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公开(公告)号：US10947196B2
公开(公告)日：2021-03-16
申请号：US16831370
申请日：2020-03-26
发明人： Anthony P. Ford , Wei Chen , David Scott Carter , Jiaxin Yu
IPC分类号： C07D213/30 , C07D209/42 , A61K9/00 , A61P25/30 , A61P25/28 , A61P25/16
摘要： The present disclosure is directed to chemical compounds and to the use of such compounds in the treatment of diseases associated with an adrenergic receptor.
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公开(公告)号：US20230263749A1
公开(公告)日：2023-08-24
申请号：US18023693
申请日：2021-08-31
发明人： Anthony P. Ford , Gabriel Vargas , Wei Chen , Renee S. Martin
IPC分类号： A61K31/138 , A61K31/165 , A61K31/18 , A61K31/166 , A61K31/137 , A61P25/28 , A61B6/00 , A61B6/03
CPC分类号： A61K31/138 , A61K31/165 , A61K31/18 , A61K31/166 , A61K31/137 , A61P25/28 , A61B6/501 , A61B6/037 , A61B5/055
摘要： In various aspects and embodiments provided are compositions and methods for identifying patients in need of improving cognition and/or treating a neurodegenerative disease in a patient and treating such patient. More specifically, the disclosure in some embodiments includes administration of a β-AR agonist (such as a β-agent) and a peripherally acting β-blocker (PABRA) to a patient in need thereof.
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公开(公告)号：US11040944B2
公开(公告)日：2021-06-22
申请号：US16831285
申请日：2020-03-26
发明人： Anthony P. Ford , Wei Chen , David Scott Carter , Jiaxin Yu
IPC分类号： C07D209/42 , A61K9/00 , A61P25/30 , A61P25/28 , A61P25/16
摘要： The present disclosure is directed to chemical compounds and to the use of such compounds in the treatment of diseases associated with an adrenergic receptor.
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公开(公告)号：US20240352002A1
公开(公告)日：2024-10-24
申请号：US18035262
申请日：2021-11-18
发明人： Jiaxin Yu , David Scott Carter , Anthony P. Ford , Wei Chen
IPC分类号： C07D403/06 , A61K31/397 , A61K31/4035 , A61K31/422 , A61K31/427 , A61K31/4439 , A61K31/444 , A61K31/4709 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/5377 , A61K31/55 , C07D205/04 , C07D207/08 , C07D213/30 , C07D213/73 , C07D213/84 , C07D239/42 , C07D401/06 , C07D405/06 , C07D413/06 , C07D417/06
CPC分类号： C07D403/06 , A61K31/397 , A61K31/4035 , A61K31/422 , A61K31/427 , A61K31/4439 , A61K31/444 , A61K31/4709 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/5377 , A61K31/55 , C07D205/04 , C07D207/08 , C07D213/30 , C07D213/73 , C07D213/84 , C07D239/42 , C07D401/06 , C07D405/06 , C07D413/06 , C07D417/06
摘要： The present disclosure is directed to chemical compounds and to the use of such compounds in the treatment of diseases associated with an adrenergic receptor. Disclosed herein is a compound according to Formula (I) or an optically pure stereoisomer, pharmaceutically acceptable salt, solvate, or prodrug thereof. Further disclosed herein is a compound according to Formula (II) or an optically pure stereoisomer, pharmaceutically acceptable salt, solvate, or prodrug thereof.
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公开(公告)号：US20200308115A1
公开(公告)日：2020-10-01
申请号：US16831370
申请日：2020-03-26
发明人： Anthony P. Ford , Wei Chen , David Scott Carter , Jiaxin Yu
IPC分类号： C07D209/42 , A61K9/00 , A61P25/28 , A61P25/16 , A61P25/30
摘要： The present disclosure is directed to chemical compounds and to the use of such compounds in the treatment of diseases associated with an adrenergic receptor.
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公开(公告)号：US20200308114A1
公开(公告)日：2020-10-01
申请号：US16831285
申请日：2020-03-26
发明人： Anthony P. Ford , Wei Chen , David Scott Carter , Jiaxin Yu
IPC分类号： C07D209/42 , A61K9/00 , A61P25/28 , A61P25/16 , A61P25/30
摘要： The present disclosure is directed to chemical compounds and to the use of such compounds in the treatment of diseases associated with an adrenergic receptor.
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公开(公告)号：US20230312524A1
公开(公告)日：2023-10-05
申请号：US18022949
申请日：2021-08-26
发明人： David Scott Carter , Counde O'Yang , Anthony P. Ford , Wei Chen
IPC分类号： C07D403/10 , C07D233/22 , C07D405/06
CPC分类号： C07D403/10 , C07D233/22 , C07D405/06
摘要： The present disclosure relates generally to chemical compounds and, in some embodiments, to α1A-adrenergic receptor agonists and uses of such agonists in the treatment of diseases associated with an adrenergic receptor. Disclosed herein is a compound according to Formula (I) or an optically pure stereoisomer, pharmaceutically acceptable salt, solvate, or prodrug thereof.
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公开(公告)号：US20230219892A1
公开(公告)日：2023-07-13
申请号：US18007726
申请日：2021-06-03
发明人： Wei Chen , Bing Xue , David Scott Carter
IPC分类号： C07D213/84 , C07C69/78 , C07C61/06 , C07C59/08 , C07C59/11 , C07C59/245 , C07C59/255 , C07C59/06 , C07C57/15 , C07C57/145 , C07C309/30
CPC分类号： C07D213/84 , C07C57/15 , C07C57/145 , C07C59/06 , C07C59/08 , C07C59/11 , C07C59/245 , C07C59/255 , C07C61/06 , C07C69/78 , C07C309/30 , C07B2200/13
摘要： The present disclosure relates generally to various forms and compositions useful as beta adrenergic agonists and uses of the same in the treatment of diseases associated with an adrenergic receptor. In one aspect, the disclosure provides a crystalline solid form of Compound 1: selected from Form A and Form B and salt forms thereof.
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公开(公告)号：US20220315534A1
公开(公告)日：2022-10-06
申请号：US17620065
申请日：2020-06-30
发明人： Anthony P. Ford , Jiaxin Yu , David Scott Carter , Wei Chen
IPC分类号： C07D213/73 , C07D237/20 , C07D241/20 , C07D213/64 , C07D215/227 , C07D309/38 , C07D471/04 , C07D491/056 , C07D498/04 , C07D265/36 , C07D215/14 , C07D231/56 , C07D261/20 , C07D209/86 , C07D263/58 , C07D235/14 , C07D223/16 , C07D277/68 , C07D209/08
摘要： The present disclosure is directed to chemical compounds and to the use of such compounds in the treatment of diseases associated with an adrenergic receptor.
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公开(公告)号：US20220169612A1
公开(公告)日：2022-06-02
申请号：US17440705
申请日：2020-03-26
发明人： Anthony P. Ford , Wei Chen , David Scott Carter , Jiaxin Yu
IPC分类号： C07D213/38
摘要： The present disclosure is directed to chemical compounds and to the use of such compounds in the treatment of diseases associated with an adrenergic receptor. In certain embodiments of the methods disclosed herein, the methods include administering to the subject a compound as disclosed herein and a peripherally acting P-blocker (PABRA).
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