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    Reagent and method for providing coatings on surfaces
    1.
    发明授权
    Reagent and method for providing coatings on surfaces 失效
    用于在表面上提供涂层的试剂和方法

    公开(公告)号：US08039524B2

    公开(公告)日：2011-10-18

    申请号：US12783907

    申请日：2010-05-20

    申请人： Ralph A. Chappa ,  Sean M. Stucke ,  Richard A. Amos ,  Terrence P. Everson ,  Stephen J. Chudzik ,  Pam Read, legal representative ,  Dale G. Swan ,  Peter H. Duquette

    发明人： Ralph A. Chappa ,  Sean M. Stucke ,  Richard A. Amos ,  Terrence P. Everson ,  Stephen J. Chudzik ,  Dale G. Swan ,  Peter H. Duquette

    IPC分类号： C08F2/50

    CPC分类号： B82Y30/00 ,  A61L27/34 ,  C09D4/00 ,  Y10S522/904 ,  Y10T428/249991 ,  Y10T428/249992 ,  C08F220/56 ,  C08F220/54

    摘要： A grafting reagent and related method of using the reagent to form a polymeric layer on a support surface, and particularly a porous support surface, in a manner that provides and/or preserves desired properties (such as porosity) of the surface. The reagent and method can be used to provide a thin, conformable, uniform, uncrosslinked coating having desired properties onto the surface of a preformed, and particularly a porous, polymeric substrate. The method includes the steps of a) providing a porous support surface, b) providing a nonpolymeric grafting reagent comprising a photoinitator group, c) providing one or more polymerizable monomers adapted to be contacted with the surface, in the presence of the grafting reagent, and to be polymerized upon activation of the photoinitiator; and d) applying the grafting reagent and monomer(s) to the surface in a manner, and under conditions, suitable to coat the surface with the grafting reagent and to cause the polymerization of monomers to the surface upon activation of the grafting reagent.

    摘要翻译： 以提供和/或保留表面的所需性质（例如孔隙率）的方式使用试剂在支撑表面上，特别是多孔载体表面上形成聚合物层的接枝试剂和相关方法。 试剂和方法可用于提供具有所需性质的薄的，一致的，均匀的未交联的涂层，其具有预先形成的，特别是多孔的聚合物基材的表面。 该方法包括以下步骤：a）提供多孔载体表面，b）提供包含光引发剂基团的非聚合物接枝剂，c）在接枝剂存在下，提供适于与表面接触的一种或多种可聚合单体， 并在激活光引发剂时聚合; 和d）以接枝试剂的方式和条件下将接枝试剂和单体施用于表面，并且在接枝试剂活化时使单体聚合成表面。

    REAGENT AND METHOD FOR PROVIDING COATINGS ON SURFACES
    3.
    发明申请
    REAGENT AND METHOD FOR PROVIDING COATINGS ON SURFACES 失效
    用于提供表面涂层的试剂和方法

    公开(公告)号：US20100240789A1

    公开(公告)日：2010-09-23

    申请号：US12783907

    申请日：2010-05-20

    申请人： Ralph A. Chappa ,  Sean M. Stucke ,  Richard A. Amos ,  Terrence P. Everson ,  Stephen J. Chudzik ,  Dale G. Swan ,  Peter H. Duquette

    发明人： Ralph A. Chappa ,  Sean M. Stucke ,  Richard A. Amos ,  Terrence P. Everson ,  Stephen J. Chudzik ,  Dale G. Swan ,  Peter H. Duquette

    IPC分类号： C08F2/46

    CPC分类号： B82Y30/00 ,  A61L27/34 ,  C09D4/00 ,  Y10S522/904 ,  Y10T428/249991 ,  Y10T428/249992 ,  C08F220/56 ,  C08F220/54

    摘要： A grafting reagent and related method of using the reagent to form a polymeric layer on a support surface, and particularly a porous support surface, in a manner that provides and/or preserves desired properties (such as porosity) of the surface. The reagent and method can be used to provide a thin, conformable, uniform, uncrosslinked coating having desired properties onto the surface of a preformed, and particularly a porous, polymeric substrate. The method includes the steps of a) providing a porous support surface, b) providing a nonpolymeric grafting reagent comprising a photoinitator group, c) providing one or more polymerizable monomers adapted to be contacted with the surface, in the presence of the grafting reagent, and to be polymerized upon activation of the photoinitiator; and d) applying the grafting reagent and monomer(s) to the surface in a manner, and under conditions, suitable to coat the surface with the grafting reagent and to cause the polymerization of monomers to the surface upon activation of the grafting reagent.

    摘要翻译： 以提供和/或保留表面的所需性质（例如孔隙率）的方式使用试剂在支撑表面上，特别是多孔载体表面上形成聚合物层的接枝试剂和相关方法。 试剂和方法可用于提供具有所需性质的薄的，一致的，均匀的未交联的涂层，其具有预先形成的，特别是多孔的聚合物基材的表面。 该方法包括以下步骤：a）提供多孔载体表面，b）提供包含光引发剂基团的非聚合物接枝剂，c）在接枝剂存在下，提供适于与表面接触的一种或多种可聚合单体， 并在激活光引发剂时聚合; 和d）以接枝试剂的方式和条件下将接枝试剂和单体施用于表面，并且在接枝试剂活化时使单体聚合成表面。

    Reagent and method for providing coatings on surfaces
    5.
    发明授权
    Reagent and method for providing coatings on surfaces 有权
    用于在表面上提供涂层的试剂和方法

    公开(公告)号：US07348055B2

    公开(公告)日：2008-03-25

    申请号：US10028518

    申请日：2001-12-21

    申请人： Ralph A. Chappa ,  Sean M. Stucke ,  Richard A. Amos ,  Terrence P. Everson ,  Stephen J. Chudzik ,  Dale G. Swan ,  Peter H. Duquette

    发明人： Ralph A. Chappa ,  Sean M. Stucke ,  Richard A. Amos ,  Terrence P. Everson ,  Stephen J. Chudzik ,  Dale G. Swan ,  Peter H. Duquette

    IPC分类号： B32B27/00

    CPC分类号： B82Y30/00 ,  A61L27/34 ,  C09D4/00 ,  Y10S522/904 ,  Y10T428/249991 ,  Y10T428/249992 ,  C08F220/56 ,  C08F220/54

    摘要： A grafting reagent and related method of using the reagent to form a polymeric layer on a support surface, and particularly a porous support surface, in a manner that provides and/or preserves desired properties (such as porosity) of the surface. The reagent and method can be used to provide a thin, conformable, uniform, uncrosslinked coating having desired properties onto the surface of a preformed, and particularly a porous, polymeric substrate. The method includes the steps of a) providing a porous support surface, b) providing a nonpolymeric grafting reagent comprising a photoinitator group, c) providing one or more polymerizable monomers adapted to be contacted with the surface, in the presence of the grafting reagent, and to be polymerized upon activation of the photoinitiator; and d) applying the grafting reagent and monomer(s) to the surface in a manner, and under conditions, suitable to coat the surface with the grafting reagent and to cause the polymerization of monomers to the surface upon activation of the grafting reagent.

    摘要翻译： 以提供和/或保留表面的所需性质（例如孔隙率）的方式使用试剂在支撑表面上，特别是多孔载体表面上形成聚合物层的接枝试剂和相关方法。 试剂和方法可用于提供具有所需性质的薄的，一致的，均匀的未交联的涂层，其具有预先形成的，特别是多孔的聚合物基材的表面。 该方法包括以下步骤：a）提供多孔载体表面，b）提供包含光引发剂基团的非聚合物接枝剂，c）在接枝剂存在下，提供适于与表面接触的一种或多种可聚合单体， 并在激活光引发剂时聚合; 和d）以接枝试剂的方式和条件下将接枝试剂和单体施用于表面，并且在接枝试剂活化时使单体聚合成表面。

    REAGENT AND METHOD FOR PROVIDING COATINGS ON SURFACES
    6.
    发明申请
    REAGENT AND METHOD FOR PROVIDING COATINGS ON SURFACES 审中-公开
    用于提供表面涂层的试剂和方法

    公开(公告)号：US20120004339A1

    公开(公告)日：2012-01-05

    申请号：US13234270

    申请日：2011-09-16

    申请人： Ralph A. Chappa ,  Sean M. Stucke ,  Richard A. Amos ,  Terrence P. Everson ,  Stephen J. Chudzik ,  Dale G. Swan ,  Peter H. Duquette

    发明人： Ralph A. Chappa ,  Sean M. Stucke ,  Richard A. Amos ,  Terrence P. Everson ,  Stephen J. Chudzik ,  Dale G. Swan ,  Peter H. Duquette

    IPC分类号： C08F8/00

    CPC分类号： B82Y30/00 ,  A61L27/34 ,  C09D4/00 ,  Y10S522/904 ,  Y10T428/249991 ,  Y10T428/249992 ,  C08F220/56 ,  C08F220/54

    摘要： A grafting reagent and related method of using the reagent to form a polymeric layer on a support surface, and particularly a porous support surface, in a manner that provides and/or preserves desired properties (such as porosity) of the surface. The reagent and method can be used to provide a thin, conformable, uniform, uncrosslinked coating having desired properties onto the surface of a preformed, and particularly a porous, polymeric substrate. The method includes the steps of a) providing a porous support surface, b) providing a nonpolymeric grafting reagent comprising a photoinitator group, c) providing one or more polymerizable monomers adapted to be contacted with the surface, in the presence of the grafting reagent, and to be polymerized upon activation of the photoinitiator; and d) applying the grafting reagent and monomer(s) to the surface in a manner, and under conditions, suitable to coat the surface with the grafting reagent and to cause the polymerization of monomers to the surface upon activation of the grafting reagent.

    摘要翻译： 以提供和/或保留表面的所需性质（例如孔隙率）的方式使用试剂在支撑表面上，特别是多孔载体表面上形成聚合物层的接枝试剂和相关方法。 试剂和方法可用于提供具有所需性质的薄的，一致的，均匀的未交联的涂层，其具有预先形成的，特别是多孔的聚合物基材的表面。 该方法包括以下步骤：a）提供多孔载体表面，b）提供包含光引发剂基团的非聚合物接枝剂，c）在接枝剂存在下，提供适于与表面接触的一种或多种可聚合单体， 并在激活光引发剂时聚合; 和d）以接枝试剂的方式和条件下将接枝试剂和单体施用于表面，并且在接枝试剂活化时使单体聚合成表面。

    Reagent and method for providing coatings on surfaces
    7.
    发明授权
    Reagent and method for providing coatings on surfaces 失效
    用于在表面上提供涂层的试剂和方法

    公开(公告)号：US07736689B2

    公开(公告)日：2010-06-15

    申请号：US11846955

    申请日：2007-08-29

    申请人： Ralph A. Chappa ,  Sean M. Stucke ,  Richard A. Amos ,  Terrence P. Everson ,  Stephen J. Chudzik ,  Dale G. Swan ,  Peter H. Duquette

    发明人： Ralph A. Chappa ,  Sean M. Stucke ,  Richard A. Amos ,  Terrence P. Everson ,  Stephen J. Chudzik ,  Dale G. Swan ,  Peter H. Duquette

    IPC分类号： A61L33/00

    CPC分类号： B82Y30/00 ,  A61L27/34 ,  C09D4/00 ,  Y10S522/904 ,  Y10T428/249991 ,  Y10T428/249992 ,  C08F220/56 ,  C08F220/54

    摘要： A grafting reagent and related method of using the reagent to form a polymeric layer on a support surface, and particularly a porous support surface, in a manner that provides and/or preserves desired properties (such as porosity) of the surface. The reagent and method can be used to provide a thin, conformable, uniform, uncrosslinked coating having desired properties onto the surface of a preformed, and particularly a porous, polymeric substrate. The method includes the steps of a) providing a porous support surface, b) providing a nonpolymeric grafting reagent comprising a photoinitator group, c) providing one or more polymerizable monomers adapted to be contacted with the surface, in the presence of the grafting reagent, and to be polymerized upon activation of the photoinitiator; and d) applying the grafting reagent and monomer(s) to the surface in a manner, and under conditions, suitable to coat the surface with the grafting reagent and to cause the polymerization of monomers to the surface upon activation of the grafting reagent.

    摘要翻译： 以提供和/或保留表面的所需性质（例如孔隙率）的方式使用试剂在支撑表面上，特别是多孔载体表面上形成聚合物层的接枝试剂和相关方法。 试剂和方法可用于提供具有所需性质的薄的，一致的，均匀的未交联的涂层，其具有预先形成的，特别是多孔的聚合物基材的表面。 该方法包括以下步骤：a）提供多孔载体表面，b）提供包含光引发剂基团的非聚合物接枝剂，c）在接枝剂存在下，提供适于与表面接触的一种或多种可聚合单体， 并在激活光引发剂时聚合; 和d）以接枝试剂的方式和条件下将接枝试剂和单体施用于表面，并且在接枝试剂活化时使单体聚合成表面。

    Photoactivatable water soluble cross-linking agents containing an onium group
    8.
    发明授权
    Photoactivatable water soluble cross-linking agents containing an onium group 失效
    含有鎓基的可光活化的水溶性交联剂

    公开(公告)号：US5714360A

    公开(公告)日：1998-02-03

    申请号：US552758

    申请日：1995-11-03

    申请人： Dale G. Swan ,  Richard A. Amos ,  Terrence P. Everson

    发明人： Dale G. Swan ,  Richard A. Amos ,  Terrence P. Everson

    IPC分类号： C12N11/06 ,  C07B61/00 ,  C07C45/63 ,  C07C225/16 ,  C07C309/14 ,  C07D295/10 ,  C07D295/112 ,  C07D487/18 ,  C07K17/06 ,  C08J3/24 ,  C09K3/00 ,  G01N33/543 ,  C12N11/00 ,  C07C49/76 ,  G01N33/549

    CPC分类号： C07D295/112 ,  C07C225/16 ,  C07C309/14 ,  C07C45/63 ,  C07K17/06 ,  G01N33/54353 ,  Y10S530/81 ,  Y10S530/816

    摘要： A chemical linking agent is formed of a di- or higher functional photoactivatable compound having at least one group that is charged under the conditions of use in order to provide improved water solubility. The linking agent contains two or more photoreactive groups in order to allow the agent to be used as a cross-linking agent in aqueous systems. The charged group can be provided by a radical that includes one or more salts of organic acids, onium compounds, or protonated amines, (and optionally one or more additional photoreactive groups) and the photoreactive groups can be provided by two or more radicals that include an aryl ketone. The onium compound can provide a quaternary ammonium, sulfonium or phosphonium group. A surface can be coated with a target molecule such as a synthetic polymer, carbohydrate, protein, lipid, nucleic acid, drug, vitamin, cofactor or dye by forming an aqueous solution of the linking agent and the target molecule, placing the solution in contact with the surface and activating the photoreactive groups of the linking agent to cross-link the target molecule to the surface.

    摘要翻译： 化学连接剂由具有至少一个在使用条件下带电的至少一个基团的二官能或更高官能的可光活化化合物形成，以提供改善的水溶性。 连接剂含有两种或更多种光反应性基团，以使该试剂在水性体系中用作交联剂。 带电基团可以由包括一种或多种有机酸，鎓化合物或质子化胺盐（以及任选的一种或多种另外的光反应性基团）的基团提供，并且光反应性基团可以由两个或更多个基团提供，所述基团包括 芳基酮。 鎓化合物可以提供季铵，锍或鏻基团。 通过形成连接剂和目标分子的水溶液，可以用靶分子如合成聚合物，碳水化合物，蛋白质，脂质，核酸，药物，维生素，辅因子或染料涂覆表面，将溶液接触 并且激活连接剂的光反应性基团以使靶分子与表面交联。

    Photoactivatable cross-linking agents containing charged groups for water solubility
    9.
    发明授权
    Photoactivatable cross-linking agents containing charged groups for water solubility 失效
    含有电荷基团的可光活化交联剂用于水溶性

    公开(公告)号：US6077698A

    公开(公告)日：2000-06-20

    申请号：US2457

    申请日：1998-01-02

    申请人： Dale G. Swan ,  Richard A. Amos ,  Terrence P. Everson

    发明人： Dale G. Swan ,  Richard A. Amos ,  Terrence P. Everson

    IPC分类号： C12N11/06 ,  C07B61/00 ,  C07C45/63 ,  C07C225/16 ,  C07C309/14 ,  C07D295/10 ,  C07D295/112 ,  C07D487/18 ,  C07K17/06 ,  C08J3/24 ,  C09K3/00 ,  G01N33/543 ,  C12N11/00 ,  C07C49/76 ,  G01N33/549

    CPC分类号： C07D295/112 ,  C07C225/16 ,  C07C309/14 ,  C07C45/63 ,  C07K17/06 ,  G01N33/54353 ,  Y10S530/81 ,  Y10S530/816

    摘要： A chemical linking agent is formed of a di- or higher functional photoactivatable compound having at least one group that is charged to improve water solubility, and two or more photoreactive groups (preferably comprising an aryl ketone such as benzophenone) that allow use of the agent in aqueous systems. Charged groups include salts of organic acids such as sulfonate, phosphonate and carboxylate groups, onium groups such as quaternary ammonium, sulfonium and phosphonium groups, and protonated amines. A surface can be coated with a substance such as a synthetic polymer, carbohydrate, protein, lipid, nucleic acid, drug, vitamin, cofactor or dye by forming an aqueous solution of the linking agent and the substance, placing the solution in contact with the surface and activating the photoreactive groups of the linking agent to cross-link the substance to the surface.

    摘要翻译： 化学连接剂由具有至少一个被加入以改善水溶性的基团的二官能或更高官能的可光活化化合物形成，以及允许使用该试剂的两种或多种光反应性基团（优选包含芳基酮如二苯甲酮） 在水系统中。 带电基团包括有机酸的盐，例如磺酸盐，膦酸盐和羧酸盐基团，鎓基团如季铵盐，锍盐和鏻基团以及质子化胺。 通过形成连接剂和物质的水溶液，将表面与合成聚合物，碳水化合物，蛋白质，脂质，核酸，药物，维生素，辅因子或染料等物质包衣，将溶液与 表面并活化连接剂的光反应性基团以使物质与表面交联。