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公开(公告)号：US12044663B2
公开(公告)日：2024-07-23
申请号：US16067628
申请日：2017-01-06
Applicant: Cytiva BioProcess R&D AB
Inventor： Klaus Gebauer , Dan Hermansson
CPC classification number: G01N30/6004 , B01D15/206 , B01D15/22 , G01N30/56 , G01N2030/565 , G01N30/6021 , G01N30/606
Abstract: A method for packing a chromatography column with chromatography media, comprising the steps of: providing a system comprising a column tube (3,19,21) having a closed first end (5) comprising an inlet/outlet (7), a media inlet (15) adjacent a second end of the column tube and an adaptor (9) positioned inside the column tube initially adjacent the second end of the column tube for sliding and sealing contact with an inner face of the column tube, the column tube and adaptor arranged initially such that they define an internal volume and such that the media inlet is in fluid connection with the internal volume; connecting a media slurry source to the media inlet; at least partially filling the internal volume with media slurry via the media inlet; forcing the adaptor towards the first end of the column tube to reduce the internal volume such that the media inlet is no longer in fluid connection with the reduced internal volume.
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公开(公告)号：US20230094241A1
公开(公告)日：2023-03-30
申请号：US18056581
申请日：2022-11-17
Applicant: Cytiva BioProcess R&D AB
Inventor： Klaus Gebauer , Manoj Kumar Ramakrishna , Daniel Salomonsson , Per Lofving
Abstract: A parallel assembly of chromatography column modules connected in a rigid housing the assembly having one common assembly inlet and one common assembly outlet each column module comprising a bed space filled with chromatography medium and each column module comprises integrated fluid conduits which when the column module is connected with other column modules in the rigid housing are adapted to connect the bed space of the column module with the assembly inlet and the assembly outlet wherein the total length and/or volume of the fluid conduit from the assembly inlet to one bed space together with the length and/or volume of the fluid conduit from the same bed space to the assembly outlet is substantially the same for all bed spaces and modules installed in the parallel assembly.
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公开(公告)号：US11529570B2
公开(公告)日：2022-12-20
申请号：US17102801
申请日：2020-11-24
Applicant: Cytiva BioProcess R&D AB
Inventor： Klaus Gebauer , Manoj Kumar Ramakrishna , Daniel Salomonsson , Per Lofving
Abstract: A parallel assembly (2; 11; 51) of chromatography column modules (3a,b,c; 13a,b,c; 53a,b,c, 90a, b) connected in a rigid housing (21; 61), the assembly having one common assembly inlet (15; 55) and one common assembly outlet (17; 57), each column module comprising a bed space (29) filled with chromatography medium and each column module comprises integrated fluid conduits which when the column module is connected with other column modules in the rigid housing are adapted to connect the bed space (29) of the column module with the assembly inlet (15; 55) and the assembly outlet (17; 57), wherein the total length and/or volume of the fluid conduit from the assembly inlet to one bed space together with the length and/or volume of the fluid conduit from the same bed space to the assembly outlet is substantially the same for all bed spaces and modules installed in the parallel assembly.
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公开(公告)号：US11141681B2
公开(公告)日：2021-10-12
申请号：US15458667
申请日：2017-03-14
Applicant: Cytiva BioProcess R&D AB
Inventor： Klaus Gebauer
Abstract: The invention relates to a method for providing an aseptic chromatography column, said method comprising the steps of: pre-sterilize an empty chromatography column; pre-sterilize a chromatography medium; introducing the pre-sterilized chromatography medium into the pre-sterilized chromatography column using aseptic equipment, thereby providing an aseptic chromatography column comprising chromatography medium.
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公开(公告)号：US20240216831A1
公开(公告)日：2024-07-04
申请号：US18413586
申请日：2024-01-16
Applicant: Cytiva BioProcess R&D AB
Inventor： Klaus Gebauer
CPC classification number: B01D15/14 , B01D15/1864 , B01D15/1885 , B01D15/22 , G01N30/466 , G01N30/6043 , G01N30/6091 , G01N30/6039 , G01N2030/8881 , Y10T29/49826
Abstract: A parallel assembly of chromatography column modules, the assembly having one common assembly inlet and one common assembly outlet, each column module comprising a bed space filled with chromatography medium and each column module comprises integrated fluid conduits which when the column module is connected with other column modules are adapted to connect the bed space of the column module with the assembly inlet and the assembly outlet, wherein the total length and/or volume of the fluid conduit from the assembly inlet to one bed space together with the length and/or volume of the fluid conduit from the same bed space to the assembly outlet is substantially the same for all bed spaces and modules installed in the parallel assembly.
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Patent Agency Ranking
公开(公告)号：US20220016547A1
公开(公告)日：2022-01-20
申请号：US17488046
申请日：2021-09-28
Applicant: Cytiva BioProcess R&D AB
Inventor： Klaus Gebauer
Abstract: A separation system may include a number of parallel fluid paths. Each parallel fluid path may include a separation module, and an adjustable flow restrictor. Each adjustable flow restrictor is operable sequentially and operable such that the hydraulic resistance of all the parallel fluid paths is substantially the same and is equal to or higher than the hydraulic resistance of a fluid path identified to have the highest hydraulic resistance. The system includes a pressure sensor that measures pressure loss over the whole separation system. The system is operable such that the hydraulic resistances of the respective separation modules are synchronised, and such that when operated in parallel and at substantially the same time, the respective modules have substantially the same time residence times. The system may include a control system for automated operation.
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公开(公告)号：US11927573B2
公开(公告)日：2024-03-12
申请号：US17156939
申请日：2021-01-25
Applicant: CYTIVA BIOPROCESS R&D AB
Inventor： Klaus Gebauer
CPC classification number: G01N30/6004 , B01D15/18 , B01D15/206 , B01D15/22 , G01N30/56 , G01N30/606 , G01N30/8658 , G01N2030/565 , G01N30/6017 , G01N30/6021 , G01N30/6052
Abstract: The present invention relates to axial flow chromatography columns, methods for separating one or more analytes in a liquid by the use of such columns, and systems employing such columns. The column comprises a first port and a second port, the first port and said second port being at essentially the same level or elevation above the level of the bed space on the chromatography column.
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公开(公告)号：US20230040131A1
公开(公告)日：2023-02-09
申请号：US17938653
申请日：2022-10-06
Applicant: Cytiva BioProcess R&D AB
Inventor： Klaus Gebauer
Abstract: A parallel assembly of chromatography column modules, the assembly having one common assembly inlet and one common assembly outlet, each column module comprising a bed space filled with chromatography medium and each column module comprises integrated fluid conduits which when the column module is connected with other column modules are adapted to connect the bed space of the column module with the assembly inlet and the assembly outlet, wherein the total length and/or volume of the fluid conduit from the assembly inlet to one bed space together with the length and/or volume of the fluid conduit from the same bed space to the assembly outlet is substantially the same for all bed spaces and modules installed in the parallel assembly.
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公开(公告)号：US11491417B2
公开(公告)日：2022-11-08
申请号：US17125645
申请日：2020-12-17
Applicant: Cytiva BioProcess R&D AB
Inventor： Klaus Gebauer
Abstract: A parallel assembly of chromatography column modules, the assembly having one common assembly inlet and one common assembly outlet, each column module comprising a bed space filled with chromatography medium and each column module comprises integrated fluid conduits which when the column module is connected with other column modules are adapted to connect the bed space of the column module with the assembly inlet and the assembly outlet, wherein the total length and/or volume of the fluid conduit from the assembly inlet to one bed space together with the length and/or volume of the fluid conduit from the same bed space to the assembly outlet is substantially the same for all bed spaces and modules installed in the parallel assembly.
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公开(公告)号：US20240402142A1
公开(公告)日：2024-12-05
申请号：US18748622
申请日：2024-06-20
Applicant: CYTIVA BIOPROCESS R&D AB
Inventor： Klaus Gebauer , Dan Hermansson
Abstract: A method for packing a chromatography column with chromatography media, comprising the steps of: providing a system comprising a column tube having a closed first end comprising an inlet/outlet, a media inlet adjacent a second end of the column tube and an adaptor positioned inside the column tube initially adjacent the second end of the column tube for sliding and sealing contact with an inner face of the column tube, the column tube and adaptor arranged initially such that they define an internal volume and such that the media inlet is in fluid connection with the internal volume; connecting a media slurry source to the media inlet; at least partially filling the internal volume with media slurry via the media inlet; forcing the adaptor towards the first end of the column tube to reduce the internal volume such that the media inlet is no longer in fluid connection with the reduced internal volume.
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