公开(公告)号：US20250069873A1

公开(公告)日：2025-02-27

申请号：US18725973

申请日：2022-12-22

Applicant: DH Technologies Development Pte. Ltd.

Inventor： Gordana IVOSEV ,  Chang LIU ,  David M. COX

IPC: H01J49/00

Abstract: A method and system for detecting a signal measurement error, the method including providing a well plate including error correction wells and sample wells, each sample well including a single sample, and each error correction well including a mixture of samples from two or more sample wells. The method includes receiving an aliquot from the wells at a sample receiver, measuring a signal for the received aliquot, calculating an expected signal for each of the error correction wells, comparing the measured signal to the calculated expected signal for each error correction well, and determining whether an error exists in the signal of at least one sample well. When the error exists, the method correlates the error to one or more sample wells.

公开(公告)号：US20240272101A1

公开(公告)日：2024-08-15

申请号：US18568410

申请日：2022-06-08

Applicant: DH Technologies Development Pte. Ltd.

Inventor： Thomas COVEY ,  Chang LIU ,  Yuzhu GUO

IPC: G01N23/2208 ,  G16C20/30

CPC classification number: G01N23/2208 ,  G16C20/30 ,  G01N2223/071

Abstract: In one aspect, a method of assessing hydrophobicity of a target analyte is disclosed, which includes introducing a sin-gle-phase system containing a concentration of the target analyte into a mass spectrometer to acquire at least one mass signal associated with the target analyte, introducing a phase-separated system (e.g., a two-phase system) containing substantially the same concentration of the target analyte into the mass spectrometer to acquire at least one mass signal associated with said target analyte, and utilizing a ratio of the intensities of the mass signals to assess hydrophobicity of the target analyte.

公开(公告)号：US20240096614A1

公开(公告)日：2024-03-21

申请号：US18261918

申请日：2022-01-20

Applicant: DH Technologies Development Pte. Ltd.

Inventor： Peter KOVARIK ,  Chang LIU

IPC: H01J49/16

CPC classification number: H01J49/167

Abstract: A method of adjusting a position of a tip of an electrode relative to an end of a nebulizer nozzle of a mass spectrometry device includes providing a conduit and the electrode connected to the conduit at a first end of the conduit. The electrode tip is disposed at a first position relative to the nebulizer nozzle end. The pressure gauge is connected to a second end of the conduit. A gas ejection is initiated from the nozzle with the electrode tip at the first position. During the gas ejection, the position of the electrode tip is adjusted from the first position towards a second position relative to the nozzle end. Adjusting the position from the first position towards the second position is terminated when the pressure gauge displays a pressure condition. Once adjusting is terminated, the electrode tip is at the second position.

公开(公告)号：US20240203717A1

公开(公告)日：2024-06-20

申请号：US18286160

申请日：2022-04-07

Applicant: DH Technologies Development Pte. Ltd.

Inventor： Thomas R. COVEY ,  Chang LIU

IPC: H01J49/04

CPC classification number: H01J49/0445 ,  H01J49/0409 ,  H01J49/0454

Abstract: In one aspect, a method of extracting a target analyte from a sample for introduction into a mass spectrometer is disclosed, which includes mixing the sample with a paramagnetic medium to form a mixture, subjecting the mixture to a magnetic field gradient to form a non-homogenous distribution of at least one of the analyte and at least one interfering component of the sample, if any, thereby enhancing a concentration of the target analyte within a spatial location of said mixture, extracting at least a portion of the target analyte from that spatial location, and introducing at least a portion of the extracted target analyte into said mass spectrometer.

公开(公告)号：US20240112901A1

公开(公告)日：2024-04-04

申请号：US18257611

申请日：2021-12-21

Applicant: DH Technologies Development Pte. Ltd.

Inventor： Chang LIU ,  Thomas COVEY ,  Peter KOVARIK

IPC: H01J49/06 ,  H01J49/16

CPC classification number: H01J49/068 ,  H01J49/165

Abstract: A method of adjusting a position of an electrode within a nebulizer probe of a mass spectrometry device having an open port interface for receiving a sample includes performing a first analysis of the sample at a first analysis condition including a first position of the electrode and a first flow rate. After performing the first analysis, a second analysis of the sample is performed at a second analysis condition including the first position of the electrode and a second flow rate higher than the first flow rate. Thereafter, a third analysis of the sample is performed at a third analysis condition including a second position of the electrode and the second flow rate.

公开(公告)号：US20240053356A1

公开(公告)日：2024-02-15

申请号：US18264613

申请日：2022-02-10

Applicant: DH Technologies Development Pte. Ltd.

Inventor： Chang LIU

IPC: G01N33/68 ,  G01N33/543 ,  G01N33/574

CPC classification number: G01N33/6848 ,  G01N33/54326 ,  G01N33/54346 ,  G01N33/57488

Abstract: Methods and systems for conducting affinity selection by mass spectrometry in high throughput assays are disclosed herein. The methods can comprise identifying a set of hit com-pounds having a selected affinity to a binding target immobilized onto a magnetic particle. Methods can comprise forming an assay mixture within an assay vessel comprising a plurality of drug candidates and a binding target immobilized onto a magnetic particle. Methods also can comprise preparing at least a portion of the assay mixture for mass analysis transferring a sample containing the set of hit compounds to an open port sampling interface of a mass spectrometer.

公开(公告)号：US20230238230A1

公开(公告)日：2023-07-27

申请号：US17999814

申请日：2021-05-25

Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.

Inventor： Thomas R. COVEY ,  Chang LIU

IPC: H01J49/04 ,  H01J49/16 ,  B25J15/00

CPC classification number: H01J49/0413 ,  H01J49/165 ,  B25J15/0052

Abstract: Technology for analyzing collections of substance samples. Systems in accordance with the disclosure can include one or more sample handlers, sample capture devices, mass analysis instruments, and controllers; the controllers being operative, in accordance with instructions received from at least one of an operator input device and machine-interpretable instructions stored in memory accessible by the controller, to generate signals configured to cause the sample handler to collectively retrieve from a sample source a plurality of samples of one or more substances, and deliver the plurality of collected samples to the at least one sample capture device; cause the sample capture device to independently capture at least one of the collectively retrieved samples delivered by the sample handler, and transfer the at least one captured sample to a mass analysis instrument; and cause the mass analysis instrument to ionize and detect one or more particles of the transferred treated sample.

公开(公告)号：US20240272173A1

公开(公告)日：2024-08-15

申请号：US18568398

申请日：2022-06-08

Applicant: DH Technologies Development Pte. Ltd.

Inventor： Thomas COVEY ,  Yuzhu GUO ,  Chang LIU

IPC: G01N33/68 ,  G01N30/06 ,  G01N30/72

CPC classification number: G01N33/6851 ,  G01N30/06 ,  G01N30/7233

Abstract: In one aspect, a method of introducing a sample into an open port interface (OPI) of a mass spectrometer is disclosed, which includes mixing the sample with a solvent in which a matrix of an aqueous phase of the sample is immiscible and in which at least a target analyte, when present in the sample, is miscible so as to extract at least a portion of the target analyte into said at least one solvent, thereby generating a multi-phase liquid having said aqueous phase and one or more organic phases, wherein at least one of those organic phases contains at least a portion of the target analyte. In some embodiments, the method further calls for ejecting a plurality of droplets from at least one of the phases of the multi-phase liquid for introduction into the OPI of the mass spectrometer.

公开(公告)号：US20240234117A9

公开(公告)日：2024-07-11

申请号：US18275342

申请日：2022-01-31

Applicant: DH Technologies Development Pte. Ltd.

Inventor： Thomas R. COVEY ,  Tim HAEBE ,  Chang LIU

IPC: H01J49/04 ,  H01J49/24

CPC classification number: H01J49/0431 ,  H01J49/24

Abstract: Methods and systems for delivering a liquid sample to an ion source for the generation of ions and subsequent analysis by mass spectrometry are provided herein. In accordance with various aspects of the present teachings, MS-based systems and methods are provided in which an open port of a sampling probe for receiving a specimen may be exposed to washing solvent to wash the sampling probe while fluid within the sampling probe remains continuously flowing.

公开(公告)号：US20240136168A1

公开(公告)日：2024-04-25

申请号：US18275342

申请日：2022-01-31

Applicant: DH Technologies Development Pte. Ltd.

Inventor： Thomas R. COVEY ,  Tim HAEBE ,  Chang LIU

IPC: H01J49/04 ,  H01J49/24

CPC classification number: H01J49/0431 ,  H01J49/24

Abstract: Methods and systems for delivering a liquid sample to an ion source for the generation of ions and subsequent analysis by mass spectrometry are provided herein. In accordance with various aspects of the present teachings, MS-based systems and methods are provided in which an open port of a sampling probe for receiving a specimen may be exposed to washing solvent to wash the sampling probe while fluid within the sampling probe remains continuously flowing.