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公开(公告)号：US20220000147A1
公开(公告)日：2022-01-06
申请号：US17479111
申请日：2021-09-20
Applicant: DSM IP Assets B.V.
Inventor： Kirk E. APT , Paul Warren BEHRENS , Jon Milton HANSEN , Joseph W. PFEIFER , Tracey Lynn STAHL , Ross ZIRKLE
IPC: A23K20/158 , A61K8/36 , A61K31/201 , A61Q19/00 , A23L2/52 , A23C9/152 , A23D9/007 , A23D9/00 , A61K31/202 , C11B1/10 , C11B3/04 , C12P7/64 , A23L33/00 , A23L33/115 , A61K35/68 , A23K10/12 , A23K50/00 , A23K50/40 , A23K50/80 , C12N1/10 , C12N1/12
Abstract: The present invention is directed to isolated microorganisms as well as strains and mutants thereof, biomasses, microbial oils, compositions, and cultures; methods of producing the microbial oils, biomasses, and mutants; and methods of using the isolated microorganisms, biomasses, and microbial oils.
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2.发明申请Production of High Levels of DHA-Containing Biomass in Microalgae Using Modified Amounts of Chloride and Potassium 有权使用改性量的氯化钾和钾在微藻中生产高含量的含DHA的生物质公开(公告)号：US20160108443A1
公开(公告)日：2016-04-21
申请号：US14975670
申请日：2015-12-18
Applicant: DSM IP Assets B.V.
Inventor： Paul W. BEHRENS , John M. THOMPSON , Kirk APT , Joseph W. PFEIFER , James P. WYNN , James Casey LIPPMEIER , Jaouad FICHTALI , Jon HANSEN
CPC classification number: C12P7/6427 , A61K36/02 , C11B1/10 , C12P7/6409 , C12P7/6472
Abstract: Methods for production of highly unsaturated fatty acids by marine microorganisms, including the heterotrophic marine dinoflagellate Crypthecodinium, using low levels of chloride ion are disclosed. Specifically, methods of increasing production of highly unsaturated fatty acids by marine microorganisms while growing in low chloride media by manipulating sodium ion and potassium ion levels. The invention also relates to methods of production of highly unsaturated fatty acids by marine organisms at low pH levels, and includes methods for generation of low pH tolerant strains.
Abstract translation: 公开了使用低水平氯离子的海洋微生物生产高度不饱和脂肪酸的方法，包括异养海洋鞭毛藻Crypthecodinium。 具体地说，通过操纵钠离子和钾离子水平，在低氯化物培养基中生长时，通过海洋微生物增加高度不饱和脂肪酸的生产的方法。 本发明还涉及在低pH水平下由海洋生物生产高度不饱和脂肪酸的方法，并且包括产生低pH耐受菌株的方法。
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3.发明申请PRODUCTION OF HIGH LEVELS OF DHA IN MICROALGAE USING MODIFIED AMOUNTS OF CHLORIDE AND POTASSIUM 有权使用氯化物和钾的改性剂在微藻中生产高水平的DHA公开(公告)号：US20140142331A1
公开(公告)日：2014-05-22
申请号：US14165459
申请日：2014-01-27
Applicant: DSM IP ASSETS B.V.
Inventor： Paul W. BEHRENS , John M. THOMPSON , Kirk APT , Joseph W. PFEIFER , James P. WYNN , James Casey LIPPMEIER , Jaouad FICHTALI , Jon HANSEN
IPC: C12P7/64
CPC classification number: C12P7/6427 , A61K36/02 , C11B1/10 , C12P7/6409 , C12P7/6472
Abstract: Methods for production of highly unsaturated fatty acids by marine microorganisms, including the heterotrophic marine dinoflagellate Crypthecodinium, using low levels of chloride ion are disclosed. Specifically, methods of increasing production of highly unsaturated fatty acids by marine microorganisms while growing in low chloride media by manipulating sodium ion and potassium ion levels. The invention also relates to methods of production of highly unsaturated fatty acids by marine organisms at low pH levels, and includes methods for generation of low pH tolerant strains.
Abstract translation: 公开了使用低水平氯离子的海洋微生物生产高度不饱和脂肪酸的方法，包括异养海洋鞭毛藻Crypthecodinium。 具体地说，通过操纵钠离子和钾离子水平，在低氯化物培养基中生长时，通过海洋微生物增加高度不饱和脂肪酸的生产的方法。 本发明还涉及在低pH水平下由海洋生物生产高度不饱和脂肪酸的方法，并且包括产生低pH耐受菌株的方法。
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