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    Tryptamine compounds, and methods of cerebrovascular treatment therewith
    4.
    发明授权
    Tryptamine compounds, and methods of cerebrovascular treatment therewith 失效
    色胺化合物，以及脑血管治疗方法

    公开(公告)号：US4980368A

    公开(公告)日：1990-12-25

    申请号：US946387

    申请日：1986-12-23

    申请人： Dietrich Thielke ,  Dagmar Hoeltje

    发明人： Dietrich Thielke ,  Dagmar Hoeltje

    IPC分类号： C07D209/10 ,  A61K31/40 ,  A61K31/403 ,  A61K31/404 ,  A61P9/00 ,  C07D209/16 ,  C07D209/30 ,  C07D209/42

    CPC分类号： C07D209/42 ,  C07D209/16

    摘要： A compound of formula (I) or a pharmaceutically acceptable salt thereof: ##STR1## wherein: R.sub.1 is hydrogen, C.sub.1-6 alkyl, C.sub.1-6 alkoxy or halogen;R.sub.2 and R.sub.3 are both hydrogen or together represent a bond;R.sub.4 is selected from C.sub.1-6 alkyl, phenyl, phenyl C.sub.1-4 alkyl, COR.sub.8 where R.sub.8 is hydroxy, C.sub.1-6 alkoxy or NR.sub.9 R.sub.10 where R.sub.9 and R.sub.10 are independently hydrogen or C.sub.1-4 alkyl and CH.sub.2 OR.sub.11 and R.sub.11 is hydrogen, C.sub.1-4 alkyl or C.sub.1-4 alkanoyl;R.sub.5 is hydrogen, C.sub.1-6 alkyl or phenyl C.sub.1-4 alkyl;R.sub.6 is phenyl C.sub.1-7 alkyl in which the phenyl moiety is optionally substituted by one or two of halogen, ortho-nitro, meta- or para-methoxy, methyl or NR.sub.12 R.sub.13 wherein R.sub.12 and R.sub.13 are independently hydrogen or C.sub.1-6 alkyl or R.sub.12 and R.sub.13 together are C.sub.2-6 polymethylene or the phenyl moiety is 3,4-disubstituted by methylenedioxy or ethylenedioxy; andR.sub.7 is hydrogen or C.sub.1-4 alkyl, processes for its preparation and its use as a pharmaceutical.

    摘要翻译： 式（I）化合物或其药学上可接受的盐：其中：R 1是氢，C 1-6烷基，C 1-6烷氧基或卤素; R2和R3都是氢或一起代表键; R4选自C1-6烷基，苯基，苯基C1-4烷基，COR8，其中R8是羟基，C1-6烷氧基或NR9R10，其中R9和R10独立地是氢或C1-4烷基，CH2OR11和R11是氢，C1- 4烷基或C 1-4烷酰基; R5是氢，C1-6烷基或苯基C1-4烷基; R6是苯基C1-7烷基，其中苯基部分任选被一个或两个卤素，邻硝基，间位或对甲氧基，甲基或NR12R13取代，其中R12和R13独立地是氢或C1-6烷基或R12 和R 13一起是C2-6聚亚甲基或苯基部分被亚甲二氧基或亚乙二氧基3,4-二取代; 并且R 7是氢或C 1-4烷基，其制备及其用作药物的方法。