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    Method for producing thermoplastic copolymer
    3.
    发明授权
    Method for producing thermoplastic copolymer 失效
    生产热塑性共聚物的方法

    公开(公告)号：US08334349B2

    公开(公告)日：2012-12-18

    申请号：US13003253

    申请日：2009-07-07

    申请人： Taro Yamashita ,  Hajime Takamura

    发明人： Taro Yamashita ,  Hajime Takamura

    IPC分类号： C08F2/00 ,  C08F12/28 ,  C08F220/44 ,  C08G85/00

    CPC分类号： C08F2/06 ,  C08F2/001 ,  C08F2/01 ,  C08F212/10 ,  C08F220/42 ,  C08F279/04 ,  C08L55/02 ,  C09D155/02 ,  C08F2/22

    摘要： A thermoplastic copolymer having an excellent balance among properties such as coating resistance, color stability and fluidity and having high operability and productivity can be obtained by a method for producing a thermoplastic copolymer, comprising step (I) of supplying a monomer mixture (a) containing an aromatic vinyl monomer (a1) and a vinyl cyanide monomer (a2) to a complete mixing type reactor continuously to produce a copolymer (A) and step (II) of supplying the copolymer (A) continuously to a tubular reactor with a static mixing structure therein, which is placed in series with the complete mixing type reactor, and reacting the copolymer (A) to produce a copolymer (B).

    摘要翻译： 通过制造热塑性共聚物的方法可以获得具有耐涂层性，颜色稳定性和流动性等特性和具有高可操作性和生产率的性能之间优异平衡的热塑性共聚物，该方法包括供给单体混合物（a）的步骤（I） 将芳族乙烯基单体（a1）和乙烯基氰单体（a2）连续混合到完全混合型反应器中以产生共聚物（A）和将共聚物（A）连续供给到具有静态混合的管式反应器的步骤（II） 结构，其与完全混合型反应器串联放置，并使共聚物（A）反应生成共聚物（B）。

    Process for production of thermoplastic copolymer
    4.
    发明授权
    Process for production of thermoplastic copolymer 失效
    热塑性共聚物生产工艺

    公开(公告)号：US08258244B2

    公开(公告)日：2012-09-04

    申请号：US12919171

    申请日：2009-02-27

    申请人： Taro Yamashita ,  Hajime Takamura

    发明人： Taro Yamashita ,  Hajime Takamura

    IPC分类号： C08F2/00 ,  C08F12/28 ,  C08F14/06 ,  C08F12/02

    CPC分类号： C08F2/01 ,  C08F2/38 ,  C08F212/10 ,  C08F220/44 ,  C08F222/40

    摘要： Disclosed is a process for producing a thermoplastic copolymer, which comprises step of supplying a monomer mixture (a) to a loop reactor continuously to produce a copolymer (A), the monomer mixture (a) comprising an aromatic vinyl monomer (a1), a vinyl cyanide monomer (a2) and an N-substituted maleimide monomer (a3). The process enables the production of a thermoplastic copolymer which has an excellent balance among physical properties such as heat resistance, color and flow property, reduces the amount of bleeding that may cause mold staining during molding processing and has excellent handleability and productivity.

    摘要翻译： 公开了一种生产热塑性共聚物的方法，其包括将单体混合物（a）连续供给到环管反应器以制备共聚物（A）的步骤，包含芳族乙烯基单体（a1）的单体混合物（a） 乙烯基氰单体（a2）和N-取代马来酰亚胺单体（a3）。 该方法能够生产在诸如耐热性，颜色和流动性的物理性能之间具有优异平衡的热塑性共聚物，减少在模塑加工期间可能引起模子污染的渗色量，并且具有优异的可操作性和生产率。

    METHOD FOR PRODUCING THERMOPLASTIC COPOLYME
    5.
    发明申请
    METHOD FOR PRODUCING THERMOPLASTIC COPOLYME 失效
    生产热塑性共聚物的方法

    公开(公告)号：US20110118424A1

    公开(公告)日：2011-05-19

    申请号：US13003253

    申请日：2009-07-07

    申请人： Taro Yamashita ,  Seiichiro Murase ,  Hajime Takamura

    发明人： Taro Yamashita ,  Seiichiro Murase ,  Hajime Takamura

    IPC分类号： C08F2/01 ,  C08F220/44 ,  C08F220/42

    CPC分类号： C08F2/06 ,  C08F2/001 ,  C08F2/01 ,  C08F212/10 ,  C08F220/42 ,  C08F279/04 ,  C08L55/02 ,  C09D155/02 ,  C08F2/22

    摘要： A thermoplastic copolymer having an excellent balance among properties such as coating resistance, color stability and fluidity and having high operability and productivity can be obtained by a method for producing a thermoplastic copolymer, comprising step (I) of supplying a monomer mixture (a) containing an aromatic vinyl monomer (a1) and a vinyl cyanide monomer (a2) to a complete mixing type reactor continuously to produce a copolymer (A) and step (II) of supplying the copolymer (A) continuously to a tubular reactor with a static mixing structure therein, which is placed in series with the complete mixing type reactor, and reacting the copolymer (A) to produce a copolymer (B).

    摘要翻译： 通过制造热塑性共聚物的方法可以获得具有耐涂层性，颜色稳定性和流动性等特性和具有高可操作性和生产率的性能之间优异平衡的热塑性共聚物，该方法包括供给单体混合物（a）的步骤（I） 将芳族乙烯基单体（a1）和乙烯基氰单体（a2）连续混合到完全混合型反应器中以产生共聚物（A）和将共聚物（A）连续供给到具有静态混合的管式反应器的步骤（II） 结构，其与完全混合型反应器串联放置，并使共聚物（A）反应生成共聚物（B）。

    PROCESS FOR PRODUCTION OF THERMOPLASTIC COPOLYMER
    6.
    发明申请
    PROCESS FOR PRODUCTION OF THERMOPLASTIC COPOLYMER 失效
    生产热塑性共聚物的方法

    公开(公告)号：US20100324231A1

    公开(公告)日：2010-12-23

    申请号：US12919171

    申请日：2009-02-27

    申请人： Taro Yamashita ,  Hajime Takamura

    发明人： Taro Yamashita ,  Hajime Takamura

    IPC分类号： C08F2/01

    CPC分类号： C08F2/01 ,  C08F2/38 ,  C08F212/10 ,  C08F220/44 ,  C08F222/40

    摘要： Disclosed is a process for producing a thermoplastic copolymer, which comprises step of supplying a monomer mixture (a) to a loop reactor continuously to produce a copolymer (A), the monomer mixture (a) comprising an aromatic vinyl monomer (a1), a vinyl cyanide monomer (a2) and an N-substituted maleimide monomer (a3). The process enables the production of a thermoplastic copolymer which has an excellent balance among physical properties such as heat resistance, color and flow property, reduces the amount of bleeding that may cause mold staining during molding processing and has excellent handleability and productivity.

    摘要翻译： 公开了一种生产热塑性共聚物的方法，其包括将单体混合物（a）连续供给到环管反应器以制备共聚物（A）的步骤，包含芳族乙烯基单体（a1）的单体混合物（a） 乙烯基氰单体（a2）和N-取代马来酰亚胺单体（a3）。 该方法能够生产在诸如耐热性，颜色和流动性的物理性能之间具有优异平衡的热塑性共聚物，减少在模塑加工期间可能引起模子污染的渗色量，并且具有优异的可操作性和生产率。

    Josephson quantum computing device and integrated circuit using such devices
    7.
    发明申请
    Josephson quantum computing device and integrated circuit using such devices 有权
    约瑟夫森量子计算设备和使用这种设备的集成电路

    公开(公告)号：US20090261319A1

    公开(公告)日：2009-10-22

    申请号：US11658647

    申请日：2005-07-25

    申请人： Sadamichi Maekawa ,  Taro Yamashita ,  Saburo Takahshi

    发明人： Sadamichi Maekawa ,  Taro Yamashita ,  Saburo Takahshi

    IPC分类号： H01L39/22

    CPC分类号： G06N99/002 ,  B82Y10/00

    摘要： A Josephson quantum computing device and an integrated circuit using Josephson quantum computing devices which can realize a NOT gate operation controlled with 2 bits will be provided. The Josephson quantum computing device (1) comprises: a superconducting ring member (10) having a π-junction (6) and a 0-junction (7); and a quantum state detecting member (20) constituted by a superconducting quantum interference device arranged outside of the superconducting ring member, wherein a bonding and an antibonding state brought about by a tunneling effect between a |↑> and a |↓> state as two states degenerate in energy of the superconducting ring member (10) are regarded as quantum bits. The bonding and antibonding states as the quantum bits are read out by the quantum state detecting member (20). The two bit controlled NOT gate operation can be performed by the two quantum bits comprising said quantum bits.

    摘要翻译： 将提供约瑟夫森量子计算设备和使用约瑟夫森量子计算设备的集成电路，其可以实现以2位控制的非门操作。 约瑟夫森量子计算装置（1）包括：具有π结（6）和0结（7）的超导环构件（10）; 和由超导量子干涉元件构成的量子态检测元件（20），该超导量子干涉元件设置在超导环形元件外部，其中由|↑>↑>状态之间的隧道效应引起的接合和反应状态为二 超导环构件（10）的能量退化的状态被认为是量子位。 作为量子比特的键合反应状态由量子状态检测部件（20）读出。 两位控制的非门操作可以由包括所述量子位的两个量子位执行。

    Josephson quantum computing device and integrated circuit using such devices
    8.
    发明授权
    Josephson quantum computing device and integrated circuit using such devices 有权

    公开(公告)号：US08437168B2

    公开(公告)日：2013-05-07

    申请号：US13607516

    申请日：2012-09-07

    申请人： Sadamichi Maekawa ,  Taro Yamashita ,  Saburo Takahashi

    发明人： Sadamichi Maekawa ,  Taro Yamashita ,  Saburo Takahashi

    IPC分类号： G11C11/00

    CPC分类号： G06N99/002 ,  B82Y10/00

    摘要： A Josephson quantum computing device and an integrated circuit using Josephson quantum computing devices which can realize a NOT gate operation controlled with 2 bits will be provided. The Josephson quantum computing device (1) comprises: a superconducting ring member (10) having a π-junction (6) and a 0-junction (7); and a quantum state detecting member (20) constituted by a superconducting quantum interference device arranged outside of the superconducting ring member, wherein a bonding and an antibonding state brought about by a tunneling effect between a |↑> and a |↓> state as two states degenerate in energy of the superconducting ring member (10) are regarded as quantum bits. The bonding and antibonding states as the quantum bits are read out by the quantum state detecting member (20). The two bit controlled NOT gate operation can be performed by the two quantum bits comprising said quantum bits.

    Dna nanocage by self-organization of dna and process for producing the same, and dna nanotube and molecule carrier using the same
    9.
    发明申请
    Dna nanocage by self-organization of dna and process for producing the same, and dna nanotube and molecule carrier using the same 审中-公开
    通过dna的自组织和生产相同的方法，和dna纳米管和分子载体使用相同的纳米纳米颗粒

    公开(公告)号：US20050112578A1

    公开(公告)日：2005-05-26

    申请号：US10505551

    申请日：2003-03-06

    申请人： Kazunori Matsuura ,  Nobuo Kimizuka ,  Taro Yamashita

    发明人： Kazunori Matsuura ,  Nobuo Kimizuka ,  Taro Yamashita

    IPC分类号： C12N15/09 ,  A61K9/51 ,  C07H21/04 ,  C12N15/10 ,  C12Q1/68

    CPC分类号： C12N15/10 ,  A61K9/5115 ,  B82Y10/00 ,  B82Y30/00 ,  G11C13/025

    摘要： The invention provides a process for producing DNA nanocages, characterized by comprising a step of two-dimensionally assembling three types of oligonucleotides by hybridization to form tridirectionally branched double-strand DNA having self-complementary chains in the terminals, and a step of three-dimensionally self-organizing the resulting tridirectionally branched double-strand DNAs so as to consume all of the self-complementary terminals. Since the DNA nanocages according to the invention can easily be formed from DNAs by one-step procedure and include nanoparticles in the interior, the DNA nanocages are significantly effective for the development of functional materials using DNAs.

    摘要翻译： 本发明提供了一种生产DNA纳米笼的方法，其特征在于包括通过杂交二维组装三种类型的寡核苷酸的步骤，以形成在末端中具有自互补链的三向分支的双链DNA，以及三维 自组织得到的三向分支双链DNA，以便消耗所有的自互补末端。 由于根据本发明的DNA纳米笼可以通过一步法由DNA形成，并且在内部包括纳米颗粒，所以DNA纳米笼对于使用DNA开发功能材料是显着有效的。

    Detection of digestive organ cancer, gastric cancer, colorectal cancer, pancreatic cancer, and biliary tract cancer by gene expression profiling
    10.
    发明授权
    Detection of digestive organ cancer, gastric cancer, colorectal cancer, pancreatic cancer, and biliary tract cancer by gene expression profiling 有权
    通过基因表达谱检测消化器官癌，胃癌，结肠直肠癌，胰腺癌和胆道癌

    公开(公告)号：US08932990B2

    公开(公告)日：2015-01-13

    申请号：US13391858

    申请日：2010-08-03

    申请人： Shuichi Kaneko ,  Masao Honda ,  Yoshio Sakai ,  Taro Yamashita

    发明人： Shuichi Kaneko ,  Masao Honda ,  Yoshio Sakai ,  Taro Yamashita

    IPC分类号： C40B30/04 ,  C12Q1/68 ,  C40B40/06

    CPC分类号： C12Q1/6886 ,  C12Q2600/158 ,  C12Q2600/16

    摘要： The present invention provides a method and a reagent for detecting a digestive organ cancer, gastric cancer, colorectal cancer, pancreatic cancer, or biliary tract cancer patient by analyzing genes with expression levels (in peripheral blood) that vary in association with digestive organ cancer, gastric cancer, colorectal cancer, pancreatic cancer, or biliary tract cancer cases, compared with normal healthy subjects. Specifically, the method for detecting a digestive organ cancer, gastric cancer, colorectal cancer, pancreatic cancer, or biliary tract cancer patient based on expression profiles comprises obtaining the expression profile of at least one gene selected from the group consisting of probes corresponding to genes with expression levels (in peripheral blood) that vary in digestive organ cancer, gastric cancer, colorectal cancer, pancreatic cancer, and biliary tract cancer cases, compared with normal healthy subjects. The reagent for detecting digestive organ cancer, gastric cancer, colorectal cancer, pancreatic cancer, or biliary tract cancer contains nucleotides or partial sequences thereof consisting of the nucleotide sequence of at least one gene selected from the group consisting of probes with expression levels that vary in digestive organ cancer, gastric cancer, colorectal cancer, pancreatic cancer, or biliary tract cancer, or nucleotides containing sequences complementary thereto.

    摘要翻译： 本发明提供了通过分析与消化器官癌相关的变化的表达水平（外周血）的基因来检测消化器官癌，胃癌，结肠直肠癌，胰腺癌或胆道癌患者的方法和试剂， 胃癌，结肠直肠癌，胰腺癌或胆道癌，与正常健康人相比。 具体地，基于表达谱，检测消化器官癌，胃癌，结肠直肠癌，胰腺癌或胆道癌患者的方法包括获得至少一种基因的表达谱，所述基因选自对应于具有 与正常健康受试者相比，消化器官癌，胃癌，结肠直肠癌，胰腺癌和胆道癌患者的表达水平（外周血）差异不大。 用于检测消化器官癌，胃癌，结肠直肠癌，胰腺癌或胆道癌的试剂含有由至少一种基因的核苷酸序列组成的核苷酸或其部分序列，所述核苷酸序列选自下组的探针：表达水平在 消化器官癌，胃癌，结肠直肠癌，胰腺癌或胆道癌，或含有与其互补的序列的核苷酸。