公开(公告)号：US20190126167A1

公开(公告)日：2019-05-02

申请号：US15800781

申请日：2017-11-01

Applicant: Dionex Corporation

Inventor： Melvin Hatch ,  Christopher A. Pohl ,  Manikandan Jayaraman

IPC: B01D15/36 ,  B01J41/20 ,  B01J41/13

Abstract: An ion exchange resin for use as a stationary phase in an ion chromatography column. The ion exchange resin has a negatively charged substrate particle, a positively charged polymer layer bound to the negatively charged substrate particle, a linker, and an ion exchange group. The ion exchange group includes a sulfonamide group and an amine, in which the ion exchange group is coupled to the positively charged polymer layer via the linker. When the sulfonamide is in a neutral form, a positively charged amine group provides retention; while when the sulfonamide is in an anionic form, the sulfonamide anion becomes a counter ion to the positively charged amine group, forming a zwitterion that reduces retention at that site. Accordingly, the retention time is able to be controlled by adjusting the mobile phase pH.

公开(公告)号：US11448626B2

公开(公告)日：2022-09-20

申请号：US16865696

申请日：2020-05-04

Applicant: DIONEX CORPORATION

Inventor： Manikandan Jayaraman ,  Christopher A. Pohl ,  Charanjit Saini

IPC: G01N30/96 ,  B01D15/36 ,  B01J39/20 ,  B01J39/26 ,  B01J41/20 ,  B01J39/05 ,  B01J39/07 ,  B01J41/07 ,  B01D15/20 ,  B01J47/02

Abstract: An ion exchange chromatographic packing material is described that includes support resin particles and a copolymer grafted to the support resin particles. The copolymer includes polymerized functional monomers such as a first ion exchange group monomer and a second ion exchange group monomer. At a first pH, the first ion exchange group monomer is configured to have a first charge at a first pH, and the second ion exchange group monomer is configured to have a net neutral charge. At a second pH, the first ion exchange group monomer is configured to have the first charge at a second pH, and the second ion exchange group monomer is configured to have a second charge at the second pH where the first charge and second charge both have a same polarity.

公开(公告)号：US20210308599A1

公开(公告)日：2021-10-07

申请号：US17354058

申请日：2021-06-22

Applicant: Melvin Hatch ,  Dionex Corporation

Inventor： Melvin Hatch ,  Christopher A. Pohl ,  Manikandan Jayaraman

IPC: B01D15/36 ,  B01J41/13 ,  B01J41/20 ,  B01J41/14 ,  B01J41/05

Abstract: An ion exchange resin for use as a stationary phase in an ion chromatography column. The ion exchange resin has a negatively charged substrate particle, a positively charged polymer layer bound to the negatively charged substrate particle, a linker, and an ion exchange group. The ion exchange group includes a sulfonamide group and an amine, in which the ion exchange group is coupled to the positively charged polymer layer via the linker. When the sulfonamide is in a neutral form, a positively charged amine group provides retention: while when the sulfonamide is in an anionic form, the sulfonamide anion becomes a counter ion to the positively charged amine group, forming a zwitterion that reduces retention at that site. Accordingly, the retention time is able to be controlled by adjusting the mobile phase pH.