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公开(公告)号：US5646042A
公开(公告)日：1997-07-08
申请号：US373124
申请日：1995-01-13
IPC分类号： C12N15/09 , A61K31/35 , A61K31/47 , A61K31/70 , A61K35/76 , A61K38/00 , A61K48/00 , A61P9/08 , A61P35/00 , C07H21/04 , C07K14/47 , C12N5/10 , C12N9/00 , C12N9/64 , C12N15/113 , C12R1/91 , C12N5/22 , C12N5/16 , C12N9/22 , C12Q1/68
CPC分类号： C12N15/113 , C07K14/4702 , C12N15/1135 , C12N15/1136 , C12N15/1137 , C12N15/1138 , C12N9/6491 , A61K38/00 , A61K48/00 , C12N2310/111 , C12N2310/121 , C12N2310/122 , C12N2310/123 , C12N2310/124 , C12N2310/126 , C12N2310/315 , C12N2310/317 , C12N2310/321 , C12N2310/322 , C12N2310/332 , C12N2310/335 , C12N2310/3517
摘要： Enzymatic nucleic acid molecules which cleave c-myb RNA or other RNAs associated with restenosis or cancer.
摘要翻译： 切割c-myb RNA或与再狭窄或癌症相关的其他RNA的酶学核酸分子。
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公开(公告)号：US5817796A
公开(公告)日：1998-10-06
申请号：US435628
申请日：1995-05-05
IPC分类号： C12N15/09 , A61K31/35 , A61K31/47 , A61K31/70 , A61K35/76 , A61K38/00 , A61K48/00 , A61P9/08 , A61P35/00 , C07H21/04 , C07K14/47 , C12N5/10 , C12N9/00 , C12N9/64 , C12N15/113 , C12R1/91 , C12Q1/68
CPC分类号： C12N15/113 , C07K14/4702 , C12N15/1135 , C12N15/1136 , C12N15/1137 , C12N15/1138 , C12N9/6491 , A61K38/00 , A61K48/00 , C12N2310/111 , C12N2310/121 , C12N2310/122 , C12N2310/123 , C12N2310/124 , C12N2310/126 , C12N2310/315 , C12N2310/317 , C12N2310/321 , C12N2310/322 , C12N2310/332 , C12N2310/335 , C12N2310/3517
摘要： Enzymatic nucleic acid molecules which cleave c-myb RNA or other RNAs associated with restenosis or cancer.
摘要翻译： 切割c-myb RNA或与再狭窄或癌症相关的其他RNA的酶学核酸分子。
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公开(公告)号：US5811300A
公开(公告)日：1998-09-22
申请号：US311486
申请日：1994-09-23
IPC分类号： A61K38/00 , A61K48/00 , C07K14/47 , C12N9/64 , C12N15/10 , C12N15/113 , C12N15/85 , C12Q1/68
CPC分类号： C07K14/4702 , C12N15/101 , C12N15/113 , C12N15/1131 , C12N15/1135 , C12N15/1136 , C12N15/1137 , C12N15/1138 , C12N9/6491 , A61K38/00 , A61K48/00 , C12N2310/111 , C12N2310/121 , C12N2310/122 , C12N2310/123 , C12N2310/1241 , C12N2310/126 , C12N2310/127 , C12N2310/32 , C12N2310/322 , C12N2310/333 , C12N2310/334 , C12N2310/335 , C12N2310/336 , C12N2310/3513 , C12N2310/3523 , C12N2310/3527 , C12N2310/3533 , C12N2310/3535
摘要： Enzymatic RNA molecules which cleave TNF-.alpha. mRNA.
摘要翻译： 切割TNF-αmRNA的酶RNA分子。
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公开(公告)号：US5693532A
公开(公告)日：1997-12-02
申请号：US334847
申请日：1994-11-04
申请人： James McSwiggen , Kenneth Draper , Pam Pavco , Tod Woolf
发明人： James McSwiggen , Kenneth Draper , Pam Pavco , Tod Woolf
CPC分类号： C12N15/113 , C12N15/101 , C12N15/1131 , C12N15/1136 , C12N15/1138 , A61K38/00 , A61K48/00 , C12N2310/111 , C12N2310/121 , C12N2310/122 , C12N2310/123 , C12N2310/1241 , C12N2310/126 , C12N2310/127 , C12N2310/32 , C12N2310/322 , C12N2310/333 , C12N2310/334 , C12N2310/335 , C12N2310/336 , C12N2310/3513 , C12N2310/3523 , C12N2310/3527 , C12N2310/3533 , C12N2310/3535
摘要： An enzymatic RNA molecule which cleaves respiratory syncytial virus (RSV) genomic and RSV encoded RNA.
摘要翻译： 一种切断呼吸道合胞病毒（RSV）基因组和RSV编码RNA的酶RNA分子。
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5.发明授权
公开(公告)号：US5442049A
公开(公告)日：1995-08-15
申请号：US9263
申请日：1993-01-25
申请人： Kevin Anderson , Kenneth Draper , Brenda Baker
发明人： Kevin Anderson , Kenneth Draper , Brenda Baker
IPC分类号： A61K38/00 , C12N15/113 , C07H21/04 , A61K48/00
CPC分类号： A61K31/711 , C12N15/1133 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/322
摘要： Compositions and methods for modulating the effects of cytomegalovirus (CMV) infections are disclosed, comprising contacting CMV mRNA with an oligonucleotide which can bind with at least portions of the CMV RNA. In accordance with the preferred embodiments, oligonucleotides such as ISIS 2922 are designed to bind with portions of the CMV mRNAs which code for the IE1, IE2 or DNA polymerase proteins. In accordance with a preferred embodiment, methods of treatment of human cytomegalovirus are disclosed.
摘要翻译： 公开了用于调节巨细胞病毒（CMV）感染的作用的组合物和方法，包括使CMV mRNA与可以与CMV RNA的至少一部分结合的寡核苷酸接触。 根据优选的实施方案，设计诸如ISIS 2922的寡核苷酸与编码IE1，IE2或DNA聚合酶蛋白的部分CMV mRNA结合。 根据优选实施方案，公开了治疗人巨细胞病毒的方法。
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