公开(公告)号：US20120190634A1

公开(公告)日：2012-07-26

申请号：US13392429

申请日：2010-08-26

申请人： Dae Kyun Chung ,  Kyoung Soon Jang ,  Byung Gee Kim ,  Han Geun Kim ,  Na Ra Kim ,  Hea Young Lee ,  Bong Jun Jung ,  Tae Rahk Kim ,  Ji Hye Jeong

发明人： Dae Kyun Chung ,  Kyoung Soon Jang ,  Byung Gee Kim ,  Han Geun Kim ,  Na Ra Kim ,  Hea Young Lee ,  Bong Jun Jung ,  Tae Rahk Kim ,  Ji Hye Jeong

IPC分类号： A61K31/7032 ,  A61K8/92 ,  A61P29/00 ,  A61P37/00 ,  A61P9/10 ,  A61P31/04 ,  A61P35/00 ,  A61P19/10 ,  A61P19/04 ,  A61P19/02 ,  A61P21/00 ,  A61P9/00 ,  A61P7/06 ,  A61P7/00 ,  A61P3/10 ,  A61P13/12 ,  A61P25/00 ,  A61P1/16 ,  A61P31/12 ,  A61P1/00 ,  A61P37/06 ,  A61P17/00 ,  A61P17/06 ,  A61P37/08 ,  A61P11/06 ,  A61P11/02 ,  A61P11/00 ,  A61Q19/00 ,  C07H15/10

CPC分类号： C07H13/06 ,  C07H11/04 ,  C07H15/04

摘要： A lipoteichoic acid (LTA)-derived glycolipid, and a pharmaceutical, food or cosmetic composition and a vaccine adjuvant including the same are provided. The LTA-derived glycolipid can inhibit the production of inflammatory cytokines and thus have anti-inflammatory effects. Therefore, the pharmaceutical, food or cosmetic compositions including the LTA-derived glycolipid can be used to prevent and treat inflammatory diseases, and the LTA-derived glycolipid can be also used as the vaccine adjuvant.

摘要翻译： 提供了脂磷壁酸（LTA）衍生的糖脂，以及药物，食品或化妆品组合物和包含其的疫苗佐剂。 LTA衍生的糖脂可以抑制炎性细胞因子的产生，从而具有抗炎作用。 因此，包含LTA衍生的糖脂的药物，食品或化妆品组合物可用于预防和治疗炎性疾病，并且LTA衍生的糖脂也可以用作疫苗佐剂。

公开(公告)号：US08852891B2

公开(公告)日：2014-10-07

申请号：US12517015

申请日：2007-12-07

申请人： Jin Suk Woo ,  Jae Kyung Sohng ,  Byung Gee Kim ,  Sun Youp Kang ,  Dea Hee Kim ,  Kyoung Soon Jang ,  Ji Young Yang ,  Young Soo Jung ,  Won Min Seo ,  Tae Geon Gil ,  Sang Hee Shim ,  In Kang Hur

发明人： Jin Suk Woo ,  Jae Kyung Sohng ,  Byung Gee Kim ,  Sun Youp Kang ,  Dea Hee Kim ,  Kyoung Soon Jang ,  Ji Young Yang ,  Young Soo Jung ,  Won Min Seo ,  Tae Geon Gil ,  Sang Hee Shim ,  In Kang Hur

IPC分类号： C12P19/30 ,  C12N9/90 ,  C12P19/26 ,  C12P19/34 ,  C07H21/04 ,  C07K1/00 ,  C12P17/16

CPC分类号： C12N9/90 ,  C12P17/16

摘要： The present invention relates to a novel N-acetylglucosamine-2-epimerase and a method for preparing CMP-N-acetylneuraminic acid, more specifically, relates to a N-acetylglucosamine-2-epimerase derived from Bacteroides fragilis NCTC 9343, and a method for preparing CMP-N-acetylneuraminic acid using said N-acetylglucosamine-2-epimerase. According to the present invention, CMP-N-acetylneuraminic acid can be produced economically in a large amount through a one-step reaction using cytidine monophosphate and N-acetyl-D-glucosamine which are inexpensive substrates.

摘要翻译： 本发明涉及一种新的N-乙酰葡糖胺-2-差向异构酶和一种制备CMP-N-乙酰神经氨酸的方法，更具体地涉及衍生自脆弱拟杆菌NCTC 9343的N-乙酰氨基葡萄糖-2-差向异构酶，以及一种用于 使用所述N-乙酰葡糖胺-2-差向异构酶制备CMP-N-乙酰神经氨酸。 根据本发明，通过使用作为便宜的底物的胞苷一磷酸和N-乙酰基-D-葡糖胺的一步反应，可以经济地生产CMP-N-乙酰神经氨酸。

公开(公告)号：US20110287488A1

公开(公告)日：2011-11-24

申请号：US12517015

申请日：2007-12-07

申请人： Jin Suk Woo ,  Jae Kyung Sohng ,  Byung Gee Kim ,  Sun Youp Kang ,  Dea Hee Kim ,  Kyoung Soon Jang ,  Ji Young Yang ,  Young Soo Jung ,  Won Min Seo ,  Tae Geon Gil ,  Sang Hee Shim ,  In Kang Hur

发明人： Jin Suk Woo ,  Jae Kyung Sohng ,  Byung Gee Kim ,  Sun Youp Kang ,  Dea Hee Kim ,  Kyoung Soon Jang ,  Ji Young Yang ,  Young Soo Jung ,  Won Min Seo ,  Tae Geon Gil ,  Sang Hee Shim ,  In Kang Hur

IPC分类号： C12P19/30 ,  C07H21/04 ,  C12P19/26 ,  C12N1/21 ,  C12N9/90 ,  C12N15/63

CPC分类号： C12N9/90 ,  C12P17/16

摘要： The present invention relates to a novel N-acetylglucosamine-2-epimerase and a method for preparing CMP-N-acetylneuraminic acid, more specifically, relates to a N-acetylglucosamine-2-epimerase derived from Bacteroides fragilis NCTC 9343, and a method for preparing CMP-N-acetylneuraminic acid using said N-acetylglucosamine-2-epimerase. According to the present invention, CMP-N-acetylneuraminic acid can be produced economically in a large amount through a one-step reaction using cytidine monophosphate and N-acetyl-D-glucosamine which are inexpensive substrates.

摘要翻译： 本发明涉及一种新的N-乙酰葡糖胺-2-差向异构酶和一种制备CMP-N-乙酰神经氨酸的方法，更具体地涉及衍生自脆弱拟杆菌NCTC 9343的N-乙酰氨基葡萄糖-2-差向异构酶，以及一种用于 使用所述N-乙酰葡糖胺-2-差向异构酶制备CMP-N-乙酰神经氨酸。 根据本发明，通过使用作为便宜的底物的胞苷一磷酸和N-乙酰基-D-葡糖胺的一步反应，可以经济地生产CMP-N-乙酰神经氨酸。

公开(公告)号：US20110033904A1

公开(公告)日：2011-02-10

申请号：US12937876

申请日：2008-04-25

申请人： Jun Seong Park ,  Hye Yoon Park ,  Ho Sik Rho ,  Duck Hee Kim ,  Ih Seop Chang ,  Byung Gee Kim ,  Chang Hyun Roh ,  Su Hyun Seo ,  Kwon Young Choi ,  June Hyung Kim ,  Min-Ho Cha ,  Prasad Pandey Bishnu

发明人： Jun Seong Park ,  Hye Yoon Park ,  Ho Sik Rho ,  Duck Hee Kim ,  Ih Seop Chang ,  Byung Gee Kim ,  Chang Hyun Roh ,  Su Hyun Seo ,  Kwon Young Choi ,  June Hyung Kim ,  Min-Ho Cha ,  Prasad Pandey Bishnu

IPC分类号： C12P17/06

CPC分类号： C12P17/06 ,  C12N1/20

摘要： Disclosed herein is a method for preparing ortho-dihydroxyisoflavones using a biotransformation system. More specifically, disclosed is a method for preparing ortho-dihydroxyisoflavones, which comprises biotransforming daidzein or genistein by actinomycete microorganisms, particularly Streptomyces avermitilis, Nocardia farcinica or Streptomyces lincolnesis, in order to efficiently prepare ortho-dihydroxyisoflavones having an excellent antioxidant function and a whitening effect.

摘要翻译： 本文公开了使用生物转化体系制备邻二羟基异黄酮的方法。 更具体地，公开了一种制备邻二羟基异黄酮的方法，其包括通过放线菌微生物，特别是阿维链霉素（Streptomyces avermitilis），诺卡氏菌（Nocardia farcinica）或林链霉菌（Streptomyces lincolnesis））生物转化黄豆苷原或染料木黄酮，以有效制备具有优异抗氧化功能和增白效果的邻二羟基异黄酮 。

公开(公告)号：US20130084601A1

公开(公告)日：2013-04-04

申请号：US13704210

申请日：2011-06-14

申请人： Jun Seong Park ,  Duck Hee Kim ,  Han Kon Kim ,  Eun Mi Kim ,  Byung Gee Kim

发明人： Jun Seong Park ,  Duck Hee Kim ,  Han Kon Kim ,  Eun Mi Kim ,  Byung Gee Kim

IPC分类号： C12P33/00 ,  C12N9/00 ,  C12P17/06 ,  C12N1/20

CPC分类号： C12P33/20 ,  C12N1/20 ,  C12N9/0004 ,  C12P17/06 ,  C12P19/02 ,  C12P33/00 ,  C12R1/41 ,  Y02P20/52

摘要： The present invention relates to the novel Rhizobium sp. GIN611 KCTC11708BP or to cell extracts thereof, to a novel oxidoreductase which exhibits a glycolytic activity, to a gene encoding the oxidoreductase, to a recombinant strain comprising recombinant vector proteins or to an expression vector encoding recombinant proteins, and to a method for the glycolysis of natural products using same as a biocatalyst. The present invention also relates to a method for producing aglycones from a variety of natural products using same. The novel oxidoreductase separated from the novel microorganism of the present invention does not belong to a glucosidase group but belongs to an oxidoreductase group, and has a glycolytic activity for natural products. The novel oxidoreductase oxidizes the sugar in the aglycones of natural products, thereby producing a variety of aglycones.