公开(公告)号：US20240358634A1

公开(公告)日：2024-10-31

申请号：US18603065

申请日：2024-03-12

申请人： DOMPE FARMACEUTICI S.P.A ,  The Regents of the University of California

发明人： Jay LICHTER ,  Andrew M. TRAMMEL ,  Fabrice PIU ,  Qiang YE ,  Michael Christopher SCAIFE ,  Benedikt VOLLRATH ,  Sergio G. DURON ,  Luis A. DELLAMARY ,  Carl LEBEL ,  Jeffrey P. HARRIS

IPC分类号： A61K9/00 ,  A61K9/06 ,  A61K9/127 ,  A61K9/14 ,  A61K9/16 ,  A61K31/05 ,  A61K31/13 ,  A61K31/137 ,  A61K31/325 ,  A61K31/43 ,  A61K31/436 ,  A61K31/519 ,  A61K31/5513 ,  A61K31/5517 ,  A61K38/18 ,  A61K39/00 ,  A61K47/14 ,  A61K47/18 ,  A61K47/32 ,  A61K47/38 ,  C07K16/24

CPC分类号： A61K9/0046 ,  A61K9/06 ,  A61K9/127 ,  A61K9/14 ,  A61K9/16 ,  A61K31/05 ,  A61K31/13 ,  A61K31/137 ,  A61K31/325 ,  A61K31/43 ,  A61K31/436 ,  A61K31/519 ,  A61K31/5513 ,  A61K31/5517 ,  A61K38/18 ,  A61K38/1808 ,  A61K38/1825 ,  A61K38/185 ,  A61K38/1858 ,  A61K38/1883 ,  A61K47/14 ,  A61K47/18 ,  A61K47/32 ,  A61K47/38 ,  C07K16/241 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/76

摘要： Disclosed herein are compositions and methods for the treatment of otic disorders with immunomodulating agents and auris pressure modulators. In these methods, the auris compositions and formulations are administered locally to an individual afflicted with an otic disorder, through direct application of the immunomodulating and/or auris pressure modulating compositions and formulations onto the auris media and/or Auris interna target areas, or via perfusion into the auris media and/or Auris interna structures.

公开(公告)号：US20190192425A1

公开(公告)日：2019-06-27

申请号：US16287838

申请日：2019-02-27

申请人： OTONOMY, INC. ,  THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

发明人： Jay LICHTER ,  Andrew M. TRAMMEL ,  Fabrice PIU ,  Qiang YE ,  Michael Christopher SCAIFE ,  Benedikt VOLLRATH ,  Sergio G. DURON ,  Luis A. DELLAMARY ,  Carl LEBEL ,  Jeffrey P. HARRIS

IPC分类号： A61K9/00 ,  A61K47/40 ,  A61K47/34 ,  A61K9/51 ,  A61K9/16 ,  A61K9/06 ,  A61K47/38 ,  A61K47/36

CPC分类号： A61K9/0046 ,  A61K9/0019 ,  A61K9/06 ,  A61K9/122 ,  A61K9/127 ,  A61K9/1647 ,  A61K9/5153 ,  A61K9/7007 ,  A61K47/34 ,  A61K47/36 ,  A61K47/38 ,  A61K47/40

摘要： Disclosed herein are delivery devices for use in the treatment of otic disorders wherein the delivery device is administered locally to an individual afflicted with an otic disorder, through direct application or via perfusion into the targeted auris structure(s).

公开(公告)号：US20190307678A1

公开(公告)日：2019-10-10

申请号：US16389213

申请日：2019-04-19

申请人： Otonomy, Inc. ,  The Regents of the University of California

发明人： Jay LICHTER ,  Andrew M. TRAMMEL ,  Fabrice PIU ,  Qiang YE ,  Michael Christopher SCAIFE ,  Benedikt VOLLRATH ,  Sergio G. DURON ,  Luis A. DELLAMARY ,  Carl LEBEL ,  Jeffrey P. HARRIS

IPC分类号： A61K9/00 ,  A61K38/18 ,  A61K9/127 ,  A61K9/14 ,  C07K16/24 ,  A61K47/38 ,  A61K47/32 ,  A61K47/18 ,  A61K47/14 ,  A61K9/06 ,  A61K31/5517 ,  A61K31/5513 ,  A61K31/519 ,  A61K31/436 ,  A61K31/43 ,  A61K31/325 ,  A61K31/137 ,  A61K31/13 ,  A61K31/05 ,  A61K9/16

摘要： Disclosed herein are compositions and methods for the treatment of otic disorders with immunomodulating agents and auris pressure modulators. In these methods, the auris compositions and formulations are administered locally to an individual afflicted with an otic disorder, through direct application of the immunomodulating and/or auris pressure modulating compositions and formulations onto the auris media and/or auris interna target areas, or via perfusion into the auris media and/or auris interna structures.

公开(公告)号：US20190298799A1

公开(公告)日：2019-10-03

申请号：US16387320

申请日：2019-04-17

申请人： Otonomy, Inc. ,  The Regents of the University of California

发明人： Jay LICHTER ,  Andrew M. TRAMMEL ,  Fabrice PIU ,  Qiang YE ,  Michael Christopher SCAIFE ,  Benedikt VOLLRATH ,  Sergio G. DURON ,  Luis A. DELLAMARY ,  Carl LEBEL ,  Jeffrey P. HARRIS

IPC分类号： A61K38/17 ,  A61K47/36 ,  A61K9/06 ,  A61K9/00 ,  C12N7/00 ,  A61K38/00 ,  A61K38/16

摘要： Disclosed herein are compositions and methods for the treatment of otic disorders with anti-apoptotic agent or pro-apoptotic agent compositions and compositions administered locally to an individual afflicted with an otic disorder, through direct application of these compositions and compositions onto or via perfusion into the targeted auris structure(s).

公开(公告)号：US20210220263A1

公开(公告)日：2021-07-22

申请号：US17146909

申请日：2021-01-12

申请人： Otonomy, Inc. ,  The Regents of the University of California

发明人： Jay LICHTER ,  Andrew M. TRAMMEL ,  Fabrice PIU ,  Qiang YE ,  Michael Christopher SCAIFE ,  Benedikt VOLLRATH ,  Sergio G. DURON ,  Luis A. DELLAMARY ,  Carl LEBEL ,  Jeffrey P. HARRIS

IPC分类号： A61K9/00 ,  A61K9/06 ,  A61K31/167 ,  A61K31/195 ,  A61K31/5513 ,  A61K45/06 ,  A61K47/10 ,  A61K47/14 ,  A61K47/38 ,  A61K47/44 ,  A61K31/00 ,  A61K31/197

摘要： Disclosed herein are compositions and methods for the treatment of otic disorders with CNS modulating agent compositions and compositions administered locally to an individual afflicted with an otic disorder, through direct application of these compositions and compositions onto or via perfusion into the targeted auris structure(s).

公开(公告)号：US20200230051A1

公开(公告)日：2020-07-23

申请号：US16824646

申请日：2020-03-19

申请人： Otonomy, Inc. ,  The Regents of the University of California

发明人： Jay LICHTER ,  Andrew M. TRAMMEL ,  Fabrice PIU ,  Qiang YE ,  Michael Christopher SCAIFE ,  Benedikt VOLLRATH ,  Sergio G. DURON ,  Luis A. DELLAMARY ,  Carl LEBEL ,  Jeffrey P. HARRIS

IPC分类号： A61K9/00 ,  A61K9/14 ,  A61K9/06 ,  A61K38/18 ,  A61K9/127 ,  A61K9/16 ,  A61K31/05 ,  A61K31/13 ,  A61K31/137 ,  A61K31/325 ,  A61K31/43 ,  A61K31/436 ,  A61K31/519 ,  A61K31/5513 ,  A61K31/5517 ,  A61K47/14 ,  A61K47/18 ,  A61K47/32 ,  A61K47/38 ,  C07K16/24

摘要： Disclosed herein are compositions and methods for the treatment of otic disorders with immunomodulating agents and auris pressure modulators. In these methods, the auris compositions and formulations are administered locally to an individual afflicted with an otic disorder, through direct application of the immunomodulating and/or auris pressure modulating compositions and formulations onto the auris media and/or auris interna target areas, or via perfusion into the auris media and/or auris interna structures.

公开(公告)号：US20130116210A1

公开(公告)日：2013-05-09

申请号：US13645126

申请日：2012-10-04

申请人： The Regents of the University of California ,  Otonomy, Inc.

发明人： Jay LICHTER ,  Andrew M. TRAMMEL ,  Fabrice PIU ,  Qiang YE ,  Luis A. DELLAMARY ,  Carl LEBEL ,  Jeffrey P. Harris

IPC分类号： A61K9/00

CPC分类号： A61K9/0046 ,  A61K8/042 ,  A61K9/0019 ,  A61K9/0024 ,  A61K9/06 ,  A61K9/10 ,  A61K9/14 ,  A61K9/1641 ,  A61K31/43 ,  A61K31/496 ,  A61K31/522 ,  A61K31/573 ,  A61K31/7036 ,  A61K47/02 ,  A61K47/10 ,  A61K47/34

摘要： Disclosed herein are compositions and methods for the treatment of otic diseases or conditions with antimicrobial agent compositions and formulations administered locally to an individual afflicted with an otic disease or condition, through direct application of these compositions and formulations onto or via perfusion into the targeted auris structure(s).

摘要翻译： 本文公开的是通过将这些组合物和制剂直接施用到或通过灌注到目标耳结构中来治疗耳科疾病或病症的组合物和方法，所述抗微生物剂组合物和制剂局部施用于患有耳科疾病或病症的个体 （s）。

公开(公告)号：US20190350845A1

公开(公告)日：2019-11-21

申请号：US16447776

申请日：2019-06-20

申请人： OTONOMY, INC. ,  THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

发明人： Jay LICHTER ,  Andrew M. TRAMMEL ,  Fabrice PIU ,  Qiang YE ,  Michael Christopher SCAIFE ,  Benedikt VOLLRATH ,  Sergio G. DURON ,  Luis A. DELLAMARY ,  Carl LEBEL ,  Jeffrey P. HARRIS

IPC分类号： A61K9/00 ,  A61K47/44 ,  A61K47/38 ,  A61K47/14 ,  A61K47/10 ,  A61K45/06 ,  A61K31/197 ,  A61K31/195 ,  A61K31/167 ,  A61K31/00 ,  A61K9/06 ,  A61K31/5513

摘要： Disclosed herein are compositions and methods for the treatment of otic disorders with CNS modulating agent compositions and compositions administered locally to an individual afflicted with an otic disorder, through direct application of these compositions and compositions onto or via perfusion into the targeted auris structure(s).