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    Antagonist and agonist which bind to a strong binding site of chemokine receptor
    1.
    发明申请
    Antagonist and agonist which bind to a strong binding site of chemokine receptor 审中-公开
    拮抗剂和激动剂，其结合趋化因子受体的强结合位点

    公开(公告)号：US20060251651A1

    公开(公告)日：2006-11-09

    申请号：US10538364

    申请日：2003-12-12

    申请人： Shiro Shibayama ,  Kenji Sagawa ,  Noriki Watanabe ,  Kazuhiko Takeda ,  Hideaki Tada ,  Daikichi Fukushima

    发明人： Shiro Shibayama ,  Kenji Sagawa ,  Noriki Watanabe ,  Kazuhiko Takeda ,  Hideaki Tada ,  Daikichi Fukushima

    IPC分类号： A61K39/395 ,  G01N33/567 ,  C07K16/28

    CPC分类号： A61K31/49 ,  A61K31/00 ,  A61K31/503 ,  A61K31/5377 ,  G01N2333/715 ,  G01N2500/04

    摘要： An antagonist or an agonist which binds to a strong binding site of CCR5; a preventive and/or therapeutic agent for an allergic disease, an inflammatory disease, an immune disease and/or a cancer which comprises the same; a method for screening a compound which binds to a strong binding site of CCR5; a preventive and/or therapeutic agent for an allergic disease, an inflammatory disease, an immune disease and/or a cancer which comprises the antagonist or the agonist selected by the screening method; an antagonist or an agonist which binds to a strong binding site of a chemokine receptor; a preventive and/or therapeutic agent for an allergic disease, an inflammatory disease, an immune disease and/or a cancer which comprises the same; a method for screening a compound which binds to a strong binding site of a chemokine receptor; and a preventive and/or therapeutic agent for an allergic disease, an inflammatory disease, an immune disease and/or a cancer which comprises the antagonist or the agonist selected by the screening method. The antagonist or the agonist of the present invention is useful as a preventive and/or therapeutic agent for an allergic disease, an inflammatory disease, an immune disease and/or a cancer.

    摘要翻译： 结合CCR5的强结合位点的拮抗剂或激动剂; 用于过敏性疾病，炎性疾病，免疫疾病和/或包含该疾病的癌症的预防和/或治疗剂; 用于筛选结合CCR5的强结合位点的化合物的方法; 包含通过筛选方法选择的拮抗剂或激动剂的过敏性疾病，炎性疾病，免疫疾病和/或癌症的预防和/或治疗剂; 结合趋化因子受体的强结合位点的拮抗剂或激动剂; 用于过敏性疾病，炎性疾病，免疫疾病和/或包含该疾病的癌症的预防和/或治疗剂; 用于筛选结合趋化因子受体的强结合位点的化合物的方法; 以及包含通过筛选方法选择的拮抗剂或激动剂的过敏性疾病，炎性疾病，免疫疾病和/或癌症的预防和/或治疗剂。 本发明的拮抗剂或激动剂可用作过敏性疾病，炎性疾病，免疫疾病和/或癌症的预防和/或治疗剂。

    Polypeptide, cDNA encoding the same and use of them
    2.
    发明授权
    Polypeptide, cDNA encoding the same and use of them 失效
    多肽，编码相同的cDNA并使用它们

    公开(公告)号：US07638281B2

    公开(公告)日：2009-12-29

    申请号：US11703200

    申请日：2007-02-07

    申请人： Daikichi Fukushima ,  Shiro Shibayama ,  Hideaki Tada

    发明人： Daikichi Fukushima ,  Shiro Shibayama ,  Hideaki Tada

    IPC分类号： C07H21/04 ,  C12N15/00 ,  C12N5/06

    CPC分类号： C07K14/47 ,  A61K38/00

    摘要： A new polypeptide prepared from human library by the SST method and a process for preparation of it; a cDNA encoding the polypeptide; a fragment selectively hybridizing with the sequence of the cDNA; a replication or expression plasmid containing the cDNA integrated thereinto; a host cell transformed with plasmid; an antibody against the polypeptide; and a pharmaceutical composition containing the polypeptide or the antibody.

    摘要翻译： 通过SST方法从人类文库制备的新多肽及其制备方法; 编码该多肽的cDNA; 选择性地与cDNA序列杂交的片段; 包含其中整合的cDNA的复制或表达质粒; 用质粒转化的宿主细胞; 抗多肽的抗体; 和含有多肽或抗体的药物组合物。

    Polypeptide, cDNA encoding the same, and use of them
    3.
    发明授权
    Polypeptide, cDNA encoding the same, and use of them 失效
    多肽，编码相同的cDNA，并使用它们

    公开(公告)号：US07189546B2

    公开(公告)日：2007-03-13

    申请号：US10414378

    申请日：2003-04-16

    申请人： Daikichi Fukushima ,  Shiro Shibayama ,  Hideaki Tada

    发明人： Daikichi Fukushima ,  Shiro Shibayama ,  Hideaki Tada

    IPC分类号： C07K14/47 ,  C12P21/02

    CPC分类号： C07K14/47 ,  A61K38/00

    摘要： A new polypeptide prepared from human library by the SST method and a process for preparation of it; a cDNA encoding the polypeptide; a fragment selectively hybridizing with the sequence of the cDNA; a replication or expression plasmid containing the cDNA integrated thereinto; a host cell transformed with plasmid; an antibody against the polypeptide; and a pharmaceutical composition containing the polypeptide or the antibody.

    摘要翻译： 通过SST方法从人类文库制备的新多肽及其制备方法; 编码该多肽的cDNA; 选择性地与cDNA序列杂交的片段; 包含其中整合的cDNA的复制或表达质粒; 用质粒转化的宿主细胞; 抗多肽的抗体; 和含有多肽或抗体的药物组合物。

    Polypeptide, cDNA encoding the same and use of them
    4.
    发明申请
    Polypeptide, cDNA encoding the same and use of them 失效
    多肽，编码相同的cDNA并使用它们

    公开(公告)号：US20080009056A1

    公开(公告)日：2008-01-10

    申请号：US11703200

    申请日：2007-02-07

    申请人： Daikichi Fukushima ,  Shiro Shibayama ,  Hideaki Tada

    发明人： Daikichi Fukushima ,  Shiro Shibayama ,  Hideaki Tada

    IPC分类号： C12N15/00 ,  C07H21/04 ,  C12N5/06

    CPC分类号： C07K14/47 ,  A61K38/00

    摘要： A new polypeptide prepared from human library by the SST method and a process for preparation of it; a cDNA encoding the polypeptide; a fragment selectively hybridizing with the sequence of the cDNA; a replication or expression plasmid containing the cDNA integrated thereinto; a host cell transformed with plasmid; an antibody against the polypeptide; and a pharmaceutical composition containing the polypeptide or the antibody.

    摘要翻译： 通过SST方法从人类文库制备的新多肽及其制备方法; 编码该多肽的cDNA; 选择性地与cDNA序列杂交的片段; 包含其中整合的cDNA的复制或表达质粒; 用质粒转化的宿主细胞; 抗多肽的抗体; 和含有多肽或抗体的药物组合物。

    Polypeptides, cDNA encoding the same and utilization thereof
    5.
    发明授权
    Polypeptides, cDNA encoding the same and utilization thereof 失效
    多肽，编码其的cDNA及其利用

    公开(公告)号：US06664383B1

    公开(公告)日：2003-12-16

    申请号：US09700397

    申请日：2000-11-14

    申请人： Daikichi Fukushima ,  Shiro Shibayama ,  Hideaki Tada

    发明人： Daikichi Fukushima ,  Shiro Shibayama ,  Hideaki Tada

    IPC分类号： C12Q168

    CPC分类号： C07K14/4702 ,  A61K38/00 ,  C07K14/47 ,  C12N9/6421

    摘要： A new human polypeptide, a cDNA encoding the same and a pharmaceutical use of it. The polypeptides of the present invention possess hematopoiesis regulating activity, tissue generation/regeneration activity, activin/inhibin activity, chemotactic/chemokinetic activity, hemostatic and thrombolytic activity, and receptor/ligand activity, therefore, they are expected to be useful for prevention and/or treatment of various diseases.

    摘要翻译： 新的人多肽，编码它的cDNA及其药学用途。本发明的多肽具有造血调节活性，组织产生/再生活性，激活素/抑制素活性，趋化性/动力学活性，止血和溶栓活性，以及 受体/配体活性，因此预期它们可用于预防和/或治疗各种疾病。

    Novel Polypeptide, cDNA Encoding the Same, and Use Thereof
    6.
    发明申请
    Novel Polypeptide, cDNA Encoding the Same, and Use Thereof 审中-公开
    新型多肽，编码它的cDNA及其用途

    公开(公告)号：US20100285527A1

    公开(公告)日：2010-11-11

    申请号：US12772617

    申请日：2010-05-03

    申请人： Daikichi FUKUSHIMA ,  Shiro Shibayama ,  Hideaki Tada

    发明人： Daikichi FUKUSHIMA ,  Shiro Shibayama ,  Hideaki Tada

    IPC分类号： C12P21/02 ,  C07K14/00 ,  C07H21/04 ,  C12N15/63 ,  C12N1/19

    CPC分类号： C07K14/705 ,  A61K38/00 ,  C07K14/4703

    摘要： Novel polypeptides produced by a human adult brain tissue, a cell line derived therefrom, a cell line derived from human bone marrow and a human umbilical cord venous endothelial cell line; a process for producing these polypeptides; cDNAs encoding the polypeptides; fragments hybridizable selectively with the cDNA sequences; replication or expression plasmids having the cDNAs integrated thereinto; host cells transformed by the plasmids; antibodies against the above polypeptides; and medicinal compositions containing the peptides or the antibodies.

    摘要翻译： 由人成人脑组织产生的新型多肽，源自其的细胞系，源自人骨髓的细胞系和人脐带静脉内皮细胞系; 一种生产这些多肽的方法; 编码多肽的cDNA; 片段可与cDNA序列选择性杂交; 具有整合cDNA的复制或表达质粒; 由质粒转化的宿主细胞; 针对上述多肽的抗体; 以及含有肽或抗体的药物组合物。

    Novel polypeptide, cDNA encoding the same, and use thereof
    7.
    发明申请
    Novel polypeptide, cDNA encoding the same, and use thereof 审中-公开
    新型多肽，编码其的cDNA及其用途

    公开(公告)号：US20070054310A1

    公开(公告)日：2007-03-08

    申请号：US11593037

    申请日：2006-11-06

    申请人： Daikichi Fukushima ,  Shiro Shibayama ,  Hideaki Tada

    发明人： Daikichi Fukushima ,  Shiro Shibayama ,  Hideaki Tada

    IPC分类号： C12Q1/68 ,  C07H21/04 ,  C12P21/06 ,  C07K14/705

    CPC分类号： C07K14/705 ,  A61K38/00 ,  C07K14/4703

    摘要： Novel polypeptides produced by a human adult brain tissue, a cell line derived therefrom, a cell line derived from human bone marrow and a human umbilical cord venous endothelial cell line; a process for producing these polypeptides; cDNAs encoding the polypeptides; fragments hybridizable selectively with the cDNA sequences; replication or expression plasmids having the cDNAs integrated thereinto; host cells transformed by the plasmids; antibodies against the above polypeptides; and medicinal compositions containing the peptides or the antibodies.

    摘要翻译： 由人成人脑组织产生的新型多肽，源自其的细胞系，源自人骨髓的细胞系和人脐带静脉内皮细胞系; 一种生产这些多肽的方法; 编码多肽的cDNA; 片段可与cDNA序列选择性杂交; 具有整合cDNA的复制或表达质粒; 由质粒转化的宿主细胞; 针对上述多肽的抗体; 以及含有肽或抗体的药物组合物。