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    AMPK POTENTIATOR CONTAINING CHITO-OLIGOSACCHARIDE
    1.
    发明申请
    AMPK POTENTIATOR CONTAINING CHITO-OLIGOSACCHARIDE 审中-公开
    AMPK电位器含有低密度脂蛋白胆固醇

    公开(公告)号：US20100120711A1

    公开(公告)日：2010-05-13

    申请号：US12515928

    申请日：2007-10-23

    申请人： Dae Bang Seo ,  Jong Hee Sohn ,  Eui Seok Shin ,  Wan Gi Kim ,  Nam Hoon Cho ,  Myung Hwa Lee ,  Sang Jun Lee

    发明人： Dae Bang Seo ,  Jong Hee Sohn ,  Eui Seok Shin ,  Wan Gi Kim ,  Nam Hoon Cho ,  Myung Hwa Lee ,  Sang Jun Lee

    IPC分类号： A61K31/722 ,  A61P3/00

    CPC分类号： A61K31/722

    摘要： Disclosed herein is a composition for promoting AMPK activity, which comprises a chito-oligosaccharide as an active ingredient. The present composition affects the enzymes related to AMPK and lipid metabolism, and thus helps recovery from the condition lacking energy by various functions of controlling metabolism. Therefore, the present composition can enhance energy metabolism, thus making the composition effective for improving exercise capacity and reducing fatigue. The present composition can be used in the preparation of food or medicinal product as an endurance builder or for the prevention and improvement of fatigue.

    摘要翻译： 本文公开了一种用于促进AMPK活性的组合物，其包含作为活性成分的低聚半乳糖。 本发明的组合物影响与AMPK和脂质代谢相关的酶，因此通过控制代谢的各种功能帮助从缺乏能量的状态中恢复。 因此，本发明的组合物能够增强能量代谢，从而使组合物有效地提高运动能力并减轻疲劳。 本发明的组合物可用于制备作为耐力助剂的食品或药用产品，或用于预防和改善疲劳。

    COMPOSITION FOR PREVENTING OR TREATING OBESITY-RELATED DISEASES MEDIATED BY THE ACTIVATION OF AMPK AND INCLUDING 2,5-BIS-ARYL-3,4-DIMETHYLTETRAHYDROFURAN LIGNANS AS ACTIVE INGREDIENTS
    3.
    发明申请
    COMPOSITION FOR PREVENTING OR TREATING OBESITY-RELATED DISEASES MEDIATED BY THE ACTIVATION OF AMPK AND INCLUDING 2,5-BIS-ARYL-3,4-DIMETHYLTETRAHYDROFURAN LIGNANS AS ACTIVE INGREDIENTS 审中-公开
    用于预防或治疗由AMPK激活引起的与相关疾病相关的疾病的组合物，包括2,5-BIS-ARYL-3,4-DIMETHYLTETRAHYDROFURAN LIGNANS作为活性成分

    公开(公告)号：US20120083525A1

    公开(公告)日：2012-04-05

    申请号：US13375446

    申请日：2009-06-26

    申请人： Won Keun Oh ,  Phi Hung Nguyen ,  Thi Van Thu Le ,  Hu Won Kang ,  Eui Seok Shin ,  Jin Kyu Chio ,  Dae Bang Seo ,  Sang Jun Lee

    发明人： Won Keun Oh ,  Phi Hung Nguyen ,  Thi Van Thu Le ,  Hu Won Kang ,  Eui Seok Shin ,  Jin Kyu Chio ,  Dae Bang Seo ,  Sang Jun Lee

    IPC分类号： A61K31/341 ,  A61P3/04 ,  A61P3/00 ,  C07D307/12

    摘要： The present invention relates to a 2,5-bis-aryl-3,4-dimethyltetrahydrofuran lignan compound which activates nutmeg-derived AMP-activated protein kinase (AMPK), and to a composition including same as active ingredients for preventing and treating metabolic syndromes such as obesity. More particularly, the present invention relates to an AMPK-activating compound comprising one of the 2,5-bis-aryl-3,4-dimethyltetrahydrofuran lignan-based compounds produced by extracting Myristica fragrans with a solution of 30% or less of ethanol and separating and purifying the extracts using chromatography, as expressed in chemical formula 1 below, and to a composition comprising same as an active ingredient for preventing and treating metabolic syndrome caused by AMPK enzyme activation, such as obesity, diabetes, high cholesterol and cardiopulmonary diseases.

    摘要翻译： 本发明涉及活化肉豆蔻衍生的AMP活化蛋白激酶（AMPK）的2,5-双 - 芳基-3,4-二甲基四氢呋喃木脂素化合物，以及包含其作为预防和治疗代谢综合征的活性成分的组合物 如肥胖。 更具体地说，本发明涉及一种AMPK活化化合物，其包含通过用30％或更少乙醇的溶液提取肉豆蔻酸所制备的2,5-双 - 芳基-3,4-二甲基四氢呋喃木酚素基化合物之一和 使用如下述化学式1所示的色谱法分离纯化提取物，以及包含其作为活性成分的组合物，用于预防和治疗由AMPK酶活化引起的代谢综合征，如肥胖症，糖尿病，高胆固醇和心肺疾病。