公开(公告)号：US20240230602A9

公开(公告)日：2024-07-11

申请号：US17969779

申请日：2022-10-20

申请人： Dionex Corporation

发明人： Mrinal K. Sengupta ,  George Tang ,  Husam Al-Esawi

IPC分类号： G01N30/14 ,  B01D15/24 ,  B01D15/36 ,  B01D15/42 ,  B01D61/46 ,  G01N30/32 ,  G01N30/64

CPC分类号： G01N30/14 ,  B01D15/24 ,  B01D15/361 ,  B01D15/424 ,  B01D61/46 ,  G01N30/32 ,  G01N30/64 ,  G01N2030/027

摘要： Systems and methods are described for ion chromatography systems and electrolytic suppressors. By varying the operating frequency of an electrolytic suppressor, the generation of bubbles and noise can be minimized. This leads to more accurate results in e.g., a conductivity detector downstream of an electrolytic suppressor within an ion chromatography system. In certain embodiments, it has been found that frequencies of around 700-750 Hz, 100-150 Hz and 925-975 Hz have achieved the best results.

公开(公告)号：US20240159721A1

公开(公告)日：2024-05-16

申请号：US18055064

申请日：2022-11-14

申请人： Dionex Corporation

发明人： Yan Liu ,  Rong Lin

IPC分类号： G01N30/96 ,  B01D15/36 ,  G01N30/02

CPC分类号： G01N30/96 ,  B01D15/361 ,  G01N30/02 ,  G01N2030/645

摘要： An ion exchange device comprises a primary channel member, a first regenerant flow channel member, a second regenerant flow channel member, a first ion exchange membrane, a second ion exchange membrane, and a first electrode and a second electrode. The first and second regenerant flow channels are configured to have consistent flow.

公开(公告)号：US11860143B2

公开(公告)日：2024-01-02

申请号：US17558464

申请日：2021-12-21

申请人： DIONEX CORPORATION

发明人： Akinde F. Kadjo

IPC分类号： G01N30/86 ,  G01N30/96 ,  G01N30/02 ,  G01N30/64

CPC分类号： G01N30/8658 ,  G01N30/96 ,  G01N30/02 ,  G01N30/64 ,  G01N2030/027 ,  G01N2030/965

摘要： A system for self-regulating a suppressor includes an ion chromatography suppressor, a power supply for applying an electric potential to the suppressor, and a control unit configured to provide an offset voltage VOS and an applied voltage VA to the suppressor, measure a current of the suppressor responsive to the offset and applied voltages VOS and VA, determine a suppressor state of the suppressor based upon the measured current, and adjust the offset voltage VOS based upon the suppressor state. A method for self-regulating a suppressor is also disclosed.

公开(公告)号：US11821000B2

公开(公告)日：2023-11-21

申请号：US17094522

申请日：2020-11-10

申请人： DIONEX CORPORATION

发明人： Kenneth George Cook ,  Alexander Boris Schwahn ,  Jung Un Baek ,  Shanhua Lin Liehr

IPC分类号： C12N7/02 ,  C12N15/864 ,  C12N7/00 ,  G01N30/02 ,  G01N30/62 ,  C12N15/86 ,  G01N30/72 ,  G01N30/86

CPC分类号： C12N15/86 ,  C12N7/00 ,  G01N30/7233 ,  G01N30/86 ,  G01N2030/027

摘要： A method of separating a liquid sample containing viral vectors includes flowing the liquid sample into an anion exchange column. A first viral vector contains a targeted genetic material and a second viral vector contains essentially no genetic material or a non-targeted genetic material, wherein the targeted genetic material is different than the non-targeted genetic material. A mobile phase can be flowed into the anion exchange column, wherein the mobile phase includes a buffer solution A and a buffer solution B. The buffer solutions A and B both include volatile buffer salts. The first viral vector and the second viral vector can be separated so that the first viral vector and the second viral vector elute off the anion exchange column at different times and then be detected.

公开(公告)号：US11802857B2

公开(公告)日：2023-10-31

申请号：US17545249

申请日：2021-12-08

申请人： DIONEX CORPORATION

发明人： Yongjing Chen

IPC分类号： G01N30/96 ,  H01J49/04

CPC分类号： G01N30/96 ,  H01J49/0431 ,  G01N2030/965

摘要： The eluent used in IC separation contains non-volatile salt which is not compatible with electrospray ionization-mass spectrometry (ESI-MS). A suppressor is required to convert the non-volatile salt into water or the volatile acid form (i.e. acetic acid). When the suppressor fails, the non-volatile salts will enter the MS and cause extensive shutdown and maintenance of the mass spectrometer. The suppressor voltage derivative is used to evaluate the most common suppressor failure modes, including disruption of regenerant flow and excessive backpressure on the suppressor due to clogging in the downstream, and to trigger the eluent pump to stop the eluent flow or to trigger the auxiliary valve to switch the flow to the mass spectrometer from eluent to water.

公开(公告)号：US20230341357A1

公开(公告)日：2023-10-26

申请号：US18341712

申请日：2023-06-26

申请人： DIONEX CORPORATION

发明人： Brandon Howard Robson ,  Xuefei Sun ,  Carla Marie Medlin ,  Shane Bechler

IPC分类号： G01N30/72 ,  G01N30/60 ,  H01J49/04 ,  H01J49/16

CPC分类号： G01N30/7266 ,  G01N30/6004 ,  G01N30/6047 ,  H01J49/0445 ,  H01J49/167

摘要： An integrated system for liquid separation and electrospray ionization includes an emitter-enabled capillary column including an emitter portion and a column portion; and a retractable protective sleeve for covering and/or supporting the emitter portion along at least a portion of its axis. The protective sleeve is mounted around the emitter-enabled capillary column. The retractable protective sleeve is moveable to an extended position wherein a tip of the emitter portion is covered by the protective sleeve. A resilient member is provided to bias the protective sleeve towards the extended position. The protective sleeve is enclosed and moveable within an outer electrically conductive sheath adapted for insertion within a holder having a high-voltage contact point. The sheath is adapted to contact the high-voltage contact point and provide an electrical connection to enable the emitter-enabled capillary column to receive a high voltage. The sheath has a recess to receive the high-voltage contact point.

公开(公告)号：US20230271117A1

公开(公告)日：2023-08-31

申请号：US18314929

申请日：2023-05-10

申请人： DIONEX CORPORATION

发明人： Weichiat Chen ,  Kannan Srinivasan

IPC分类号： B01D29/96 ,  B01D46/24

CPC分类号： B01D29/96 ,  B01D46/2414 ,  B01D2201/0415 ,  B01D2201/291 ,  B01D2201/34 ,  B01D2271/027

摘要： An extraction cell cap assembly allows for toolless disassembly. The assembly includes a cap body having a threaded base releasably engaged with a cell vessel, a support member extending axially upward from the base, and a bore axially extending through the support member. The assembly also includes a locking cap having a plunger slidably received within the bore, a recess disposed within the plunger, and a locking portion that releasably engages the support member. Rotation of the locking cap in a first direction engages the locking portion with the support member, and rotation in an opposite direction disengages the locking portion. A filter is received in the recess and a seal member received in the bore, wherein the seal member forms a fluid-tight seal between the cell vessel and the assembly when the locking portion and the support member are engaged and the assembly is secured to the cell vessel.

公开(公告)号：US20230194485A1

公开(公告)日：2023-06-22

申请号：US17553956

申请日：2021-12-17

申请人： Dionex Corporation

发明人： Yongjing Chen ,  Yan Liu

IPC分类号： G01N30/86 ,  G01N30/72

CPC分类号： G01N30/8675 ,  G01N30/72 ,  G01N2030/328

摘要： An analytical system comprises a chromatography column configured to separate a sample into one or more analytes; an ion removal device configured to remove at least ions of one charge from the mobile phase, the ion removal device fluidly coupled to an output of the chromatography column; an ion selective sensor configured to measure a signal corresponding to an activity of the ions of one charge in the mobile phase, the ion selective sensor fluidly coupled to an output of the ion removal device; an optional diverter valve that can interrupt the flow of the mobile phase; and a microprocessor configured to monitor the signal of the ion selective sensor and to either switch the optional diverter valve to interrupt the flow of the mobile phase or turn off the pump when the signal is greater than a predetermined threshold.

公开(公告)号：US20230077924A1

公开(公告)日：2023-03-16

申请号：US17472875

申请日：2021-09-13

申请人： DIONEX CORPORATION

发明人： Shaun Anders QUINN ,  Matthew A. GRULKE ,  Patrick Michael KENNY

IPC分类号： G06F21/44 ,  G06F9/451 ,  G06F8/61

摘要： A system for self-directed computer system validation includes first logic to provide a graphical user interface to enable a user to select a set of selected requirements from a plurality of available requirements; second logic to select a set of procedures to satisfy the need to test against each of the requirements and document evidence of the outcomes and generate a set of documents for installing and configuring the system and test protocols including all methods and objects needed to validate the system; and third logic to provide the set of documents for installing and configuring the system and test protocols including all methods and objects needed to validate the system.

公开(公告)号：US20220315720A1

公开(公告)日：2022-10-06

申请号：US17559830

申请日：2021-12-22

申请人： DIONEX CORPORATION

发明人： John M. Riviello ,  Christopher A. Pohl

IPC分类号： C08J7/04

摘要： A coated substrate that comprises a polyolefin substrate having a functional polymer layer disposed thereon. The polyolefin substrate has a flow through pore structure with a pore size ranging from about 5 microns to about 250 microns. The functional polymer layer has a thickness ranging from about 1 micron to about 20 microns and a layer pore structure having a pore size ranging from about 1 nm to about 100 nm.