公开(公告)号：US20150018435A1

公开(公告)日：2015-01-15

申请号：US14495406

申请日：2014-09-24

Applicant: DSM IP Assets B.V.

Inventor： Jaouad FICHTALI ,  Neil Francis LEININGER ,  Jesus Ruben ABRIL ,  Naseer AHMED ,  S. P. Janaka Namal SENANAYAKE

IPC: A23D7/04 ,  C11B15/00 ,  C11B3/00 ,  A23D9/06 ,  C11B3/08 ,  A23D7/06 ,  A23D9/04 ,  A61K47/12 ,  C11B1/10

CPC classification number: A23D7/04 ,  A23D7/06 ,  A23D9/013 ,  A23D9/04 ,  A23D9/06 ,  A61K47/12 ,  C11B1/025 ,  C11B1/10 ,  C11B3/001 ,  C11B3/008 ,  C11B3/08 ,  C11B3/10 ,  C11B5/0092 ,  C11B7/0075 ,  C11B15/00

Abstract: The present invention includes a solid fat composition that includes an oil having saturated fat and a microbial oil having a long chain polyunsaturated fatty acid and an emulsifier. In particular, the solid fat composition can have high levels of long chain polyunsaturated fatty acid and low amounts of emulsifiers. In preferred embodiments, the polyunsaturated oil is an unwinterized microbial oil. The invention also relates to methods for making such compositions and food, nutritional, and pharmaceutical products comprising said compositions. The present invention also includes a microbial oil product prepared by extracting an oil-containing fraction comprising at least one LC-PUFA from a microbial biomass, and treating the fraction by a process of vacuum evaporation, wherein the oil product has not been subject to one or more of a solvent winterization step, a caustic refining process, a chill filtration process, or a bleaching process.

Abstract translation: 本发明包括具有饱和脂肪的油和具有长链多不饱和脂肪酸和乳化剂的微生物油的固体脂肪组合物。 特别地，固体脂肪组合物可以具有高水平的长链多不饱和脂肪酸和少量的乳化剂。 在优选的实施方案中，多不饱和的油是未连续的微生物油。 本发明还涉及制备这种组合物的方法以及包含所述组合物的食品，营养和药物产品。 本发明还包括通过从微生物生物质提取包含至少一种LC-PUFA的含油馏分制备的微生物油产物，并通过真空蒸发处理该馏分，其中该油产品未被一个 或更多的溶剂冬季化步骤，苛性碱精炼方法，冷却过滤方法或漂白方法。

公开(公告)号：US20140142331A1

公开(公告)日：2014-05-22

申请号：US14165459

申请日：2014-01-27

Applicant: DSM IP ASSETS B.V.

Inventor： Paul W. BEHRENS ,  John M. THOMPSON ,  Kirk APT ,  Joseph W. PFEIFER ,  James P. WYNN ,  James Casey LIPPMEIER ,  Jaouad FICHTALI ,  Jon HANSEN

IPC: C12P7/64

CPC classification number: C12P7/6427 ,  A61K36/02 ,  C11B1/10 ,  C12P7/6409 ,  C12P7/6472

Abstract: Methods for production of highly unsaturated fatty acids by marine microorganisms, including the heterotrophic marine dinoflagellate Crypthecodinium, using low levels of chloride ion are disclosed. Specifically, methods of increasing production of highly unsaturated fatty acids by marine microorganisms while growing in low chloride media by manipulating sodium ion and potassium ion levels. The invention also relates to methods of production of highly unsaturated fatty acids by marine organisms at low pH levels, and includes methods for generation of low pH tolerant strains.

Abstract translation: 公开了使用低水平氯离子的海洋微生物生产高度不饱和脂肪酸的方法，包括异养海洋鞭毛藻Crypthecodinium。 具体地说，通过操纵钠离子和钾离子水平，在低氯化物培养基中生长时，通过海洋微生物增加高度不饱和脂肪酸的生产的方法。 本发明还涉及在低pH水平下由海洋生物生产高度不饱和脂肪酸的方法，并且包括产生低pH耐受菌株的方法。

公开(公告)号：US20200078464A1

公开(公告)日：2020-03-12

申请号：US16556559

申请日：2019-08-30

Applicant: DSM IP ASSETS B.V.

Inventor： S. P. Janaka Namal SENANAYAKE ,  Naseer AHMED ,  Jaouad FICHTALI

IPC: A61K47/44 ,  A23D9/007 ,  A23L33/00 ,  A23K20/158 ,  A23D7/005 ,  A23D7/00 ,  A21D2/16 ,  A23D9/00 ,  C11B5/00 ,  C11B1/02 ,  C11B1/10

Abstract: The present invention provides a solid fat composition that includes an oil having saturated fat and an oil having at least one long chain polyunsaturated fatty acid. In particular, the solid fat composition can have high levels of long chain polyunsaturated fatty acid and low to no presence of emulsifiers. In preferred embodiments, the polyunsaturated oil is an unwinterized microbial oil. The invention also relates to methods for making such compositions and food, nutritional, and pharmaceutical products comprising said compositions.

公开(公告)号：US20160108443A1

公开(公告)日：2016-04-21

申请号：US14975670

申请日：2015-12-18

Applicant: DSM IP Assets B.V.

Inventor： Paul W. BEHRENS ,  John M. THOMPSON ,  Kirk APT ,  Joseph W. PFEIFER ,  James P. WYNN ,  James Casey LIPPMEIER ,  Jaouad FICHTALI ,  Jon HANSEN

IPC: C12P7/64 ,  C11B1/10

CPC classification number: C12P7/6427 ,  A61K36/02 ,  C11B1/10 ,  C12P7/6409 ,  C12P7/6472

Abstract: Methods for production of highly unsaturated fatty acids by marine microorganisms, including the heterotrophic marine dinoflagellate Crypthecodinium, using low levels of chloride ion are disclosed. Specifically, methods of increasing production of highly unsaturated fatty acids by marine microorganisms while growing in low chloride media by manipulating sodium ion and potassium ion levels. The invention also relates to methods of production of highly unsaturated fatty acids by marine organisms at low pH levels, and includes methods for generation of low pH tolerant strains.

Abstract translation: 公开了使用低水平氯离子的海洋微生物生产高度不饱和脂肪酸的方法，包括异养海洋鞭毛藻Crypthecodinium。 具体地说，通过操纵钠离子和钾离子水平，在低氯化物培养基中生长时，通过海洋微生物增加高度不饱和脂肪酸的生产的方法。 本发明还涉及在低pH水平下由海洋生物生产高度不饱和脂肪酸的方法，并且包括产生低pH耐受菌株的方法。