公开(公告)号：US06528994B2

公开(公告)日：2003-03-04

申请号：US09941752

申请日：2001-08-30

申请人： Daisuke Suzuki ,  Atsushi Ninomiya ,  Tsuyoshi Miyashita ,  Akihiko Kandori ,  Keiji Tsukada ,  Koichi Yokosawa

发明人： Daisuke Suzuki ,  Atsushi Ninomiya ,  Tsuyoshi Miyashita ,  Akihiko Kandori ,  Keiji Tsukada ,  Koichi Yokosawa

IPC分类号： G01R3302

CPC分类号： G01R33/24

摘要： A magnetic field measuring apparatus has a magnetic field shielding apparatus including non-magnetic cylindrical members on which high-permeability sheets are located in a state of being partially overlapped with each other. The cylindrical members are located to surround an axis of a first direction concentrically and having a hollow portion, the cylindrical member located on an innermost-side having a first opening at one end of the first direction, a second opening at the other end of the first direction, and a third opening penetrating the cylindrical members in a direction perpendicular to the axis of the first direction. In addition, the magnetic field measuring apparatus has a living-body holder located in an inner-side space of the cylindrical member and a cryostat inserted into the third opening and maintaining SQUID magnetic-flux meters.

公开(公告)号：US06681131B2

公开(公告)日：2004-01-20

申请号：US09977213

申请日：2001-10-16

申请人： Akihiko Kandori ,  Tsuyoshi Miyashita ,  Daisuke Suzuki ,  Koichi Yokosawa ,  Keiji Tsukada

发明人： Akihiko Kandori ,  Tsuyoshi Miyashita ,  Daisuke Suzuki ,  Koichi Yokosawa ,  Keiji Tsukada

IPC分类号： A61B505

CPC分类号： A61B5/04007 ,  A61B5/7239 ,  A61B5/7285

摘要： An apparatus for measuring bio-magnetic fields includes a plurality of magnetometers for detecting magnetic fields generated from a live body; a driving circuit for driving the magnetometers; a computer for collecting output signals of the driving circuit in the form of data representing at least one waveform of the magnetic fields generated from the live body and for performing an arithmetic processing on the data representing the waveform of magnetic fields, a display unit, and at least one signal processing circuit for processing output signals of the driving circuit. The computer further performs an arithmetic processing of first-order differentiation on the waveform of the magnetic fields in a z direction with respect to time in order to create an arrow map and a contour map. The apparatus can also detect mechanical movement which occurs as blood flows in organs and organs move.

摘要翻译： 一种用于测量生物磁场的装置包括：用于检测从活体产生的磁场的多个磁力计; 用于驱动磁力计的驱动电路; 用于以表示从活体产生的磁场的至少一个波形的数据形式收集驱动电路的输出信号并且对表示磁场波形的数据执行算术处理的计算机，显示单元和 至少一个信号处理电路，用于处理驱动电路的输出信号。 计算机进一步对z方向上的磁场波形进行一阶微分的运算处理，以便产生箭头图和轮廓图。 该装置还可以检测器官和器官中的血液流动时发生的机械运动。

公开(公告)号：US06665552B2

公开(公告)日：2003-12-16

申请号：US09940507

申请日：2001-08-29

申请人： Koichi Yokosawa ,  Daisuke Suzuki ,  Keiji Tsukada ,  Tsuyoshi Miyashita ,  Akihiko Kandori

发明人： Koichi Yokosawa ,  Daisuke Suzuki ,  Keiji Tsukada ,  Tsuyoshi Miyashita ,  Akihiko Kandori

IPC分类号： A61B505

CPC分类号： G01R33/022 ,  G01R33/0358

摘要： A gradiometer integrating pickup coils comprises pickup coils 11Xp, 11Xn magnetically connected to a SQUID through associated input coils 2, and pickup coils 11Yp, 11Yn magnetically connected to a SQUID through associated input coils 2, respectively. Two superconducting loops are connected in series to each of the SQUIDs, when viewed from Josephson junctions 5. The input coils 2 form superconducting closed loops together with the pickup coils 11Xp, 11Xn, 11Yp, 11Yn associated therewith. The SQUIDs are respectively connected to form an 8-figured shape as a whole such that currents flow in two superconducting loops of each SQUID in opposite directions to each other, with respect to the application of a uniform field, in order to reduce environmental magnetic field noise.

公开(公告)号：US06745063B2

公开(公告)日：2004-06-01

申请号：US09940542

申请日：2001-08-29

申请人： Keiji Tsukada ,  Tsuyoshi Miyashita ,  Akihiko Kandori ,  Daisuke Suzuki ,  Koichi Yokosawa

发明人： Keiji Tsukada ,  Tsuyoshi Miyashita ,  Akihiko Kandori ,  Daisuke Suzuki ,  Koichi Yokosawa

IPC分类号： A61B505

CPC分类号： A61B5/04005 ,  A61B5/4064

摘要： A biomagnetic field measuring apparatus includes a plurality of SQUID magneto-meters for measuring a biomagnetic field generated from a living body, living-body signal measuring devices and for measuring and collecting living-body signals generated periodically, an operation processing device for operation processing the biomagnetic field signal and the living-body signal measured simultaneously as pairs in a plurality of directions, and a display unit for displaying a result of the operation processing. Change in time of excitation can be grasped in detail by using a small number of maps without presumption of a magnetic field source and display of many iso-magnetic field maps.

摘要翻译： 生物磁场测量装置包括多个用于测量从生物体产生的生物磁场的SQUID磁电表，生物体信号测量装置，以及用于测量和收集周期性生成的生物体信号的操作处理装置， 生物磁场信号和在多个方向上成对测量的生物体信号以及用于显示操作结果的显示单元。 可以通过使用少量地图来详细了解激发时间的变化，而不考虑磁场源和显示许多等磁场图。

公开(公告)号：US06815949B2

公开(公告)日：2004-11-09

申请号：US10162748

申请日：2002-06-06

申请人： Akihiko Kandori ,  Tsuyoshi Miyashita ,  Keiji Tsukada ,  Koichi Yokosawa ,  Daisuke Suzuki ,  Akira Tsukamoto

发明人： Akihiko Kandori ,  Tsuyoshi Miyashita ,  Keiji Tsukada ,  Koichi Yokosawa ,  Daisuke Suzuki ,  Akira Tsukamoto

IPC分类号： G01R33035

CPC分类号： G01R33/0356 ,  A61B5/04005 ,  A61B5/04007 ,  A61B5/04008 ,  A61B5/0522

摘要： An apparatus can detect a magnetic field with a high sensitivity using an ordinary-temperature pickup coil even when the pickup coil is arranged outside a cryostat. Specifically, the apparatus for measuring a magnetic field includes a pickup coil for detecting an external magnetic field, a SQUID electrically or magnetically connected to the pickup coil, a cryostat for holding the SQUID at low temperatures, and a driving device for driving the SQUID. The pickup coil is made of a normal-conducting material and is placed at an ordinary temperature outside the cryostat. By arranging outside the cryostat, the pickup coil can be brought close to a subject and can thereby detect a weak magnetic field in the subject with a high sensitivity.

公开(公告)号：US06853185B2

公开(公告)日：2005-02-08

申请号：US10844480

申请日：2004-05-13

申请人： Akira Tsukamoto ,  Koichi Yokosawa ,  Daisuke Suzuki ,  Akihiko Kandori ,  Keiji Tsukada

发明人： Akira Tsukamoto ,  Koichi Yokosawa ,  Daisuke Suzuki ,  Akihiko Kandori ,  Keiji Tsukada

IPC分类号： A61B5/05 ,  G01R33/025 ,  G01R33/035 ,  G01R33/02

CPC分类号： G01R33/0358 ,  G01R33/025

摘要： A magnetic field measurement system for canceling an external field is provided, in which plurality of sensing magnetometers (3) for measuring a magnetic field signal in a direction perpendicular to the center axis of a cylindrical magnetic shield (1) are arranged in two dimensions on a plane parallel to the center axis and a reference magnetometer (4) for measuring the external field parallel to the center axis as a reference signal is disposed on a plane perpendicular to the plane parallel to the center axis. The reference signal multiplied by a specified factor is subtracted from a difference between signals from the adjacent sensing magnetometers (3). The magnetic field measurement system allows measurement of an extremely weak magnetic field by efficiently canceling the external field.

摘要翻译： 提供了用于消除外部场的磁场测量系统，其中用于在与圆柱形磁屏蔽（1）的中心轴垂直的方向上测量磁场信号的多个感测磁力计（3）被二维地布置在 平行于中心轴的平面和用于测量与中心轴平行的外场作为参考信号的参考磁力计（4）设置在垂直于平行于中心轴的平面的平面上。 从相邻感测磁力计（3）的信号之间的差中减去乘以指定因子的参考信号。 磁场测量系统允许通过有效地消除外部场来测量极弱的磁场。

公开(公告)号：US06665553B2

公开(公告)日：2003-12-16

申请号：US10120406

申请日：2002-04-12

申请人： Akihiko Kandori ,  Tsuyoshi Miyashita ,  Keiji Tsukada ,  Masahiro Murakami

发明人： Akihiko Kandori ,  Tsuyoshi Miyashita ,  Keiji Tsukada ,  Masahiro Murakami

IPC分类号： A61B505

CPC分类号： A61B5/04009 ,  A61B5/04007 ,  A61B2562/02 ,  A61B2562/046 ,  G01R33/0354 ,  G06F19/00

摘要： A biomagnetic field measuring apparatus including: a plurality of magnetometers each employing a superconducting quantum interference device for measuring the magnetic field generated from an organism; a unit for calculating a pseudo-current from a normal component of the magnetic field; a unit for calculating the pseudo-current from the magnetic field obtained from the plurality of magnetometers to integrate the pseudo-current in a fixed direction on the circumference at a fixed distance from each of the associated ones of the sensors; a unit for calculating a maximum value or a minimum value of the integral value obtained by the unit for performing the integral; and a unit for calculating a difference value between the absolute value of the maximum value and the absolute value of the minimum value.

摘要翻译： 一种生物磁场测量装置，包括：多个磁力计，每个磁力计采用超导量子干涉装置来测量从生物体产生的磁场; 用于从磁场的正常分量计算伪电流的单元; 用于从所述多个磁力计获得的磁场计算所述伪电流以将固定方向上的所述伪电流与所述相关传感器中的每一个固定距离的圆周上积分的单元; 用于计算由用于执行积分的单元获得的积分值的最大值或最小值的单元; 以及用于计算最大值的绝对值和最小值的绝对值之间的差值的单元。

公开(公告)号：US06462540B1

公开(公告)日：2002-10-08

申请号：US09635450

申请日：2000-08-10

申请人： Akihiko Kandori ,  Tsuyoshi Miyashita ,  Keiji Tsukada

发明人： Akihiko Kandori ,  Tsuyoshi Miyashita ,  Keiji Tsukada

IPC分类号： G01R33035

CPC分类号： G01R33/025 ,  A61B5/0046 ,  A61B5/04005 ,  G01R33/0354 ,  Y10S505/846

摘要： A magnetic field measuring apparatus for precise cancellation of environmental noise includes a plurality of first SQUID gradiometers to detect noise and biomagnetic fields, a plurality of second SQUID gradiometers to detect noise, a driving circuit to drive these gradiometers, and a computer to execute signal processing after collecting the signals detected by these gradiometers. First and second SQUID gradiometers are provided which include first-order gradient pickup coils with the baselines formed by the coils of second gradiometers being shorter than those of first gradiometers. The apparatus cancels noise, from detected biomagnetic signal waveforms, caused by variant noise cancellation rates of the coils of first gradiometers, different baselines of the coils of second gradiometers, and the frequency property of a magnetically shielded room in which the apparatus is installed.

摘要翻译： 用于精确地消除环境噪声的磁场测量装置包括多个用于检测噪声和生物磁场的第一SQUID梯度计，用于检测噪声的多个第二SQUID梯度计，用于驱动这些梯度计的驱动电路以及计算机执行信号处理 收集这些梯度仪检测到的信号后。 提供了第一和第二SQUID梯度计，其包括一级梯度拾取线圈，其中由第二梯度仪的线圈形成的基线比第一梯度计的线圈短。 该装置从由第一梯度仪的线圈的不同噪声消除率，第二梯度仪的线圈的不同基线以及安装该装置的磁屏蔽室的频率特性引起的检测到的生物磁信号波形中消除噪声。

公开(公告)号：US07455648B2

公开(公告)日：2008-11-25

申请号：US10788377

申请日：2004-03-01

申请人： Akihiko Kandori ,  Tsuyoshi Miyashita ,  Keiji Tsukada ,  Kenko Uchida ,  Hideo Kawaguchi ,  Minoru Sakairi

发明人： Akihiko Kandori ,  Tsuyoshi Miyashita ,  Keiji Tsukada ,  Kenko Uchida ,  Hideo Kawaguchi ,  Minoru Sakairi

IPC分类号： A61B5/103 ,  A61B5/05

CPC分类号： A61B5/1101 ,  A61B5/4082 ,  A61B5/6824 ,  A61B5/6826 ,  A61B5/6828 ,  A61B5/6838 ,  A61B5/7239

摘要： A living body inspection apparatus including an oscillation coil which passes an AC current, a detection coil which detects an AC magnetic field generated from the detection coil, an amplification circuit which amplifies a voltage generated by the magnetic field induced by the detection coil, a detecting unit for detecting the output signal of the amplification circuit, a low pass filter to which the output signal of the detecting unit is input, a unit for setting the oscillation coil and detection coil in first and second regions of the living body, a recording unit for recording the output of the low pass filter while the first region and the second region of the living body are moving and a displaying unit for displaying the data recorded in the recording unit or results of analysis of the recorded data.

摘要翻译： 一种生物体检查装置，包括通过交流电流的振荡线圈，检测由检测线圈产生的交流磁场的检测线圈，放大电路，放大电路，放大由检测线圈感应出的磁场产生的电压， 用于检测放大电路的输出信号的单元，输入检测单元的输出信号的低通滤波器，用于在生物体的第一和第二区域设置振荡线圈和检测线圈的单元，记录单元 用于在活体的第一区域和第二区域移动时记录低通滤波器的输出，以及用于显示记录在记录单元中的数据的显示单元或记录数据的分析结果。

公开(公告)号：US20050065422A1

公开(公告)日：2005-03-24

申请号：US10788377

申请日：2004-03-01

申请人： Akihiko Kandori ,  Tsuyoshi Miyashita ,  Keiji Tsukada ,  Kenko Uchida ,  Hideo Kawaguchi ,  Minoru Sakairi

发明人： Akihiko Kandori ,  Tsuyoshi Miyashita ,  Keiji Tsukada ,  Kenko Uchida ,  Hideo Kawaguchi ,  Minoru Sakairi

IPC分类号： A61B5/05 ,  A61B5/11 ,  A61B5/00

CPC分类号： A61B5/1101 ,  A61B5/4082 ,  A61B5/6824 ,  A61B5/6826 ,  A61B5/6828 ,  A61B5/6838 ,  A61B5/7239

摘要： A living body inspection apparatus including an oscillation coil which passes an AC current, a detection coil which detects an AC magnetic field generated from the detection coil, an amplification circuit which amplifies a voltage generated by the magnetic field induced by the detection coil, a detecting unit for detecting the output signal of the amplification circuit, a low pass filter to which the output signal of the detecting unit is input, a unit for setting the oscillation coil and detection coil in first and second regions of the living body, a recording unit for recording the output of the low pass filter while the first region and the second region of the living body are moving and a displaying unit for displaying the data recorded in the recording unit or results of analysis of the recorded data.

摘要翻译： 一种生物体检查装置，包括通过交流电流的振荡线圈，检测由检测线圈产生的交流磁场的检测线圈，放大电路，放大电路，放大由检测线圈感应出的磁场产生的电压， 用于检测放大电路的输出信号的单元，输入检测单元的输出信号的低通滤波器，用于在生物体的第一和第二区域设置振荡线圈和检测线圈的单元;记录单元 用于在活体的第一区域和第二区域移动时记录低通滤波器的输出，以及用于显示记录在记录单元中的数据的显示单元或记录数据的分析结果。