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    METHOD FOR ANALYZING RNA
    6.
    发明申请
    METHOD FOR ANALYZING RNA 有权

    公开(公告)号：US20210180106A1

    公开(公告)日：2021-06-17

    申请号：US16077366

    申请日：2016-02-12

    申请人： CureVac AG

    发明人： Aniela WOCHNER ,  Tilmann ROOS ,  Fabian Johannes EBER ,  Philipp HOFMANN

    IPC分类号： C12Q1/6806

    摘要： The present invention relates to the field of RNA analysis. In particular, the invention concerns the use of one or more nucleic acid molecules for the analysis of an RNA molecule. In particular, the method is suitable for use in quality control during or following production of RNA. Furthermore, the present invention provides methods for analyzing a mixture of RNA molecules or an RNA population.

    METHOD OF PRODUCING RNA FROM CIRCULAR DNA AND CORRESPONDING TEMPLATE DNA
    7.
    发明申请
    METHOD OF PRODUCING RNA FROM CIRCULAR DNA AND CORRESPONDING TEMPLATE DNA 审中-公开

    公开(公告)号：US20200040370A1

    公开(公告)日：2020-02-06

    申请号：US16658700

    申请日：2019-10-21

    申请人： CureVac AG

    发明人： Fabian Johannes EBER ,  Stefanie SEWING ,  Wenke WAGNER

    IPC分类号： C12P19/34 ,  C12Q1/6865 ,  C12N15/52

    摘要： The present invention is concerned with a method of producing a target RNA using a circular DNA, wherein said method does not comprise a step of linearizing said circular DNA. The present invention further relates to a circular DNA comprising an RNA polymerase promoter sequence, followed by a sequence encoding a target RNA, followed by a sequence encoding a self-cleaving ribozyme, followed by an RNA polymerase terminator sequence element, wherein the latter element may comprise several RNA polymerase terminator sequences. Multimeric DNA obtained by rolling circle amplification of said circular DNA is also within the scope of the present invention.

    METHOD FOR ANALYSIS OF AN RNA MOLECULE
    9.
    发明申请
    METHOD FOR ANALYSIS OF AN RNA MOLECULE 审中-公开

    公开(公告)号：US20190017100A1

    公开(公告)日：2019-01-17

    申请号：US15738641

    申请日：2016-07-01

    申请人： CureVac AG

    发明人： Aniela WOCHNER ,  Fabian Johannes EBER

    IPC分类号： C12Q1/6811 ,  C12Q1/6806 ,  C12Q1/6809 ,  C12N15/11

    摘要： The present invention relates to the field of RNA analysis. In particular, the invention concerns the use of a catalytic nucleic acid molecule for the analysis of an RNA molecule and/or of a population of RNA molecules. In one aspect, the invention concerns methods for analyzing RNA molecules having at least one cleavage site for at least one catalytic nucleic acid molecule. In particular, the invention concerns a method for determining a physical property of an RNA molecule by analyzing a 5′ terminal fragment, a 3′ terminal fragment and/or at least one optional central RNA fragment obtained by cleavage of the RNA molecule by at least one catalytic nucleic acid molecule. Moreover, the present invention provides novel uses of a catalytic nucleic acid molecule for analyzing RNA molecules. In particular, the invention relates to the use of a catalytic nucleic acid molecule in a method for analyzing RNA molecules, wherein the resulting 5′ terminal RNA fragment, the 3′ terminal RNA fragment and/or the at least one optional central RNA fragment are analyzed.