公开(公告)号：US20130137944A1

公开(公告)日：2013-05-30

申请号：US13816035

申请日：2011-08-11

申请人： Dae Hong Jeong ,  Keon Wook Kang ,  Dong Soo Lee ,  Yoon Sik Lee ,  Gun Sung Kim ,  Bong Hyun Jun ,  Jin Chul Paeng ,  Ho Young Lee ,  Yun Sang Lee

发明人： Dae Hong Jeong ,  Keon Wook Kang ,  Dong Soo Lee ,  Yoon Sik Lee ,  Gun Sung Kim ,  Bong Hyun Jun ,  Jin Chul Paeng ,  Ho Young Lee ,  Yun Sang Lee

IPC分类号： A61B5/00

CPC分类号： A61B5/0071 ,  A61B1/00165 ,  A61B1/00172 ,  A61B1/00186 ,  A61B1/015 ,  A61B1/043 ,  A61B1/063 ,  A61B1/126 ,  A61B5/0062 ,  A61B5/0068 ,  A61B5/0075 ,  A61B5/0084 ,  A61K49/0065 ,  B82Y30/00

摘要： Method pertains to a medical imaging device for simultaneously detecting fluorescence and Raman signals for multiple fluorescence and Raman signal targets. The method includes: injecting at least one marker particle including Raman markers and receptors into the body of an animal, which can be a human; irradiating a laser beam onto the body of the animal; and detecting the optical signals emitted by the marker particle after the irradiation of the laser beam separately as fluorescence signals and Raman signals. The simultaneous detection of multiple targets may be performed even without scanning optical signals emitted by the marker particle individually with different optical fibers. As an examination may be performed by injecting surface-enhanced Raman marker particles, into which fluorescent components are introduced, into the body of the animal using a spray or the like, weak Raman signals may be augmented so as to obtain a more accurate diagnosis result in real time.

摘要翻译： 方法涉及用于同时检测多个荧光和拉曼信号靶的荧光和拉曼信号的医学成像装置。 该方法包括：将至少一种包括拉曼标记物和受体的标记物质注射到可以是人的动物体内; 将激光束照射到动物的身体上; 并且在激光束照射之后分别检测由标记物粒子发射的光信号作为荧光信号和拉曼信号。 即使不使用不同的光纤单独地扫描由标记颗粒发射的光信号，也可以执行多个目标的同时检测。 作为检查可以通过使用喷雾等将引入了荧光成分的表面增强拉曼标记颗粒注入动物的体内，可以增强弱拉曼信号，以获得更准确的诊断结果 实时。

公开(公告)号：US20090081459A1

公开(公告)日：2009-03-26

申请号：US12159948

申请日：2007-02-08

申请人： Jong-Hyeon Yoon ,  Beom-Gyu Baek ,  Yoon-Sik Lee

发明人： Jong-Hyeon Yoon ,  Beom-Gyu Baek ,  Yoon-Sik Lee

IPC分类号： B32B15/02 ,  C08J9/35

CPC分类号： C08J9/224 ,  C08J9/232 ,  C08J2201/038 ,  Y10T428/2993

摘要： Disclosed is an expanded organic foam material having excellent thermal resistance and durability. The expanded plastic foam material is produced by preparing plastic beads or plastic foams, modifying silicate with at least one selected from among an alkaline earth metal compound, an alkaline earth metal compound-containing material, and an acid, coating the modified silicate on the prepared plastic beads or plastic foams, melt-molding the coated plastic beads or plastic foams while applying heat and pressure thereto, and drying the molded material. Also, the expanded organic plastic foam material has good impact-absorbing properties, easy formability, excellent sound-insulating and sound-absorbing performance and thermal insulating performance, good flame retardancy and thermal resistance, and improved water resistance and durability.

摘要翻译： 公开了具有优异的耐热性和耐久性的膨胀型有机泡沫材料。 膨胀塑料泡沫材料通过制备塑料珠或塑料泡沫来制备，用选自碱土金属化合物，含碱土金属化合物的材料和酸中的至少一种改性硅酸盐，将改性硅酸盐涂覆在所制备的 塑料珠或塑料泡沫塑料，将涂覆的塑料珠或塑料泡沫熔融成型，同时向其施加热量和压力，并干燥模塑材料。 此外，膨胀型有机塑料泡沫材料具有良好的冲击吸收性能，易成型性，优良的隔音和吸音性能，隔热性能，良好的阻燃性和耐热性，以及改善的耐水性和耐久性。

公开(公告)号：US20110259830A1

公开(公告)日：2011-10-27

申请号：US13122829

申请日：2009-09-23

申请人： Yoon-Sik Lee ,  Seung-Ryeoul Paik

发明人： Yoon-Sik Lee ,  Seung-Ryeoul Paik

IPC分类号： B01D21/01 ,  C08F12/08 ,  C08F283/06 ,  C08G63/91 ,  C07K14/47 ,  C08G65/48 ,  C08G73/06 ,  C08F20/14 ,  C08F8/30 ,  B32B5/16 ,  C08G59/14

CPC分类号： C07K17/08 ,  C07K14/70539 ,  Y10T428/2982

摘要： The present invention relates to a seed-conjugated polymer support. In particular, the present invention is directed to a seed-conjugated polymer support for aggregating biomolecules, a method for preparing the same, and a method for removing β-2-microglobulin.

摘要翻译： 本发明涉及一种种子共轭聚合物载体。 特别地，本发明涉及用于聚集生物分子的种子共轭聚合物载体，其制备方法和用于除去β-微球蛋白的方法。

公开(公告)号：US08018582B2

公开(公告)日：2011-09-13

申请号：US12442109

申请日：2007-08-30

申请人： Dae-Hong Jeong ,  Yoon-Sik Lee ,  Myung-Haing Cho ,  Yong-Kweon Kim

发明人： Dae-Hong Jeong ,  Yoon-Sik Lee ,  Myung-Haing Cho ,  Yong-Kweon Kim

IPC分类号： G01J3/44 ,  G01N21/47 ,  G01N21/64 ,  G01N21/65

CPC分类号： G01J3/02 ,  G01J3/0227 ,  G01J3/0291 ,  G01J3/44 ,  G01N2015/0038 ,  G01N2015/0092 ,  G01N2015/1493

摘要： Provided is a detection apparatus of Raman scattering and light scattering, and more particularly, a simultaneous detection apparatus of Raman scattering and dynamic light scattering and a detection method using the same. The simultaneous detection apparatus of Raman scattering and light scattering includes: a detection unit for applying incident light to a sample, and detecting Raman scattering in 90° or 180° geometry and light scattering in 90° or 180° geometry in order to simultaneously collect Raman scattering and light scattering; and a computer connected to the detection unit to obtain at least one of the size and distribution of particles from the detected light scattering, and to obtain information of the molecular structure from the detected Raman scattering. This apparatus may simultaneously observe the size of nano-sized or larger material and molecular information thereof, and phenomena accompanying changes in molecular environment according to material variation and changes of the material in size and distribution, and thus is very useful for studying nano materials and protein antigens and antibodies.

摘要翻译： 提供了拉曼散射和光散射的检测装置，更具体地，涉及拉曼散射和动态光散射的同时检测装置以及使用该检测装置的检测方法。 拉曼散射和光散射的同时检测装置包括：用于将入射光施加到样品的检测单元，并且以90°或180°几何形状检测拉曼散射并以90°或180°几何形状的光散射检测拉曼散射，以便同时收集拉曼 散射和光散射; 以及连接到检测单元的计算机，以从所检测到的光散射中获得粒子的大小和分布中的至少一个，并且从检测到的拉曼散射获得分子结构的信息。 该装置可以根据材料的尺寸和分布的材料变化和材料的变化同时观察纳米尺寸或更大的材料的尺寸及其分子信息，以及伴随分子环境变化的现象，因此对于研究纳米材料和 蛋白质抗原和抗体。

公开(公告)号：US20110212511A1

公开(公告)日：2011-09-01

申请号：US13128149

申请日：2008-11-11

申请人： Kyo Seon Hwang ,  Tae Song Kim ,  Sang Kyung Kim ,  Sang Myung Lee ,  Yoon Sik Lee

发明人： Kyo Seon Hwang ,  Tae Song Kim ,  Sang Kyung Kim ,  Sang Myung Lee ,  Yoon Sik Lee

IPC分类号： G01N33/566

CPC分类号： G01N33/54373

摘要： Provided is a protein detection system using a micro-cantilever and based on immune responses, wherein the micro-cantilever shows significantly improved sensitivity to allow detection of a trace amount of biomolecule. To the micro-cantilever, sandwich immunoassay is applied, and the sandwich immunoassay uses a polyclonal antibody or silica nanoparticles having a monoclonal antibody bound thereto, so that variations in the output signals of the cantilever are amplified and the detection sensitivity is significantly improved. The system enables detection of disease specific antigen at several femtomolar levels, and makes it possible to detect a trace amount of protein related to diseases, particularly to cancers, with ease.

摘要翻译： 提供了使用微悬臂梁并基于免疫应答的蛋白质检测系统，其中微悬臂梁显示显着改善的灵敏度以允许检测微量的生物分子。 对微悬臂梁进行夹心免疫测定，夹心免疫测定使用结合有单克隆抗体的多克隆抗体或二氧化硅纳米粒子，扩大悬臂输出信号的变化，检测灵敏度明显提高。 该系统能够以几个摩尔体积水平检测疾病特异性抗原，并且可以容易地检测与疾病，特别是癌症相关的痕量的蛋白质。

公开(公告)号：US20100020312A1

公开(公告)日：2010-01-28

申请号：US12442109

申请日：2007-08-30

申请人： Dae-Hong Jeong ,  Yoon-Sik Lee ,  Myung-Haing Cho ,  Yong-Kweon Kim

发明人： Dae-Hong Jeong ,  Yoon-Sik Lee ,  Myung-Haing Cho ,  Yong-Kweon Kim

IPC分类号： G01N21/65 ,  G01N21/47

CPC分类号： G01J3/02 ,  G01J3/0227 ,  G01J3/0291 ,  G01J3/44 ,  G01N2015/0038 ,  G01N2015/0092 ,  G01N2015/1493

摘要： Provided is a detection apparatus of Raman scattering and light scattering, and more particularly, a simultaneous detection apparatus of Raman scattering and dynamic light scattering and a detection method using the same. The simultaneous detection apparatus of Raman scattering and light scattering includes: a detection unit for applying incident light to a sample, and detecting Raman scattering in 90° or 180° geometry and light scattering in 90° or 180° geometry in order to simultaneously collect Raman scattering and light scattering; and a computer connected to the detection unit to obtain at least one of the size and distribution of particles from the detected light scattering, and to obtain information of the molecular structure from the detected Raman scattering. This apparatus may simultaneously observe the size of nano-sized or larger material and molecular information thereof, and phenomena accompanying changes in molecular environment according to material variation and changes of the material in size and distribution, and thus is very useful for studying nano materials and protein antigens and antibodies.

摘要翻译： 提供了拉曼散射和光散射的检测装置，更具体地，涉及拉曼散射和动态光散射的同时检测装置以及使用该检测装置的检测方法。 拉曼散射和光散射的同时检测装置包括：用于将入射光施加到样品的检测单元，并且以90°或180°几何形状检测拉曼散射并以90°或180°几何形状的光散射检测拉曼散射，以便同时收集拉曼 散射和光散射; 以及连接到检测单元的计算机，以从所检测到的光散射中获得粒子的大小和分布中的至少一个，并且从检测到的拉曼散射获得分子结构的信息。 该装置可以根据材料的尺寸和分布的材料变化和材料的变化同时观察纳米尺寸或更大的材料的尺寸及其分子信息，以及伴随分子环境变化的现象，因此对于研究纳米材料和 蛋白质抗原和抗体。

公开(公告)号：US06369169B1

公开(公告)日：2002-04-09

申请号：US09582839

申请日：2000-09-07

申请人： Yoon Sik Lee ,  Sun Jong Ryoo

发明人： Yoon Sik Lee ,  Sun Jong Ryoo

IPC分类号： C08F800

CPC分类号： C02F1/285 ,  C02F2101/308 ,  C08F8/00 ,  C08F210/08 ,  C08F8/32 ,  C08F212/14 ,  C08F8/12 ,  C08F212/08

摘要： An adsorbent, polystyrene spherical resin grafted with polyethylene glycol characterized in that polystyrene resin is crosslinked with 1 to 10 wt % of divinylbenzene, the content of polyethylene glycol is more than 50 wt % and the molecular weight of polyethylene glycol part, is more than 500 Da, is described. In addition processes for decontaminating dye contained in waste water of dye industry, heavy metal ion contained in waste water, surfactant, humic substance contained in trash sediment effectively and quickly by using the said adsorbent, are disclosed.

摘要翻译： 用聚乙二醇接枝的吸附剂，聚苯乙烯球形树脂，其特征在于聚苯乙烯树脂与1至10重量％的二乙烯基苯交联，聚乙二醇的含量大于50重量％，聚乙二醇部分的分子量大于500 Da，被描述。 另外公开了通过使用所述吸附剂有效且快速地对染料工业的废水中所含的染料进行净化染色，废水中包含的重金属离子，表面活性剂，包含在垃圾沉淀物中的腐殖质的方法。

公开(公告)号：US06291726B1

公开(公告)日：2001-09-18

申请号：US09622285

申请日：2000-10-18

申请人： Bon-Su Lee ,  Kyoo-Hyun Chung ,  Yoon-Sik Lee ,  Young-Gyu Kim

发明人： Bon-Su Lee ,  Kyoo-Hyun Chung ,  Yoon-Sik Lee ,  Young-Gyu Kim

IPC分类号： C07C20500

CPC分类号： C07C201/08 ,  C07C205/06

摘要： The nitration of aromatic compounds is achieved in high yield and selectivity by using oxygen activated by an inorganic catalyst and nitrogen dioxide. Since this process uses neither concentration nitric nor sulfuric acids, the generation of spent waste acid does not occur. Furthermore, the process does not encounter the problem of high costs associated with the generation of ozone as in an alternative nitration process. Since the solubility of oxygen in a reaction medium is increased by using pressurized oxygen, nitrogen dioxide is activated by a porous inorganic oxide and thus an aromatic compound(e.g., benzene) is nitrated into a nitro compound (e.g., PhNO2), the reaction rate is significantly increased, and the recovery of reactants is easy due to the insolubility of the catalyst.

摘要翻译： 芳族化合物的硝化通过使用由无机催化剂和二氧化氮活化的氧而以高产率和选择性实现。 由于该方法既不使用浓硝酸还是硫酸，不会发生废废酸的产生。 此外，该过程不会像在替代硝化过程中那样遇到与臭氧产生相关的高成本的问题。 由于通过使用加压氧来增加氧在反应介质中的溶解度，因此二氧化氮被多孔无机氧化物活化，因此将芳族化合物（例如苯）硝化成硝基化合物（例如PhNO 2），反应速率 显着增加，并且由于催化剂的不溶性，反应物的回收容易。

公开(公告)号：US07982870B2

公开(公告)日：2011-07-19

申请号：US12308505

申请日：2006-09-29

申请人： Yoon-Sik Lee ,  Dae-Hong Jeong ,  Jong-Ho Kim ,  Hee-Jeong Choi ,  Sang-Myung Lee

发明人： Yoon-Sik Lee ,  Dae-Hong Jeong ,  Jong-Ho Kim ,  Hee-Jeong Choi ,  Sang-Myung Lee

IPC分类号： G01J3/44 ,  G01N21/65

CPC分类号： G01N21/658 ,  B82Y15/00

摘要： There is provided a method for manufacturing a surface enhanced Raman scattering nano-tagging particle, the method including the steps of: introducing silver nanoparticles on the surface of a silica core particle; immobilizing tagging materials and silica shell precursors on the silver nanoparticles; and forming a silica shell surrounding the silica core particle to which the tagging materials and the silica shell precursor are immobilized.

摘要翻译： 提供了一种制造表面增强拉曼散射纳米标记颗粒的方法，所述方法包括以下步骤：在二氧化硅核颗粒的表面上引入银纳米颗粒; 将标记材料和二氧化硅壳前体固定在银纳米颗粒上; 并且形成围绕二氧化硅核心颗粒的二氧化硅壳，所述标记材料和二氧化硅壳前体被固定在该二氧化硅芯颗粒上。

公开(公告)号：US20100072067A1

公开(公告)日：2010-03-25

申请号：US11992017

申请日：2006-09-15

申请人： Yoon-Sik Lee ,  Yong-Kweon Kim ,  Dae-Hong Jeong ,  Jong-Ho Kim ,  Min-Soo Kim ,  Hee-Jeong Choi ,  Bong-Hyun Jun

发明人： Yoon-Sik Lee ,  Yong-Kweon Kim ,  Dae-Hong Jeong ,  Jong-Ho Kim ,  Min-Soo Kim ,  Hee-Jeong Choi ,  Bong-Hyun Jun

IPC分类号： G01N27/26

CPC分类号： G01N33/54346 ,  G01N33/54373

摘要： Provided is a method for screening a biological molecule rapidly and economically with high-throughput using microbeads encoded with silver nanoparticles and a chemical compound and dielectrophoresis. A biological screening method particularly utilizes microbeads encoded with silver nanoparticles and a specific chemical compound and dielectrophoresis. Since this screening method does not use a fluorescent material and a dying agent, which are typically used in the conventional screening method, it is non-toxic and economical. Also, this screening method allows simultaneous identification of many target materials. Accordingly, a leading compound can be screened within a short period of time, and thus, this screening method can be implemented as an economical and effective system for developing new pharmaceutical products.

摘要翻译： 本发明提供了一种利用银纳米颗粒和化学化合物和介电电泳编织的微珠以高通量快速且经济地筛选生物分子的方法。 生物筛选方法特别利用银纳米颗粒和特定化学化合物和介电电泳编码的微珠。 由于该筛选方法不使用通常在常规筛选方法中使用的荧光材料和染色剂，因此是无毒和经济的。 此外，该筛选方法允许同时鉴定许多目标材料。 因此，可以在短时间内筛选前导化合物，因此，该筛选方法可以实现为开发新药品的经济有效的系统。