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    Method and Apparatus for Analyzing Samples Using Mass Spectrometry
    1.
    发明申请
    Method and Apparatus for Analyzing Samples Using Mass Spectrometry 审中-公开

    公开(公告)号：US20200279727A1

    公开(公告)日：2020-09-03

    申请号：US16063104

    申请日：2016-12-15

    Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.

    Inventor： Takashi BABA ,  Paul BAKER ,  John Lawrence CAMPBELL ,  Yves LeBLANC

    IPC: H01J49/00 ,  G01N33/92

    Abstract: A method and apparatus for analyzing samples using mass spectrometry are disclosed. The apparatus includes a reaction device configured to dissociate sample ions into fragments by reacting the sample ions with a charged species (e.g., electrons) such as through ECD, EID, or EIEIO. The kinetic energy of the charged species is such that the fragments may be detected and produce spectra that allow for the determination of isomeric species in the sample and the location of double bonds and/or the orientation of those double bonds within the sample molecules. The fragments may include radical fragments and non-radical fragments. Spectra resulting from analysis of the fragments may allow for the determination of the oxygen-radical fragments resulting from the dissociation of the sample molecules as confirmation of the presence of those radical fragments.

    Differential Mobility Spectrometry Method
    2.
    发明申请
    Differential Mobility Spectrometry Method 审中-公开

    公开(公告)号：US20180003675A1

    公开(公告)日：2018-01-04

    申请号：US15540770

    申请日：2015-12-16

    Applicant: DH Technologies Development PTE Ltd.

    Inventor： John Lawrence CAMPBELL ,  Yves LE BLANC

    IPC: G01N27/62 ,  H01J49/00

    CPC classification number: G01N27/624 ,  H01J49/004

    Abstract: Methods and systems are provided herein for varying the CoV about a nominal CoV-apex while monitoring the ion of interest corresponding to the nominal CoV-apex as it is transmitted by a DMS. In various aspects, the CoV can be swept or stepped across a series of values during the injection of ions into the DMS such that a composite spectra of the ion of interest transmitted by the DMS (or its product ions following one or more stages of fragmentation) can be generated so as to include the transmission of the particular ion at a CoV with optimum sensitivity (i.e., if distinct from the CoV-apex), thereby improving the robustness, accuracy, and/or selectivity during experimental conditions relative to known DMS techniques, which typically used a fixed CoV value for each ion of interest.

    Electron-Based Fragmentation Method
    3.
    发明申请
    Electron-Based Fragmentation Method 有权

    公开(公告)号：US20250029823A1

    公开(公告)日：2025-01-23

    申请号：US18569781

    申请日：2022-06-24

    Applicant: DH Technologies Development Pte. Ltd.

    Inventor： John Lawrence CAMPBELL ,  Bill LOYD ,  Pavel RYUMIN

    IPC: H01J49/00 ,  H01J49/42

    Abstract: The present disclosure provides methods and systems for performing mass spectrometry in which at least two batches of precursor ions generated via ionization of at least two different portions of a sample are exposed to electron beams at different energies to cause fragmentation of at least a portion of the precursor ions. In some embodiments, the electron energies can be selected such at one of the electron energies, EIEIO fragmentation can occur while at the other electron energy, EIEO fragmentation channel is not available. The mass spectra corresponding to the two energies can then be utilized to generate a resultant mass spectrum in which mass peaks corresponding to ion fragments generated by EIEIO dissociation are more readily identifiable.

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