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公开(公告)号：US20240175787A1
公开(公告)日：2024-05-30
申请号：US18547787
申请日：2022-02-24
Applicant: Stephen TATE , Andras GUTTMAN , DH Technologies Development Pte. Ltd.
Inventor： Stephen TATE , Yves LE BLANC , Thomas R. COVEY
CPC classification number: G01N1/14 , G01N1/38 , G01N30/7233 , G01N2001/149 , G01N2030/027
Abstract: A system includes a capillary having a first end connected to a sampling device and a second end. The sampling device is configured to separate a sample with a separation solution and deliver the sample and the separation solution to the second end. The second end is coupled to a capillary ground contact. A transport liquid supply system in fluidic communication with a transport liquid supply conduit provides a transport liquid from a transport liquid source through the transport liquid supply conduit. The transport liquid provided from the transport liquid supply conduit includes a receiving volume defined at least in part by a meniscus. The second end of the capillary is in fluidic communication with the receiving volume. A liquid exhaust system in fluidic communication with a removal conduit removes liquid from the receiving volume. An analysis system is in fluidic communication with the removal conduit.
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公开(公告)号：US20240412962A1
公开(公告)日：2024-12-12
申请号：US18689495
申请日：2022-09-09
Applicant: DH Technologies Development Pte. Ltd.
Inventor： Eva DUCHOSLAV , Yves LE BLANC
IPC: H01J49/00
Abstract: Methods and systems for adjusting instrument setting, improving fidelity of isotope pattern for mass spectra, and/or determining molecular mass with improved accuracy are disclosed. In one example, a method for determining Mmono of a compound of interest in a sample using a mass spectrometer is provided. The method comprises: (1) tuning or adjusting instrument setting of the mass spectrometer using at least one known compound, wherein the instrument setting comprises at least one parameter for improving accuracy; (2) analyzing the compound of interest using the adjusted instrument setting to obtain a mass spectrum thereof, wherein the mass spectrum comprises an isotope pattern thereof; and determining the Mmono of the compound of interest from the mass spectrum thereof.
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公开(公告)号：US20220293406A1
公开(公告)日：2022-09-15
申请号：US17636745
申请日：2020-08-21
Applicant: DH Technologies Development PTE. LTD.
Inventor： Yves LE BLANC
Abstract: Apparatus, systems and methods disclosed herein utilize an ion source region generally disposed between a sample introduction port and an ion guide of a mass spectrometry system to thermally fragment ions for transmission to and analysis by a downstream mass analyzer. In various aspects, the present disclosure provides methods of thermally fragmenting ions in an ion source region of a mass spectrometry system. Thermally fragmenting a plurality of ions can include increasing a temperature of the ions present in an ion source region. Thermally fragmenting a plurality of ions can include increasing the temperature of the ions in an ionization/fragmentation region associated with an ion source region defined by a substantially collision-free path. Implementations of the present disclosure are useful in mass spectrometry systems, including, for example, generating an enhanced fragmentation pattern.
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Patent Agency Ranking
公开(公告)号：US20180003675A1
公开(公告)日：2018-01-04
申请号：US15540770
申请日：2015-12-16
Applicant: DH Technologies Development PTE Ltd.
Inventor： John Lawrence CAMPBELL , Yves LE BLANC
CPC classification number: G01N27/624 , H01J49/004
Abstract: Methods and systems are provided herein for varying the CoV about a nominal CoV-apex while monitoring the ion of interest corresponding to the nominal CoV-apex as it is transmitted by a DMS. In various aspects, the CoV can be swept or stepped across a series of values during the injection of ions into the DMS such that a composite spectra of the ion of interest transmitted by the DMS (or its product ions following one or more stages of fragmentation) can be generated so as to include the transmission of the particular ion at a CoV with optimum sensitivity (i.e., if distinct from the CoV-apex), thereby improving the robustness, accuracy, and/or selectivity during experimental conditions relative to known DMS techniques, which typically used a fixed CoV value for each ion of interest.
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公开(公告)号：US20240355605A1
公开(公告)日：2024-10-24
申请号：US18688423
申请日：2022-09-02
Applicant: DH Technologies Development Pte. Ltd.
Inventor： Yves LE BLANC , Gordana IVOSEV
IPC: H01J49/00 , G01N27/623 , G01N27/624
CPC classification number: H01J49/005 , G01N27/623 , G01N27/624 , H01J49/0036
Abstract: A method for improved mass spectrometry by determining charge state of precursor ions from an analysis of product ions, includes receiving sample ions. A group of precursor ions is selected from the received sample ions based on mobility. A fragmentation device fragments the group of precursor ions to produce a group of product ions. A tandem mass spectrometry analysis is performed on the group of product ions to generate an intensity and mass-to-charge ratio (m/z) of the group of product ions. An ionogram is generated, based on the generated intensities and mass, to charge ratios for the groups of product ions generated for each of the mobility selection. The ionogram includes a first axis representing compensation voltage value and another axis representing intensity. A product ion peak is identified in the ionogram. At least one peak characteristic is identified of the product ion peak. A charge state of a precursor ion that was fragmented to form the product ions represented in the product ion peak is determined based on the at least one peak characteristic of the produce ion peak.
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6.发明公开公开(公告)号：US20240258090A1
公开(公告)日：2024-08-01
申请号：US18560458
申请日：2022-05-11
Applicant: DH Technologies Development Pte. Ltd.
Inventor： Yves LE BLANC , Stephen TATE
CPC classification number: H01J49/0031 , H01J49/165
Abstract: Systems and methods for performing mass analysis. An example method may include ejecting, from a first well of a well plate, a first sample into a transport fluid; ionizing the first sample and the transport fluid to generate first ions; detecting the first ions over a first period of time; and when a count rate of the detected first ions is above a background count rate threshold, accumulating a count of the detected first ions. The method may also include ejecting, from a second well of the well plate, a second sample into the transport fluid; ionizing the second sample and the transport fluid to generate second ions; detecting the second ions over a second period of time; and when a count rate of the detected second ions is above the background count rate threshold, accumulating a count of the detected second ions.
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7.发明公开公开(公告)号：US20240272121A1
公开(公告)日：2024-08-15
申请号：US18569701
申请日：2022-06-16
Applicant: DH Technologies Development Pte. Ltd.
Inventor： Bradley B. SCHNEIDER , Leigh BEDFORD , Yves LE BLANC , Eva DUCHOSLAV
IPC: G01N27/623 , G01N27/624 , H01J49/00
CPC classification number: G01N27/623 , G01N27/624 , H01J49/0031
Abstract: An automated method of operating a mass spectrometer (MS) comprising a differential mobility spectrometer (DMS) includes: introducing a first compound to the DMS; calculating a first alpha function for the first compound; introducing a second compound to the DMS; calculating a second alpha function for the second compound; and determining operation parameters of the DMS to achieve sufficient separation of the first compound and the second compound, based on the first alpha function and the second alpha function.
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8.发明公开公开(公告)号：US20240162022A1
公开(公告)日：2024-05-16
申请号：US18283109
申请日：2022-03-24
Applicant: DH Technologies Development Pte. Ltd.
Inventor： Yves LE BLANC
CPC classification number: H01J49/0045 , H01J49/022 , H01J49/063 , H01J49/24
Abstract: Systems and methods described herein provide for charge state control of multiply-charged anions in a front end, high pressure ion guide. In some example aspects, a mass spectrometer system is provided comprising a first vacuum chamber (121) maintained at a pressure above about 500 mTorr. At least one ion guide (106) is disposed within the first vacuum chamber, the at least one ion guide comprising a plurality of rods extending along a central longitudinal axis. A controller (193) is configured to adjust an amplitude of an RF voltage signal provided to the plurality of rods so as to alternatively operate the ion guide in a first mode of operation with a lower amplitude of the RF voltage signal so as to reduce the likelihood of charge reduction by electron detachment so as to substantially maintain the isotopic distribution of the ions during transmission of ions through the ion guide, and a second mode of operation with a higher amplitude of the RF voltage signal so as to increase the likelihood of electron detachment from ions being transmitted therethrough.
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