公开(公告)号：US20130137944A1

公开(公告)日：2013-05-30

申请号：US13816035

申请日：2011-08-11

申请人： Dae Hong Jeong ,  Keon Wook Kang ,  Dong Soo Lee ,  Yoon Sik Lee ,  Gun Sung Kim ,  Bong Hyun Jun ,  Jin Chul Paeng ,  Ho Young Lee ,  Yun Sang Lee

发明人： Dae Hong Jeong ,  Keon Wook Kang ,  Dong Soo Lee ,  Yoon Sik Lee ,  Gun Sung Kim ,  Bong Hyun Jun ,  Jin Chul Paeng ,  Ho Young Lee ,  Yun Sang Lee

IPC分类号： A61B5/00

CPC分类号： A61B5/0071 ,  A61B1/00165 ,  A61B1/00172 ,  A61B1/00186 ,  A61B1/015 ,  A61B1/043 ,  A61B1/063 ,  A61B1/126 ,  A61B5/0062 ,  A61B5/0068 ,  A61B5/0075 ,  A61B5/0084 ,  A61K49/0065 ,  B82Y30/00

摘要： Method pertains to a medical imaging device for simultaneously detecting fluorescence and Raman signals for multiple fluorescence and Raman signal targets. The method includes: injecting at least one marker particle including Raman markers and receptors into the body of an animal, which can be a human; irradiating a laser beam onto the body of the animal; and detecting the optical signals emitted by the marker particle after the irradiation of the laser beam separately as fluorescence signals and Raman signals. The simultaneous detection of multiple targets may be performed even without scanning optical signals emitted by the marker particle individually with different optical fibers. As an examination may be performed by injecting surface-enhanced Raman marker particles, into which fluorescent components are introduced, into the body of the animal using a spray or the like, weak Raman signals may be augmented so as to obtain a more accurate diagnosis result in real time.

摘要翻译： 方法涉及用于同时检测多个荧光和拉曼信号靶的荧光和拉曼信号的医学成像装置。 该方法包括：将至少一种包括拉曼标记物和受体的标记物质注射到可以是人的动物体内; 将激光束照射到动物的身体上; 并且在激光束照射之后分别检测由标记物粒子发射的光信号作为荧光信号和拉曼信号。 即使不使用不同的光纤单独地扫描由标记颗粒发射的光信号，也可以执行多个目标的同时检测。 作为检查可以通过使用喷雾等将引入了荧光成分的表面增强拉曼标记颗粒注入动物的体内，可以增强弱拉曼信号，以获得更准确的诊断结果 实时。

公开(公告)号：US20110212511A1

公开(公告)日：2011-09-01

申请号：US13128149

申请日：2008-11-11

申请人： Kyo Seon Hwang ,  Tae Song Kim ,  Sang Kyung Kim ,  Sang Myung Lee ,  Yoon Sik Lee

发明人： Kyo Seon Hwang ,  Tae Song Kim ,  Sang Kyung Kim ,  Sang Myung Lee ,  Yoon Sik Lee

IPC分类号： G01N33/566

CPC分类号： G01N33/54373

摘要： Provided is a protein detection system using a micro-cantilever and based on immune responses, wherein the micro-cantilever shows significantly improved sensitivity to allow detection of a trace amount of biomolecule. To the micro-cantilever, sandwich immunoassay is applied, and the sandwich immunoassay uses a polyclonal antibody or silica nanoparticles having a monoclonal antibody bound thereto, so that variations in the output signals of the cantilever are amplified and the detection sensitivity is significantly improved. The system enables detection of disease specific antigen at several femtomolar levels, and makes it possible to detect a trace amount of protein related to diseases, particularly to cancers, with ease.

摘要翻译： 提供了使用微悬臂梁并基于免疫应答的蛋白质检测系统，其中微悬臂梁显示显着改善的灵敏度以允许检测微量的生物分子。 对微悬臂梁进行夹心免疫测定，夹心免疫测定使用结合有单克隆抗体的多克隆抗体或二氧化硅纳米粒子，扩大悬臂输出信号的变化，检测灵敏度明显提高。 该系统能够以几个摩尔体积水平检测疾病特异性抗原，并且可以容易地检测与疾病，特别是癌症相关的痕量的蛋白质。

公开(公告)号：US06369169B1

公开(公告)日：2002-04-09

申请号：US09582839

申请日：2000-09-07

申请人： Yoon Sik Lee ,  Sun Jong Ryoo

发明人： Yoon Sik Lee ,  Sun Jong Ryoo

IPC分类号： C08F800

CPC分类号： C02F1/285 ,  C02F2101/308 ,  C08F8/00 ,  C08F210/08 ,  C08F8/32 ,  C08F212/14 ,  C08F8/12 ,  C08F212/08

摘要： An adsorbent, polystyrene spherical resin grafted with polyethylene glycol characterized in that polystyrene resin is crosslinked with 1 to 10 wt % of divinylbenzene, the content of polyethylene glycol is more than 50 wt % and the molecular weight of polyethylene glycol part, is more than 500 Da, is described. In addition processes for decontaminating dye contained in waste water of dye industry, heavy metal ion contained in waste water, surfactant, humic substance contained in trash sediment effectively and quickly by using the said adsorbent, are disclosed.

摘要翻译： 用聚乙二醇接枝的吸附剂，聚苯乙烯球形树脂，其特征在于聚苯乙烯树脂与1至10重量％的二乙烯基苯交联，聚乙二醇的含量大于50重量％，聚乙二醇部分的分子量大于500 Da，被描述。 另外公开了通过使用所述吸附剂有效且快速地对染料工业的废水中所含的染料进行净化染色，废水中包含的重金属离子，表面活性剂，包含在垃圾沉淀物中的腐殖质的方法。