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公开(公告)号：US08680483B2
公开(公告)日：2014-03-25
申请号：US13141127
申请日：2009-12-22
IPC分类号： G01J1/58
CPC分类号： G01N21/6452 , G01N2021/6421 , G01N2021/6441 , G01N2021/6478
摘要： A fluorescence detector in which a sample substrate is provided with a structure unit comprising a prism or a diffraction grating. After excitation light falling on the sample substrate is totally reflected at a biomolecule-immobilized face that is located in the opposite side of the structure unit, the structure unit allows the emission of the reflected light therefrom. To ensure multiple visual field measurement, a sample substrate-driving unit is provided to scan the sample substrate.
摘要翻译： 一种荧光检测器，其中样品基板设置有包括棱镜或衍射光栅的结构单元。 落在样品基板上的激发光在位于结构单元的相对侧的生物分子固定面全面反射，结构单元允许从其发射反射光。 为了确保多个视野测量，提供了样品基板驱动单元以扫描样品基板。
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公开(公告)号：US20140065704A1
公开(公告)日：2014-03-06
申请号：US14111036
申请日：2012-04-10
IPC分类号： C12M1/26
摘要： The present invention provides a simple and highly reliable cell collection system with high throughput and improved in cell collection efficiency. In the present invention, one or more pores are formed in a cell collection plate. One surface of the plate can be directly introduced in e.g., a petri dish, so as to be in contact with a solution containing cells. In this case, means for obtaining an optical image of collected cells from its rear surface is provided to improve reliability and convenience during a cell collection process. Alternatively, the vicinities of the pores in the cell collection plate are only hydrophilized and the other region is made water repellent to improve the efficiency of cell collection.
摘要翻译： 本发明提供了一种具有高通量并提高了细胞收集效率的简单且高度可靠的细胞收集系统。 在本发明中，在细胞收集板中形成一个以上的孔。 板的一个表面可以直接引入例如陪替氏培养皿中，以便与含有细胞的溶液接触。 在这种情况下，提供用于从其后表面获得收集的细胞的光学图像的装置，以提高细胞收集过程中的可靠性和便利性。 或者，细胞收集板中的孔附近仅被亲水化，另一区域被制成防水剂，以提高细胞收集的效率。
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公开(公告)号：US08293191B2
公开(公告)日：2012-10-23
申请号：US11675749
申请日：2007-02-16
CPC分类号： B01L3/0244 , B01F7/00258 , B01F11/0071 , B01F11/0258 , B01F13/0071 , B01L3/0251 , B01L3/0255 , B01L3/50 , B01L2300/0845 , B01L2300/089 , B01L2300/12 , G01N21/03 , G01N21/64 , G01N2021/0346 , G01N2021/035 , G01N2035/1037 , G01N2035/1046
摘要： The invention provides a method in which an annular or spiral droplet holder formed of wire is used to hold a droplet in a state of being hung therefrom or being contained therein. A means for moving the droplet holder is added to the droplet holder to enable droplet transfer. To merge two droplets, they are brought into contact. To drip the droplet held by a droplet holder formed of wire, the droplet holder is deformed using an external force. A light path which passes through a droplet is set to enable optical measurement. The present invention enables inexpensive, simple droplet transfer. An inexpensive, simple configuration for handling droplets in the fields of chemical analysis, biochemical analysis, and automatic blood analysis can be realized according to the present invention.
摘要翻译： 本发明提供一种方法，其中使用由线形成的环形或螺旋液滴保持器将其悬挂在其中或被容纳在其中的状态。 用于移动液滴保持器的装置被添加到液滴保持器以使液滴转移。 为了合并两个液滴，它们被接触。 为了滴落由线形成的液滴保持器保持的液滴，液滴保持器使用外力而变形。 设置通过液滴的光路以进行光学测量。 本发明可实现廉价的简单的液滴转印。 根据本发明，可以实现用于处理化学分析，生化分析和自动血液分析领域中的液滴的廉价，简单的构造。
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公开(公告)号：US08197751B2
公开(公告)日：2012-06-12
申请号：US12976031
申请日：2010-12-22
申请人： Hideyuki Noda , Satoshi Ozawa , Masahiro Okanojo , Kenko Uchida
发明人： Hideyuki Noda , Satoshi Ozawa , Masahiro Okanojo , Kenko Uchida
摘要： An apparatus includes a system for guiding chemiluminescence and a system for preventing a variation in dark currents. The apparatus includes a first light shielding BOX having a sample container holder and a shutter unit therein, the shutter unit including a top plate which is partly formed by a movement of a plate member, and a second light shielding BOX having a photodetector therein. While a measurement is not implemented, the shutter unit is closed to block entrance of stray light to the photodetector, and while a measurement is implemented, the plate member is moved to open the shutter unit, and the tip of the photodetector is inserted into a through hole formed in the top plate, so that the distance between the bottom of the sample container and a sensitive area of the photodetector is reduced to several millimeters or less.
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公开(公告)号：US20110091355A1
公开(公告)日：2011-04-21
申请号：US12976031
申请日：2010-12-22
申请人： Hideyuki NODA , Satoshi Ozawa , Masahiro Okanojo , Kenko Uchida
发明人： Hideyuki NODA , Satoshi Ozawa , Masahiro Okanojo , Kenko Uchida
IPC分类号： G01N21/76
摘要： An apparatus includes a system for guiding chemiluminescence and a system for preventing a variation in dark currents. The apparatus includes a first light shielding BOX having a sample container holder and a shutter unit therein, the shutter unit including a top plate which is partly formed by a movement of a plate member, and a second light shielding BOX having a photodetector therein. While a measurement is not implemented, the shutter unit is closed to block entrance of stray light to the photodetector, and while a measurement is implemented, the plate member is moved to open the shutter unit, and the tip of the photodetector is inserted into a through hole formed in the top plate, so that the distance between the bottom of the sample container and a sensitive area of the photodetector is reduced to several millimeters or less.
摘要翻译： 一种装置包括用于引导化学发光的系统和用于防止暗电流变化的系统。 该装置包括：第一遮光箱，其具有样本容器保持器和其中的快门单元，所述快门单元包括部分地由板构件的运动形成的顶板和在其中具有光电检测器的第二遮光箱。 虽然没有实现测量，但是快门单元被关闭以阻止杂散光入射到光电检测器，并且在实现测量的同时，移动板构件以打开快门单元，并且将光电检测器的末端插入到 通孔形成在顶板中，使得样品容器的底部与光电检测器的敏感区域之间的距离减小到几毫米或更小。
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公开(公告)号：US07879290B2
公开(公告)日：2011-02-01
申请号：US12034880
申请日：2008-02-21
申请人： Hideyuki Noda , Satoshi Ozawa , Masahiro Okanojo , Kenko Uchida
发明人： Hideyuki Noda , Satoshi Ozawa , Masahiro Okanojo , Kenko Uchida
摘要： An apparatus includes a system for guiding chemiluminescence and a system for preventing a variation in dark currents. The apparatus includes a first light shielding BOX having a sample container holder and a shutter unit therein, the shutter unit including a top plate which is partly formed by a movement of a plate member and a second light shielding BOX having a photodetector therein. While a measurement is not implemented, the shutter unit is closed to block entrance of stray light to the photodetector, and while a measurement is implemented, the plate member is moved to open the shutter unit, and the tip of the photodetector is inserted into a through hole formed in the top plate, so that the distance between the bottom of the sample container and a sensitive area of the photodetector is reduced to several millimeters or less.
摘要翻译： 一种装置包括用于引导化学发光的系统和用于防止暗电流变化的系统。 该装置包括：第一遮光盒，其具有样品容器保持器和其中的快门单元，所述快门单元包括顶板，该顶板部分地通过板构件的运动和在其中具有光电检测器的第二遮光箱而形成。 虽然没有实现测量，但是快门单元被关闭以阻止杂散光入射到光电检测器，并且在实现测量的同时，移动板构件以打开快门单元，并且将光电检测器的末端插入到 通孔形成在顶板中，使得样品容器的底部与光电检测器的敏感区域之间的距离减小到几毫米或更小。
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公开(公告)号：US20080239311A1
公开(公告)日：2008-10-02
申请号：US12051245
申请日：2008-03-19
CPC分类号： G01N21/6452 , G02B2207/113
摘要： In order to provide a fluorescence detection apparatus having a high sensitivity, a high processing capacity and a competitive edge in cost, the fluorescence detection apparatus according to this invention irradiate the sample with light so that the aspect ratio of the form of the irradiated region by light on the arrangement surface of the sample may be 1±0.1. The preferable form of irradiate region is not limited to one and varies to some extent depending on the item to be optimized. The form of irradiated region may be, for example, a circle, an equilateral triangle, a square, a regular hexagon and the like.
摘要翻译： 为了提供具有高灵敏度，高处理能力和成本方面的竞争优势的荧光检测装置，根据本发明的荧光检测装置用光照射样品，使得照射区域的形式的纵横比由 样品排列表面上的光可能为1±0.1。 照射区域的优选形式不限于一个，并且根据要优化的项目而在一定程度上变化。 照射区域的形式可以是例如圆形，等边三角形，正方形，正六边形等。
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公开(公告)号：US5523058A
公开(公告)日：1996-06-04
申请号：US240733
申请日：1994-05-12
申请人： Shinichiro Umemura , Kenichi Kawabata , Kenko Uchida , Kenji Yasuda , Yasuo Wada , Atsushi Hiraiwa
发明人： Shinichiro Umemura , Kenichi Kawabata , Kenko Uchida , Kenji Yasuda , Yasuo Wada , Atsushi Hiraiwa
CPC分类号： A61N7/02 , A61B17/22004 , A61N2007/006 , A61N2007/0078 , A61N2007/0095
摘要： By providing an ultrasonic irradiation apparatus for generating acoustic cavitation efficiently, it is intended to realize an ultrasonic therapeutic apparatus for generating the action of cavitation on a living body suitable for medical treatment of malignant tumors and medical treatment of thrombi and calculi, an ultrasonic diagnostic apparatus for generating cavitation for emphasizing an ultrasonic echo image such as a blood flow and utilizing the reflection capability of the cavitation, an ultrasonic chemical reaction accelerating apparatus, an ultrasonic cleaning apparatus or an ultrasonic sterilizing apparatus. Irradiation focus/code signals for defining irradiated acoustic fields of a fundamental wave and a second harmonic wave as well as focus positions/acoustic pressure distribution forms of the respective waves are applied from an irradiation unit main control circuit to drive phase generating circuits. Generated drive phases are applied to drive signal generating circuits, generated drive signals are applied to element drive circuits and a group of fundamental frequency elements and a group of second harmonic elements are driven. The drive phases are controlled such that the fundamental wave and second harmonic wave are superimposed on each other in a medium near a focal point, thus generating acoustic caviation locally and efficiently.
摘要翻译： PCT No.PCT / JP93 / 01310 Sec。 371日期：1994年5月12日 102（e）日期1994年5月12日PCT提交1993年9月14日PCT公布。 公开号WO94 / 06380 日期为1994年3月31日。通过提供用于有效产生声孔的超声波照射装置，旨在实现用于产生适于恶性肿瘤治疗的生物体上的空化作用的超声波治疗装置和血栓的治疗 和结石，用于产生用于强调超声波回波图像如血流并利用空化反射能力的超声波诊断装置，超声波化学反应加速装置，超声波清洗装置或超声波消毒装置。 用于定义基波和二次谐波的辐射声场以及各波的聚焦位置/声压分布形式的照射焦点/码信号从照射单元主控制电路施加到驱动相位产生电路。 产生的驱动相位被施加到驱动信号发生电路，所产生的驱动信号被施加到元件驱动电路，并且一组基频元件和一组二次谐波元件被驱动。 控制驱动相位使得基波和二次谐波在焦点附近的介质中彼此叠加，从而局部且有效地产生声空化。
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公开(公告)号：US5183744A
公开(公告)日：1993-02-02
申请号：US425028
申请日：1989-10-23
申请人： Yoshio Kawamura , Shinji Tanaka , Kazuo Sato , Kenko Uchida , Hiroyuki Kohida
发明人： Yoshio Kawamura , Shinji Tanaka , Kazuo Sato , Kenko Uchida , Hiroyuki Kohida
摘要： A method and an apparatus for the treatment of particles or biological cells are disclosed, wherein the particles or cells are precipitated or ascended depending on the specific gravity of a liquid used, and the particles or cells are handled with the aid of a holding plate. A method and an apparatus for the fusion of particles or cells are also disclosed, wherein an electric voltage is loaded on a position between electrodes in a microchamber to fuse the particles or cells held in the microchamber.
摘要翻译： 公开了一种用于处理颗粒或生物细胞的方法和装置，其中所述颗粒或细胞根据所用液体的比重而沉淀或上升，并且借助于保持板处理颗粒或细胞。 还公开了一种用于熔化颗粒或细胞的方法和装置，其中电压被加载在微室中的电极之间的位置，以熔化保持在微室中的颗粒或细胞。
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10.发明授权公开(公告)号：US09834806B2
公开(公告)日：2017-12-05
申请号：US13001465
申请日：2009-06-25
申请人： Hideyuki Noda , Masahiro Okanojo , Kenko Uchida , Norihito Kuno
发明人： Hideyuki Noda , Masahiro Okanojo , Kenko Uchida , Norihito Kuno
CPC分类号： C12Q1/008 , B01L3/502 , B01L2300/0681 , B01L2300/069 , B01L2300/1805 , B01L2400/0487 , G01N1/2208 , G01N1/2273
摘要： A disposable microbe-collecting carrier cartridge and a carrier treating apparatus which efficiently convert microbes collected on a carrier into a solution and prevent variations in the amount of retrieval of microbes upon concentration on a filter are provided. A cartridge formed of an upper lid having a plurality of through holes, a container in an inverted-cone shape having both of a liquid storage sink unit having a filter at the bottom and an air suction path, and a support base for setting up a thermoplastic carrier, and a carrier treating apparatus formed of a dispensing nozzle for liquid supply, a liquid supply mechanism, a liquid heating mechanism, and a suction pump for filtration are prepared. Warm water is supplied onto the filter set up on a bottom surface of the inverted-cone-shaped. The contact with the warm water causes the carrier to be solated filtered through the filter.
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