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1.发明申请EXPANDABLE CATHETER SYSTEM FOR VESSEL WALL INJECTION AND MUSCLE AND NERVE FIBER ABLATION 有权用于船舶注射和肌肉和神经纤维的膨胀导管系统公开(公告)号：US20130053821A1
公开(公告)日：2013-02-28
申请号：US13216495
申请日：2011-08-24
申请人： DAVID R. FISCHELL , TIM A. FISCHELL
发明人： DAVID R. FISCHELL , TIM A. FISCHELL
IPC分类号： A61M25/10
CPC分类号： A61M25/0662 , A61B5/6848 , A61M25/0084 , A61M25/0097 , A61M2025/0086 , A61M2025/0681
摘要： A vascular nerve ablation (denervation) system includes a multiplicity of expandable needles which open around a central axis to engage the wall of a blood vessel allowing the injection of a cytotoxic or neurotoxic solution for ablating conducting tissue in and near the vessel wall of a renal artery or pulmonary vein. The expandable needles are formed of self-expanding materials and include structures which limit the distance of penetration of the injection needles into the tissue of the wall of the blood vessel.
摘要翻译： 血管神经消融（去神经支配）系统包括多个可展开的针，其围绕中心轴线开放以接合血管壁，允许注射细胞毒性或神经毒性溶液以消除肾脏血管壁内和附近的传导组织 动脉或肺静脉。 可膨胀针由自膨胀材料形成，并且包括限制注射针穿入血管壁组织的距离的结构。
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2.发明申请EXPANDABLE CATHETER SYSTEM FOR PERI-OSTIAL INJECTION AND MUSCLE AND NERVE FIBER ABLATION 有权膀胱注射和肌肉和神经纤维的放大导管系统公开(公告)号：US20120271301A1
公开(公告)日：2012-10-25
申请号：US13092363
申请日：2011-04-22
申请人： DAVID R. FISCHELL , TIM A. FISCHELL
发明人： DAVID R. FISCHELL , TIM A. FISCHELL
IPC分类号： A61B18/12
CPC分类号： A61B18/1492 , A61B2018/00214 , A61B2018/0022 , A61B2018/00375 , A61B2018/00404 , A61B2018/00434 , A61B2018/00511 , A61B2018/00577 , A61B2018/143 , A61M5/00
摘要： At the present time, physicians often treat patients with atrial fibrillation (AF) using radiofrequency (RF) catheter systems to ablate conducting tissue in the wall of the Left Atrium of the heart around the ostium of the pulmonary veins. These systems are expensive and take time consuming to use. The present invention circular ablation system CAS includes a multiplicity of expandable needles that can be expanded around a central axis and positioned to inject a fluid like ethanol to ablate conductive tissue in a ring around the ostium of a pulmonary vein quickly and without the need for expensive capital equipment. The expansion of the needles is accomplished by self-expanding or balloon expandable structures. The invention includes centering means so that the needles will be situated in a pattern surrounding the outside of the ostium of a vein. Also included are members that limit the distance of penetration of the needles into the wall of the left atrium. The present invention also has application to ablating tissue around the ostium of a renal artery for the treatment of hypertension.
摘要翻译： 目前，医生经常使用射频（RF）导管系统治疗房颤患者，以消融肺静脉周围心脏左心房壁的导电组织。 这些系统是昂贵的并且花费耗时的使用。 本发明的圆形消融系统CAS包括多个可扩展的针，其可以围绕中心轴线扩张并且被定位成像乙醇一样注入流体，以便快速地在肺静脉的口周围环绕环中的导电组织，而不需要昂贵的 资本设备。 针的膨胀通过自膨胀或球囊可膨胀结构来实现。 本发明包括定心装置，使得针头将位于围绕静脉口的外侧的图案中。 还包括限制针头进入左心房壁的距离的成员。 本发明还可用于消除肾动脉口周围的组织用于治疗高血压。
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3.发明申请EXPANDABLE CATHETER SYSTEM FOR PERI-OSTIAL INJECTION AND MUSCLE AND NERVE FIBER ABLATION 有权膀胱注射和肌肉和神经纤维的放大导管系统公开(公告)号：US20120271277A1
公开(公告)日：2012-10-25
申请号：US13196104
申请日：2011-08-02
申请人： DAVID R. FISCHELL , TIM A. FISCHELL
发明人： DAVID R. FISCHELL , TIM A. FISCHELL
IPC分类号： A61M29/00
CPC分类号： A61B18/06 , A61B5/042 , A61B18/1477 , A61B18/1492 , A61B90/39 , A61B2017/22038 , A61B2017/22068 , A61B2018/0016 , A61B2018/00214 , A61B2018/0022 , A61B2018/00285 , A61B2018/00375 , A61B2018/00404 , A61B2018/00434 , A61B2018/00511 , A61B2018/00577 , A61B2018/00839 , A61B2018/143 , A61B2018/1475 , A61B2090/3966 , A61M2025/0087
摘要： At the present time, physicians often treat patients with atrial fibrillation (AF) using radiofrequency (RF) catheter systems to ablate conducting tissue in the wall of the Left Atrium of the heart around the ostium of the pulmonary veins. These systems are expensive and take time consuming to use. The present invention circular ablation system CAS includes a multiplicity of expandable needles that can be expanded around a central axis and positioned to inject a fluid like ethanol to ablate conductive tissue in a ring around the ostium of a pulmonary vein quickly and without the need for expensive capital equipment. The expansion of the needles is accomplished by self-expanding or balloon expandable structures. The invention includes centering means so that the needles will be situated in a pattern surrounding the outside of the ostium of a vein. Also included are members that limit the distance of penetration of the needles into the wall of the left atrium, or the aortic wall. The present invention also has an important application to ablate tissue around the ostium of one or both renal arteries, for the ablation of the sympathetic nerve fibers and/or other afferent or efferent nerves going to or from each kidney in order to treat hypertension.
摘要翻译： 目前，医生经常使用射频（RF）导管系统治疗房颤患者，以消融肺静脉周围心脏左心房壁的导电组织。 这些系统是昂贵的并且花费耗时的使用。 本发明的圆形消融系统CAS包括多个可扩展的针，其可以围绕中心轴线扩张并且被定位成像乙醇一样注入流体，以便快速地在肺静脉的口周围环绕环中的导电组织，而不需要昂贵的 资本设备。 针的膨胀通过自膨胀或球囊可膨胀结构来实现。 本发明包括定心装置，使得针头将位于围绕静脉口的外侧的图案中。 还包括限制针穿入左心房壁或主动脉壁的距离的构件。 本发明还具有重要的应用，用于消除一个或两个肾动脉周围的组织，用于消除去往或来自每个肾脏的交感神经纤维和/或其他传入或传出神经以治疗高血压。
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4.发明申请公开(公告)号：US20130053822A1
公开(公告)日：2013-02-28
申请号：US13342521
申请日：2012-01-03
申请人： DAVID R. FISCHELL , TIM A. FISCHELL
发明人： DAVID R. FISCHELL , TIM A. FISCHELL
CPC分类号： A61M5/46 , A61B5/6848 , A61M25/0026 , A61M25/0084 , A61M25/0097 , A61M25/0662 , A61M2025/0039 , A61M2025/0085 , A61M2025/0086 , A61M2025/0681 , A61M2202/0007 , A61M2205/0266 , A61M2210/12
摘要： A catheter-based/intravascular fluid injection system with application to renal denervation includes a multiplicity of needles which expand open around a central axis to engage the wall of a blood vessel, or the wall of the left atrium, allowing the injection of a cytotoxic and/or neurotoxic solution for ablating conducting tissue, or nerve fibers around the ostium of the pulmonary vein, or circumferentially in or just beyond the outer layer of the renal artery. The expandable delivery system includes expandable components that facilitate positioning of a multiplicity of injection needles against the inside wall of a blood vessel from where they can be advanced. The system also includes means to limit and/or adjust the depth of penetration of the ablative fluid into the tissue of the wall of the targeted blood vessel.
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5.发明申请EXPANDABLE CATHETER SYSTEM FOR VESSEL WALL INJECTION AND MUSCLE AND NERVE FIBER ABLATION 审中-公开用于船舶注射和肌肉和神经纤维的膨胀导管系统公开(公告)号：US20130053792A1
公开(公告)日：2013-02-28
申请号：US13294439
申请日：2011-11-11
申请人： DAVID R. FISCHELL , TIM A. FISCHELL
发明人： DAVID R. FISCHELL , TIM A. FISCHELL
IPC分类号： A61M31/00
CPC分类号： A61M25/0084 , A61B5/6848 , A61M25/0074 , A61M25/0097 , A61M25/0108 , A61M25/0662 , A61M2025/0039 , A61M2025/0086 , A61M2025/0087 , A61M2025/0681 , A61M2202/0468 , A61M2210/12
摘要： A catheter-based/intravascular ablation (denervation) system includes a multiplicity of needles which expand open around a central axis to engage the wall of a blood vessel, or the wall of the left atrium, allowing the injection of a cytotoxic or/or neurotoxic solution for ablating conducting tissue, or nerve fibers around the ostium of the pulmonary vein, or circumferentially in or just beyond the outer layer of the renal artery. The expandable needle delivery system is formed with self-expanding materials and include structures, near the end portion of the needles, or using separate guide tubes. The system also includes means to limit and/or adjust the depth of penetration of the ablative fluid into the tissue of the wall of the targeted blood vessel.
摘要翻译： 基于导管的/血管内消融（去神经支配）系统包括多个针，其围绕中心轴线开放，以与血管的壁或左心房的壁接合，允许注射细胞毒性和/或神经毒性 用于烧蚀导管组织的解决方案，或在肺静脉口周围的神经纤维，或在肾动脉的外层周向或刚好超出肾动脉的外层。 可扩展针递送系统由自膨胀材料形成，并且包括在针的端部附近的结构，或者使用单独的导管。 该系统还包括限制和/或调节烧蚀液体渗透到目标血管壁的组织中的深度的装置。
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公开(公告)号：US20110301684A1
公开(公告)日：2011-12-08
申请号：US12795707
申请日：2010-06-08
CPC分类号： A61M25/0662 , A61F2/95 , A61M25/0041 , A61M25/0097 , A61M29/00 , A61M2025/0004 , A61M2025/0006 , A61M2025/0681
摘要： An integrated catheter system for performing angiography on a human patient, the integrated catheter system consisting of an angiographic catheter onto which a thin-walled sheath is co-axially mounted. The angiographic catheter having an essentially straight and elongated proximal section in the form of a cylindrical shaft that is surrounded for less than one-half of its length by the thin-walled sheath that has an outer diameter that is less than 0.25 mm greater than the outside diameter of the angiography catheter. The strength to prevent buckling of the thin-walled sheath being provided by the shaft of the angiographic catheter. The integrated catheter system also being ideal for the placement of stents using small diameter stent delivery systems such as the stent-on-a-wire system.
摘要翻译： 一种用于对人类患者执行血管造影的集成导管系统，由血管造影导管组成的整体导管系统，薄壁鞘同轴安装在该血管造影导管上。 血管造影导管具有圆柱形轴的基本上直的和细长的近端部分，其通过薄壁护套被围绕其长度小于其长度的一半，外壳的外径小于 血管造影导管的外径。 防止由血管造影导管的轴提供的薄壁鞘的屈曲的强度。 集成的导管系统也是使用小直径支架输送系统（如支架在线系统）放置支架的理想选择。
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公开(公告)号：US20080183091A1
公开(公告)日：2008-07-31
申请号：US12059146
申请日：2008-03-31
IPC分类号： A61B5/0402
CPC分类号： A61L27/54 , A61L2300/236 , A61L2300/254 , A61L2300/42
摘要： Disclosed are methods for detecting an acute myocardial infarction (i.e., a heart attack) at the earliest possible time and promptly warning the patient that he should immediately seek medical care. The present invention includes an implantable electronic system that can sense a change in the patient's electrogram that is indicative of a heart attack. If a heart attack is sensed, the device would then cause an implantable and/or externally located alarm to be actuated to warn the patient of his condition and a medical practitioner at a remote diagnostic center would receive the patient's electrogram for analysis. The patient or a caretaker would then be informed to self-inject medication through a subcutaneous, pass-through drug port that can be a separate device or integrated into the implanted device that is designed for the early detection of a heart attack. The methods of the present invention include determining if a human patient is likely to have a heart attack and, if he is, then implanting within that patient a device that can sense when a heart attack occurs and alarm the patient to take appropriate actions if a heart attack does occur.
摘要翻译： 公开了在早期检测急性心肌梗塞（即心脏病发作）的方法，并且及时警告患者他应该立即求医。 本发明包括可以感测指示心脏病发作的患者电描记图变化的可植入电子系统。 如果感测到心脏病发作，则该装置然后将致动可植入和/或外部定位的警报器，以警告患者其状况，并且远程诊断中心的医务人员将接收患者的电描记图以进行分析。 然后将患者或看守者通知皮下，通过的药物口，自动注射药物，该药物口可以是单独的装置，或者整合到被设计用于早期发现心脏病发作的植入装置中。 本发明的方法包括确定人类患者是否可能患有心脏病发作，并且如果他是，则在患者体内植入可以感测发生心脏病发作的装置，并且如果 心脏病发作确实发生。
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8.发明申请INTRODUCER SHEATH WITH THIN-WALLED SHAFT AND IMPROVED MEANS FOR ATTACHMENT TO THE SKIN 有权介绍带有薄壁纱线的鞋子和改善与皮肤接触的手段公开(公告)号：US20120215174A1
公开(公告)日：2012-08-23
申请号：US13032876
申请日：2011-02-23
CPC分类号： A61M25/0662 , A61M5/1418 , A61M25/005 , A61M25/0108 , A61M25/02 , A61M2025/0266 , A61M2025/028 , A61M2025/0286 , A61M2209/088
摘要： An introducer sheath for placement into the vascular system of a human subject. The introducer sheath has a tubular shaft, a side arm, and a hemostasis valve with an integrated attachment mechanism for attaching and detaching a proximal end of the introducer sheath to and from the skin of the human subject.
摘要翻译： 用于放置在人类受试者的血管系统中的导引鞘。 引导器护套具有管状轴，侧臂和具有集成附接机构的止血阀，用于将引导器护套的近端附接到人类受试者的皮肤和从皮肤脱离皮肤。
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公开(公告)号：US20120150271A1
公开(公告)日：2012-06-14
申请号：US12964071
申请日：2010-12-09
摘要： A buddy wire guide wire has a wire section for guiding a catheter to a particular site in the human body. The buddy wire guide wire has a distal section with a distal end and an opposing proximal end. The wire section is attached to the proximal end of the distal section with the distal section being placed coaxially around the shaft of some existing medical device which has been inserted into the human body. The distal section permits the buddy wire to be advanced into the human body over the medical device by using the medical device as a guide.
摘要翻译： 好友线导丝具有用于将导管引导到人体的特定部位的线段。 好友线导线具有远端部分，其具有远端和相对的近端。 电线部分附接到远端部分的近端，远侧部分同轴地放置在已插入人体内的一些现有医疗装置的轴上。 远端部分通过使用医疗装置作为指导，允许伙伴线通过医疗装置前进到人体内。
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公开(公告)号：US20120041469A1
公开(公告)日：2012-02-16
申请号：US12854464
申请日：2010-08-11
申请人： DAVID R. FISCHELL , TIM A. FISCHELL
发明人： DAVID R. FISCHELL , TIM A. FISCHELL
IPC分类号： A61F2/01
CPC分类号： A61F2/013 , A61F2/958 , A61F2/966 , A61F2002/018 , A61F2230/0006 , A61F2230/008 , A61F2250/0098
摘要： A percutaneous system to open a stenosed vessel has a catheter for insertion into a vessel. An expandable filter mechanism is within a deployable sheath for expansion against a vessel wall when the sheath is displaced by a first displacement distance. A stenosis opening mechanism is within the deployable sheath and is radially expandable near the expandable filter mechanism with the stenosis opening mechanism being expandable against the stenosis when the stenosis opening mechanism is located within the vessel in longitudinal alignment with the stenosis following displacement of the sheath by a second displacement distance. Radiopaque markers align the stenosis opening mechanism with the stenosis.
摘要翻译： 用于打开狭窄血管的经皮系统具有用于插入血管的导管。 可扩展的过滤器机构在可展开的护套内，用于当护套移位第一位移距离时，用于在血管壁上膨胀。 狭缝开放机构在可展开的护套内，并且在可扩张的过滤器机构附近可径向扩张，当狭窄开放机构位于容器内时，狭窄开口机构可扩张以抵抗狭窄， 第二个位移距离。 不透射线标记使狭窄开放机制与狭窄相对应。
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