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公开(公告)号：US20080152660A1
公开(公告)日：2008-06-26
申请号：US11817668
申请日：2006-03-03
IPC分类号： A61K39/395 , C07K7/00 , A61K38/08
CPC分类号： C07K7/02 , A61K38/00 , C07K7/06 , C07K16/40 , C07K2319/30
摘要： The present invention provides AA targeting compounds which comprise AA targeting agent-linker conjugates which are linked to a combining site of an antibody. Various uses of the compounds are provided, including methods to treat disorders connected to abnormal angiogenesis.
摘要翻译： 本发明提供了AA靶向化合物，其包含与抗体的组合位点连接的AA靶向剂 - 接头缀合物。 提供了化合物的各种用途，包括治疗与异常血管发生相关的病症的方法。
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公开(公告)号：US07521425B2
公开(公告)日：2009-04-21
申请号：US11368338
申请日：2006-03-03
IPC分类号： A61K38/04
CPC分类号： C07K7/02 , A61K38/00 , C07K7/06 , C07K16/40 , C07K2319/30
摘要： The present invention provides AA targeting compounds which comprise AA targeting agent-linker conjugates which are linked to a combining site of an antibody. Various uses of the compounds are provided, including methods to treat disorders connected to abnormal angiogenesis.
摘要翻译： 本发明提供了AA靶向化合物，其包含与抗体的组合位点连接的AA靶向剂 - 接头缀合物。 提供了化合物的各种用途，包括治疗与异常血管发生相关的病症的方法。
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公开(公告)号：US5342767A
公开(公告)日：1994-08-30
申请号：US085347
申请日：1993-06-30
申请人： Chi-Huey Wong , Curt W. Bradshaw
发明人： Chi-Huey Wong , Curt W. Bradshaw
IPC分类号： C07F7/08 , C12N9/04 , C12P7/02 , C12P7/22 , C12P7/26 , C12P9/00 , C12P17/00 , C12P41/00 , C12P11/00 , C12P17/12
CPC分类号： C12N9/0006 , C07F7/0818 , C07F7/083 , C12P17/00 , C12P41/002 , C12P7/02 , C12P7/22 , C12P7/26 , C12P9/00 , Y10S435/853
摘要： The present invention discloses the preparation of R-configured trialkylsilylethynyl .alpha.-alcohols from similarly substituted .alpha.-ketones, and vice versa, catalyzed by the alcohol dehydrogenase of Lactobacillus kefir, ATCC No. 35411. Also disclosed is the acceptance or transfer of a hydride ion from or to the pro-R face of NADPH or NADP, respectively, as catalyzed by that enzyme.
摘要翻译： 本发明公开了由来自类似取代的α-酮的R-配位的三烷基甲硅烷基乙炔基α-醇的制备，反之亦然，由Kactir Lactobacillus kefir的醇脱氢酶，ATCC No.35411催化。还公开了氢化物离子的接受或转移 分别从NADPH或NADP的pro-R表面催化，由该酶催化。
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公开(公告)号：US5225339A
公开(公告)日：1993-07-06
申请号：US841701
申请日：1992-02-26
申请人： Chi-Huey Wong , Curt W. Bradshaw
发明人： Chi-Huey Wong , Curt W. Bradshaw
CPC分类号： C12N9/0006 , C07F7/0818 , C07F7/083 , C12P17/00 , C12P41/002 , C12P7/02 , C12P7/22 , C12P7/26 , C12P9/00 , Y10S435/853
摘要： The present invention discloses the preparation of R-configured trialkylsilylethynyl .alpha.-alcohols from similarly substituted .alpha.-ketones, and vice versa, catalyzed by the alcohol dehydrogenase of Lactobacillus kefir, ATCC No. 35411. Also disclosed is the acceptance or transfer of a hydride ion from or to the pro-R face of NADPH or NADP, respectively, as catalyzed by that enzyme.
摘要翻译： 本发明公开了由来自类似取代的α-酮的R-配位的三烷基甲硅烷基乙炔基α-醇的制备，反之亦然，由Kactir Lactobacillus kefir的醇脱氢酶，ATCC No.35411催化。还公开了氢化物离子的接受或转移 分别从NADPH或NADP的pro-R表面催化，由该酶催化。
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公开(公告)号：US5385833A
公开(公告)日：1995-01-31
申请号：US841718
申请日：1992-02-26
申请人： Curt W. Bradshaw , Chi-Huey Wong , Gwo-Jenn Shen
发明人： Curt W. Bradshaw , Chi-Huey Wong , Gwo-Jenn Shen
CPC分类号： C12N9/0006 , C12P7/02 , C12R1/38 , Y10S435/874
摘要： The present invention provides a substantially pure culture of Pseudomonas sp. strain PED having the ATCC designation 49794. Processes for making R-configured alcohols and for transferring a hydride ion from an R-configured alcohol to the pro-R face of NAD using PED alcohol dehydrogenase isolated and purified from Pseudomonas sp. strain PED are also provided.
摘要翻译： 本发明提供了基本上纯的假单胞菌属培养物。 具有ATCC命名为49794的菌株PED。使用从假单胞菌属（Pseudomonas sp。）分离和纯化的PED醇脱氢酶制备R-构型的醇并将氢离子从R构型的醇转移到NAD的前R面的方法。 还提供了菌株PED。
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