公开(公告)号：US20200060971A1

公开(公告)日：2020-02-27

申请号：US16679536

申请日：2019-11-11

Applicant: CureVac AG

Inventor： Fabian Johannes EBER ,  Benyamin YAZDAN PANAH ,  Stefanie SEWING ,  Thomas KETTERER ,  Thorsten MUTZKE ,  Tilmann ROOS ,  Michael SONNTAG ,  Michael WIGGENHORN ,  Katharina KOLLAND

IPC: A61K9/16 ,  A61P31/00 ,  A61P31/12 ,  A61P37/06 ,  A61P37/08 ,  A61P31/04 ,  A61P33/02 ,  A61P35/00 ,  A61K39/145 ,  A61K48/00

Abstract: The present invention is directed to a storage-stable formulation of long-chain RNA. In particular, the invention concerns a dry powder composition comprising a long-chain RNA molecule. The present invention is furthermore directed to methods for preparing a dry powder composition comprising a long-chain RNA molecule by spray-drying. The invention further concerns the use of such a dry powder composition comprising a long-chain RNA molecule in the preparation of pharmaceutical compositions and vaccines, to a method of treating or preventing a disorder or a disease, to first and second medical uses of such a dry powder composition comprising a long-chain RNA molecule and to kits, particularly to kits of parts, comprising such a dry powder composition comprising a long-chain RNA molecule.

公开(公告)号：US20210030683A1

公开(公告)日：2021-02-04

申请号：US16904993

申请日：2020-06-18

Applicant: CureVac AG

Inventor： Fabian Johannes EBER ,  Benyamin YAZDAN PANAH ,  Stefanie SEWING ,  Thomas KETTERER ,  Thorsten MUTZKE ,  Tilmann ROOS ,  Michael SONNTAG ,  Michael WIGGENHORN ,  Katharina KOLLAND

IPC: A61K9/16 ,  A61K48/00 ,  A61K9/19 ,  A61K31/7105

Abstract: The present invention is directed to a storage-stable formulation of long-chain RNA. In particular, the invention concerns a dry powder composition comprising a long-chain RNA molecule. The present invention is furthermore directed to methods for preparing a dry powder composition comprising a long-chain RNA molecule by spray-freeze drying. The invention further concerns the use of such a dry powder composition comprising a long-chain RNA molecule in the preparation of pharmaceutical compositions and vaccines, to a method of treating or preventing a disorder or a disease, to first and second medical uses of such a dry powder composition comprising a long-chain RNA molecule and to kits, particularly to kits of parts, comprising such a dry powder composition comprising a long-chain RNA molecule.

公开(公告)号：US20220168225A1

公开(公告)日：2022-06-02

申请号：US17676586

申请日：2022-02-21

Applicant: CureVac AG

Inventor： Fabian Johannes EBER ,  Benyamin YAZDAN PANAH ,  Stefanie SEWING ,  Thomas KETTERER ,  Thorsten MUTZKE ,  Tilmann ROOS ,  Michael SONNTAG ,  Michael WIGGENHORN ,  Katharina KOLLAND

IPC: A61K9/16 ,  A61K48/00 ,  A61K9/19 ,  A61K31/7105

Abstract: The present invention is directed to a storage-stable formulation of long-chain RNA. In particular, the invention concerns a dry powder composition comprising a long-chain RNA molecule. The present invention is furthermore directed to methods for preparing a dry powder composition comprising a long-chain RNA molecule by spray-freeze drying. The invention further concerns the use of such a dry powder composition comprising a long-chain RNA molecule in the preparation of pharmaceutical compositions and vaccines, to a method of treating or preventing a disorder or a disease, to first and second medical uses of such a dry powder composition comprising a long-chain RNA molecule and to kits, particularly to kits of parts, comprising such a dry powder composition comprising a long-chain RNA molecule.

公开(公告)号：US20180147146A1

公开(公告)日：2018-05-31

申请号：US15575284

申请日：2016-05-20

Applicant: CureVac AG

Inventor： Fabian Johannes EBER ,  Benyamin YAZDAN PANAH ,  Stefanie SEWIG ,  Thomas KETTERER ,  Thorsten MUTZKE ,  Tilmann ROOS ,  Michael SONNTAG ,  Michael WIGGENHORN ,  Katharina KOLLAND

IPC: A61K9/16 ,  A61K39/145 ,  A61P31/00 ,  A61P35/00 ,  A61P31/12 ,  A61P31/04 ,  A61P33/02 ,  A61P37/06 ,  A61P37/08

CPC classification number: A61K9/16 ,  A61K9/1682 ,  A61K39/145 ,  A61K48/00 ,  A61K48/005 ,  A61K48/0091 ,  A61K2039/53 ,  A61P31/00 ,  A61P31/04 ,  A61P31/12 ,  A61P33/02 ,  A61P35/00 ,  A61P37/06 ,  A61P37/08

Abstract: The present invention is directed to a storage-stable formulation of long-chain RNA. In particular, the invention concerns a dry powder composition comprising a long-chain RNA molecule. The present invention is furthermore directed to methods for preparing a dry powder composition comprising a long-chain RNA molecule by spray-drying. The invention further concerns the use of such a dry powder composition comprising a long-chain RNA molecule in the preparation of pharmaceutical compositions and vaccines, to a method of treating or preventing a disorder or a disease, to first and second medical uses of such a dry powder composition comprising a long-chain RNA molecule and to kits, particularly to kits of parts, comprising such a dry powder composition comprising a long-chain RNA molecule.

公开(公告)号：US20220387320A1

公开(公告)日：2022-12-08

申请号：US17811808

申请日：2022-07-11

Applicant: CureVac AG

Inventor： Fabian Johannes EBER ,  Benyamin YAZDAN PANAH ,  Stefanie SEWING ,  Thomas KETTERER ,  Thorsten MUTZKE ,  Tilmann ROOS ,  Michael SONNTAG ,  Michael WIGGENHORN ,  Katharina KOLLAND

IPC: A61K9/16 ,  A61K48/00 ,  A61P31/00 ,  A61P31/12 ,  A61P37/06 ,  A61P37/08 ,  A61P31/04 ,  A61P33/02 ,  A61P35/00 ,  A61K39/145

Abstract: The present invention is directed to a storage-stable formulation of long-chain RNA. In particular, the invention concerns a dry powder composition comprising a long-chain RNA molecule. The present invention is furthermore directed to methods for preparing a dry powder composition comprising a long-chain RNA molecule by spray-drying. The invention further concerns the use of such a dry powder composition comprising a long-chain RNA molecule in the preparation of pharmaceutical compositions and vaccines, to a method of treating or preventing a disorder or a disease, to first and second medical uses of such a dry powder composition comprising a long-chain RNA molecule and to kits, particularly to kits of parts, comprising such a dry powder composition comprising a long-chain RNA molecule.

公开(公告)号：US20190133950A1

公开(公告)日：2019-05-09

申请号：US15575301

申请日：2016-05-20

Applicant: CureVac AG

Inventor： Fabian Johannes EBER ,  Benyamin YAZDAN PANAH ,  Stefanie SEWIG ,  Thomas KETTERER ,  Thorsten MUTZKE ,  Tilmann ROOS ,  Michael SONNTAG ,  Michael WIGGENHORN ,  Katharina KOLLAND

IPC: A61K9/16 ,  A61K31/7105 ,  A61K9/19

Abstract: The present invention is directed to a storage-stable formulation of long-chain RNA. In particular, the invention concerns a dry powder composition comprising a long-chain RNA molecule. The present invention is furthermore directed to methods for preparing a dry powder composition comprising a long-chain RNA molecule by spray-freeze drying. The invention further concerns the use of such a dry powder composition comprising a long-chain RNA molecule in the preparation of pharmaceutical compositions and vaccines, to a method of treating or preventing a disorder or a disease, to first and second medical uses of such a dry powder composition comprising a long-chain RNA molecule and to kits, particularly to kits of parts, comprising such a dry powder composition comprising a long-chain RNA molecule.

公开(公告)号：US20180214537A1

公开(公告)日：2018-08-02

申请号：US15566010

申请日：2016-04-13

Applicant: CureVac AG

Inventor： Thorsten MUTZKE ,  Markus KREUZ ,  Stefanie SEWING ,  Fabian Johannes EBER ,  Wenke WAGNER ,  Michael SONNTAG ,  Michael WIGGENHORN ,  Katharina KOLLAND

IPC: A61K39/145

CPC classification number: A61K39/145 ,  A61K9/5169 ,  A61K9/5192 ,  A61K39/12 ,  A61K47/6455 ,  A61K47/646 ,  A61K2039/55555 ,  C12N2760/16134

Abstract: The present invention relates to a method for producing a liquid composition comprising a nanoparticle comprising at least one RNA and at least one cationic or polycationic compound, advantageously on a large scale suitable for pharmaceutical applications. The present invention further concerns the use of the inventive method in the manufacture of a medicament or a vaccine. Furthermore, the invention relates to compositions containing the RNA-comprising nanoparticle, and to pharmaceutical compositions comprising the same.