to chemical compounds and to the use of such compounds in the treatment of diseases associated with an adrenergic receptor.
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公开(公告)号：US11040944B2
公开(公告)日：2021-06-22
申请号：US16831285
申请日：2020-03-26
发明人： Anthony P. Ford , Wei Chen , David Scott Carter , Jiaxin Yu
IPC分类号： C07D209/42 , A61K9/00 , A61P25/30 , A61P25/28 , A61P25/16
摘要： The present disclosure is directed to chemical compounds and to the use of such compounds in the treatment of diseases associated with an adrenergic receptor.
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公开(公告)号：US20240352002A1
公开(公告)日：2024-10-24
申请号：US18035262
申请日：2021-11-18
发明人： Jiaxin Yu , David Scott Carter , Anthony P. Ford , Wei Chen
IPC分类号： C07D403/06 , A61K31/397 , A61K31/4035 , A61K31/422 , A61K31/427 , A61K31/4439 , A61K31/444 , A61K31/4709 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/5377 , A61K31/55 , C07D205/04 , C07D207/08 , C07D213/30 , C07D213/73 , C07D213/84 , C07D239/42 , C07D401/06 , C07D405/06 , C07D413/06 , C07D417/06
CPC分类号： C07D403/06 , A61K31/397 , A61K31/4035 , A61K31/422 , A61K31/427 , A61K31/4439 , A61K31/444 , A61K31/4709 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/5377 , A61K31/55 , C07D205/04 , C07D207/08 , C07D213/30 , C07D213/73 , C07D213/84 , C07D239/42 , C07D401/06 , C07D405/06 , C07D413/06 , C07D417/06
摘要： The present disclosure is directed to chemical compounds and to the use of such compounds in the treatment of diseases associated with an adrenergic receptor. Disclosed herein is a compound according to Formula (I) or an optically pure stereoisomer, pharmaceutically acceptable salt, solvate, or prodrug thereof. Further disclosed herein is a compound according to Formula (II) or an optically pure stereoisomer, pharmaceutically acceptable salt, solvate, or prodrug thereof.
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公开(公告)号：US20200308115A1
公开(公告)日：2020-10-01
申请号：US16831370
申请日：2020-03-26
发明人： Anthony P. Ford , Wei Chen , David Scott Carter , Jiaxin Yu
IPC分类号： C07D209/42 , A61K9/00 , A61P25/28 , A61P25/16 , A61P25/30
摘要： The present disclosure is directed to chemical compounds and to the use of such compounds in the treatment of diseases associated with an adrenergic receptor.
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公开(公告)号：US20200308114A1
公开(公告)日：2020-10-01
申请号：US16831285
申请日：2020-03-26
发明人： Anthony P. Ford , Wei Chen , David Scott Carter , Jiaxin Yu
IPC分类号： C07D209/42 , A61K9/00 , A61P25/28 , A61P25/16 , A61P25/30
摘要： The present disclosure is directed to chemical compounds and to the use of such compounds in the treatment of diseases associated with an adrenergic receptor.
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公开(公告)号：US20240270701A1
公开(公告)日：2024-08-15
申请号：US18694362
申请日：2022-09-22
发明人： Jiaxin Yu , Anthony P. Ford , Wei Chen
IPC分类号： C07D241/42 , A61K31/4045 , A61K31/416 , A61K31/417 , A61K31/426 , A61K31/437 , A61K31/44 , A61K31/47 , A61K31/498 , A61K31/517 , C07D209/34 , C07D213/38 , C07D213/61 , C07D213/73 , C07D215/14 , C07D215/233 , C07D231/56 , C07D235/08 , C07D235/26 , C07D237/20 , C07D239/42 , C07D239/74 , C07D277/40 , C07D277/68 , C07D471/04
CPC分类号： C07D241/42 , A61K31/4045 , A61K31/416 , A61K31/417 , A61K31/426 , A61K31/437 , A61K31/44 , A61K31/47 , A61K31/498 , A61K31/517 , C07D209/34 , C07D213/38 , C07D213/61 , C07D213/73 , C07D215/14 , C07D215/233 , C07D231/56 , C07D235/08 , C07D235/26 , C07D237/20 , C07D239/42 , C07D239/74 , C07D277/40 , C07D277/68 , C07D471/04
摘要： The present disclosure is directed to chemical compounds and to the use of such compounds in the treatment of diseases associated with an adrenergic receptor. An advantage of the compounds provided herein is that a broad range of pharmacological activities is possible, consistent with modulation of beta-adrenergic receptors. In addition, the disclosure provides methods of using the compounds described herein for the treatment of diseases associated with an adrenergic receptor, including but not limited to neurodegenerative diseases and disorders.
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公开(公告)号：US20210371380A1
公开(公告)日：2021-12-02
申请号：US17355063
申请日：2021-06-22
发明人： Anthony P. Ford , Wei Chen , David Scott Carter , Jiaxin Yu
IPC分类号： C07D209/42 , A61K9/00 , A61P25/30 , A61P25/28 , A61P25/16
摘要： The present disclosure is directed to chemical compounds and to the use of such compounds in the treatment of diseases associated with an adrenergic receptor.
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公开(公告)号：US20220315534A1
公开(公告)日：2022-10-06
申请号：US17620065
申请日：2020-06-30
发明人： Anthony P. Ford , Jiaxin Yu , David Scott Carter , Wei Chen
IPC分类号： C07D213/73 , C07D237/20 , C07D241/20 , C07D213/64 , C07D215/227 , C07D309/38 , C07D471/04 , C07D491/056 , C07D498/04 , C07D265/36 , C07D215/14 , C07D231/56 , C07D261/20 , C07D209/86 , C07D263/58 , C07D235/14 , C07D223/16 , C07D277/68 , C07D209/08
摘要： The present disclosure is directed to chemical compounds and to the use of such compounds in the treatment of diseases associated with an adrenergic receptor.
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公开(公告)号：US20220169612A1
公开(公告)日：2022-06-02
申请号：US17440705
申请日：2020-03-26
发明人： Anthony P. Ford , Wei Chen , David Scott Carter , Jiaxin Yu
IPC分类号： C07D213/38
摘要： The present disclosure is directed to chemical compounds and to the use of such compounds in the treatment of diseases associated with an adrenergic receptor. In certain embodiments of the methods disclosed herein, the methods include administering to the subject a compound as disclosed herein and a peripherally acting P-blocker (PABRA).
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