-
公开(公告)号：US20060205670A1
公开(公告)日：2006-09-14
申请号：US11368338
申请日：2006-03-03
申请人： Curt Bradshaw , Venkata Doppalapudi , Jing-Yu Lai , John Rizzo
发明人： Curt Bradshaw , Venkata Doppalapudi , Jing-Yu Lai , John Rizzo
CPC分类号： C07K7/02 , A61K38/00 , C07K7/06 , C07K16/40 , C07K2319/30
摘要： The present invention provides AA targeting compounds which comprise AA targeting agent-linker conjugates which are linked to a combining site of an antibody. Various uses of the compounds are provided, including methods to treat disorders connected to abnormal angiogenesis.
-
2.发明授权Methods of treating a disease or condition associated with abnormal angiogenesis 有权治疗与异常血管发生相关的疾病或病症的方法公开(公告)号：US08912148B2
公开(公告)日：2014-12-16
申请号：US13584721
申请日：2012-08-13
申请人： Curt Bradshaw , Abhijit Bhat , Jing Yu Lai , Venkata Doppalapudi , Dingguo Liu
发明人： Curt Bradshaw , Abhijit Bhat , Jing Yu Lai , Venkata Doppalapudi , Dingguo Liu
IPC分类号： A61K38/10 , C07K14/00 , C07K14/515 , A61K38/00
CPC分类号： C07K14/47 , A61K38/00 , C07K14/515 , C07K2319/30
摘要： The present invention provides methods of treating (including preventing) a disease or condition associated with abnormal angiogenesis in a subject include administering a therapeutically effective amount of an AA targeting compound of the invention to the subject. The AA targeting compounds comprise AA targeting agent-linker conjugates which are linked to a combining site of an antibody.
摘要翻译： 本发明提供了治疗（包括预防）与受试者异常血管生成相关的疾病或病症的方法，包括向受试者施用治疗有效量的本发明的AA靶向化合物。 AA靶向化合物包含与抗体的结合位点连接的AA靶向剂 - 接头缀合物。
-
3.发明申请METHODS OF TREATING A DISEASE OR CONDITION ASSOCIATED WITH ABNORMAL ANGIOGENESIS 有权治疗与异常血管发生相关的疾病或病症的方法公开(公告)号：US20120301431A1
公开(公告)日：2012-11-29
申请号：US13584721
申请日：2012-08-13
申请人： Curt Bradshaw , Abhijit Bhat , Jing Yu Lai , Venkata Doppalapudi , Dingguo Liu
发明人： Curt Bradshaw , Abhijit Bhat , Jing Yu Lai , Venkata Doppalapudi , Dingguo Liu
IPC分类号： A61K38/17 , A61K39/395 , A61K38/50 , A61K33/24 , A61P35/02 , A61P19/02 , A61P17/06 , A61P27/02 , A61P35/00 , A61K39/44 , A61K38/21
CPC分类号： C07K14/47 , A61K38/00 , C07K14/515 , C07K2319/30
摘要： The present invention provides methods of treating (including preventing) a disease or condition associated with abnormal angiogenesis in a subject include administering a therapeutically effective amount of an AA targeting compound of the invention to the subject. The AA targeting compounds comprise AA targeting agent-linker conjugates which are linked to a combining site of an antibody.
摘要翻译： 本发明提供了治疗（包括预防）与受试者异常血管生成相关的疾病或病症的方法，包括向受试者施用治疗有效量的本发明的AA靶向化合物。 AA靶向化合物包含与抗体的结合位点连接的AA靶向剂 - 接头缀合物。
-
公开(公告)号：US20080166364A1
公开(公告)日：2008-07-10
申请号：US11938766
申请日：2007-11-12
申请人： Curt Bradshaw , Abhijit Bhat , Jing Yu Lai , Venkata Doppalapudi
发明人： Curt Bradshaw , Abhijit Bhat , Jing Yu Lai , Venkata Doppalapudi
IPC分类号： A61K39/395 , C07K14/00 , A61P35/04 , C12N5/00 , C07K16/00
CPC分类号： C07K14/47 , A61K38/00 , C07K14/515 , C07K2319/30
摘要： The present invention provides AA targeting compounds which comprise AA targeting agent-linker conjugates which are linked to a combining site of an antibody. Various uses of the compounds are provided, including methods to treat disorders connected to abnormal angiogenesis.
摘要翻译： 本发明提供了AA靶向化合物，其包含与抗体的组合位点连接的AA靶向剂 - 接头缀合物。 提供了化合物的各种用途，包括治疗与异常血管发生相关的病症的方法。
-
公开(公告)号：US20050096254A1
公开(公告)日：2005-05-05
申请号：US10511489
申请日：2003-04-17
CPC分类号： C12Q1/18 , A61K47/556 , A61K47/65 , A61K47/67 , A61K49/0004 , B82Y5/00
摘要： This invention provides a method for inhibiting the growth of a microorganism that expresses Peptide Deformylase by contacting the microorganism with an effective amount of the compound described herein. This method inhibits the growth of gram-positive and gram-negative microorganism, e.g., S. aureus, S. epidermidis, K. pneumoniae, E. aerogenes, and E. cloacae. This method can be practiced in vitro, ex vivo and in vivo. Further provided is a method for alleviating the symptoms of an infection by a Peptide Deformylase expressing microorganism in a subject by administering or delivering to the subject an effective amount of the compound described above.
摘要翻译： 本发明提供了通过使微生物与有效量的本文所述化合物接触来抑制表达肽脱甲硅烷基化酶的微生物生长的方法。 该方法抑制革兰氏阳性和革兰氏阴性微生物例如金黄色葡萄球菌，表皮葡萄球菌，肺炎克雷伯菌，产气荚膜梭菌和阴沟肠杆菌的生长。 该方法可以在体外，离体和体内实施。 还提供了一种通过向受试者施用或递送有效量的上述化合物来减轻受试者中表达肽变态酶的微生物的感染症状的方法。
-
公开(公告)号：US20060063743A1
公开(公告)日：2006-03-23
申请号：US11256061
申请日：2005-10-21
CPC分类号： C07F9/4084 , A61K47/65 , C07F9/4006
摘要： This invention provides compounds and methods for using them to inhibit the growth of microorganism that expresses Peptide Deformylase, the compounds having the general formula:
摘要翻译： 本发明提供了使用它们抑制表达肽变形酶的微生物生长的化合物和方法，该化合物具有以下通式：
-
-
-
-
-
搜索结果
6 条记录 (耗时 0.027 秒)
