公开(公告)号：US20200060971A1

公开(公告)日：2020-02-27

申请号：US16679536

申请日：2019-11-11

Applicant: CureVac AG

Inventor： Fabian Johannes EBER ,  Benyamin YAZDAN PANAH ,  Stefanie SEWING ,  Thomas KETTERER ,  Thorsten MUTZKE ,  Tilmann ROOS ,  Michael SONNTAG ,  Michael WIGGENHORN ,  Katharina KOLLAND

IPC: A61K9/16 ,  A61P31/00 ,  A61P31/12 ,  A61P37/06 ,  A61P37/08 ,  A61P31/04 ,  A61P33/02 ,  A61P35/00 ,  A61K39/145 ,  A61K48/00

Abstract: The present invention is directed to a storage-stable formulation of long-chain RNA. In particular, the invention concerns a dry powder composition comprising a long-chain RNA molecule. The present invention is furthermore directed to methods for preparing a dry powder composition comprising a long-chain RNA molecule by spray-drying. The invention further concerns the use of such a dry powder composition comprising a long-chain RNA molecule in the preparation of pharmaceutical compositions and vaccines, to a method of treating or preventing a disorder or a disease, to first and second medical uses of such a dry powder composition comprising a long-chain RNA molecule and to kits, particularly to kits of parts, comprising such a dry powder composition comprising a long-chain RNA molecule.

公开(公告)号：US20220168225A1

公开(公告)日：2022-06-02

申请号：US17676586

申请日：2022-02-21

Applicant: CureVac AG

Inventor： Fabian Johannes EBER ,  Benyamin YAZDAN PANAH ,  Stefanie SEWING ,  Thomas KETTERER ,  Thorsten MUTZKE ,  Tilmann ROOS ,  Michael SONNTAG ,  Michael WIGGENHORN ,  Katharina KOLLAND

IPC: A61K9/16 ,  A61K48/00 ,  A61K9/19 ,  A61K31/7105

Abstract: The present invention is directed to a storage-stable formulation of long-chain RNA. In particular, the invention concerns a dry powder composition comprising a long-chain RNA molecule. The present invention is furthermore directed to methods for preparing a dry powder composition comprising a long-chain RNA molecule by spray-freeze drying. The invention further concerns the use of such a dry powder composition comprising a long-chain RNA molecule in the preparation of pharmaceutical compositions and vaccines, to a method of treating or preventing a disorder or a disease, to first and second medical uses of such a dry powder composition comprising a long-chain RNA molecule and to kits, particularly to kits of parts, comprising such a dry powder composition comprising a long-chain RNA molecule.

公开(公告)号：US20180147146A1

公开(公告)日：2018-05-31

申请号：US15575284

申请日：2016-05-20

Applicant: CureVac AG

Inventor： Fabian Johannes EBER ,  Benyamin YAZDAN PANAH ,  Stefanie SEWIG ,  Thomas KETTERER ,  Thorsten MUTZKE ,  Tilmann ROOS ,  Michael SONNTAG ,  Michael WIGGENHORN ,  Katharina KOLLAND

IPC: A61K9/16 ,  A61K39/145 ,  A61P31/00 ,  A61P35/00 ,  A61P31/12 ,  A61P31/04 ,  A61P33/02 ,  A61P37/06 ,  A61P37/08

CPC classification number: A61K9/16 ,  A61K9/1682 ,  A61K39/145 ,  A61K48/00 ,  A61K48/005 ,  A61K48/0091 ,  A61K2039/53 ,  A61P31/00 ,  A61P31/04 ,  A61P31/12 ,  A61P33/02 ,  A61P35/00 ,  A61P37/06 ,  A61P37/08

Abstract: The present invention is directed to a storage-stable formulation of long-chain RNA. In particular, the invention concerns a dry powder composition comprising a long-chain RNA molecule. The present invention is furthermore directed to methods for preparing a dry powder composition comprising a long-chain RNA molecule by spray-drying. The invention further concerns the use of such a dry powder composition comprising a long-chain RNA molecule in the preparation of pharmaceutical compositions and vaccines, to a method of treating or preventing a disorder or a disease, to first and second medical uses of such a dry powder composition comprising a long-chain RNA molecule and to kits, particularly to kits of parts, comprising such a dry powder composition comprising a long-chain RNA molecule.

公开(公告)号：US20220387320A1

公开(公告)日：2022-12-08

申请号：US17811808

申请日：2022-07-11

Applicant: CureVac AG

Inventor： Fabian Johannes EBER ,  Benyamin YAZDAN PANAH ,  Stefanie SEWING ,  Thomas KETTERER ,  Thorsten MUTZKE ,  Tilmann ROOS ,  Michael SONNTAG ,  Michael WIGGENHORN ,  Katharina KOLLAND

IPC: A61K9/16 ,  A61K48/00 ,  A61P31/00 ,  A61P31/12 ,  A61P37/06 ,  A61P37/08 ,  A61P31/04 ,  A61P33/02 ,  A61P35/00 ,  A61K39/145

Abstract: The present invention is directed to a storage-stable formulation of long-chain RNA. In particular, the invention concerns a dry powder composition comprising a long-chain RNA molecule. The present invention is furthermore directed to methods for preparing a dry powder composition comprising a long-chain RNA molecule by spray-drying. The invention further concerns the use of such a dry powder composition comprising a long-chain RNA molecule in the preparation of pharmaceutical compositions and vaccines, to a method of treating or preventing a disorder or a disease, to first and second medical uses of such a dry powder composition comprising a long-chain RNA molecule and to kits, particularly to kits of parts, comprising such a dry powder composition comprising a long-chain RNA molecule.

公开(公告)号：US20210030683A1

公开(公告)日：2021-02-04

申请号：US16904993

申请日：2020-06-18

Applicant: CureVac AG

Inventor： Fabian Johannes EBER ,  Benyamin YAZDAN PANAH ,  Stefanie SEWING ,  Thomas KETTERER ,  Thorsten MUTZKE ,  Tilmann ROOS ,  Michael SONNTAG ,  Michael WIGGENHORN ,  Katharina KOLLAND

IPC: A61K9/16 ,  A61K48/00 ,  A61K9/19 ,  A61K31/7105

Abstract: The present invention is directed to a storage-stable formulation of long-chain RNA. In particular, the invention concerns a dry powder composition comprising a long-chain RNA molecule. The present invention is furthermore directed to methods for preparing a dry powder composition comprising a long-chain RNA molecule by spray-freeze drying. The invention further concerns the use of such a dry powder composition comprising a long-chain RNA molecule in the preparation of pharmaceutical compositions and vaccines, to a method of treating or preventing a disorder or a disease, to first and second medical uses of such a dry powder composition comprising a long-chain RNA molecule and to kits, particularly to kits of parts, comprising such a dry powder composition comprising a long-chain RNA molecule.

公开(公告)号：US20190133950A1

公开(公告)日：2019-05-09

申请号：US15575301

申请日：2016-05-20

Applicant: CureVac AG

Inventor： Fabian Johannes EBER ,  Benyamin YAZDAN PANAH ,  Stefanie SEWIG ,  Thomas KETTERER ,  Thorsten MUTZKE ,  Tilmann ROOS ,  Michael SONNTAG ,  Michael WIGGENHORN ,  Katharina KOLLAND

IPC: A61K9/16 ,  A61K31/7105 ,  A61K9/19

Abstract: The present invention is directed to a storage-stable formulation of long-chain RNA. In particular, the invention concerns a dry powder composition comprising a long-chain RNA molecule. The present invention is furthermore directed to methods for preparing a dry powder composition comprising a long-chain RNA molecule by spray-freeze drying. The invention further concerns the use of such a dry powder composition comprising a long-chain RNA molecule in the preparation of pharmaceutical compositions and vaccines, to a method of treating or preventing a disorder or a disease, to first and second medical uses of such a dry powder composition comprising a long-chain RNA molecule and to kits, particularly to kits of parts, comprising such a dry powder composition comprising a long-chain RNA molecule.

公开(公告)号：US20180243219A1

公开(公告)日：2018-08-30

申请号：US15566980

申请日：2016-04-15

Applicant: CureVac AG

Inventor： Thomas KETTERER ,  Thorsten MUTZKE ,  Michael WIGGENHORN ,  Frank SCHAUBHUT ,  Florian VON DER MÜLBE

IPC: A61K9/19 ,  A61K31/7105 ,  A61K47/54 ,  A61K47/64

Abstract: The present invention is directed to the field of RNA formulation, in particular to lyophilization of RNA. The invention provides a method for lyophilization of RNA. The present invention further concerns a lyophilized composition obtainable by the inventive method, a pharmaceutical composition, a vaccine and a kit or kit of parts. Moreover, the present invention provides a novel use of a lyoprotectant for lyophilizing RNA, the use of the inventive method in the manufacture of a medicament as well as the first and second medical use of the composition obtainable by the inventive method, the pharmaceutical composition, the vaccine or the kit or kit of parts according to the invention.

公开(公告)号：US20180214537A1

公开(公告)日：2018-08-02

申请号：US15566010

申请日：2016-04-13

Applicant: CureVac AG

Inventor： Thorsten MUTZKE ,  Markus KREUZ ,  Stefanie SEWING ,  Fabian Johannes EBER ,  Wenke WAGNER ,  Michael SONNTAG ,  Michael WIGGENHORN ,  Katharina KOLLAND

IPC: A61K39/145

CPC classification number: A61K39/145 ,  A61K9/5169 ,  A61K9/5192 ,  A61K39/12 ,  A61K47/6455 ,  A61K47/646 ,  A61K2039/55555 ,  C12N2760/16134

Abstract: The present invention relates to a method for producing a liquid composition comprising a nanoparticle comprising at least one RNA and at least one cationic or polycationic compound, advantageously on a large scale suitable for pharmaceutical applications. The present invention further concerns the use of the inventive method in the manufacture of a medicament or a vaccine. Furthermore, the invention relates to compositions containing the RNA-comprising nanoparticle, and to pharmaceutical compositions comprising the same.